8ROH


Conserved Protein Domain Family
Rad21_Rec8_N
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pfam04825: Rad21_Rec8_N (This model is not part of the current CDD release)
N terminus of Rad21 / Rec8 like protein
This family represents a conserved N-terminal region found in eukaryotic cohesins of the Rad21, Rec8 and Scc1 families. Members of this family mediate sister chromatid cohesion during mitosis and meiosis, as part of the cohesin complex. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation. These proteins may also be involved in chromosome condensation. Dissociation at the metaphase to anaphase transition causes loss of cohesion and chromatid segregation.
Links
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Statistics
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PSSM-Id: 516457
Aligned: 101 rows
Threshold Bit Score: 57.5272
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
8ROH_B         1 MFYAhfv-lskRGPLAKIWLAAHWd------kKLTKAHVFECNLESSVESIIS-PKVKMALRTSGHLLLGVVRIYHRKAK 72  human
Q7SGX9         1 MFYSheiltnqQYGVATVWLVSTFglrs-snrKISRKAIQEVNVRKACETILQ-PGAPIALRLQGSLLYGVSRVFSQQCS 78  Neurospora crassa
KLU83324       1 MFYSheiltshKHGVATVWVLATLgqnc-gsrRISRKAIQEVDVPKACMTIDNpPGAPIALRLQASLLYGVSRAYSQQYD 79 
XP_003721082   1 MFYSheiltsqKHGVATVWVLATLdrsc-asrKVSRKAIQEVNVPKACVTIDEpPGAPIALRLQASLLYGVSRVYQQQCH 79 
XP_008096773   1 MFYSheilnsrQFGVATIWVVATIgprgggkrKISRKAIEEVDIRKACEKIIE-PGAPISLRLQSNLLFGVSRVYSSKCN 79 
ERS99517       1 MFYSteilcdkRYALSTVWRAGNTaiga-rttGIRRNAVLEVSVKQTCGTIKDpPGAPIALRLQGTLLYGTARIYQEQCR 79 
EQB58408       1 MFYSheilnnkQYGVATIWHIANFgqsn-slkRVTRKVIDEVKISKACAKFMD-PGPPIALRTQSKLLFGTVRVFERQCY 78 
XP_006668943   1 MFYSnqiltstQYGVSTIWLIATVgks--nqkRVTKRAIQDVNVPRACDKILD-PGAPLALRLQGNLLYGVSRVFADQCG 77 
XP_018237508   1 MFYSheilsntQYGVATIWLVATVgks--nqkRLTRKAIQQVNVPKACETIIN-PGAPLALRLQGNLLYGVSRVYAQQCR 77 
EMR62330       1 MFYSheiltsrQYGVATIWLVATIgnks-sakKVTRKAIQEVDVEKACGKILD-PGAPIALRLQGNLLYGVSRVYRDQCT 78 

8ROH_B        73 YLLADCNEAFIKIKMAFRp-gV----VDLPEeNR 101 human
Q7SGX9        79 YVLTDAEKIHMHMRCFYNvlgGtenaLDPQA-GK 111 Neurospora crassa
KLU83324      80 YLLSDAEKARLGMSILFKnles-sdtLDPKA-GK 111
XP_003721082  80 YVLGDAEKFRISMRGLMRvld--sgtLDPNA-GR 110
XP_008096773  80 YMLNDAEKVQTLMKTFFRlia--nneTVPNA-GR 110
ERS99517      80 YVLNDSERAQRAMAKLHNgfl--ddkLDKNA-GR 110
EQB58408      79 YTLHDAEKVRQLMKDLFAsid---naIDMNA-GK 108
XP_006668943  78 YLLSDTEKTQSDMMTFFRaik--gshLDLPD-TR 108
XP_018237508  78 YMLSDAEKTQSDMMTFFRvmd--tseTDPNA-GK 108
EMR62330      79 YMLTDTQKIQTHLLTLFNkfg--dnhLDPEA-GH 109
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