Conserved Protein Domain Family
PP4R3

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pfam04802: PP4R3 (This model is not part of the current CDD release)
Phosphatase 4 regulatory subunit 3
This entry represents the Serine/threonine-protein phosphatase 4 regulatory subunit 3 (also known as SMEK homologue) PP4R3, which forms a complex with the phosphatase 4 catalytic subunit (PP4c), localising it to the DNA damage repair machinery and regulates its activity. PP4c is involved in developmental progression, chemotaxis, expression of stress response genes and cell movement. These proteins contain an N-terminal EVH1 domain and this alpha solenoid region.
Statistics
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PSSM-Id: 516443
Aligned: 92 rows
Threshold Bit Score: 291.315
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007328979   197 EIERAIKAl-sRTQPVKERICEYIQQEE--YIKSLIDVLRAAEDLESLENLHALCSLMQTILMLNDHTLYEHILE-DDIF 272 
XP_002908623    30 EILLVLKT---SHPTVRSKVLKDLADKDgaYIVKLLDLFDVCELDADKTVLYQFFDIFYAMLEMCNRGVIEILLS-EANF 105 
XP_002296002   134 SIVDVIAG---GQIQQREDLLIFLSQSDcaYIKALLQLFHVGEENLEYGGLATLAVCVKSILLLNDPEIIEYVTTdVQTF 210 
A0D074         116 LILETMSKliqGGTQTKQMLSSYLLNKKd-YFEMLNNLFNQLEKDHNQELLEIMCSIVKNIVTVSEHELFQTILS-DQIY 193  Paramecium t...
XP_002672057   188 AILSIITD-------HRFRLPSYIKSD---YILKLFQVFDDCEDLDSVENCRILFKIFSGIIAIDDLEILEILFS-KNNI 256 
Q3V0Y1         154 NIAELFPFv-fEMPSQKERLALFLENEG--YIKKLLQLFHTCEKLKNMEGLYYLHNIIKGILFLNNTRLFNIMFS-DEFF 229  house mouse
NP_001078980   142 NIADLFTFv-hETPSHKERLVLVLEKGV--YIKKLLQHFNTCEKLKNMESLYYLNNIIKGILFLDNTHLFNIMFS-DEFF 217 
7_pfamImport     1 QIADLINSi-lASADGREKMAVILESDD--YIKKLLQLFRACEILQNMKSLHYLHEIIKGILCLNKTPLTEVMFS-DECI 76  
13_pfamImport    1 EIADLVTSv-rLSRIRKGKLALALRNEG--YIPKLLQLFRVCERVKNTEGLHLLFDIVRGILYLDKAILFEVMFS-DECI 76  
8_pfamImport     1 EIAELVASv-cLSRICRKKLALTLKKKG--YIPKLLQLFQECESAKNTEGLHLLFDIVRGILYLDKAILFEVLFS-DECI 76  
XP_007328979   273 YGVVGMLEYDPDFPTHKa-NYRDFLKQAARFRQPIPMQEEVIQRKIHHTYRLQFLKDVVL--ARALDDSTFNVLNSCIIF 349 
XP_002908623   106 ISVVGVFGYNPGLIREI--DFRTALEGDGGFNEVISISDRTIVERVHMNFRIQVIKDNVL--SRSLPDGCVLLLEHMANE 181 
XP_002296002   211 EAVCAALEYDPELRERA--NHRWYIREQAKFRTVVKMEDEELISYIHRLFRVNYLRDTIL--RPTMDESSLSTLVSLAQF 286 
A0D074         194 MFIFGALEYDKEMAKSQfvPHRQFLEKNVQFLQVVQIKSKERLKTIHFIYRLQYLRDCGL--AYYI-DEYQQMFIKIVLT 270  Paramecium t...
XP_002672057   257 MKLIGVLEYDPDLPTKKa-NHRNFLNNRVIFKEVIPFNNHNVLDKIHQTFKIQYIKETIL--ASIIDDQTFSTLSTIIFK 333 
Q3V0Y1         230 MDIVGCLEYDPALDQPK--QYREFLTQNSKFKEVIPIIHSQLRQKIQQTYRMQYVHDIMLptPSIFQTNLLSDITTMIFF 307  house mouse
NP_001078980   218 MDMVGCLEYDPALDHPK--QYREFLTQNAKFKEILPITHFQLRQTIQQTYRMQYVHDIVLpiPSICESNLLYGLNTMIIY 295 
7_pfamImport    77 LDVVGCLEYDPAFPEPK--RYREFLTQNAKFKEVIPIADIELRQKIHQTYRAQFIYDILLpvPTVFDENYLSTITTFIFF 154 
13_pfamImport   77 LDVVGCLEYDPCLAQPR--WHRESLTKRAKLQEVIPTRDPELRRKIRLASRAQYIRAIIMpnPSDFEEGFLSTLNSFISS 154 
8_pfamImport    77 LGVVGCLEYDPCLAQPG--WHRDFLAKTEKLQEVIPIRDPELRQKFLQTSRVEYIHTIIMrnPPYLKVRCLSTLNSFIGS 154 
XP_007328979   350 NQIDIITHIQSD--QMFLKEIVRLFVDEDvliggaqryqiqlqmmqqqqqqmhqmhqrlqqgpddsmdvdtapkpipsvs 427 
XP_002908623   182 NNFHILSFISET--EDYWKAIKDLVTSED--------------------------------------------------- 208 
XP_002296002   287 TQSDIIKGVIRGenENYLTKVLRMLGTEIkai------------------------------------------------ 318 
A0D074         271 CYVDLLKYIENS--KEFLVDLIDQLRNFNfl------------------------------------------------- 299  Paramecium t...
XP_002672057   334 NNTMIINSIKED--QEFLKKVFSTLLADDtp------------------------------------------------- 362 
Q3V0Y1         308 NKINIITMIQED--ENFLLEVFSQLKDNSig------------------------------------------------- 336  house mouse
NP_001078980   296 NKIEIITMLQDD--ENFLLEVLARLKDNTvg------------------------------------------------- 324 
7_pfamImport   155 NKVEIVSMLQGD--DKFLTEVFAQLKDKTts------------------------------------------------- 183 
13_pfamImport  155 SKEEILRGLQQD--EEFLPEIFTQLTKEAta------------------------------------------------- 183 
8_pfamImport   155 SKNEIFHALQQD--EEFLPEVFAKLTNGAta------------------------------------------------- 183 
XP_007328979   428 ppasapissptaysfappddlteaeinQRREVVLLIQQLCIMGK-NVQ---LPARMAL---------FRVLVDR-GILFA 493 
XP_002908623   209 ---------------------------KRLEGLGLLKAIISLARvTKPvdrPQRREPFgappifaslIDDLFGDgELYVA 261 
XP_002296002   319 ------------------------rkmKRKGCLSFLKELFNMARaSLQ---QHEKEEF---------IATVVSM-----S 357 
A0D074         300 -------------------------------aLRFLNEICSVFK-EYQ---DLNKAFI---------YQRLSEH-GLYEI 334  Paramecium t...
XP_002672057   363 -------------------------kdKQRDLSKFLSEFFALLK-HQN---INNKIDT---------YKRLTLDhQLLDV 404 
Q3V0Y1         337 -------------------------deRRIELLLFLKEFCEFAK-TLQ---SQKKNEL---------LKTLIKL-GIMSV 377  house mouse
NP_001078980   325 -------------------------ndRRHELLLFFKEFCTFAK-TLE---NLEKHEL---------LKTLINL-GVMSA 365 
7_pfamImport   184 -------------------------ddKRYELLSFFKEFCNFSR-TLQ---PQSKDAL---------FKTLTHL-GILPV 224 
13_pfamImport  184 -------------------------geQRCELMKFFKEFCAFSF-TLS----EKRDEF---------LQTLAKL-GFLPT 223 
8_pfamImport   184 -------------------------geQQYELMKFFKEFCAFSI-AL----PEKRDEF---------LQTLSKL-RFLPI 223 
XP_007328979   494 VQ-------------------WAMNSP-EVsevdkQM--IAAGGEILSALLDH-DLNGVRGHVLK---QIMaieker-aa 546 
XP_002908623   262 FS-------------------TILGSC-DS-----KLeeVALSVDILNMLVVYrGPDMLRSYLAG---EGKcipaptsdk 313 
XP_002296002   358 VQ-------------------LLEGGNvGS-----SLacGRASLEVLSVIAIH-DPSIIRRHCLD---AAA--------- 400 
A0D074         335 IEdyivdslqsfqkqkakfkkLKIKIQdDIf---eKT--STLILELVISCLQH-YPYNFRQYIVSehqQVL--------- 399  Paramecium t...
XP_002672057   405 AE-------------------KHLQNE-NV-----SI--RHIYSEILLSIAQTiHLSFLGEIK-----QRH--------- 443 
Q3V0Y1         378 LK-------------------VVVHMN-DY-----QI--QVGALDIFAYLVEY-SPCLVRAYAMEeaqDSE--------- 420  house mouse
NP_001078980   366 LK-------------------AVVHMH-DY-----QI--QIAALDIFPYLVEY-NPCLVREYLLD---EAH--------- 405 
7_pfamImport   225 LK-------------------IIMSAE-NL-----PI--RSTATDIFAYIIEY-NPSLIRKFAIE---EAR--------- 264 
13_pfamImport  224 LE-------------------MLMGVD-DL-----QV--KSAATDILSYLVEF-SPAMVQEFVMQ---EAR--------- 263 
8_pfamImport   224 LK-------------------MLMGMD-DL-----RI--RSDATDILSYLVDF-NTATIHKFVIQ---EAQ--------- 263 
XP_007328979   547 gkrGADKAETLLEMVCr-iMARS-KDLAVQSLVGDALKVWMDIPSEIppagageahaigaskmparkddsgTERFLEYFY 624 
XP_002908623   314 eriMWTPDSSLFTALL---VVFE-RNEPTRIQLFNLLREIFRVPLGQ------------------------DDKFLSVFY 365 
XP_002296002   401 ---ATSRDHDLLQSLLf-iMSTE-TDAGLLLQTSEIIRIILDTEMMGe-----------------------QGSLGNGFL 452 
A0D074         400 -------KYPLFNVIVdhaFDND--------SYLEILKLLIDNTQDEqn--------------------eiLDCFLSLFY 444  Paramecium t...
XP_002672057   444 ----LRNDFNLLKVIIk-tIVSE-PELGIQDNLTEVIKLLLDPETLLt----------------------nSDVFIDQFY 495 
Q3V0Y1         421 -----DNDDLLINIMIkqmICDFdPEFSQGIIMTAVLHELLNPENMRttak-----------------gceRKVFLNFFY 478  house mouse
NP_001078980   406 ---DTDDDDLFLNIMIkqmICNSdPRFSQGIILPAILCALLDPENMHvtan-----------------gceEKEFLNFFY 465 
7_pfamImport   265 ---KGGDHDFLINIVIsqmICDTdPELAGAIHLMEIIRALLDPETMVttss-----------------kceRSEFLNFFY 324 
13_pfamImport  264 ---QSENDTQLIIEVIkqiICSPdPEFGGDNQLMEILHALIDPEKMLttas-----------------nleIFEFLDIFY 323 
8_pfamImport   264 ---QSENDTQLITEIIkriICRPdPEFGGDIQLMDILCALIDPKEMLatas-----------------hleVFEFLDVFY 323 
XP_007328979   625 KECVHILFKPLvelqeWKSCKDNVlal--------trEQSNRYVYLCDLLYNFIQQHNFRSnFYVLSSNNILSRVATLLR 696 
XP_002908623   366 PNYMHWLLQPL-----KNNAFVPDe-----------sAMFDLQDSIMELLTFCTENHGYRV-KYLFGRQPVATYAEKMLR 428 
XP_002296002   453 DDENDFTSGgdf--knRNTAGDDSlrl--------vpPCAIRAAFTLEILSFCVRAHVYRM-KLFVLRTRLLGTILKIVG 521 
A0D074         445 PKISQSISHQSrie---------------------------qkTLFVELSLGLSRNLKASV-KDVLIQNQIALKMGFILQ 496  Paramecium t...
XP_002672057   496 KHHVELLASPIlnpqtTINHFTKPs------------IKVSCINHALDLLSFTVIHHKHRS-KNFLIANDIISKAVHLLD 562 
Q3V0Y1         479 KRYMRKLIAPIlsirvKYDSNDNRvyic-----pdnyQNAQLLGAVLEILTFCVQYHSMYI-KHYIFSNNLLRSILVLMS 552  house mouse
NP_001078980   466 TRCINNLIAPIlsatvEKENANNRanic-----pdnyQNAQLLGVVIEILTFCVQYHSTYI-KSYILDNNLLSRILVLMT 539 
7_pfamImport   325 KRCMNKLVAPLmattsEEISEEENidgsnenitslnyQRAHLLSLIVELLSFCVQHHTYYI-KNYIFNKDLLRKVLILMK 403 
13_pfamImport  324 DHYIHILTAPLladtsEEWYEIDNy------------QTAEILASVLELLSFCVERHKYHM-KIYIMNKDLLRRILVLMK 390 
8_pfamImport   324 DRYIHVLTAPLladtsEEWYEIDNy------------QTAETLASVLELLSFCVEQHKYHM-KNFVMKKDLLRRILVLLK 390 
XP_007328979   697 --------AKDKYLRHAsfrifrlLLRQNNAHIHGLVMKH--DVIKPILNLTLQESRRDNLLSCSCQEYFESM---RRDN 763 
XP_002908623   429 --------SKNKLFVIP-------CAVRAEAFFSRFLIQN--DLFTPMLANLEIGKPNTGAVGSAILEVLSFI---GKTN 488 
XP_002296002   522 qkssvpmtSSDRCLILAslkllrsVLSVKDEFYHRHIVQY--NLFAPVFEVFRAIPVGNNLVSSTVLEMCDFI---RTEN 596 
A0D074         497 --------EKNKILQMKclqffkiLILQRDEEINKEVIMAfpNLISPLL---LYKGLRENLIFSQFLEIVKIIyegGNQN 565  Paramecium t...
XP_002672057   563 v-------YREKDLILGvirffksIISRGDLLLCTNILTN--NLFDPIMEVWRRNGSVYNLINSAIIDLFEAL---RNTT 630 
Q3V0Y1         553 --------SKHTFLILCavrfmrkIIGLKDKMYNHYIIKK--NLFEPVVNAFMHNGHRYNMLNSAIIELFEFI---RKEN 619  house mouse
NP_001078980   540 --------SKHTFLILCavrfmrkLIGLKDEIYNLYIIKE--NLFEPVVNAFMHNGHRYNMLNSAIIELFEFI---RQEN 606 
7_pfamImport   404 --------SKHTFVILCairfmrnIVGLKDEFYNRYIIKG--NFLEPVVTAFLDNGTRYNMLNSAIIEMFDYI---RVEN 470 
13_pfamImport  391 --------SKHKFLALCalrfmrrIIGLKDELYNRYITLG--NLFEPVVNAVLDNRNRYNLLNSALLEMFEFI---RMED 457 
8_pfamImport   391 --------SKHKFLALSalrfmrrIIGLKDELYNCYITVG--NLFEPVVNAVLDNGNKCNLFKSASMELFEFI---QKED 457 
XP_007328979   764 -MKELIKFCMIQH--------EED-VRKLAetplgGQRFELLIR-RPTD 801 
XP_002908623   489 -LTSLVEHIHTKF--------YET-YKAEC-----PLVFEAIRA-RHDG 521 
XP_002296002   597 -IKSLLEYIVSKHllepmdlnGIIsLEEIAnp--hVDTFKQLRK-KHDE 641 
A0D074         566 iIKSLEQEL--KF--------WEQ-HSNYLk---iHDIFKSIKSnCMKQ 600  Paramecium tetraurelia
XP_002672057   631 -TGRLKQHCVERF--------RQD-FEAVNy----VETFAQLIE-ECDQ 664 
Q3V0Y1         620 -ITSLIVNIVENF--------FRA-FKSIEy----VQTFKGLKT-KYEE 653  house mouse
NP_001078980   607 -IKSLIANIVENF--------FIS-FESIEy----VQTFKGLKI-KYEE 640 
7_pfamImport   471 -IKSLVAHIMENY--------YKS-LEEIEy----VQTFKGLKV-RYEQ 504 
13_pfamImport  458 -IQFLIAHIVENF--------SDA-LESLKy----IHTFQGLKI-KYEQ 491 
8_pfamImport   458 -IQILITHIVENF--------SDA-LQSVKh----FHTFQALKT-KYEH 491 
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