Conserved Protein Domain Family
HNF-1B_C

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pfam04812: HNF-1B_C 
Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus
This family consists of a region found within the alpha isoform and at the C terminus of the beta isoform of the homeobox-containing transcription factor of HNF-1. Different isoforms of HNF-1 are generated by the differential use of polyadenylation sites and by alternative splicing. The C-terminal region of HNF-1 is responsible for the activation of transcription. Mutations and polymorphisms in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).
Statistics
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PSSM-Id: 487358
Aligned: 9 rows
Threshold Bit Score: 233.334
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q90867       285 AMDNFSGPQPTSAP-PLTPHNSSSLQPPPALSP--TKVH-GVRYNQQPASEAESSSS-NHHGNSS---MVTTQTILHQVS 356 chicken
3_pfamImport   1 AMDAYSTGQPHTMN-LLLSHNSPHHVQASASPP--SKMT-GVRYGQAGPNDVPSSSSiGHHVNSTsamVTSSQAILQQVS 76 
P23899       314 AMDAYSSNQTHNLN-PLLTHGSPHH-QPSSSPP--NKLS-GVRYSQPGNNEVTSSSTiSHHGNSA---MVTSQSVLQQVS 385 Norway rat
XP_014345048 286 AMDSYSNQQPNTVT-PVTPHNTS--LQHGALSP--NKVQvGVRYGQQSTSDDMSPSV-SHHGNSA---MVTTQTILQQVS 356
XP_006151581 282 AMDTYSGPPPGPGPgPTLPAHSSPGLPPPALSP--SKVH-GVRYGQPANSEAADVPS-SSGG--P---LVTVSAPLHQVS 352
2_pfamImport   1 ALDAPFS-QPSSAN-HALPTSPEPEAPESLCSP-------GVKYSPQMLCDGVTSARlAGGDRTG----------CLVVS 61 
4_pfamImport   1 AMDAYSGAPSHGMN-SLLSHSSPHQPPASTSPP--SKMQ-GVRYSQQGASEVTSSTTiSHHGNNV---MATSQSVLQQVS 73 
XP_007248687 322 AMDAYSG-QTHSMN-SLLSHSSPHHPQASTSPP--SKMQ-AVRYNQ-GPGEVSSSTTiSHHSGNG---MTSGQSVLQQIS 392
1_pfamImport   1 AMDAITV-PSHGMN-TLLSHNSPHHPQTSLSPPiiNKLD-LEQLQHQGPGEVTSSTTiSHHGGNA---MATSQSVLQQVS 74 
Q90867       357 PPGLEP--SQNLLSTDTKLISAPGGTLPPVSTLTALHSLeqnPHALGQQTQNLIMASLPGVMAIgagetsslaprftntg 434 chicken
3_pfamImport  77 PVGLDPghGHGLLAPDGKMITVSGGGLPPVSTLTNIHSF---SHHNPSQSQNLIMAPLSGVMAI---------------- 137
P23899       386 PASLDP--GHSLLSPDSKMISVSGGGLPPVSTLTNIHSL---SHHNPQQSQNLIMTPLSGVMAI---------------- 444 Norway rat
XP_014345048 357 SPGLEP--SQSLLTTDTKLISTSGGTLPPVSTLTALHSLhqnPHTVTQQTQNLIMASLPSVMAIgpgdtptltpslsntg 434
XP_006151581 353 PTGLEP--SHSLLSTEAKLVSTAGGPLPPVSTLTALHSLeqtSPGLNQQPQNLIMASLPGVMTIgpgepaslgptftntg 430
2_pfamImport  62 PVQLEP--SHTLLDTQNPKQVSSGGPLPPVSTLTSLHSL----SASPASSPSLIMASLPSVMSLgesslliaevnkgrhs 135
4_pfamImport  74 PGGLDP--SHSLLSPDAKMISVSGGGLPPVSTLTNIHSLsqsSHHGHQQTQNLIMTPLSGVMAI---------------- 135
XP_007248687 393 PGALDP--SHSLLSPDAKMISGSGGGLPPVSTLTSMHg----PHHAHQQTQNLIM-PISGVMAI---------------- 449
1_pfamImport  75 PGGLDH--SHSLLSPDSKMISGSGGGLPPVSTLTNIHN----SHHSHQQ--NLIM-PLSGVMAI---------------- 129
Q90867       435 gSTlviGLTSTQPQSVPVINSMGSSLTTLQPVQFSQQLHPSYQQPLMQQVQ-SHINQSPFMATMAQIQNPHaLYGPKSEV 513 chicken
3_pfamImport 138 -TQ---SLNSSQAQTVPVINTVASSLAALQPVQFSQQLHSPHQQSLMQQSP-SPMAQPPFMATVTQLQNSH-MYSHKQEP 211
P23899       445 -AQ---SLNTSQAQGVPVINSVASSLAALQPVQFSQQLHSPHQQPLMQQSPgSHMAQQPFMAAVTQLQNSH-MYAHKQEP 519 Norway rat
XP_014345048 435 pSTfviGLTTSQAPNVPVINNMGSSFATLQPVQFPQQLHSPHQQPIMQQVQ-GHMAPNSFMATMAQLQNPH-VYSHKPEL 512
XP_006151581 431 aSTlviGLASTQAQSVPVINSMGSSLTTLQPVQFSQPLHPSYQQPLMPPVQ-SHVAQSPFMATMAQLQSPHaLYSHKPEV 509
2_pfamImport 136 gSGvvtGLASTQPQSVPVINNVGAGFTTLQPISFQQQLHASPQQPIPQHLQ-GHMGSSPFMATMAPLPCH--MY--KSDS 210
4_pfamImport 136 -TQ---SLNTSQAQSVPVINSVTGGLAALQPVQFPQQLHSPHQQSLMQQSP-SHMAQQPFMATVTQLQNSH-MYSHKQEP 209
XP_007248687 450 -AQ---SLNTSQAQTVPVINSVAGSLATLQPVQFSQQLHSSHQQGLMQQSH-SHMSQQPFMATVT---HSH-MYSHKQEP 520
1_pfamImport 130 -AQ---SLNTSQSQTVPVINSVAGSLAALQPVQFSQQLHSPHHQSLMQQSP-GQMSQQPFMATVT---HSH-MYPHKQEP 200
Q90867       514 AQYTHTGLLPQTMVITDTANLSALTNLTPTK 544 chicken
3_pfamImport 212 PQYSHTSRFPSAMVVTDTSGITSLTNMSSSK 242
P23899       520 PQYSHTSRFPSAMVVTDTSSINTLTSMSSSK 550 Norway rat
XP_014345048 513 PPYTPSGLFSSTMVITDTGNLSAITGLAPTK 543
XP_006151581 510 AQYTHTGLLPQTMLITDTTNLSALASLTPTK 540
2_pfamImport 211 PQYPSSSLLSQALVIADSSSLGTLTSLTAVR 241
4_pfamImport 210 PQYSHPSRYPSAMVVTDASSISTLASMPSSK 240
XP_007248687 521 PQYSHPSRFPSAMVVTDTNSLSTLSSMSSNK 551
1_pfamImport 201 PQYSHPSRFSSAMVVTDGNSLSTLSSMSSNK 231
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