Conserved Protein Domain Family
LMBR1

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pfam04791: LMBR1 (This model is not part of the current CDD release)
LMBR1-like membrane protein
Members of this family are integral membrane proteins that are around 500 residues in length. LMBR1 is not involved in preaxial polydactyly, as originally thought. Vertebrate members of this family may play a role in limb development. Lysosomal cobalamin transport escort protein LMBD1 is a lysosomal membrane chaperone required to export cobalamin from lysosome to the cytosol, allowing its conversion to cofactors. A member of this family has been shown to be a lipocalin membrane receptor.
Statistics
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PSSM-Id: 516435
Aligned: 66 rows
Threshold Bit Score: 132.04
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P34535        68 QQIICMWLFMLLYLFAYWLISRLKRKTEREAlyagee--dyfvyrVSVWISSTATATSIGSLTLLPFSVIGVEll--qLY 143  Caenorhabditis...
Q86AH0        93 EGIVSSIFFLILMIFSHFIIRRYIRKKDDEKki-----------yIPRLLCTVCLSISISAMLLIPITIISNEim--tTF 159  Dictyostelium ...
XP_025178010  26 QNIIAFLLFVSLYSISYSLLQRFRRKNRITDieeeeddpygidslIIIILCAGGLAMALAGFLLWPFTMIATAllhneIF 105 
1_pfamImport   1 EKIIFLLLFVLLLALSYAIINHYRKRDNIVVsvqded--ditvykYSLLLCTIALAVAVGAALLLPISIASNEvl--sLY 76  
KYB25110      22 EQIIFLLLFLLLYLLSFALLGRFKRKGREDYystded--evtvyrISTWLCTFSLAVSIGAVLLLPISIISNEvl--iIY 97  
XP_005850504   5 LIIITVVVAILVLLVSLYLVVHFQHPEDKNqa------------wLPKLVVLLGFSVAFWTILLFPLDVANQQ-----AC 67  
XP_044956161   8 LVIVAAVVSVLVLLVSVYLLVNYQHPDDANqa------------yFPKLVVVLGITVAVLSILMLPADVANRQ-----AC 70  
Q9SR93         8 LVIVAIVVCVIVFISSIYLLVNYQHPDDANqa------------yFPKFVVVFGLSIAMISILMLPADVANRH-----AC 70   thale cress
EFJ32053       8 LLIIVIVVTVLVFLFNTYLLVNYQHPDDHNqa------------yFPKAVVVFGLSVAQLSILMLPADVANRH-----AC 70  
EFJ25483       7 LLVIVVLLTLLVFAINIYILIRYQHPDDSNqa------------yLPKIIVVIGLSIAQLSILMLPADVANRH-----SC 69  
P34535       144 DGNYYLQWLSYSL-IGALWNYVFVLSNVSLFVLLPFSYFFIESQGFSTSKIGndmtQRIYEAMAISFLFAFVLLCLAEVV 222  Caenorhabditis...
Q86AH0       160 PSSYYTQWLDREL-IFSFWNKIFWGANISLFIILPFTYFLYESEGIRGRSLL----NRIKEALLILLLVAVIFVGFVFVV 234  Dictyostelium ...
XP_025178010 106 SGNYYLTWLDVEL-LVTLWNYAFIGCNISLFALLPFAFFYSETDQLRTFF------AKARETLIIMGLVGMLMYGFIYTL 178 
1_pfamImport  77 PSSYYVQWLNHSL-IHGLWSLVFLFSNLSLFVFLPFAFLFNESEGFPGHRKGl--kARVYETCTVLLLLSIFVLVLTYLL 153 
KYB25110      98 PNSYYIKWLNSSL-IQGLWNYIFLFSNLSLFVLLPFAYLFTESEGFFGHRKGl--mARVYETFTVLGLLGLVVLGMTYVI 174 
XP_005850504  68 ELDIPLSSCS-TMpMKELWYAMYIANMAITFIAVPFCIFYYEADSDWSv------fRRS-LSGALWAAGTVFVMAILIGI 139 
XP_044956161  71 KRAVYSGACSLTLpMKTLWLVVYIIDAVLVFLVIPFAMFYYEGDQDKSv------gKRL-KSALIWVVASAVVCGLVLGI 143 
Q9SR93        71 RHAIYNGACNLTLpMKDLWLAIYIVDAILVFFVIPFAMFFYEGDQDKTl------gKRI-KSALIWVVTTAVVCALVLGI 143  thale cress
EFJ32053      71 QRALYNGACDLTLpMKDLWYAVYIIDAVLVFLVIPFTMFYYEGDQEKSv------aRRA-VGALMWVIVIAIVVGLVLGI 143 
EFJ25483      70 EKNLYVGACKLTLpMKQLWWAVYIIDTVLVYLVIPFAIFFYEGDQEKTv------tQRI-KNALLWVVILLTVFCLLLGI 142 
P34535       223 LTIl--------------------------------------------------------------dYPVSFLsITsVNL 240  Caenorhabditis...
Q86AH0       235 FKLfygqq------------------------------------------------------kqpstLMENISiIStDYL 260  Dictyostelium ...
XP_025178010 179 KMLf------------------------------------------------------------------GISnVDeLEM 192 
1_pfamImport 154 YTIfyt----------------------------------------------------------eqsLFYMLFnLWnNYL 175 
KYB25110     175 SALidk----------------------------------------------------------dksSFQTLLnLWsYYL 196 
XP_005850504 140 PYAfagnaqytvqgarsgllpisylsnaedsftnciglfsyydqdsgqpklnstlvslgyncdtlinQLSEVWtIRvSII 219 
XP_044956161 144 LYAligkvdftvrhlsssvqtfpgpnqf---------------gaftsgqpciapltrqcsantapaNSQTTWtMRaTFP 208 
Q9SR93       144 LYGvigkvdfsvrhlasatstfptsw------------------qfsntqpcigntarqcsaftanpTSEKTWtMRtTFP 205  thale cress
EFJ32053     144 LYGligkvdftvrhlssttigfttdysq---------------ltsrspclvptnspnacsaynagyGAEATWsMRtTFP 208 
EFJ25483     143 LYAvigyadftvrrlssttlaftndfssl-------------nakapclfpagfslssncaaytsgsLVKTTWsVRaPFP 209 
P34535       241 PLIYSCVSFIGAVLLLISTPYGFAKM----FSLARdflvteetadieeenseqsedvtepknsssdetihqvdrsdtphl 316  Caenorhabditis...
Q86AH0       261 PFSYSLISTFGTVVVMYSIPSGFNFLiskcISLr---------------------------------------------- 294  Dictyostelium ...
XP_025178010 193 LNLFTCIG--GALICLKATPRGYIEI----FSCISklpl----------------------------------------- 225 
1_pfamImport 176 PFLYSCISFIGVLMLLICTPVGFATL----FTILSrfmi----------------------------------------- 210 
KYB25110     197 PFLYSCISFLGVLMLLVCTPLGFVRL----FDVVSqfli----------------------------------------- 231 
XP_005850504 220 VYAMAIVATLGWVLFMVFGGIGLVALp---IDWIRefiarpkat------------------------------------ 260 
XP_044956161 209 EYVVALATIVGSVLFTIFGGVGIACLp---LSLIFsfvrrpkav------------------------------------ 249 
Q9SR93       206 EYVVALATIVGSVLFTIFGGVGIACLp---LGLITafirrpkav------------------------------------ 246  thale cress
EFJ32053     209 QYLIALTTIVGSVLFTIFGGVGIACLp---LSLIFaffkrptav------------------------------------ 249 
EFJ25483     210 TYVIALNTIIGSILFTMFGGVGMATLp---LSLIFafknrpkcv------------------------------------ 250 
P34535       317 edvvnditenvdadgefRKDSDSGIESGSTEEMRLNTDDEEMGindsddksafgddgdlgnstptknkkkrrkhdyaatt 396  Caenorhabditis...
Q86AH0       295 ----------------iVRPIEDEIKAAKMEIESITFTLDKAEaagfvnleikksklkkrllncsinsgnnnnnnnnnnn 358  Dictyostelium ...
XP_025178010 226 -------------rpnyRRSLKEKLKRNKMDITVWQQRLENLE------------------------------------- 255 
1_pfamImport 211 -------------kpqlQKTTDEEISILRLEVDCLA-------------------------------------------- 233 
KYB25110     232 -------------kpqfLRDINEEYYACALEEECLR-------------------------------------------- 254 
XP_005850504 261 --------itrsqyidrARDLA---RRA---------------------------------------------------- 277 
XP_044956161 250 --------itrsqyikeATELG---KKA---------------------------------------------------- 266 
Q9SR93       247 --------itrsqyikeATELG---KKA---------------------------------------------------- 263  thale cress
EFJ32053     250 --------itrsqyikeATILG---KRA---------------------------------------------------- 266 
EFJ25483     251 --------itraqyvkeATDLA---KRS---------------------------------------------------- 267 
P34535       397 pivrkwdkdvpkkpknpnfdyRNLKEYVKEARRQRSSLSESDdywfgspprssfsanyyssrfsrwkhNSETGLNpsssl 476  Caenorhabditis...
Q86AH0       359 nnnnnnnnnnngnncndnkveKKKDNKNKNEMKSDKKTNHSN--------------------------VNSDIISssssp 412  Dictyostelium ...
XP_025178010 256 ---------------------RGLRsiysvnn------------------------------------------------ 266 
1_pfamImport 234 ---------------------RRLD----QVTINGLTYMSPE-------------------------------------- 250 
KYB25110     255 ---------------------RRLK----HVQTTGKYYVSPA-------------------------------------- 271 
XP_005850504 278 ---------------------KDILal----------------------------------------------------- 283 
XP_044956161 267 ---------------------KELKka----------------------------------------------------- 272 
Q9SR93       264 ---------------------RELKka----------------------------------------------------- 269  thale cress
EFJ32053     267 ---------------------RELKet----------------------------------------------------- 272 
EFJ25483     268 ---------------------NELKaa----------------------------------------------------- 273 
P34535       477 lvdpfasgd-fheassseasstpLSPA----------------------------------------------------- 502  Caenorhabditis...
Q86AH0       413 sspltpssplsqasnanesnstvNTPNiiatttnsniviindeynnnnnnnninfengnnsnnennnnidndnletnien 492  Dictyostelium ...
XP_025178010 267 -----------------tsrsaiLVPStesqysysseklya--------------------------------------- 290 
1_pfamImport     --------------------------------------------------------------------------------     
KYB25110         --------------------------------------------------------------------------------     
XP_005850504     --------------------------------------------------------------------------------     
XP_044956161     --------------------------------------------------------------------------------     
Q9SR93           --------------------------------------------------------------------------------      thale cress
EFJ32053         --------------------------------------------------------------------------------     
EFJ25483         --------------------------------------------------------------------------------     
P34535       503 --------------RRTKSE----EAIWKP----------------VLHTVKSSKLYKRAIEKQgrl------------- 535  Caenorhabditis...
Q86AH0       493 kkkinnylikkkkvNVNSNF----KITPEE----------------IQKLEDTRDELYLYIDKIsrp------------- 539  Dictyostelium ...
XP_025178010 291 -sgianniitnrsgHLSNSR----NEIIAK----------------INKLEEEEKRLQKDLSHS---------------- 333 
1_pfamImport 251 --------------PMLEGK----KQNITRtekelwplqngklkrgLTDRLSIHQERLDVLEKQrki------------- 299 
KYB25110     272 --------------PMSIGLngpfHDDDYKlpdnllrlrngelqsgLGSRLVEVETRRKMLDKQrht------------- 324 
XP_005850504 284 ------------adALKREE----------------------------RERGRSWRWRRNIKALnnqlivleedetqlel 323 
XP_044956161 273 ------------aeALHQEE----------------------------RSGNKGRKWRKNVKAVekellllendmnalee 312 
Q9SR93       270 ------------adGLHQEE----------------------------RSGAKGRKWRKNVKAVekellqleedvnllee 309  thale cress
EFJ32053     273 ------------tlALQREE----------------------------RSSGKGRKWRKEMKKVqqellyleedvqrlee 312 
EFJ25483     274 ------------tlGLQREE----------------------------RGGKKGRKFRKNVKKVqqelvfleddvealne 313 
P34535       536 ---------vklFMSLRFPVAAAAL----LVLTTCSLIMVATNTL----KLLFgyrsLP-----VYAQYIeVHTRHSFGL 593  Caenorhabditis...
Q86AH0       540 ---------syfSSTLVRILSSILLtiinFTITGWVIFKVFITLIkrifELFElesiKAyfdswMSSAIDlSKGSSKLGP 610  Dictyostelium ...
XP_025178010 334 ------------------PLYRNMLflvlFIVSHFIWLLILGHILyalmKSLLvddgKEl---kNLEALIgKQTVSLFG- 391 
1_pfamImport 300 ---------svfRKLFLYPTFMLLL----LALTVVTVLLVVQNLL----LILIgikaLPl---nTRQFTLgVSSLSKLGP 359 
KYB25110     325 ---------sflRRNVLHPIAMILL----IGLTVIAVLLVVQNTL----SLLIgikaLPl---sSKQFTLgVSSLSKLGP 384 
XP_005850504 324 vypqsedpdykwVLTVMGFWLKFFGgllgLAMSICWVLQIILYILi-----------DPpvtplLNDMFIkA--NDAFPL 390 
XP_044956161 313 mypqgekaeatwAFTVLAYIGKLIFgivgLIVSIAWVAHIIIYLLv-----------DPplssfLNEIFIkL--DSVWGL 379 
Q9SR93       310 mypqgeqaetawAFTVLGYLAKFILgivgLIVSIAWVAHIIIYLLv-----------DPplspfLNEVFIkL--DDVWGL 376  thale cress
EFJ32053     313 aypqgekadttwALTVLGYLSKLLLglvgLVVSGAWVAHIIVYMLi-----------KPpfssfLNQVFIkL--DDVWGL 379 
EFJ25483     314 afpqgekadtswALTVLFYLAKLVFgivgLALSIIWLLHIIVFMLv-----------NPpafpfLNQVFIqL--DSAWGL 380 
P34535       594 FGACIETLLIIYVMITSFVGLYSL---PVLRSLRPv-RKDTPMPTIIINSSIVLVVASa--------------lPVAVNT 655  Caenorhabditis...
Q86AH0       611 FESLLETTIIIYLMISAFVGFLNE---PYFANIKPr-IHSTSLRKMIINTGIILLMSSs--------------fPVVVRI 672  Dictyostelium ...
XP_025178010 392 FGTLNEITLIFCFTSATIIGVYSI---SPFKRIRPr-LGKMTVQQIIANVTVLLVISSs--------------wPVLVRV 453 
1_pfamImport 360 FGAGLEIVIILYMLVASSVGLYSL---PIVSTYRPh-IKQTPLTHIVGNCTLLLILSSa--------------lPLLSRI 421 
KYB25110     385 FGAALEIVLILYLIATSSIGLYTA---PVMSRIRPr-PRSTPFCLIIGNCAVVLILSSa--------------lPLLSKI 446 
XP_005850504 391 FGTLLFGLFAFYLQLCVTKGNFKFglnLLIFRVHPmrRGATIMSSFLFNVALILLATTasiqfctaafalyadgTAINDI 470 
XP_044956161 380 LGTAAFAFFCFYLLIAVIAGEMMLglkLVFITIHPmkWGGTLMNSFLFNVGLILLCSIsviqfcatafayyaqaTAAQEI 459 
Q9SR93       377 LGTAAFAFFCFYLLLAVIAGAMMLglkLVFITIHPmkWGATLMNSFLFNVGLILLCSIsviqfcatafgyyaqaTAAQEI 456  thale cress
EFJ32053     380 LGTVAFAFFCLYLILAVISGEMHLglnFGLIAIHPmkYGGTLMNSFLFNVGLILLCSVsviqfcskafalyaraTTAQEI 459 
EFJ25483     381 LGTTAFAIFCYYLVMSVISGEMHLgmrLLFLSIHPmkYQGTLMNSFLFNVAIILLCSTsviqfctkafslyaeaTAAQEI 460 
P34535       656 VGMTTFDLLGSHSSLQWLGsF--RVVVAYNTLFVVLSVAFLFNQL 698  Caenorhabditis elegans
Q86AH0       673 LEISRFDLMGYYSHTNYLRgD--FFKIIYSISFLFMVIRSYMLSF 715  Dictyostelium discoideum
XP_025178010 454 LGLTRLSSAGPYENFSTMTnIgqYLAMAFRVSALITTVFSTLEYY 498 
1_pfamImport 422 LGITDFDLLADYGRIEWLGnF--TIVALYNFVFASAATLCLFNKF 464 
KYB25110     447 LGITNFDLLGDFGSIEWLGnF--QIVLLYNLSFAAASTLCVVNKF 489 
XP_005850504 471 FGNQ----------LSSIKgL--KYIYNENIFIYCLLGFMALTLV 503 
XP_044956161 460 FGHT----------LQSLRgI--KYLYKYNVFQYGFVALAILTLF 492 
Q9SR93       457 FGHT----------LQSLRgI--KYLYKYNVFQIGFVILAGLTFL 489  thale cress
EFJ32053     460 FGLT----------LESLRgI--KYLFRYNVFQIAFCVLSVVTLV 492 
EFJ25483     461 FGHS----------LESLRgL--KYLFIFNVFQIAFIVFAFLSFL 493 
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