Conserved Protein Domain Family
Sarcoglycan_1

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pfam04790: Sarcoglycan_1 
Sarcoglycan complex subunit protein
The dystrophin glycoprotein complex (DGC) is a membrane-spanning complex that links the interior cytoskeleton to the extracellular matrix in muscle. The sarcoglycan complex is a subcomplex within the DGC and is composed of several muscle-specific, transmembrane proteins (alpha-, beta-, gamma-, delta- and zeta-sarcoglycan). The sarcoglycans are asparagine-linked glycosylated proteins with single transmembrane domains. This family contains beta, gamma and delta members.
Statistics
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PSSM-Id: 398454
Aligned: 55 rows
Threshold Bit Score: 136.582
Threshold Setting Gi: 972967507
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_624162           131 RLGVYGWRKKCLYSLVLALMLIVILNLALTVWLLKVMGFSsEGIGSLKVVPG--GIELrGQAAVLDALVASS---LRSRR 205 honey bee
OWR50510             53 rdvrKGRRTFVFWILVFLLLVTAVGNLVLTFSILGVLRLG-SGLESMEFLPLhdAVKF-LGDTNLDNIYKKDg-lIESFR 129 Danaus p...
ETN63430             16 chmydERSSFAFWLVLVLLFCLALGNLCLTLSITAILRIY-RGMENIELIEDadTIKF-YGNIDFDRVYKMDg-qLESFY 92  Anophele...
EDS29487             18 cqlynEKNSFAFWIVIILLFSLALGNLCLTLTIAGVLKIY-KGMENIELIQGaeTVKF-FGNIDFDRVLKVDg-kLEGFH 94  southern...
Q177R0               18 cqmynEKNSFAFWVVMILLFSLALGNLCLTLTITGILKIY-KGMENIELIQGeeTVKF-FGNIDFDRVYKRDg-kLEGFH 94  yellow f...
XP_002023875         67 HPGQHGRNSFAFWTVVIILLALTVGNLILTLTIVGVLRLG-KGVHGMELIPEvdVVKF-YGSTELERLQTNSigqVHGFT 144 Drosophi...
WGS:AAPU:GI22789-PA 110 HPGRQNRNSYAFWTAVVVLLMLTIGNLILTLTIMSVLRLG-KGVKGMELIPEvdLIKF-YDETDLDRVQTNAl-gIHGFS 186 Drosophi...
XP_001994846         70 qpvrKGRSSFAFWTAVTILLLLTIGNLILTLTIMGVLRLG-KGLQGMELIPEvdLIKF-YDETDLDRIQTNFi-gIHGFS 146 Drosophi...
Q9VG77               68 HPGHQGRNTFAFWTIVVLLLVLTVGNLLLTLTIVGVLRLG-KGVQGMEVIPEvdLVKF-YGTTDLERVQTNSigqIHGFS 145 fruit fly
WGS:AAQB:GK12845-PB  67 HPGRQGRNTFAFWTIVIILLALTVGNMILTLTIVGVLRLG-KGVHGMEVIPEvdVIKF-YGTTDMEKVYTHSigqIHGFT 144 Drosophi...
XP_624162           206 GKNLVLESWNN-----FTAS---ARSHDGRL--------------------LARFTVGED-RVDCVSRGFRITDPQG-GI 255 honey bee
OWR50510            130 DTPLSITSENG-----SVLItlqTRAPRS----------------------ETKLIVNTTgVFIKGVTTFNINDPDSgVQ 182 Danaus p...
ETN63430             93 DEPLELTGDDG-----AVSInlvNRNGHS----------------------HNKIQLSKNgSFLKGINHFDVKDPVTgKQ 145 Anophele...
EDS29487             95 EEPVEISGDNG-----PVSIslvNRNAHP----------------------HNKIHLSKNgSILKGINHFEVKDGASgRQ 147 southern...
Q177R0               95 DEPMEITGENG-----PVSInlvNRNGHS----------------------HNKIHFSKNgSVLKGLNHFEVKDAVTgRQ 147 yellow f...
XP_002023875        145 DVPVTISSDGSsddnpDAGVhvrVFRNGNGas-----------------seRDRIVVDKDaIVIDATNVFDVKDPADrQS 207 Drosophi...
WGS:AAPU:GI22789-PA 187 DVPVSISSDGE-----YSGVhlrVFRNLNSAsal---------------neRDLVVLDKGgIAIEA-NMFEIKDPTDhAT 245 Drosophi...
XP_001994846        147 DVPVSISSDGG-----DSGVhfrIFRNSNSGvsgaa-----------ttneRDRVVLNKDgITIQA-NLFEVKDPNDhST 209 Drosophi...
Q9VG77              146 DVPVTISSDAGd---gEGGVhvrVFRNGNGaa-----------------seRDRIVLNREgILVQATNLFEVKDPVDkQP 205 fruit fly
WGS:AAQB:GK12845-PB 145 DVPVSISSDAV-----ENADgveDGLHEESSanevhvrvfrngngngpaqeRDRIVINKEgIVIQATNLFEVKDPTDrQP 219 Drosophi...
XP_624162           256 LFSVDREqvVVGAE-----MLKVTgdggavfqgSVQTPLVRGESGRGLRLESATRsLKISAPQQVAIESWANEISASclT 330 honey bee
OWR50510            183 LFSSGNP--EVTVNen-lnSLNAR---------QVSTKRISSPVDEDLVFRSDAS-AYLRGAEGTHMESKELYWSAD--Q 247 Danaus p...
ETN63430            146 VFATSHP--HYNMPqg-amLLHAH---------LINSGRIAAPINDTLKLQTRNR-ITLKGTEGIRMEAKEMLWSAD--Q 210 Anophele...
EDS29487            148 IFSTSRP--TYNLPqg-asMLHTN---------LINAARITSPINDTLKFQTRNR-FTLKGTEGTRLEAKEILWSAD--Q 212 southern...
Q177R0              148 VFSTSRP--SYNMPeg-atMLHTH---------LVNAGRIASPINDTLKFQTRNK-FTLKGTEGTRMEAKEIFWTAD--Q 212 yellow f...
XP_002023875        208 IFSTHRP--QYNIPag-vaALQAK---------VVSASGISSPIDVPLNMESDGR-IVVKGSEGVFFDAASIDLQAE--H 272 Drosophi...
WGS:AAPU:GI22789-PA 246 IFTTHRP--QYNIPdgvegVLQTK---------VASASRVSSPIDVPLIMDSDGH-IAIKGSEGVFFDGATIEVQVE--H 311 Drosophi...
XP_001994846        210 VFSTHRP--QYTIPagvdgMLQTK---------VASSSRITSPIGAPLILQSDGH-MAIRGSEGVFFDGATIELQVE--H 275 Drosophi...
Q9VG77              206 IFTTHRP--QYNIPgg-veALQAK---------VVSASGIVSPIDESLVLESDGR-MAIRGSEGVYFDGASVDMQAE--H 270 fruit fly
WGS:AAQB:GK12845-PB 220 VFTTHRP--QYNIPag-vnVLQAK---------AVSASGISSPLDQPLSIESDGR-LAIKGSEGAHMDGANIQVQAE--H 284 Drosophi...
XP_624162           331 DLKLESVHGAIKLEAK-TLFMKGL--KTASptsqghasreqqqqqqqqhsprtgssphQSQRDTt----iYQLCAC-ANG 402 honey bee
OWR50510            248 DIHLRSANGSVILSGKeGVFVDVRylPIAL-----------------------------PSKEHhgt-gqFKVCVCmPQG 297 Danaus p...
ETN63430            211 NIFLKSDNGSTMLIGGnGVWINVNnlPVVK----------------------------GEHGVRsgs-nqYKLCVCyPQG 261 Anophele...
EDS29487            213 NIFLKSDNGSAVLLGAnGIYVNVNslPIVK----------------------------SEHGLRagtptqFKLCVCfPQG 264 southern...
Q177R0              213 NIFLKSDNGSIVIFGGnGVYINVNsiPIVQ----------------------------GEHGPRsas-sqYKLCVCyPQG 263 yellow f...
XP_002023875        273 HVSINSTQGATVLEAGtGIFLDMDriPIVS----------------------------SELGIRtgs-vqYKICVCmPQG 323 Drosophi...
WGS:AAPU:GI22789-PA 312 HVSLNSTQGATVLEAGkGIFLDMDriPVVS----------------------------SELGLRtgs-vqYKICVCmPIG 362 Drosophi...
XP_001994846        276 HVSINSTQGATVLEAGkGVFLDMDriPIVS----------------------------SELGLRtgs-vqYKICVCmPNG 326 Drosophi...
Q9VG77              271 HILINSTQGATILEAGtGIFLDMDriPIVS----------------------------SELGLRtgs-vqYKICVCmPHG 321 fruit fly
WGS:AAQB:GK12845-PB 285 HVSINSSQGATILEAGgGIFLDMEriPIIS----------------------------SELGLRtgs-vqYKICVCmPQG 335 Drosophi...
XP_624162           403 KLFLARSEG 411 honey bee
OWR50510            298 KLFRIAVPD 306 Danaus plexippus plexippus
ETN63430            262 RIFRLAVPK 270 Anopheles darlingi
EDS29487            265 RIFRIAVPK 273 southern house mosquito
Q177R0              264 RIFRVPVPK 272 yellow fever mosquito
XP_002023875        324 TLFRIAIPR 332 Drosophila persimilis
WGS:AAPU:GI22789-PA 363 VLFRIAIPR 371 Drosophila mojavensis
XP_001994846        327 ILFRIAIPR 335 Drosophila grimshawi
Q9VG77              322 TLFRIAIPR 330 fruit fly
WGS:AAQB:GK12845-PB 336 NLFRIAIPR 344 Drosophila willistoni
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