Conserved Protein Domain Family
Uso1_p115_head

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pfam04869: Uso1_p115_head 
Uso1 / p115 like vesicle tethering protein, head region
Also known as General vesicular transport factor, Transcytosis associated protein (TAP) and Vesicle docking protein, this myosin-shaped molecule consists of an N-terminal globular head region, a coiled-coil tail which mediates dimerization, and a short C-terminal acidic region. p115 tethers COP1 vesicles to the Golgi by binding the coiled coil proteins giantin (on the vesicles) and GM130 (on the Golgi), via its C-terminal acidic region. It is required for intercisternal transport in the golgi stack. This family consists of part of the head region. The head region is highly conserved, but its function is unknown. It does not seem to be essential for vesicle tethering. The N-terminal part of the head region, not within this family, contains context-detected Armadillo/beta-catenin-like repeats (pfam00514).
Statistics
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PSSM-Id: 398505
Aligned: 77 rows
Threshold Bit Score: 183.55
Threshold Setting Gi: 765548684
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EOR02057      328 QNQHLFTHSQT---------------------QPI--LNSEAYAAGYL--KlpPRLATISLIDIALngesGDENRMVDDV 382  Wallemia icht...
EIM21331      184 QNQQFFTQSQT---------------------QPI--LNSDAYAAGYL--RlpPRLATISLIDIALngesGDENRMVDDV 238  Wallemia mell...
EXX77174      349 NGQEYLAKTVVpv------------------pHPSqsSENDAKSSSYDqiLipPRPAVMSLIVVAV----GAEYLESYST 406  Rhizophagus i...
EPB81545      347 DNQLMLGKIVVacppvlnqdgqidanvapgipRPA----------------------MVSLISIAVnedrGVS--YSYSS 402  Mucor circine...
XP_006682236  362 VNQETFGKSVItvvtrpehvgvsnqkqspgapRPS-------------------------IISIIL----VAMGRDHISI 412  Batrachochytr...
KJE89305      407 aSQDAFAQCRVsvng-------------aivaTPL------------------------ALLFAML------EPRRAFAE 443  Capsaspora ow...
PDM64042      342 TNQEYFASTSLeted--------------ggvRPS---------------------LIVLLVS-------MISEKQPFKL 379  Pristionchus ...
CAP22871      422 TNQELFASTVIdnge--------------dgpRSS---------------------LVVLLLS-------MNAEKQTYKL 459  Caenorhabditi...
XP_015795300  350 HNQQYFSS--Leapv--------------eppKSL---------------------LVLLVMS-------MVDEKQCFDL 385  two-spotted s...
Q17BY2        351 NNQEYFNS--Vmaps--------------nppRPA---------------------LIVLLMS-------MVNEKQPLPL 386  yellow fever ...
EOR02057      383 dslkghnlmlQVAALTAFESLITSNDTLKLEIIA------------SMSHSHHTLNYDgslt---htaGSLLLE------ 441  Wallemia icht...
EIM21331      239 dslkghnlmfQVAALSAFESLITSNDSLKLEIIA------------SMSHTTNEVNYDgsit---htaGSLLLE------ 297  Wallemia mell...
EXX77174      407 ----------RAAATYAFESYTFNNINAQLVLAS------------TLTPPPDDNPNSeiiiakpqsaGSLLLS------ 458  Rhizophagus i...
EPB81545      403 ----------RAAATYAVYSCLEENPDAQLVLAS------------TLKTPPEDNVNSsytdk-phsaGSLLLE------ 453  Mucor circine...
XP_006682236  413 ----------RAAATYIFQAYVYKNPDSQLALVS------------TFVPPPADNPNSnaldl-pvspGSLLIS------ 463  Batrachochytr...
KJE89305      444 ----------RSAALYLFQSLVLNNEDMQTAVAStlpgnsipfmpaRAAAGRGQSSALgsgih-psssSNNLIAtaglgs 512  Capsaspora ow...
PDM64042      380 ----------RCAVFYCLLSYLYDNEFAKTKIIE------------TLLPTSQPEHSSm--------tTGSIIC------ 423  Pristionchus ...
CAP22871      460 ----------RCAVFYCFLCYLFDNEFGKARIIE------------TLLPNSQPSNTPt---------TGSLIL------ 502  Caenorhabditi...
XP_015795300  386 ----------RCAILYCFECYLFQNEFIKDQVVQ------------TLLPNAPETSsv---------tLGQLLC------ 428  two-spotted s...
Q17BY2        387 ----------RCAVLYCFQSFLYKNESGQNALVQ------------TLLPSTAQISsl---------tSGQLLC------ 429  yellow fever ...
EOR02057      442 ---ALSTLPDGegesaggasdGALISQKVFFASLIMTHILRYSEDAKAMARNVPFTEsgetSESGdEESISLLHGIFGNL 518  Wallemia icht...
EIM21331      298 ---ALSNLPTPevs-----ldGAFDSQKVFFASLVLSHVLRYSEDARAMARNIPFNPs---EDTDeDETVSLLHGIFGNL 366  Wallemia mell...
EXX77174      459 ---ALLEWEDS-----------EADPYVVWFASVIFSHILMNNERSKEYARGIFFGD----GDDNgEENITLLHTIAGNL 520  Rhizophagus i...
EPB81545      454 ---VIENWEQT-----------LSDPYKVWFACDILSHIIRNNERAKEIAGSIVFGD----EANG-EDPVPLLHQIVAQL 514  Mucor circine...
XP_006682236  464 ---SILDLDES-----------RKDSFISWFATSIFQHLIRDNRQSKQTAALIKFEEg--------EEHISLLHKCMYTL 521  Batrachochytr...
KJE89305      513 ggvTLVAHVQGagellanglfNAQDPLANWLCSIALGSVITNSTVAKDMALSSHIS-----ARLG-EKPLSLMSQCTNAM 586  Capsaspora ow...
PDM64042      424 ---QAL---------------SSAESVQSWFGCISLLHCVLDVDHLREQLLRVQL------TVAA-DETMGLLHHLTHLL 478  Pristionchus ...
CAP22871      503 ---QAM---------------SSAESVQAWFGCVTLMHCLYDVDHLCEQLLRVKI------NIVTeQPELALLDHVSQLL 558  Caenorhabditi...
XP_015795300  429 ---GGL---------------FSNDPLSNWFVSTALSHTLIGNNILKEQLLKVQL------ATEGkTTSTSLMEQCCSLL 484  two-spotted s...
Q17BY2        430 ---GGL---------------FSTDPLSNWFSAVSLAHALLENPTQKEQLLRVLL------ATSVgSTPVSLLQQCTQLL 485  yellow fever ...
EOR02057      519 -------------TVCARerAA-----ADAraraaefssinrgeggederegelgekamknrdekeeeehdsvdsgnnnn 580  Wallemia icht...
EIM21331      367 -------------ITCSRerSA-----ADArlrekefssinrteepekq-------------------gnqeneeeevkq 409  Wallemia mell...
EXX77174      521 -------------MIATR--QNaerqnADV-------------------------------------------------- 535  Rhizophagus i...
EPB81545      515 -------------LMSTKnpS------TNA-------------------------------------------------- 525  Mucor circine...
XP_006682236  522 -------------LCASRngVHl--------------------------------------------------------- 531  Batrachochytr...
KJE89305      587 tqvsgtgalsrssVSSPS--AAssdpsSTP-------------------------------------------------- 614  Capsaspora ow...
PDM64042      479 -------------ISLGN--R-------RP-------------------------------------------------- 486  Pristionchus ...
CAP22871      559 -------------ISAGN---------RRP-------------------------------------------------- 566  Caenorhabditi...
XP_015795300  485 -------------HSY-----------SKH-------------------------------------------------- 490  two-spotted s...
Q17BY2        486 -------------QQAN----------CKF-------------------------------------------------- 492  yellow fever ...
EOR02057      581 thtdwtRLTTSYLILLSVWVWESPRTVSDILRESSNLQLLIQPI------KHSGV---DALIQGLCAFTLAAIYRYNTEA 651  Wallemia icht...
EIM21331      410 ididwtRLTVSYLILLSVWVWDSPATVSDILKESSNLQVLIQPI------KQSSGv--DALIQGLCAFTFGAIYKFNTGP 481  Wallemia mell...
EXX77174      536 ------RVLIGYLCTLCIWLWDSPISVREFLSESGHLQMLITSI------TQSSGv--DARVQGLCAFLLGICYEFNHNL 601  Rhizophagus i...
EPB81545      526 ------RIPIGYLCLLCTWLHESPASVSLFLAESTHVQFLIQEM------QSSTN---DPTVQGLVAYLLGITYEYNDDP 590  Mucor circine...
XP_006682236  532 ------RVQIGLWTLLAQWLYDCPRAVKEFLTEGSNMQFLVEQV------NQSSGv--NAVVQGLAAFIIGLCYEFNDDS 597  Batrachochytr...
KJE89305      615 ------RTLVGLLRLLCSWLADSPAAVRTFLHSTYNLPFLVELLeqhhstSTGAV---SVVIQGMAALLLGLCFAHNDVA 685  Capsaspora ow...
PDM64042      487 ------QSRGGLLQLIGVWLHDCPRAVSTFVSHDEILHHLTAQMlde-sgEGSESe--QQVLKGLIAFVLLTCRNCLKDD 557  Pristionchus ...
CAP22871      567 ------QSRAGLLMLLGVWLQNCPLAVSAFMAKEDNLVYLTTHIvdecgeGTESE---QQALRGLMAFVLLCCLKNIQDK 637  Caenorhabditi...
XP_015795300  491 ------QTRIGLLMFLSNWLSDCPVAVSHFLQIPSNIPFLTVQL------GNMEDddmDVLISGLSAFLLGICILNNNDS 558  two-spotted s...
Q17BY2        493 ------QSKVALLMLLAVWLSHCQLAVKTFLSSPGSVAYLIAQI------AANEHddnEYLIQGLCAFLMGICIQFNDNS 560  yellow fever ...
EOR02057      652 HAeVTKTDLHTLIHKQVGVDNVIQSLARFRADRRFGRVS-----------SPDdsLMLAENphdegwWFDWHYVEFFKGS 720  Wallemia icht...
EIM21331      482 SE-VSKKDLHSIIEKQIGVDNIIQSLARFRSDKRFCKIG-----------SPDdaLAYAETpqedgwWFDWNYVEFFKGS 549  Wallemia mell...
EXX77174      602 DPqITKSTLQQILLNRIGYDQFVNRITRLRESPHFKHASqyl-----qvvPEEaaRGLPEL------YFDYAFVEFFKNN 670  Rhizophagus i...
EPB81545      591 STpLDRAKLQAIFSSR--LDQFNSLLARLRDSPAVKNAPqylqisaedesISNttHSLPSL------LLDSVFVDLFKSN 662  Mucor circine...
XP_006682236  598 EPvFSRANIQGLVMSRIGSDVFQSRLERLRESKQFNSSFlhilkk----neivdpKNGPEI------YFDHSFVEFFKSH 667  Batrachochytr...
KJE89305      686 EStFNRASIRLTIQNRINLETFNGYIANLGRCEYFTKAAsnts---------fssTKPGDV------WFDYEFTVLFKRA 750  Capsaspora ow...
PDM64042      558 DK--SLGTLTALLDRRVGRDRLADAIEGVSRTEQFVRAAqk--------tQPLa-KIPSEL------FLDFHFVKLFKSA 620  Pristionchus ...
CAP22871      638 DT---RSSIETLISRRVGKEVVLSALEGLTRTEQFVRAAqk---------------qqPSEsnknnlFLDFNFVKLFKSL 699  Caenorhabditi...
XP_015795300  559 VQsYTREDLLESIMKRVGLDIFLDKLRSVSKSEKFSSASqk---------------pqIKIlkadqlIFDYEFCKLFRTL 623  two-spotted s...
Q17BY2        561 VQgSKREDLCQLLIKRIGLETFSAKLGEVSKHENYSRSAkq---------------pqIRIrsstdlLLDYEFCKLFKAL 625  yellow fever ...
EOR02057      721 FMAVQRSV 728  Wallemia ichthyophaga EXF-994
EIM21331      550 FMAVQRSV 557  Wallemia mellicola CBS 633.66
EXX77174      671 YETIQRSI 678  Rhizophagus irregularis DAOM 197198w
EPB81545      663 YENIQKSI 670  Mucor circinelloides f. circinelloides 1006PhL
XP_006682236  668 YDLMIRSv 675  Batrachochytrium dendrobatidis JAM81
KJE89305      751 SVAIERAL 758  Capsaspora owczarzaki ATCC 30864
PDM64042      621 EGKLLKSL 628  Pristionchus pacificus
CAP22871      700 EGTLAKQL 707  Caenorhabditis briggsae
XP_015795300  624 EASIVKSv 631  two-spotted spider mite
Q17BY2        626 ESVI--TI 631  yellow fever mosquito
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