pfam04831: POPDC1-3 (This model is not part of the current CDD release)
POPDC1-3
This entry includes proteins from POPDC family, also known as the Popeye (POP) family, which includes POPDC1, 2 and 3 and is mainly restricted to vertebrates. It is preferentially expressed in developing and adult striated muscle. These proteins act as cAMP effectors and play a role in cardiac pacemaking and conduction. The PODC proteins have been shown to regulate potassium and sodium channels. PODC1 has been associated with phenotypes including limb-girdle muscular dystrophy-25, cardiac arrhythmia and changes in PODC protein expression have been linked to many cancers. POPDC3 may play a role in the maintenance of heart function mediated, through cAMP-binding and it is also important for skeletal muscle function. Pathogenic variants in POPDC3 are responsible for a novel type of autosomal recessive limb girdle muscular dystrophy.
Jiyao W et al.(2023). "The conserved domain database in 2023.",