Conserved Protein Domain Family
Sin_N

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pfam04801: Sin_N 
Sin-like protein conserved region
Family of higher eukaryotic proteins. SIN was identified as a protein that interacts specifically with SXL (sex lethal) in a yeast two-hybrid assay. The interaction is mediated by one of the SXL RNA binding domains.
Statistics
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PSSM-Id: 398461
Aligned: 49 rows
Threshold Bit Score: 244.919
Threshold Setting Gi: 122017328
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q386G3        13 D--DDEVIATYNVYASSF-AQQqqQLHIFQFPLRCRARPY-EANEVRLfateglihsdedsiansgsrvggttastprqe 88  Trypanosoma brucei
EGT47843      30 gssEDQVLWERKIVVCNSiPNT--EMFCVSYPPSKR-DAW-DGKRLPT-------------------------------- 73  Caenorhabditis ...
EFP04449      31 DgtEDQVLWEKNVVVCTSaPNT--EMFCVSYPSSKR-DAW-DGKRFPM-------------------------------- 74  Caenorhabditis ...
XP_002642969  28 eeeEDQVVWERNVAVCTSvPNT--EMFCVSYPSSKR-DAW-DAKKFPV-------------------------------- 71  Caenorhabditis ...
EDQ86070      45 D--DDPVIAELNVFVSTA-LQE--QLYLYQYPMRSALRPFvSGDGNLE-------------------------------- 87  Monosiga brevic...
CBJ26025      61 P--DDPLDRVLDVYLADE-LED--HLYLLQYPMQPADRPS---STPLA-------------------------------- 100 Ectocarpus sili...
Q4CYE9        14 D--DDEVIATYNVYASP--LQQ--QLHIFQFPLRRKTQPY-ETDEVRLfvtegvthvg-----------------keatp 69  Trypanosoma cruzi
EFC40021      64 D--GDEVVKRFEVYLSHK-LSD--KLYLLQYPLRPKNNNY-NFQQLKE-------------------------------- 105 Naegleria gruberi
EGC38572      39 D--GDYVEHEIPVYLSQG-LAN--NLYLFQYPLRQPWRPY-DMTKLEE-------------------------------- 80  Dictyostelium p...
Q86JI9        78 E--EDYVIHEIPVYLSQS-LSD--YLYLFQYPLRQPWRPY-DMSKLEE-------------------------------- 119 Dictyostelium d...
Q386G3        89 tfgavAPVIHHSSRLTMHChidtfgsSSFTEPQQDHRLdedtqraee-------rskhsynyaLQSHPFN---------- 151 Trypanosoma brucei
EGT47843      74 -----ARYKKNVRLLEMRFmtd-ttnGSYDKKKAESMYadggspqkg--------ngagipprSNEEQYEgraf---vhd 136 Caenorhabditis ...
EFP04449      75 -----ARYKKNVRFLEMRFltd-tstGSYDKKKAELMLyeggeskkaga----saapgiealrANDEVYEgraf---vhd 141 Caenorhabditis ...
XP_002642969  72 -----ARYKKNVRLLEMRFlad-tsvGSYDKKKAELMYsggadsgkgg------hksgveairANDEVYEgraf---ihd 136 Caenorhabditis ...
EDQ86070      88 -----SRFRPKAQAVELKVpiepdnnPHYDFPKGEELAdlanepypqaksdpegsndegntktFPSGLMDhllmtstctp 162 Monosiga brevic...
CBJ26025     101 -----VKVKAANHLLEVEHpik-qggKHYDKNAPGQLRratqkh------------------------------tgsrvr 144 Ectocarpus sili...
Q4CYE9        70 psassASILSPSSRLTMHCrldtfgsSSFVEPSHQQQRqlpmqqtedrfcrgeqqrrnsyhyaLQSHPFQ---------- 139 Trypanosoma cruzi
EFC40021     106 -----VRFKPNHNKMEMDFevn-trsEHYNTDSGQEYSt------------------------FSlsst--------svp 147 Naegleria gruberi
EGC38572      81 -----LRIKPKQQKVEIDLsid-petENYNSDSMVKTTkytls--------------------------------sttvs 122 Dictyostelium p...
Q86JI9       120 -----LRIKPKQQKVEMDLsid-pdsDNYNPDAQTKTTkytls--------------------------------sttvs 161 Dictyostelium d...
Q386G3       152 PHCDYMVGLIVDGVVHITPVTSIQQFTPIVkp-pdASSMHRvgdgflsvpSVPIVPgl---------------------- 208 Trypanosoma brucei
EGT47843     137 HPIANAIGFLKNDEFFVHPLAGSFEMRKSIral--nkKRKggksg-nsddDSTGDEegresnq----------------- 196 Caenorhabditis ...
EFP04449     142 HPIVNAIGFMKNGEFFIHPLTGSFEMHRSIral--nrKKKlgkgg-nsedESTEDDeevdprk----------------- 201 Caenorhabditis ...
XP_002642969 137 HPIVNAVGFMKNGEFFLHPLTGSFEMHRSIhal--nkKKKsgkg--gsdeDSSEEEdepdpkk----------------- 195 Caenorhabditis ...
EDQ86070     163 QASPYAAALIHRGEVHVAPLRNVFQLRPNLhhldeAEARQK---------AAKAAGneeeaadg---------------p 218 Monosiga brevic...
CBJ26025     145 PATNFAFGVIRSDELHLTPIHATMQMRPCFqhideAKAQEI---------EMDLDDpdnggt------------------ 197 Ectocarpus sili...
Q4CYE9       140 PRCDYAVGFIVDGAIHLTPVSTIQQFTPIVkp-ttLIAAHRvgdeftsvqSTPIVPgl---------------------- 196 Trypanosoma cruzi
EFC40021     148 VKANYAVGILRGNQLHLTPLWNMLQLRPGFqhindGYSTGKskv---vrkKKGEEGeengdkkne-------------av 211 Naegleria gruberi
EGC38572     123 HRTNYAIGLMKNGELHLTPLQSIIQLRPQFkffddKWQEEK---------LRKKQDskeedeen---------------e 178 Dictyostelium p...
Q86JI9       162 HRTNYAIGLMKSNELHLTPLQSIIQLRPQFnyfddKWQEEK---------LRKKQDtkdddeqdeesgnggggggngqsi 232 Dictyostelium d...
Q386G3       209 -----aVSDRITR------EMLRQRSVMLNNDADTA--------KElqyfpiqsvESMA--MRRRLWDRTGASHcfagpa 267 Trypanosoma brucei
EGT47843     197 kptssaVRVKFSRpeterqKKRREASALHREKKIANdlwipmnvYLneddhvtakVQQIsgkef---------------- 260 Caenorhabditis ...
EFP04449     202 aatsgaVRVKFSRpeterqKKRREASALHREKQIASdlwipmkvHLkedepvnvkKAIIstgstvkg------------- 268 Caenorhabditis ...
XP_002642969 196 agtssaIRVKFSRpeterqKKRREASALHREKKIASdlwipmkvHLkddesvgrkKEMIssnsvkt-------------- 261 Caenorhabditis ...
EDQ86070     219 aesdsrVRVKVKRvetaraAAARKKSYAHMRQQIDEetwvplq------yrhsstRVAM--EQRELLRSTAAMP------ 284 Monosiga brevic...
CBJ26025     198 keaekpQQVSFKKkeseraTAARKSSYAYKKSIEDAepwvalevHGqn-----ddRSLD--EFSRMFVDDDASAnr---- 266 Ectocarpus sili...
Q4CYE9       197 -----aISDRINR------EMLRQRSVMLNTDAATA--------KElqyfpigsvESMA--MRRRLCSTTYDVSs----- 250 Trypanosoma cruzi
EFC40021     212 pnasqgGGMNFRLqs---dRKALERSYQFMKDQENNeksinlalYSpq-----dsRQHI----ESLFEQRDDPV------ 273 Naegleria gruberi
EGC38572     179 eepekpPPIQFKKpg--akMAA--QQPNLIKQMEDSeqwikvdlVDde------fNQDLinHFEKLQCDDTINS------ 242 Dictyostelium p...
Q86JI9       233 dplnkiASMQFKKag--akVSAANQQPNIIKQIENEeqwikvnlVDde------fDGELikQFEKLQCEDIYTD------ 298 Dictyostelium d...
Q386G3       268 gcvgsnpfgdskDGHNNGPYVGPRTEDCFfPPELLVSGGITGGEHvvs-gdkMLRRYANRRSL----------------- 329 Trypanosoma brucei
EGT47843     261 --------erqiPMIEPSMSIRDLVNKAIiCGVKEELVIESGKEHm------LSKQRIDELSG----------------- 309 Caenorhabditis ...
EFP04449     269 -----eesgvteVGPPPEMNIRELVNRAIiCGMKEELVIESGKEHm------LSKQRIDELSS----------------- 320 Caenorhabditis ...
XP_002642969 262 ------egggaeTLPPPDMSIKELVNRAIiCGLKEELVIEAGKEHm------LSKQRIDELSS----------------- 312 Caenorhabditis ...
EDQ86070     285 --------------IPLEMTPEEYVNRLNaQASDSRQQTTRKTPSikestrlMTLADMKKLPL----------------- 333 Monosiga brevic...
CBJ26025     267 -----------gTTTKEFPPCERYLQGLDyMEEYDENGESFSAGG-------RGRSLADSIDLvtagtgtyspvnlpaap 328 Ectocarpus sili...
Q4CYE9       251 -----------lAQTVGNQRSNTQTEDSLfPPELLISGGISGGEDaav-arsLLRRYAHRYSV----------------- 301 Trypanosoma cruzi
EFC40021     274 ---------------RFNVPPTAYLKQLVqYREEDQSAMa-----------qGSLGAIKKIKL----------------- 310 Naegleria gruberi
EGC38572     243 --------------IDYDLNEGQYFDLLC-PVQNDDQVWQPKKSYiq---etESLESIHKLKL----------------- 287 Dictyostelium p...
Q86JI9       299 --------------IKYDLNESQYFDMLC-PRVPDE--WVSKAAYih---etVSLETVHKMSL----------------- 341 Dictyostelium d...
Q386G3       330 -----VD-QVHIYLRRCQVLTLDKLREMVVPpdgafsgg--asstnqsKVQEsvtdGQLLAALR----DGAIWMHGVWVS 397 Trypanosoma brucei
EGT47843     310 -----PElQLKAHMVKSHVMKTSEMRRLIDP--------------------NlmstEAMLKELE----KCSRLVNGVWVL 360 Caenorhabditis ...
EFP04449     321 -----PElQLKAHMVKSHVMKTSEMRRLIDS--------------------RamstDLMIEQLK----QCSRLVNGVWVL 371 Caenorhabditis ...
XP_002642969 313 -----PEmKLKAHMVKSHVMKTSEMRKLIDS--------------------SlmstDALIQNLK----ACSRLVNGVWVL 363 Caenorhabditis ...
EDQ86070     334 -----KD-MLRHFLRQAEALRYSDICKHVAPge----------------------hYQLKRLLP----SMALLINGVWVA 381 Monosiga brevic...
CBJ26025     329 ahqlgGDaKVVGYLKLAHLVPFSMLLDVTNM-----------------SPDA------VLQALSvegrQKGLLMRGNWAA 385 Ectocarpus sili...
Q4CYE9       302 -----LD-QVLVLLQRCQVMKLTELRELVVSpdqtlvppppspstapqQPQGgvtdKQLLEALR----EVAVWMHGVWVS 371 Trypanosoma cruzi
EFC40021     311 -----GErQVYYALYLAKILPFSKIREL---------------------STRiksdEEMLNALQ----RYGVFVDGRWVL 360 Naegleria gruberi
EGC38572     288 -----AG-QIKGIMTNGHVVPFSKIVQLLSP-----------------NVKRgvmeVDIIEELE----KVAVLVRGRWVV 340 Dictyostelium p...
Q86JI9       342 -----AL-QIKTIMTNGHVVPYTKIHQLVSQ-----------------AVKRglmdHQIIEHLE----TYAVLIRGRWVV 394 Dictyostelium d...
Q386G3       398 KVDpn------------------mRGNAAALREVVLLHFceSPSGALSRARLN-ALVSSNTlkRTVKEILESIATLNSGE 458 Trypanosoma brucei
EGT47843     361 DSNlmfknlpsv---hknthdlfrAELWRNARDLALCLI--DGGHRVTRSTLI-TCFKLNE--KDADEILSTFGTRCEVS 432 Caenorhabditis ...
EFP04449     372 DSNlmfqnlppahsntagktdlyrAELWRNARDLALSLI--DGGHRVTRLSLM-TCFQLNE--RDADEILSTFGVRCEKT 446 Caenorhabditis ...
XP_002642969 364 DSNlmfqnlppahsnvagktdlyrAELWRNARDLALCLI--DGGHRVTRLSLM-TCFKLSD--KDADEILSTFGVKCEAA 438 Caenorhabditis ...
EDQ86070     382 RSPlvhpdacn------sfytgapAERMQAARDYALWRF--AYGKVVTKAQVM-KYGKLRE--PDAGQVLENL-TKQDSS 449 Monosiga brevic...
CBJ26025     386 LPAdvwpr-----------gpphaADCLSVAQCLL------HRYGAVSRPDLQrRFPELEP--VTLKELLLRIAELDTVD 446 Ectocarpus sili...
Q4CYE9       372 KTAsr------------------fKGTVAALREVILLQFfeSEDASLTRSEVN-KLVNGTAlrRTVKEILESVATLNSNE 432 Trypanosoma cruzi
EFC40021     361 KSEfnekiiklkdld-knpwtclkypktAAFREYLLYLF--QTEKKVIRKKFV-EKTGIEA--DRAKQLLEEVAVLKKVS 434 Naegleria gruberi
EGC38572     341 KSFfva-----------------kdQDLEYGRDYLLLEFy-DHEDGIDKKEFC-DKTKISF--EDGRELLSKIADLNNVT 399 Dictyostelium p...
Q86JI9       395 KSEfvt-----------------kdSDLEIGRNYLLLQFf-DSDYGIDKKEFC-KDTGISF--EDARELLSKISDLDNKS 453 Dictyostelium d...
Q386G3       459 KDpal-----rvWRLRhVPADPmeraalleVAQNAYRQEIEF----Q-TMQC--KRLHSSIMS 509 Trypanosoma brucei
EGT47843     433 RS----------WKLR-IERDE--------DFLN--DPLMRKyvisE-KEKW--IQKFYELDK 471 Caenorhabditis brenneri
EFP04449     447 RS----------WKLR-IERDD--------EFLK--DPAMKKhviaE-KVKW--INTFNELEK 485 Caenorhabditis remanei
XP_002642969 439 RS----------WKLR-MERDP--------EFLN--DPSMQKhiisE-KEKW--IQTFNDLEK 477 Caenorhabditis briggsae
EDQ86070     450 RL----------HHLK-IPEDA--------SFQSSHPDLVKK----M-------QPIFIEFQR 482 Monosiga brevicollis MX1
CBJ26025     447 RR----------WVPK-VK-DGl-------TFGMEHPEIVEL----E-EERW--TLHESILKE 483 Ectocarpus siliculosus
Q4CYE9       433 PDptk-----rvWRLRhVPADAalrramlqDAENVHRQEVTF----Q-RMQW--EHFRPHIKA 483 Trypanosoma cruzi
EFC40021     435 QDadeddelaayWVLK-YDVDQ--------EFIDEFRSFAGL----TvKQMW--TKRELEINn 482 Naegleria gruberi
EGC38572     400 RR----------WYLK-KQPDE--------DFLYRNARILEN----S-ERYF--EDHREEILn 436 Dictyostelium purpureum
Q86JI9       454 RR----------WFLK-KQADD--------DFIDRNPYTVDK----F-NQQFtdENSRKELLD 492 Dictyostelium discoideum
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