7ZU0


Conserved Protein Domain Family
Vps16_C
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pfam04840: Vps16_C (This model is not part of the current CDD release)
Vps16, C-terminal region
This protein forms part of the Class C vacuolar protein sorting (Vps) complex. Vps16 is essential for vacuolar protein sorting, which is essential for viability in plants, but not yeast. The Class C Vps complex is required for SNARE-mediated membrane fusion at the lysosome-like yeast vacuole. It is thought to play essential roles in membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of transport. The role of VPS16 in this complex is not known.
Links
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Statistics
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PSSM-Id: 516464
Aligned: 5 rows
Threshold Bit Score: 494.348
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7ZU0_B 478 LQMVAVAKVAYLEGRFQLSRNLALLEKNEEARIEQLYNLDDDSIALKECIKVQNYSLTISLLIALSKKLTNSQLTKLLII 557 brewer's yeast
Q920Q4 517 VSYSDIAARAYGCGRTELAIKLLEYEPRSGEQVPLLLKMKRSKLALSKAIESGDTDLVFTVLLHLKNELNRGDFFMTLRN 596 house mouse
Q9VHG1 515 ISFCNIASKAHQAGRDDLAIKLLELESRASLHVPLLLKMRKFDRAVGSATQSGDTELITQVLLEMKMHMMLSNLHMTIRD 594 fruit fly
Q03308 478 LQMVAVAKVAYLEGRFQLSRNLALLEKNEEARIEQLYNLDDDSIALKECIKVQNYSLTISLLIALSKKLTNSQLTKLLII 557 Saccharomyces cerevis...
Q9UT38 513 ISYEKIARTAYQEGRLILSTKLLDFEPLAKHQVMLLLNMEAYEQALKKVIETMDNNLIIYVVLQIKQQMAIASFFQILNE 592 Schizosaccharomyces p...

7ZU0_B 558 DMFNNPLYLYYMR-MDKAYLYDFYRQTDRFIDLAHVLLQQG----KEQQSLHSFLPQIKDLYSQVQNsEVVNNTIEQlqr 632 brewer's yeast
Q920Q4 597 QPMALSLYRQFCKhQELDTLKDLYNQDDNHQELGSFHIRASyaaeERIEGRVAALQTAADAFYKAKN-EFAAKATED--- 672 house mouse
Q9VHG1 595 HPLALNIYKKIMReSNRAGLYGIYNTEDDQKAIAEYHFQNAi----ETEGLESNLSMIGNAYAQGRC-TLEAELCAD--- 666 fruit fly
Q03308 558 DMFNNPLYLYYMR-MDKAYLYDFYRQTDRFIDLAHVLLQQG----KEQQSLHSFLPQIKDLYSQVQNsEVVNNTIE---- 628 Saccharomyces cerevis...
Q9UT38 593 YPDAVKVYVEFAKkNDRKTLHDFFYQDDNKQGIAVLAVEDTlk-tATVNQRITSLKSAAKVCSESKElSLEEKCLGD--- 668 Schizosaccharomyces p...

7ZU0_B 633 QE----KLWIYQESLGKRFAISFTNMTLDQTLSKLIETGQDKQVKEIVKKFKISEKKLYHLKCKTLVEAKKFDELLQFAQ 708 brewer's yeast
Q920Q4 673 QM----RLLRIQRRLEDELGGRFLDLSLHDTVTTLILGGHNKRAEQLARDFRIPDKRLWWLKLAALADLEDWEELEKFSK 748 house mouse
Q9VHG1 667 TS----RLIKLQKTLSTKYNVSLNGLSIHETIQELLLIGELKEAERIRSEFKVPDRRFWWLRILTLSSQHKWEELEKLAK 742 fruit fly
Q03308 629 QLqrqeKLWIYQESLGKRFAISFTNMTLDQTLSKLIETGQDKQVKEIVKKFKISEKKLYHLKCKTLVEAKKFDELLQFAQ 708 Saccharomyces cerevis...
Q9UT38 669 EI----KLLQLQQTYEDQFTGNFVGLTVNEVVVKLIQINQTQRANKLRSDFQIPEKRFAWLKLRALVAIRDWVQIEQWAG 744 Schizosaccharomyces p...

7ZU0_B 709 S-RKSPIGYMPFYTYLKSRGHMDKASPYVNMipgLSYQEKKKLYVECRGFRDAIQLAGKEKDIPGLKEIYNIIPPNEPEL 787 brewer's yeast
Q920Q4 749 S-KKSPIGYLPFVEICMKQHNKHEAKKYASR---VGPEQKVKALLLVGDVAQAAEVAIEHRNETELSLVLSHCTGATDGA 824 house mouse
Q9VHG1 743 S-KKSPIGYDPFVEVCLKQDNVMEARKYIPR---CRDNRRVVWYMRANLFNEAIDSAFEQRDVHSLFELQKNQAIVNNGT 818 fruit fly
Q03308 709 S-RKSPIGYMPFYTYLKSRGHMDKASPYVNMipgLSyQEKKKLYVECRGFRDAIQLAGKEKDIPGLKEIYNIIPPNEPEL 787 Saccharomyces cerevis...
Q9UT38 745 SmRRSPIGFEPFVTEILSAGNKKEAAKYIPRctqLTTQEKVDMWVQVGDVKSASEEAAKSKSGSVLGDLLERVQTMPESR 824 Schizosaccharomyces p...

7ZU0_B 788 KalaNETMSRI 798 brewer's yeast
Q920Q4 825 IadkIQRARAQ 835 house mouse
Q9VHG1 819 LlskVCDCIAM 829 fruit fly
Q03308 788 KalaNETMSRI 798 Saccharomyces cerevisiae S288C
Q9UT38 825 F---VQNALDQ 832 Schizosaccharomyces pombe 972h-
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