Conserved Protein Domain Family
HAP1_N

?
pfam04849: HAP1_N (This model is not part of the current CDD release)
HAP1 N-terminal conserved region
This family represents an N-terminal conserved region found in several huntingtin-associated protein 1 (HAP1) homologues. HAP1 binds to huntingtin in a polyglutamine repeat-length-dependent manner. However, its possible role in the pathogenesis of Huntington's disease is unclear. This family also includes a similar N-terminal conserved region from hypothetical protein products of ALS2CR3 genes found in the human juvenile amyotrophic lateral sclerosis critical region 2q33-2q34.
Statistics
?
PSSM-Id: 516468
Aligned: 18 rows
Threshold Bit Score: 298.883
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
P54257        107 FVFQGPFGSRATGRGt--GKAAGIWkTPAAYvgRRPGVSGPERAAFIRELEE--ALCPNLPPPVKKiTQEDVKVMLYLLE 182  human
EFA09509      115 EEQIPKYKLRADTLTkfgGYENQDWfIPSPAl-QIDEADLKLSPDQIRETLNyfLLCSNRVSQMTK-TYDDIEAVTRLLE 192 
XP_002065090   89 EEQIPKYKVRSDFLTdfsGYANEDWfVPAPAlpIPPE-GLGLTKDQTRECLNyfLLCGNRVSQMTR-AYDDIEAVTRLLE 166 
ELW58267       33 EEQLPHYKLRADTIY---GYDHDDW-LHTPL--ISPDANIDLTTEQIEETLKyfLLCAERVGQMTK-TYNDIDAVTRLLE 105 
XP_015217853  163 QERLPLYTLRADCLF---GYDHDDW-LHTPL--LPPEAALQLTPQQIEETLKyfLLCSERVGQVTK-TYHDIEAVTQLLE 235 
8_pfamImport    1 SEGQPKYTLRADTVF---GYDNDDW-LHTPL--VPPVVVLGLTYEQIEETFKyfLLCSDRVGQVTK-TYHDIKAVTHLLE 73  
6_pfamImport    1 SEGQPRYTLRADSVF---GYDNDDW-LHTPV--LPPEVALGLTYQQMEESLKyfLLCSDRVGQVTR-TYHDIKAVTHLLE 73  
O35668         80 YVFQGPYGPRATGLGt--GKAEGIWkTPAAYigRRPGVSGPERAAFIRELQE--ALCPN-PPPTKKiTEDDVKVMLYLLE 154  house mouse
XP_013836418  108 FIFRGPFGSQASGLGt--GKAAGIWkTPAACisRRPEVSGPERTAFIRELEE--ALCPDQPLPVKKiTQEDVKVMMNLLE 183 
XP_064421405    1 ----------------------meiwssgvihdecngnvgldnnsdlivceleeVLCSERVGRVTK-TYHDIEAVSHLLE 57   coelacanth
P54257        183 EllppvwesvtygmvlqRERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSdee 262  human
EFA09509      193 E----------------KEKDLELTARIGKELLQANSKLENTIASLETDLKSALEKITQLSHEVQKKTELIQILTND--- 253 
XP_002065090  167 E----------------KEKDLELTVQIGQDLLKQNNALELRVSHLEAELKESNDDRSQLVHELHKKNELISVLTDD--- 227 
ELW58267      106 E----------------KERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTSA--- 166 
XP_015217853  236 E----------------KERDLELAARIGQSLLKQNRSLTERNELLDEQLEAATEEIAQLRHELTMRDDLLQLYASS--- 296 
8_pfamImport   74 E----------------KERDLELAARIGQSLLKQNQELTSRNETLDEQLEIATEEIAQLRHELSMRDDLLQFYAST--- 134 
6_pfamImport   74 E----------------KERDLELAARIGQSLLKQNQELTARNERLDERLEMATEEIAQLRHELSMREDLLQFYAST--- 134 
O35668        155 E----------------KERDLNTAARIGQSLVKQNSVLMEENNKLETMLGSAREEILHLRKQVNLRDDLLQLYSDSddd 218  house mouse
XP_013836418  184 E----------------RERDLNTAARIGRSLVKQNSVLTEENSKLEAMLGSAREEILHLRHQVSLRDDLLQLYSDS--- 244 
XP_064421405   58 E----------------KERDLELAARIGQSLLKQNQSLTEKDEYLEEQLQLAKEEIAQLRHEIAMRDDLLHVYTNT--- 118  coelacanth
P54257        263 dedeeEEEEEKEAEEEQEeEEAEEDLqcahpcdap-klisqealLHQHHCPQLEALQEKLRLLEEENHQLREEASQL--- 338  human
EFA09509      254 -----MDESIFENGTSGR--------------------------------INLELMQKRMAGLEEENKALKSEYNRLard 296 
XP_002065090  228 -----ADDGTDADTPTMS------------------------------KSVTLDLLQKKVNSLLDENKTLKHEATQLahq 272 
ELW58267      167 -----AEESEPESVCSTP-LKRNESS------------------SSVQNYFHLDSLQKKLKDLEEENVVLRSEACQLkte 222 
XP_015217853  297 -----AEDSEPPSACSTP-MKHSGSS------------------ASLGSYFHYDFLQQKLKGLEEENLKLRTEARDLtte 352 
8_pfamImport  135 ------EETENAQGLS-P-IKRNESS------------------SSLSNFVHYDFLHQKLKGLEEENRKLRLEATELste 188 
6_pfamImport  135 ------EELENAEAHSLCrIKRNEPC------------------SSLSSLIHYDFLQQKLKSLEDENRKLRLEASELtte 190 
O35668        219 d-deeDEEDEEEGEEEEReGQRDQDQqhdhpyga---pkphpkaeTAHRCPQLETLQQKLRLLEEENDHLREEASHL--- 291  house mouse
XP_013836418  245 -----DEEEEEEEEGEEE-EEEEEEEeeeedgeeeeeqrtplaeSELHCCPQLEALQEQLRLLEEENEQLREEASQL--- 315 
XP_064421405  119 -----AEESESSSTVSTP-LRRNESS------------------ASLQHYIHLDFLQEKLRGLEEENQKLRSEATDMvte 174  coelacanth
P54257        339 -DTLEDEEQMLILECVEQFSEASQQMAELSEVLVLRLENYerqqQEVARLQAQVLKLQQRCRMYGA--ETEKLQKQLASE 415  human
EFA09509      297 tETVEAKEQMLLKDLTGQLTCANTSMGFLEDELDRQKEENrfqhEQILTLQSKLQDMEERLNKFMS--ENYELNGLLQIT 374 
XP_002065090  273 tDEVEEHERKLMADIGAQLNDANSQYDNLSLDLERQMEENrlqhEQIVNLTARLREAEMRLHQLTE--DNEGHLSMLHIT 350 
ELW58267      223 tITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAarqqEEITHLLSQIVDLQKKAKACAV--ENEELVQHLGAA 300 
XP_015217853  353 tTNYEEQEQQLMMDCVQELASVNKQVAQLSEELARKVEDTmrqqEEISHLLAQIVDLQHRSKALSS--ENDELNQHLAAS 430 
8_pfamImport  189 tTNYEEQEQELMMVCVEELSSANKQVVDLSEELARKVEDTvrqqEEISSLLAQLVDLQARCKGLGH--ENEALNHQLSAS 266 
6_pfamImport  191 tSHYEEQEQELMMVCVEELSSVNKQVVELSEELARKVEDSlrqqEEISSLLAQIVDLQARCKMVSSphENEELNQNLGAS 270 
O35668        292 -DNLEDEEQMLILECVEQFSEASQQMAELSEVLVLRLEGYerqqKEITQLQAEITKLQQRCQSYGA--QTEKLQQMLASE 368  house mouse
XP_013836418  316 -DDLEEEEQMLILDCVEQFSEASQQMAELSEVLALRMENFeqqqREVAQLRAQVVKLQQCCRSYGV--ETEKLQQQLASE 392 
XP_064421405  175 tVDFEEQEQQLMIDCVQELAEANREVGMLSEELARKTEDIlrqqEEISQLLAQIVDLQQKCKSITT--ESEELSQHLALS 252  coelacanth
P54257        416 KEIQMQLQEEsvwvgsqLQDLREKYMDCGGMLIEMQEEVKTLRQQ 460  human
EFA09509      375 KDNQGSLAIE-------LSEFKARYYEVESLLRDTQEQLRKLRKK 412 
XP_002065090  351 KETQNALALE-------LVEFKQRYEEVLALLHSAQDQLKQQRKR 388 
ELW58267      301 KDAQRQLTAE-------LRELEDKYAECMEMLHEAQEELKNLRNK 338 
XP_015217853  431 REVQAQLRSE-------LSDLQDRYSECEDMLQEAREDIKNLRNK 468 
8_pfamImport  267 REKEAKFTSE-------LKDLQDKYSECEDMLHEAQKDIKNLRNK 304 
6_pfamImport  271 RDSQLILKLE-------LKDLQDKYSECEDMLHEAREDIKNLRNK 308 
O35668        369 KGIH----SEslragsyMQDYGSRPRD-------RQEDGKSHRQR 402  house mouse
XP_013836418  393 KEIQMQLQDE-------LQDLREKYSECGGMLIEAQDEVRTLRQQ 430 
XP_064421405  253 RERQEQLRLE-------LKDLQEKHAEYKELLQETREENKNLRNK 290  coelacanth
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap