Conserved Protein Domain Family
HNF-1_N

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pfam04814: HNF-1_N (This model is not part of the current CDD release)
Hepatocyte nuclear factor 1 (HNF-1), N terminus
This family consists of the N terminus of homeobox-containing transcription factor HNF-1. This region contains a dimerization sequence and an acidic region that may be involved in transcription activation. Mutations and the common Ala/Val 98 polymorphism in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).
Statistics
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PSSM-Id: 516448
Aligned: 14 rows
Threshold Bit Score: 190.06
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_799101      9 EQIELLRRLVRTGLTKDEIIHACDSMAKMdSELGPLPSKIEQP------------------IFTSVNSAASPPISSyhap 70 
1_pfamImport   1 LQQELLSALLSSGVTKEVLVQALEELLPS-PNFGVKLESLPLSpgsg-----------araPTPKAGSFHTAPPNG---- 64 
XP_011910514   8 LQQELLSALLSSGVTKEVLVQALEELLPS-PNFGVKLETLPLSpgsgae-------pdtkpVFHTLTNGHAK-------- 71 
XP_016158562   8 LQRELLGALLSSGATKEGLIRALEDMVPA-AGFGVKLESLPLSpggap---------dgraALPALANGHGK-------- 69 
KAG9265773     8 LQQELLSALLDSGLTKDALLRALEDLPPCpQGLGIK-TERPLSpvsdc---------dskpVLLTLGRG----------- 66 
XP_015201190  13 EQIDLLQRLRRTGMTKHEILHALDTLDRLdREHGDK-FGRRPAyggg-----------ggsGTTTTTTTSTNNSNNv--a 78 
2_pfamImport   1 EQIDLLQRLRWSGMSKPQILHALESLERLdSEQSHKPPQPRPPcydn--------------hsgSTFEPTAAASSS---- 62 
XP_011606850  12 LQQELLSALLDSGVTKDVLIQALDDMDTGpTEYGVKLESLPMSpppppggkmngadadskpVFHTLTNGHVk-------- 83  torafugu
P22361         8 LQTELLAALLESGLSKEALIQALGEPGPY--------LMVGEGpldkges-----cggsrgDLTELPNGLGE-------- 66  house mouse
NP_001393844   8 LQTELLAALLESGLSKEALIQALGEPGPY-LLAGEG----PLDkgesc--------gggrgELAELPNGLGE-------- 66  human
XP_799101     71 QQLTvtnrnSGLDTtgglgQEPASPGNRTSLVTLLsnagh----------------------------ggfqeNgDGGDG 122
1_pfamImport  65 PRQG-----AACPG-----DEGPREGRATTMTPLP--------------------------------------I-LKGAA 95 
XP_011910514  72 ---------GRLSG-----DEGSEDGDDYDTPPIL------------------------------------------KEL 95 
XP_016158562  70 ---------GKLSG-----DEGSEDGDDFDTPQIL------------------------------------------REL 93 
KAG9265773    67 ---------SKMSG-----DEASEDGEDRDTPPIL------------------------------------------REL 90 
XP_015201190  79 ASSSt---tTIATQtq-yrGLSPSPSNSYDTSPPPsaatanqngresmsatpngklspsrytvnsvgarsysfE-ATEE- 152
2_pfamImport  63 SSSSlssftSATTQtqs-laASPSPSNSYEASPPPlypaggg-------------------------qrsfsyD-LAEDM 115
XP_011606850  84 ---------GKLSG-----DEGSEDGDDYDTPPIL------------------------------------------KEL 107 torafugu
P22361        67 ---------TRGSE-----DDTDDDGEDF-APPIL------------------------------------------KEL 89  house mouse
NP_001393844  67 ---------TRGSE-----DETDDDGEDF-TPPIL------------------------------------------KEL 89  human
XP_799101    123 GRGGVDDFHVTNEEVESLFRkGHMNVKEDIKDFLTRNRLSQNLISQSTGISQSYISQFLL-HGYVMRRSTQAILYRWFLA 201
1_pfamImport  96 GRSTPKEAAEQRAEVGPDAQ-DPWRAAKMIKGYMQQHNIPQREVVDVTGLNQSHLSQHLN-KGTPMKTQKRAALYTWYVR 173
XP_011910514  96 QALNTEEAAEQRAEVDRMLSeDPWRAAKMIKGYMQQHNIPQREVVDVTGLNQSHLSQHLN-KGTPMKTQKRAALYTWYVR 174
XP_016158562  94 QSLNTEEAVEQRAEVERMISeDPWRAAKMIKGYMQQHNIPQREVVDVTGLNQSHLSQHLN-KGTPMKTQKRAALYTWYVR 172
KAG9265773    91 QALNTEEAEQQRAQVERMLAeDPWRAARTIKSYMQQHNIPQREVVDVTGLNQSHLSQHLN-KGTPMKTTKRAALYTWYAR 169
XP_015201190 153 -DLDIDD------KVEELMRrDSSIIKEEIKAFLANRRISQAVVAQVTGISQSRISHWLLqQGSDLSEQKKRAFYRWYQL 225
2_pfamImport 116 GDWDVEE------KVEEYMRrDSNVVKEEIKVFLNNRRISQAIVGQVTGISQSYISQWLLqQGLEMSDPKRRAFYRWYLL 189
XP_011606850 108 QSLNTEEGAEQRAEVDRMLAeDPWRAARMIKGYMQQHNIPQREVVDITGLNQSHLSQHLN-KGTPMKTQKRAALYTWYVR 186 torafugu
P22361        90 ENLSPEEAAHQKAVVESLLQeDPWRVAKMVKSYLQQHNIPQREVVDTTGLNQSHLSQHLN-KGTPMKTQKRAALYTWYVR 168 house mouse
NP_001393844  90 ENLSPEEAAHQKAVVETLLQeDPWRVAKMVKSYLQQHNIPQREVVDTTGLNQSHLSQHLN-KGTPMKTQKRAALYTWYVR 168 human
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