2A1R,2A1R


Conserved Protein Domain Family
CAF1

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pfam04857: CAF1 (This model is not part of the current CDD release)
CAF1 family ribonuclease
The major pathways of mRNA turnover in eukaryotes initiate with shortening of the polyA tail. CAF1 encodes a critical component of the major cytoplasmic deadenylase in yeast. Both Caf1p is required for normal mRNA deadenylation in vivo and localises to the cytoplasm. Caf1p copurifies with a Ccr4p-dependent polyA-specific exonuclease activity. Some members of this family include and inserted RNA binding domain pfam01424. This family of proteins is related to other exonucleases pfam00929. The crystal structure of Saccharomyces cerevisiae Pop2 has been resolved at 2.3 Angstrom resolution.
Statistics
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PSSM-Id: 516475
Aligned: 123 rows
Threshold Bit Score: 75.5471
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2A1R_A         7 NFKSNLHKVYQAIEEADFFAIDGEFSG-IsdgpsvsaLTNGFDTPE----ERYQKLKKHSMDFLLFQFGLCTFkydYTDs 81  human
A0CI01         7 NFEQHKQTIMDQIKHCDFLGFDLELTG-I--------KGDYQDTFEelpfERYLKARKVSMKYNIIQFGLSIFiksQKG- 76  Paramecium tetr...
Q22SB7         7 NFKDNYQKIIQLIQSCDFISFDCEFSG-Late--rfsKIRKYDSDE----DIYQKLKHTVQNYHLLQIGLCIYtfcKVQk 79  Tetrahymena the...
6_pfamImport   5 NLHEEMAILRQLVDKYPYISMDAKFPGiV---------ARPMGSFNgrgdYHYQCLRCNVDLLKLIQLGITLFsedGESl 75 
A0C6C4         7 NYLHNLAFIQQRIKEANYIALDFEFTGvLass---llRNSLLDSFQ----MRYWKVKENVRRFLPIQMGLCTFredANSn 79  Paramecium tetr...
XP_001014473   7 NIVQNLPIILDKIRQSHFIALDFEMTG-Lnrs--eilRNNGFDTIQ----QRYWKTKESVSVFQPIQLGLCPFrihSSKk 79 
Q7RNA9        20 NWNSIHKEILSKIQESDFVSIDVEYTG-Lh------lKDERYISID----SSYEAHCYGAKSFFPCQIGITIA---KKRd 85  Plasmodium yoel...
XP_001615956  41 NWNDIHREIIHKIHDSDFVSIDVEYTG-Lh------lKDERYISID----SSYEAHCYGAKSFFPCQIGITVA---RKNd 106
XP_001569280   7 NQIVALPDFAREVERCEFCAIDQEMTG-Vdvp---giPTQFGAPPE----AVYHAKRIAVETYNAFQIGIALFrktENNv 78  Leishmania braz...
XP_002260438  40 NWNDIHREIIHKIRDSDFVSIDVEYTG-Lh------lKDERYISID----SSYEAHCYGAKSFFPCQIGITVA---RRNd 105 Plasmodium know...
2A1R_A        82 ------------------------------------------------kYITKSFNFYVFPKPfnrsspDVKFVCQSSSI 113 human
A0CI01        77 -------------------------------------------------YQAYPYTFYLFPQDl-----DDFVGLQVGAI 102 Paramecium tetr...
Q22SB7        80 ------------------------------------------------kYIAYPYNIYLNP----------VYTTSSESI 101 Tetrahymena the...
6_pfamImport  76 patphsdsgldrns--------------------agrrigngvvqvpctWQF-NFKFSLS-----------DDMYAEKGI 123
A0C6C4        80 ------------------------------------------------nVIAHPFNFYIFPYGvdg-ylDKQFQLSSNSI 110 Paramecium tetr...
XP_001014473  80 -------------------------------------------------IEASPFNVYLTQYTeng-rsDKLFLYSASTF 109
Q7RNA9        86 itthdkcneiknniiknknih------nikvfenndkvskvspmkneqeWDISPYCIYIFPKE------NKYFSVSTSTL 153 Plasmodium yoel...
XP_001615956 107 tvekekrvadgggkkekeqlrkmnihnikvsrqgneqvdhkyclkgnqeWDISPYCIYVFPKE------NKYFSVSTTTL 180
XP_001569280  79 -------------------------------------------------YEVRPYNFYLLND-------SGDLRLALPAV 102 Leishmania braz...
XP_002260438 106 tqgkekqvaggrgekekeelrkmnlhnikvsrqenekvdhkyslkcnqeWDISPYCIYVFPKE------NKYFSVSTTTL 179 Plasmodium know...
2A1R_A       114 D----------FLASQGFDFNKVFRNGIPYLNQEEERQL-----REQYDEk--rSQANgagalsyvspN---------TS 167 human
A0CI01       103 F----------FNSEHGMDWNRWINKGLGYINRAQYQKL-----QEDYNKdfqqLDQE----------El-------kTQ 150 Paramecium tetr...
Q22SB7       102 KkqiiqlecfnFMAVNGLDFNKLYSSGLSYIKLAQKEKI-----LENSKYqqnhG------------------------- 151 Tetrahymena the...
6_pfamImport 124 D----------ERKAAGTDFSRLKEEGI------DPFEF----------------------------------------- 146
A0C6C4       111 S----------FLTNNNFDFNRTFNEGILYLSHQDEKILrdtkrIQDLRNeiryLD------------------------ 156 Paramecium tetr...
XP_001014473 110 N----------FLSQHNMDFNEVFKNGVYYFSRQQEEQFdsfksLQGVRNdirqQIIQ----------Sq-------sFH 162
Q7RNA9       154 I----------FLKENNFDFNEWIFNGVSYLRPNEEDEK-----KKHIFE----KIDG----------Lknll-nkcnTK 203 Plasmodium yoel...
XP_001615956 181 I----------FLKENNFDFNEWICNGVGYLTPPEEEEK-----KKNIFE----KIDE----------LknlmnkcntKT 231
XP_001569280 103 S----------FLAANHMNFQMWLTAGLPFCNAQEELDY-----EKQITT------------------------------ 137 Leishmania braz...
XP_002260438 180 I----------FLKENNFDFNEWICNGVGYLTPPEEEEK-----KKYIFE----KMDE----------LrnlmnkcntKT 230 Plasmodium know...
2A1R_A       168 ----------------K--------CPVTIPEDQKKFID-QVVEKIEDLLQSEENKNLDLEPCTGFQRKLIyqt------ 216 human
A0CI01       151 f---------------Ek-------ILDDVKAADKKTIQ-DLIDKLEKFNKSDDKQTTIETTNGYQRKVIY--------- 198 Paramecium tetr...
Q22SB7       152 ---------------------------IALSKASRDALE-QIVKQIQEYDQDNNNTKDVTIECKSQYLCTKilkkqigqa 203 Tetrahymena the...
6_pfamImport     --------------------------------------------------------------------------------    
A0C6C4       157 ---------------------------KIVTFEMINFVK-QYKVQVEQFLKVSNDPQFEIPIKRLKVKVYRhfi------ 202 Paramecium tetr...
XP_001014473 163 f---------------Ke-------FMSLNEKTIELFMEnKRRKKLEFSLTEPRYATFYKELEQFFQKKFP--------- 211
Q7RNA9       204 ndynket--genkidiNkiin-eieNYKAVDDEDKQAVI-EIVKKIGIWLSNENETQFNNIAKDELGTPTNspiqsssse 279 Plasmodium yoel...
XP_001615956 232 gdakdkelddrkkkvdVekiiqeieNYKIVDDEDKEAVI-EIIRKIGIWLTRGDMPHPEGRFTHGEGDKTKslektncad 310
XP_001569280 138 ---------------------------LFTDEVEHEISN-DLVKAIDEWIPTASAPLVKELSCSLNLAQRLqafl----- 184 Leishmania braz...
XP_002260438 231 edakekglgdrkkkvdVekiiqeieNYKIVDDEDKEAVI-EIIKKIGIWLTRGDMVHPMGRFNHGEGDKTSsvetadsad 309 Plasmodium know...
2A1R_A           --------------------------------------------------------------------------------     human
A0CI01           --------------------------------------------------------------------------------     Paramecium tetr...
Q22SB7       204 iysc---------------------------------------------------------------------------- 207 Tetrahymena the...
6_pfamImport     --------------------------------------------------------------------------------    
A0C6C4           --------------------------------------------------------------------------------     Paramecium tetr...
XP_001014473     --------------------------------------------------------------------------------    
Q7RNA9       280 gkldelkhvslsngcykdgdhknsiyetfitndknqssnkiiksdt---------------------------------- 325 Plasmodium yoel...
XP_001615956 311 grslhrsedvgephsnhinatfqrdgsnggncngvytdyvhgggrreeesatfrgstsgltes----esnghvtsahlns 386
XP_001569280     --------------------------------------------------------------------------------     Leishmania braz...
XP_002260438 310 grllhqsenvgephshhinatyqrgdsaaegcnsvytnytngrekheeksstfreiipgsleyesndhvsstviesddip 389 Plasmodium know...
2A1R_A       217 -------------------------------------------------------lswKYPKGIHVETLETEKKERYIVI 241 human
A0CI01       199 ----------------------------------------------------------TYLEAYQKNMIGESLLKGEMKI 220 Paramecium tetr...
Q22SB7       208 ---------------------------------------------qnvnvdkgqtntqLIIRKKKPTQNQYFKNKQAQDI 242 Tetrahymena the...
6_pfamImport     --------------------------------------------------------------------------------    
A0C6C4       203 --------------------------------------------------------esITKEFGKSYEFYCKYDSDILIK 226 Paramecium tetr...
XP_001014473 212 -----------------------------------------------------------QQPVHIVYDVEKHYQRRKINI 232
Q7RNA9       326 ---nldnkhkpvhnstegdekisenskdlnldnneeydkcplyieienpylrllahtlITKYFNSIFCISVKLNDKKNLA 402 Plasmodium yoel...
XP_001615956 387 gdipldckhvgsslgelnqgevvrmdfpprakpnddpsdcplyieienpylrllahtlITKYFSGIFCISVKVNDKKHLA 466
XP_001569280 185 ------------------------------------------------------shryDSRIVINYDGKPYLAQKIKFTL 210 Leishmania braz...
XP_002260438 390 ldanhvdafvggekkggnlgkvgktelppranpkddpsdcplyieienpylrllahtlITKYFNGIFCISVKVNDKKHLA 469 Plasmodium know...
2A1R_A       242 SKVDEEERKRREQQKHAKEQEELNDAV---------GFSRVIHAIAN--SGKLVIGHNMLLDVMHTVHQFYCP-LPADLS 309 human
A0CI01       221 TKLTNAEKQAKDDERQKFKADRFQTKT---------GFYQIWECILN--SKKYLVGHNCFADVMFCYSHFVQC-PPISWE 288 Paramecium tetr...
Q22SB7       243 DDDENNNNNGTEEIKQNGDGDDVSNPShssseidllGFSLIVEAIVN--SKRPIIGHYMGYDLFYFYDHFIDV-LPNTFV 319 Tetrahymena the...
6_pfamImport 147 ------------------------------------GAVLISSGLVCdeEKRWISGHAGY-DFGYLTKIMLQRaLPDDER 189
A0C6C4       227 REILYIVKGPEPPETKKQNVEEANEFA---------GVRILLDQISQ--QKTPIILHNGLMDIMHIYDKFFET-LPDSRG 294 Paramecium tetr...
XP_001014473 233 QKITEKNDIDDTQNQNSAKNTQQSQYSfeeyeimnyNFRSIIDEIIN--LKIPIIVHNGFIDILHLYDKFLYN-LPEGSQ 309
Q7RNA9       403 IYKTEKDSYNEQIKALQMEIEKINETI---------GVRLLFDEIIK--SNKILIGHNCFYDILHIYQTFYHE-LPDSIH 470 Plasmodium yoel...
XP_001615956 467 VYRTERDSYKEQIRALELEIEKINQTV---------GVRLLFDEIIK--NKKIIIGHNCFYDILHIYQTFYHE-LPNSIS 534
XP_001569280 211 TKLSKAEWISEKEKRRLRCERDRARQL---------GFRQFWKILLK--SRKPIVGHNFMQDIMFMIHMHETP-LPVDYL 278 Leishmania braz...
XP_002260438 470 IYRTEKDSYKEQIKALELEVEKINQTV---------GVRLLFDEIIK--NKKIIIGHNCFYDILHIYQTFYHE-LPNSIS 537 Plasmodium know...
2A1R_A       310 EFKEMTTCVFPRLLDTKLMAST------------Q----PFKDIINNT-------SLAEL---------EKRLketp--- 354 human
A0CI01       289 EFKEDIARNWPPIYDTKYIIQSaq---------pLe--kIRGKLETST-------SIENLaefiksnmnYIQI------- 343 Paramecium tetr...
Q22SB7       320 EFVEKVNKYFPYVIDTKVLA-----------------------RKLQNkvkklplHLEGL---------YRAVakdekcl 367 Tetrahymena the...
6_pfamImport 190 EFDMLMKKFFPSVYDIKYLMQQgtimsklgqlshVdavtA-----ELLqrnerhpNLEAM---------IDVL------- 248
A0C6C4       295 EFISKVNSLFPVIYDTKFLINQs-----------Ys---VYNKVGQFSelknsyiNLQNLepnvvfgdeCQEY------- 353 Paramecium tetr...
XP_001014473 310 EFKKEINKHFPVIFDSKLII---------------------NSSQKLSqevnfqsDLRNC---------YEKMlkykdid 359
Q7RNA9       471 AFKRKWTELFPYTVDTKYMNET------------Ne---YLYSLNGPA-------TLKGL---------CEYMaslisss 519 Plasmodium yoel...
XP_001615956 535 LFKNKWTELFPYTFDTKYLNET------------Ne---YLYALNGPA-------TLKGL---------CEYMaslisas 583
XP_001569280 279 EFKKLLQRTLPTIYDTKTMAAKlm---------gDn--aF-----QVT-------HLESL---------YQECrrragll 326 Leishmania braz...
XP_002260438 538 VFKNKWTEIFPYTFDTKYLNET------------Ne---YLYALNGPA-------TLKGL---------CEYMaslisas 586 Plasmodium know...
2A1R_A       355 -fnpPKVEsa-egFPsydTa------------------------------------------------------------ 372 human
A0CI01       344 ----DVEL-----EQ---N------------------------------------------------------------- 350 Paramecium tetr...
Q22SB7       368 kkhhNTVLtndpqFSk-yTke----------------------------------------------------------- 387 Tetrahymena the...
6_pfamImport 249 ----KV-------K----R------------------------------------------------------------- 252
A0C6C4       354 ----NNL------EE---N------------------------------------------------------------- 359 Paramecium tetr...
XP_001014473 360 sqifISTDinepqEKediDniqqntlfs---------------------------------------------------- 387
Q7RNA9       520 kdfdFFFNflngnILdlqQclipfvkdekseanssgenynerqptdaknnnyddeni---egkengknqlenstsyqyde 596 Plasmodium yoel...
XP_001615956 584 ndfdFVFNftnghSDlpqCfiplvklgdqpsdavgdflgttercasidakeeakrrad--nehpirwdveeenmhpdetv 661
XP_001569280 327 tdefTLQYrlppgFYnynDyavk--------------------------------------------------------- 349 Leishmania braz...
XP_002260438 587 ndfdFVFNftnghSDlpqCfvplvkledqtnddavgnvpgnvaryasfdgenevknhadnghsnnrgdnekdrmcpngte 666 Plasmodium know...
2A1R_A       373 ------------------SeqLHEAGYDAYITGLCF 390 human
A0CI01       351 ------------------L--YHTAGFDAYMTGFIF 366 Paramecium tetraurelia
Q22SB7       388 -----------------gQ--LHEAGFDSYITGASF 404 Tetrahymena thermophila SB210
6_pfamImport 253 ------------------LgaIHQAGSDSLVNGRVF 270
A0C6C4       360 ------------------QafEHEAGFDSYMAGSVF 377 Paramecium tetraurelia
XP_001014473 388 ---------nyqinglkeNnkMHEAGYDAMMTGYIF 414
Q7RNA9       597 kyykdantlngnanvlksD--EHNAGYDSLLTCLLF 630 Plasmodium yoelii yoelii
XP_001615956 662 lalpqgkrhdcqanaktsD--EHNAGYDSLLTCLLF 695
XP_001569280 350 ---------------qqsK--AHEAAYDAYMTGIAF 368 Leishmania braziliensis MHOM/BR/75/M2904
XP_002260438 667 lvspqgrnqdfhvnaktsD--EHNAGYDSLLTCLLF 700 Plasmodium knowlesi strain H
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