Conserved Protein Domain Family
Herpes_ORF11
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pfam04797: Herpes_ORF11 
Herpesvirus dUTPase protein
This family of proteins are found in Herpesvirus proteins. This family includes proteins called ORF10 and ORF11 amongst others. However, these proteins seem to be related to other dUTPases pfam00692 suggesting that these proteins are also dUTPases (Bateman A pers. obs.).
Links
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Statistics
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PSSM-Id: 309783
Aligned: 9 rows
Threshold Bit Score: 333.57
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q2HRC9  10 GDWEITVSNCRFTCSSLTCGPLYRSSGDytrlrIPFSLDR---LIRDHAIFGLVPNIEDLLTHGSCVAVVADAnatgGNA 86  Human herpesvirus 8 s...
Q2HRC8  26 PVWDSVIHPSHIVISNRVPLLLREQNIC-----LPSCPSVgqiLHRAYPNFTFDNTHRKQQTETYTAFYAFGD----QNN 96  Human herpesvirus 8 s...
Q66616  24 ENWKVEVTPAALTVVNTSEVPVQDPRCTii--tLPFSVWSa--MECMLCRFQPANQLHVACKLFDTTFILQNQd--lDQS 97  Equid herpesvirus typ...
O36365   9 NMWSVRIVNGIFVLSNKKPLNLPAHLSQl---nIPYSVHF---IVDSLASFGLLSSLFSLDQVKQSCALLVQHk---PND 79  Alcelaphine herpesvir...
Q8AZJ5   8 QAWRVEIGTRGLMFSNCVPLHLPEGQYHk----LRLPVSAyeaLA--VARYGLVGSLWEVPAVNSALQCLAAAa---PCK 78  Epstein-Barr virus (s...
P0C726  40 GVWKYEIFPSYVRVTNKQVLQLDAQCQE-----LPPCPSVgqiLSFKLPSFSFNTTTYGSR-YFTVAFLFFGA----EDN 109 Epstein-barr virus st...
Q66617  77 PFWSFSVYATYVKVTNKIRFVPGMLADCt----LPYLPNLkniLAGRYPNFHFTTTAHGGN-LSEVAFLAVEC----PRN 147 Equid herpesvirus typ...
O36366  25 SHWDFTIYDTYIKMTNIHHITTTSNDSC-----LPTCPPLaeiLKDKIPGYAFYSSAWQCQ-TMWMRFLIFGD----EDN 94  Alcelaphine herpesvir...
P24914  27 SFWNCSVHEHFISITNNREIHILPDDLL-----LPRCPSIraiLFKQIPSFKFSGSRSGPP-GTVTSLYVYGH----SKN 96  Herpesvirus saimiri (...

Q2HRC9  87 RRIVAPGVINNFSEPIGIWVRGPPPQ-TRKEAIKFCIFFVSPLPPREMTTYVFKGGDLPPGaeEPETLHSAEAPLPS--R 163 Human herpesvirus 8 s...
Q2HRC8  97 KVRILPTVVESSSSVLIFRLRASVSAnIAVGGLKIIILALTLVHAQGVYLRCGKDLSTPHC--APAIVQREVLSSGFe-P 173 Human herpesvirus 8 s...
Q66616  98 RYVVVETVVSDLKKPISFSLVSEGRA-LAEGELRLVLTPLRALDYVHVFSVIYNMHNE-----LPPGLELASVTEYCgsL 171 Equid herpesvirus typ...
O36365  80 QCTVLPTCVLDLEFDITVYVRSRQRV-LQPGALQLALIFIKPVNGSEMAWDVRDPPETMVGqrLYENVSQGTVKALEtpD 158 Alcelaphine herpesvir...
Q8AZJ5  79 DVKIYPSCIFQVHAPMFVTIKTSLRC-LNPHDLCLCLICVGAAILDIPLLCAPRDG-------AGARAAEGQAAAAQg-G 149 Epstein-Barr virus (s...
P0C726 110 EVFLKPFFVMHSDQDIVLSVLNPRSLfIEKGKFTWYIVPIRLVKNPYLYLQILPGQSDIQL--TRSCTQSGDKLNTSe-P 186 Epstein-barr virus st...
Q66617 148 PVRAAPTVVRCSLNEIAISLMRPLEGpVPAGGLTFYLLPVTLVKPHGLYLKIQKDRAAVGA--ATTCSQDGAHLNSEq-P 224 Equid herpesvirus typ...
O36366  95 CIKTQLMFIDRSAENINIRLQHASYQmAPAHSLVFYIFPIILLRLDGLYLRVLPDKHPGVM--DASCSQTWSCLNTPm-P 171 Alcelaphine herpesvir...
P24914  97 LIKIKPMVVSECEQELIFKITFALECtIPPGSMEIFILPITFLKLDGLYLLCLEDYTSRIM--STSCMQMGTYLASEt-P 173 Herpesvirus saimiri (...

Q2HRC9 164 ETLVTGQLRSTSPRTYTGYFHSPVPLSFLDlltfe--------------------------------------------- 198 Human herpesvirus 8 s...
Q2HRC8 174 QFTVTGIPVTSSNLNQCYFLVRKPKSRLAK-------------------------------------------------- 203 Human herpesvirus 8 s...
Q66616 172 VKELCGTAIRTRANTYTMAFKWEGARQFYRvtns---------------------------------------------- 205 Equid herpesvirus typ...
O36365 159 HLLLTGEAIGRSDGTYDMLFKDQKIPCMVNysn----------------------------------------------- 191 Alcelaphine herpesvir...
Q8AZJ5 150 KLRVWGRLSPSSPTSLSLAFPYAGPPPVAWyrhsinltrsegvgigkdcaqdhacpvppqghassaadqagvpergrkra 229 Epstein-Barr virus (s...
P0C726 187 QIFLSGSPVTSQDEC-LPYLLAQHTPPFLK-------------------------------------------------- 215 Epstein-barr virus st...
Q66617 225 QVFFSGTAAPAREGGELPFLLAQRTPRFERg------------------------------------------------- 255 Equid herpesvirus typ...
O36366 172 VVRLQGGMLSWDDED-MPFMLGQKTKPFLS-------------------------------------------------- 200 Alcelaphine herpesvir...
P24914 174 QVFLKGGPVLNKHEP-MPYLMAQKTKPFDK-------------------------------------------------- 202 Herpesvirus saimiri (...

Q2HRC9 199 ----------smgcENVEGDPEPLTPKYLTFTQTGERLYKVTVHnthsTACKKARIRFVYRPTPSA---RQL-------- 257 Human herpesvirus 8 s...
Q2HRC8 204 --------------PFARLSAETTEECRVRSIRLGKTHLRISVT----APAQETPVWGLVTTSFSLtptAPL-------- 257 Human herpesvirus 8 s...
Q66616 206 ----------yfceQYNRFKIVRLCVKECKMYRKEGNVHVLDITvvgdTQPEMVHGVVSVMGAEVD---SML-------- 264 Equid herpesvirus typ...
O36365 192 ------------vfASYHSPNEEILPRALEITMLGQKTARLTFRpgheCPSATVSFRAEVRPILQPk------------- 246 Alcelaphine herpesvir...
Q8AZJ5 230 hegpgageaasagrGDVALSQSRALLWRGLGWDTGRGRLAPGLAmsrdAASGSVHLDIQVDRAEEGwvcDVLlepgppta 309 Epstein-Barr virus (s...
P0C726 216 --------------SYARIHTFPGKVCPVNAIRRGKGYVRVSVDtpdlKREGPLN----VKVGMTLlddVII-------- 269 Epstein-barr virus st...
Q66617 256 --------------GFCKVHVTQGVTCPVNAVKLSKHYVRLPVCelrgDGGAGAAAPSQIKVGVTLvreAML-------- 313 Equid herpesvirus typ...
O36366 201 --------------KAVKVHALADEVCKVNDVCMGDNYMKIHL-----DFHFALDKHLPVDICMSPtnnTVL-------- 253 Alcelaphine herpesvir...
P24914 203 --------------KMARVHTVQNEVCEVNSIYRGENHVKVAIQ----KDSEDINFLDTVVVGLTMtnrALV-------- 256 Herpesvirus saimiri (...

Q2HRC9 258 --VMGQASPLITTPLGAR---VFAVYPDCEKTIPPQETTTLRIQLLFEQHGANAGECafVIMGLARETKFVSFP---AVL 329 Human herpesvirus 8 s...
Q2HRC8 258 --AFDRNPYNHETFACNArhyIPVIYSGPKITLAPRGRQVVWHNNSYTSSLPCKVTA--IVSNHCCNCDIFLED---SEW 330 Human herpesvirus 8 s...
Q66616 265 --VTDRYISPLYNQAWGW---ALPLYAPTQVVVPPKKTLKVPVDGMFFRGTVPGAQPvcLIGGSNINPDLVVRP---VVW 336 Equid herpesvirus typ...
O36365 247 -vLFSHFLNWIRVNYDCQ---VMPLYPEQEEVVNAHDWVRFQVNNKFLVSTAVDTPLkvFICGLGQPSFLVADP---GIW 319 Alcelaphine herpesvir...
Q8AZJ5 310 reGCSLSMDPGLVTLKDAw-tLFPLHPEHDAVVPPKEEIHVMAQGHLQGGTPSLWGF---TFQEAACDQWVLRP---RVW 382 Epstein-Barr virus (s...
P0C726 270 --AFRYNPYPKSHWRWDGe-sTDIRYFGSPVIIPPNFITELEYNNTYEAPLSSKITA--VVVSHSSNPVFYVYP---QEW 341 Epstein-barr virus st...
Q66617 314 --AFRYNPYLFSPWCWAEa-tVPIHYYGPPVIVPAGQAARVVYGNVYYAPMLDELTAv-IAPPLDGDGDRRFGLmgcCEW 389 Equid herpesvirus typ...
O36366 254 --SFKFNPFVKTPWEPTPa-kVPIVYMGEPVLIPGSCSTIVEYCNRYYVAKGLRITAi-IVSVETDDTEFETDV---CEW 326 Alcelaphine herpesvir...
P24914 257 --AFEYNPYFSCPWDWKRq-sIPIIYDGPCIRIPAGRLAPVKYNNTYSSIYPNATAI---ITNSDSCADFHISD---CEW 327 Herpesvirus saimiri (...

Q2HRC9 330 LPGKHEHLTVFNPQTHPLTIQRDTIVGVAMACYihpgKAASQAPYSFYDCKEESWHVG 387 Human herpesvirus 8 strain GK18
Q2HRC8 331 RPNKPAPLKLVNTSDHPVILEPDTHIGNALFII----APKARGLRRLTRLTTKTIELP 384 Human herpesvirus 8 strain GK18
Q66616 337 KPMTSLVLTLYNNSERPLAIRRGDLAALAVPV------NSTDIRTVYSDNSGTLITWD 388 Equid herpesvirus type 2 strain 86/87
O36365 320 NPSSTCLLTLHNISNQPVKLRTCEPVAVGLLLYc--nDAHLPSRDVCFCSETGRLEWR 375 Alcelaphine herpesvirus 1 strain C500
Q8AZJ5 383 TAHSPIKMTVYNCGHKPLHIGPSTRLGLALFWpa-erSDNLDAGRIFYQLTSGELYWG 439 Epstein-Barr virus (strain B95-8)
P0C726 342 KPGQTLKLTVRNISNNPITIVTGQSMAQAFFIYag-dPSISTIMRRYIQRQGCALTLP 398 Epstein-barr virus strain ag876
Q66617 390 PKGGHAELAVENRTCFLQVLRTGDRLGYAIFFIapriPMVNLLPARYRENLSVAVTVV 447 Equid herpesvirus type 2 strain 86/87
O36366 327 ASECTAKIMVSNKSLFPRTLAPGTHIANAHFLLaerhFFSRILSDKNLKKLSTCIKLP 384 Alcelaphine herpesvirus 1 strain C500
P24914 328 KPGKTACIVVTNTSTISVTISSGTHLGEAVFILapkfFCRKIMSKTHVQKLSSAICLP 385 Herpesvirus saimiri (strain 11)
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