6LST


Conserved Protein Domain Family
Uso1_p115_head

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pfam04869: Uso1_p115_head (This model is not part of the current CDD release)
Uso1 / p115 like vesicle tethering protein, head region
Also known as General vesicular transport factor, Transcytosis associated protein (TAP) and Vesicle docking protein, this myosin-shaped molecule consists of an N-terminal globular head region, a coiled-coil tail which mediates dimerization, and a short C-terminal acidic region. p115 tethers COP1 vesicles to the Golgi by binding the coiled coil proteins giantin (on the vesicles) and GM130 (on the Golgi), via its C-terminal acidic region. It is required for intercisternal transport in the golgi stack. This family consists of part of the head region. The head region is highly conserved, but its function is unknown. It does not seem to be essential for vesicle tethering. The N-terminal part of the head region, not within this family, contains context-detected Armadillo/beta-catenin-like repeats (pfam00514).
Statistics
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PSSM-Id: 516481
Aligned: 73 rows
Threshold Bit Score: 186.255
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6LST_A        371 HAQLEFSKIDVpyf--dpsLPVNSTANGGP--I--KlIPVVSILINWML----YANSVHTFDT----------RVACSRL 430  Saccharomyces...
XP_065994599  349 NGQEYLAKTVVpvphpsqsSENDAKSSSYDqiLipP-RPAVMSLIVVAV----GAEYLESYST----------RAAATYA 413 
EPB81545      347 DNQLMLGKIVVacppvlnqdgqi-----danvapgiprpaMVSLISIAVnedrGVS--YSYSS----------RAAATYA 409 
XP_006682236  362 VNQETFGKSVItvvtrpehvgvs--------nqkqspgaprpsIISIIL----VAMGRDHISI----------RAAATYI 419 
XP_004365674  407 aSQDAFAQCRVsvngai--------------------vatplALLFAML------EPRRAFAE----------RSAALYL 450 
KAF8375288    342 TNQEYFASTSLetedg------------------gvrpsLIVLLVS-------MISEKQPFKL----------RCAVFYC 386 
XP_002634196  422 TNQELFASTVIdnged------------------gprssLVVLLLS-------MNAEKQTYKL----------RCAVFYC 466 
5_pfamImport    3 HNQQYFSS--Leapve------------------ppkslLVLLVMS-------MVDEKQCFDL----------RCAILYC 45  
Q17BY2        351 NNQEYFNS--Vmapsn------------------pprpaLIVLLMS-------MVNEKQPLPL----------RCAVLYC 393  yellow fever ...
XP_009267224  328 QNQHLFTHSQTqp-----iLNSEAYAAGYL--KlpP-RLATISLIDIALngesGDENRMVDDVdslkghnlmlQVAALTA 399 
6LST_A        431 LKAYFMDNFDLQRDFLL------------KQVQLCNNStnnvgdnakenggsnksdkesdsdkdtdgkdgtEYEgs---- 494  Saccharomyces...
XP_065994599  414 FESYTFNNINAQLVLAS------------TLTPPPDDN---------------------------------PNSeiiiak 448 
EPB81545      410 VYSCLEENPDAQLVLAS------------TLKTPPEDN---------------------------------VNSsytdk- 443 
XP_006682236  420 FQAYVYKNPDSQLALVS------------TFVPPPADN---------------------------------PNSnaldl- 453 
XP_004365674  451 FQSLVLNNEDMQTAVAStlpgnsipfmpaRAAAGRGQS---------------------------------SALgsgih- 496 
KAF8375288    387 LLSYLYDNEFAKTKIIE------------TLLPTSQPE---------------------------------HSSm----- 416 
XP_002634196  467 FLCYLFDNEFGKARIIE------------TLLPNSQPS---------------------------------NTPt----- 496 
5_pfamImport   46 FECYLFQNEFIKDQVVQ------------TLLPNAPET---------------------------------Ssv------ 74  
Q17BY2        394 FQSFLYKNESGQNALVQ------------TLLPSTAQI---------------------------------Ssl------ 422  yellow fever ...
XP_009267224  400 FESLITSNDTLKLEIIA------------SMSHSHHTL---------------------------------NYDgslt-- 432 
6LST_A        495 ---fKANLFE---------VLLNYDAE----------LNLNPFKLFFTTDIFMFFFQQDhkysEELREITRNVTTGN--- 549  Saccharomyces...
XP_065994599  449 pqsaGSLLLS---------ALLEWEDS-----------EADPYVVWFASVIFSHILMNN----ERSKEYARGIFFGD--- 501 
EPB81545      444 phsaGSLLLE---------VIENWEQT-----------LSDPYKVWFACDILSHIIRNN----ERAKEIAGSIVFGD--- 496 
XP_006682236  454 pvspGSLLIS---------SILDLDES-----------RKDSFISWFATSIFQHLIRDN----RQSKQTAALIKFEEg-- 507 
XP_004365674  497 psssSNNLIAtaglgsggvTLVAHVQGagellanglfNAQDPLANWLCSIALGSVITNS----TVAKDMALSSHIS---- 568 
KAF8375288    417 ---tTGSIIC---------QAL---------------SSAESVQSWFGCISLLHCVLDV----DHLREQLLRVQL----- 460 
XP_002634196  497 ----TGSLIL---------QAM---------------SSAESVQAWFGCVTLMHCLYDV----DHLCEQLLRVKI----- 539 
5_pfamImport   75 ---tLGQLLC---------GGL---------------FSNDPLSNWFVSTALSHTLIGN----NILKEQLLKVQL----- 118 
Q17BY2        423 ---tSGQLLC---------GGL---------------FSTDPLSNWFSAVSLAHALLEN----PTQKEQLLRVLL----- 466  yellow fever ...
XP_009267224  433 -htaGSLLLE---------ALSTLPDGegesaggasdGALISQKVFFASLIMTHILRYS----EDAKAMARNVPFTEsge 498 
6LST_A        550 -DLED-EEPLKAIQTISELL-------------TTSLT---A-----ADI------------------------------ 576  Saccharomyces...
XP_065994599  502 -GDDNgEENITLLHTIAGNL-------------MIATRq--NaerqnADV------------------------------ 535 
EPB81545      497 -EANG-EDPVPLLHQIVAQL-------------LMSTKnp------sTNA------------------------------ 525 
XP_006682236  508 ------EEHISLLHKCMYTL-------------LCASRngvHl------------------------------------- 531 
XP_004365674  569 -ARLG-EKPLSLMSQCTNAMtqvsgtgalsrssVSSPSa--AssdpsSTP------------------------------ 614 
KAF8375288    461 -TVAA-DETMGLLHHLTHLL-------------ISLGNr---------RP------------------------------ 486 
XP_002634196  540 -NIVTeQPELALLDHVSQLL-------------ISAGN---------RRP------------------------------ 566 
5_pfamImport  119 -ATEGkTTSTSLMEQCCSLL-------------HSY-----------SKH------------------------------ 143 
Q17BY2        467 -ATSVgSTPVSLLQQCTQLL-------------QQAN----------CKF------------------------------ 492  yellow fever ...
XP_009267224  499 tSESGdEESISLLHGIFGNL-------------TVCAReraA-----ADAraraaefssinrgeggederegelgekamk 560 
6LST_A        577 --------------------------RIPISYLTFLIYWLFGDFKATNDFLSDKSVIKSLLSFS------YQIQDe--DV 622  Saccharomyces...
XP_065994599  536 --------------------------RVLIGYLCTLCIWLWDSPISVREFLSESGHLQMLITSI------TQSSGv--DA 581 
EPB81545      526 --------------------------RIPIGYLCLLCTWLHESPASVSLFLAESTHVQFLIQEM------QSSTN---DP 570 
XP_006682236  532 --------------------------RVQIGLWTLLAQWLYDCPRAVKEFLTEGSNMQFLVEQV------NQSSGv--NA 577 
XP_004365674  615 --------------------------RTLVGLLRLLCSWLADSPAAVRTFLHSTYNLPFLVELLeqhhstSTGAV---SV 665 
KAF8375288    487 --------------------------QSRGGLLQLIGVWLHDCPRAVSTFVSHDEILHHLTAQMlde-sgEGSESe--QQ 537 
XP_002634196  567 --------------------------QSRAGLLMLLGVWLQNCPLAVSAFMAKEDNLVYLTTHIvdecgeGTESE---QQ 617 
5_pfamImport  144 --------------------------QTRIGLLMFLSNWLSDCPVAVSHFLQIPSNIPFLTVQL------GNMEDddmDV 191 
Q17BY2        493 --------------------------QSKVALLMLLAVWLSHCQLAVKTFLSSPGSVAYLIAQI------AANEHddnEY 540  yellow fever ...
XP_009267224  561 nrdekeeeehdsvdsgnnnnthtdwtRLTTSYLILLSVWVWESPRTVSDILRESSNLQLLIQPI------KHSGV---DA 631 
6LST_A        623 TIKCLVTMLLGVAYEFSSKESP-FPRKEYFEFITKTLGKDNYASRIKQFKKDSYFSKVDmneds--iltpELDe-TGLPK 698  Saccharomyces...
XP_065994599  582 RVQGLCAFLLGICYEFNHNLDPqITKSTLQQILLNRIGYDQFVNRITRLRESPHFKHASqyl-----qvvPEEaaRGLPE 656 
EPB81545      571 TVQGLVAYLLGITYEYNDDPSTpLDRAKLQAIFSSR--LDQFNSLLARLRDSPAVKNAPqylqisaedesISNttHSLPS 648 
XP_006682236  578 VVQGLAAFIIGLCYEFNDDSEPvFSRANIQGLVMSRIGSDVFQSRLERLRESKQFNSSFlhilkk----neivdpKNGPE 653 
XP_004365674  666 VIQGMAALLLGLCFAHNDVAEStFNRASIRLTIQNRINLETFNGYIANLGRCEYFTKAAsnts---------fssTKPGD 736 
KAF8375288    538 VLKGLIAFVLLTCRNCLKDDDK--SLGTLTALLDRRVGRDRLADAIEGVSRTEQFVRAAqk--------tQPLa-KIPSE 606 
XP_002634196  618 ALRGLMAFVLLCCLKNIQDKDT---RSSIETLISRRVGKEVVLSALEGLTRTEQFVRAAqk---------------qqPS 679 
5_pfamImport  192 LISGLSAFLLGICILNNNDSVQsYTREDLLESIMKRVGLDIFLDKLRSVSKSEKFSSASqk---------------pqIK 256 
Q17BY2        541 LIQGLCAFLMGICIQFNDNSVQgSKREDLCQLLIKRIGLETFSAKLGEVSKHENYSRSAkq---------------pqIR 605  yellow fever ...
XP_009267224  632 LIQGLCAFTLAAIYRYNTEAHAeVTKTDLHTLIHKQVGVDNVIQSLARFRADRRFGRVS-----------SPDdsLMLAE 700 
6LST_A        699 V------YFSTYFIQLFNENIYRIRTAL 720  Saccharomyces cerevisiae S288C
XP_065994599  657 L------YFDYAFVEFFKNNYETIQRSI 678 
EPB81545      649 L------LLDSVFVDLFKSNYENIQKSI 670 
XP_006682236  654 I------YFDHSFVEFFKSHYDLMIRSv 675 
XP_004365674  737 V------WFDYEFTVLFKRASVAIERAL 758 
KAF8375288    607 L------FLDFHFVKLFKSAEGKLLKSL 628 
XP_002634196  680 EsnknnlFLDFNFVKLFKSLEGTLAKQL 707 
5_pfamImport  257 IlkadqlIFDYEFCKLFRTLEASIVKS- 283 
Q17BY2        606 IrsstdlLLDYEFCKLFKALESVI--TI 631  yellow fever mosquito
XP_009267224  701 NphdegwWFDWHYVEFFKGSFMAVQRSV 728 
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