8B9A,8OUW,8DD7


Conserved Protein Domain Family
TIMELESS

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pfam04821: TIMELESS (This model is not part of the current CDD release)
Timeless protein
The timeless gene in Drosophila melanogaster and its homologues in a number of other insects and mammals (including human) are involved in circadian rhythm control. This family includes a related proteins from a number of fungal species.
Statistics
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PSSM-Id: 516454
Aligned: 114 rows
Threshold Bit Score: 108.037
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8B9A_X         44 PYKLGDDCLACLKDLKRWFKLvdDQQKRWDVAMAVAEYRILTDDLLPILIDWENkCslaaklaknnpdheefrnkayyDK 123  brewer's yeast
XP_032510676   24 GYHINENYNAVLESILQNILT--EDKQLRSYRRSINFGQNIKKDLIPLLIN-TK-D----------------------DK 77  
XP_067750132   62 VLLRGENCDDWVHDLQRAVRR--DHAKHRLVTKQLGKWKILQKKLLPLLVHHQH-D----------------------WK 116 
XP_002186038   67 RIVPVADCLNWLQDLQRALRR--DDDQYRPISLLMAQWKIVPQKLLPLVDSCRY-D----------------------TD 121 
CBN76654       40 RFVRGENCLEWLQDLQRALRR--DDENTREICITLSSWRVVQHKLVPLILECRD-D----------------------AV 94  
XP_003056011   31 VYVRDPQCHETLQDILRFLRR--DTTSSRSIMLLLHGWNLVEKDLIPLLLNYRG-E----------------------AS 85  
XP_015692759   26 GYAKGEHCLDNLKDLQRFLRR--DDPQRREVFKQVCKWKIASRDLVPIIENFQS-D----------------------RN 80  
XP_020522242   26 GYDRRTYCLENLKDLQRFLRR--DDPQTRDVFKLVSKWNIASNHLIPIIEHYQG-D----------------------CE 80  
XP_006606156   26 GYIKGQYCLDNLKDLLRFLRR--DDPQTRDVFKQVCKWNIVSKYLIPTIELYHE-D----------------------SN 80  
XP_009119833   40 GYSKSDYCLDNLKDLLRFLRR--DDPQSREVFKQVCAWNIVSKDLIPIIEHYQD-E----------------------HS 94  
8B9A_X        124 IALNCLQLLVLMT--WPLIV-TEQ------------SSSN------QITLYGELKKHQLVYKKTIL-SMes--------- 172  brewer's yeast
XP_032510676   78 TIVLVIKILVNLT--IPVEClLSLds--------vgRTDV------GRHTIFEINNLLTSTKAAIT-DH----------- 129 
XP_067750132  117 LVFSILKVLVMLTtkPPR----------------------------DSTNIAQQLKYLRQYKHEFL-RC----------- 156 
XP_002186038  122 LVLTVAKILVILT--KPLAEsTERagklpietktktTEAVireqirLRENAVQQAEARMEYKRAIC-HYhhghthdsnpt 198 
CBN76654       95 LVNTLFKIYVMLT--MPLSKqSEEalskpinpkaqgDVRDqq--mrRRENAMSQQAALHAFKRAFI-SK----------- 158 
XP_003056011   86 VFLDSIKLLVFLT--LPADQ--------------------------ESSSYAQQRRCILNTLTALLqSQ----------- 126 
XP_015692759   81 LVITAVKVLVFLT--MPVEP--------------------------SSEGVAQQIEYLWDLKAALT-RN----------- 120 
XP_020522242   81 LVINAVKVMVFLT--MPIDP--------------------------TSDDISGQMEYLWNIKVAVT-RN----------- 120 
XP_006606156   81 LLLNAVKVLVFLT--MPIEP--------------------------SSTDISQQLEYLWGLKSALT-NS----------- 120 
XP_009119833   95 LVLNAVKVLVFLT--MPLES--------------------------DSDDVPQQIEYLWGLKSAFT-VS----------- 134 
8B9A_X        173 ---gKVLRAAIRLALDVI----KIDRLSRTPRDNMVLKLVLNFFRNVIAIEPG---EFTINTKKSmpkkgitsidtlppn 242  brewer's yeast
XP_032510676  130 ----RVTKVVIDFLKKNAeidqSSKL---SSDECTNISNGLLLLRNILHIPEEi--NNPSYNPRT--------------- 185 
XP_067750132  157 ----GVVPIMMTILVEPL----SRKGSARTPQDFLNMEIVLTLLRNLLAIPNE---DPRFVTSTTs-------------- 211 
XP_002186038  199 ksggGILSIFVSLLAEPL----SKSGTARTEADHLKIELVLHLFRNLLSAEPLlhsSAAAVAQAQ--------------- 259 
CBN76654      159 ----DVLSVVVGMLEEPL----SHTGVARTDADNFSIELCLTLLRNVLNIQDPtpgMATSLGDHY--------------- 215 
XP_003056011  127 ----EIIPVLFSALLVSLer-yEVNQLRSNDEDAKVIQLFLTLIRNLLAGTDYrvaGSRGQDHVV--------------- 186 
XP_015692759  121 ----VAMAVIVSLLEDPLd---RLERASFTEDDWKLVQLVLTLFRNVLAIQEItlaQKASGEATQ--------------- 178 
XP_020522242  121 ----DAIAVIVSLLEDPLe---HLECEAFSEDDWKLVQLVLTLFRNLLSIHEIspqQQASGCTNQ--------------- 178 
XP_006606156  121 ----DVAAVIVSFLERPLe---NLERGTFSEDDWKLVQLVLTLFRNILAVQEIpthQKSGGLATQ--------------- 178 
XP_009119833  135 ----NIVAVVVSLLETPLe---NLELDEFNEEDWKLVQLVLTLFRNLLAIHDIsplQKAGESTCY--------------- 192 
8B9A_X        243 vsmDDISLNTVISSFHKNKVFGFLLTLTSSLSKEF-DQDfiNIPLLEIMFYFTKDVNQELLFprqfet----gthskvVN 317  brewer's yeast
XP_032510676  186 ------VQNQILWNLFSQSIDKVLIKLMNIT-----DAInwGVTMVQIIALLYKDQHVTTLQkllnlwle-aslsessED 253 
XP_067750132  212 --yFSHLQEDFICTLHDENVYEMILLFTQDIEAP--ENRewNLLIMEMIDLTLDCSQPKCVVayaknqltgktsssssGQ 287 
XP_002186038  260 -----TLHDDCVVLLDQELVLEILLVLGADIEQR--ENLqyNLLLMELVHHLLRHYDPAVVArav-----------psPT 321 
CBN76654      216 ----TQMHEQLVALFKDALLLDILLLLAQDVHAR--ENAklNLLLVEIFHFIIRDQEPGAIIavhrlq----aqrgasKG 285 
XP_003056011  187 ------LKEKLLTVLFDLQFPALLSQMAKDARKN--PFTeeSALLVEIFDLLFLDQNPSLLAl--------------fFD 244 
XP_015692759  179 ---LLCLADSFLELMFQENVMDLILVLTQHIDEPSgYLKqeNLLLLEIFHYLFLGRDPELIAras-----------teVS 244 
XP_020522242  179 ---FLCLRDGFLEILFSENVMDLILVLTQHITDFHgYIHqdKLLLLEIYHYIFLHQKPQLVA----------------KV 239 
XP_006606156  179 ---LLSMRDRFLELLFRENVMDIMLVISQCVGSSNvYLRqdNLLLLEIFHYILMGQDPELIVra-------------hLK 242 
XP_009119833  193 ---FLSLRNQFLELLSRENVMDIFIVITQTIECNN-LLRhdNLLLLEIYHYIFLGQDMELIA----------------LA 252 
8B9A_X        318 KNESSSAnnivtsAGFELS--KLLQKEHQMRKNVI-KHT-SARHSRFGGLLSI 366  brewer's yeast
XP_032510676  254 NESNTSPpn---rGSDDSS--PMLTSDP------------TSDSSDAGASGKS 289 
XP_067750132  288 AAATTTPsg---aRNAASAggNLLAKLDSEKKASAlHQSgSHRHSNFGGIMKM 337 
XP_002186038  322 GAAAALPpk---pRPGLLS--QSLQREKQKFHAPI-----MSRHAHFGGTLVV 364 
CBN76654      286 SAGLPSPar---qSGGSLM--SVLAKEKTKRGLGA--GQmHSRHARFGGTLQV 331 
XP_003056011  245 QQRREAPsv---kAAKNSQswTTCQQDRHK----------HVRHSRFGSRVVS 284 
XP_015692759  245 KEHVEGNid---tSVHSLR--LMMEDEERKKRMFRqRn--SEHHSISGIFTCT 290 
XP_020522242  240 SQKNQSKge---tSPSSFR--SIKEEEEKRRVTRSkN---LIRHSLFSGTFVR 284 
XP_006606156  243 ESKEDEQpq---tSLNSLQ--FILEEEKKRRNICKlNn--LSRHSQFSGTFAR 288 
XP_009119833  253 PEKLDQGkk---aAVESLK--KLMEAEEAKRKLARlN-NaNQRHSQFGGTFTR 299 
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