3J3A


Conserved Protein Domain Family
HABP4_PAI-RBP1

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pfam04774: HABP4_PAI-RBP1 
Hyaluronan / mRNA binding family
This family includes the HABP4 family of hyaluronan-binding proteins, and the PAI-1 mRNA-binding protein, PAI-RBP1. HABP4 has been observed to bind hyaluronan (a glucosaminoglycan), but it is not known whether this is its primary role in vivo. It has also been observed to bind RNA, but with a lower affinity than that for hyaluronan. PAI-1 mRNA-binding protein specifically binds the mRNA of type-1 plasminogen activator inhibitor (PAI-1), and is thought to be involved in regulation of mRNA stability. However, in both cases, the sequence motifs predicted to be important for ligand binding are not conserved throughout the family, so it is not known whether members of this family share a common function.
Statistics
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PSSM-Id: 428114
Aligned: 72 rows
Threshold Bit Score: 55.4282
Threshold Setting Gi: 599348148
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3J3A_h       189 GKREFDRHSGSDRssfshysglKHEDKRGGSGSHNWGTVKDELtESPKYIQKQiSYNysDLDQSNVte--------eTPE 260
XP_007390441 107 GRRPFDRHSATGK---------TDSEKKVHQG---WGGDEGTAeLKAETAAE-------KDAQAEAgnpia---egwgAE 164 Phanerochaete c...
EEB10309     246 GKREFDRKSGSDKtg------vKAMEKREGGGAHNWGNHKDDLeAVNLns--------------------------tNAS 293 human body louse
EFX80179     187 GKRDFDRQSGSDKsg------vKPIEKREGSGPHNWGSVQDEIeGQLEP---------------AVaeevvegeaevVAP 245 common water flea
AGO02039     175 GKREFDRRSGSDKtg------vKSVDKREGAGPHNWGTIKDDLdELNKTGSEge----------------------tTEE 226 domestic silkworm
4_pfamImport   1 GKREFDRQSGSDKtg------iKSIDKKDGAGSHNWGTHNDEIdPSANESKE---------------------------- 46 
XP_006559219 185 GKREFDRQSGSDKtg------iKPVDKKDGAGSHNWGTHNDEIeESLNQESQD-WTNek-----------------tDGD 240 honey bee
EFN68430     194 GKREFDRQSGSDKtg------iKPVDKKDGAGSHNWGTHNDEIeESLNQETQE-WNNek-----------------pETD 249 Florida carpent...
EFN82928     208 GKREFDRQSGSDKtg------iKPVDKKDGAGSHNWGTHNDEIeESLNQESQD-WNNdk-----------------pESE 263 Jerdon's jumpin...
Q16ZT8       183 GKREFDRQSGSNKtg------vKAVEKRDGTGSHNWGSAKLDAkEFNNFQEEY--MPhe-----------------aEEE 237 yellow fever mo...
3J3A_h       261 GEEHHPVADTENKEnevee---------------vkeeGPKEMTLDEWKAIQNKDR-AKVEF-NIRKPNE 313
XP_007390441 165 ASTDAWAAPAEGAEgaevvegttpaegekaegrrreeeEDNTLTLDEYFKQQKEKQlEIIPQlETRKANE 234 Phanerochaete carnosa HHB...
EEB10309     294 EENAEWSEGKPGNNdvgennan--------gepvqveeEPKELTLDEYRA-LRGKR-ELPQY-NIRKAGE 352 human body louse
EFX80179     246 AETAEVKEGEETAPvap------------------edeEPKELTLDEWRA-LRGER-KKPEF-NIRKPGE 294 common water flea
AGO02039     227 KAPEAGAGDGQVPEterav---------------paeeEPRELTLDEYKALRNAQR-TAPQY-NLRKAGE 279 domestic silkworm
4_pfamImport  47 --SVGSGGNAGDGTeggpte------------ekpaeeEARELTLDEWKA-LRQNR-AKPQY-NLRKAGE 99 
XP_006559219 241 TNQTTTEIKEGEATtdtvee-------------kpveeESRELTLDEWKA-LRNNR-VKPQY-NLRKAGE 294 honey bee
EFN68430     250 P-QAPTEVKNGETAadttve------------ekpveeETRELTLDEWKA-LRSTR-AKPQY-NLRKAGE 303 Florida carpenter ant
EFN82928     264 ATPGTTEVKNGDATaetave------------ekpveeESRELTLDEWKA-LRNNR-VKPQY-NLRKAGE 318 Jerdon's jumping ant
Q16ZT8       238 KGQASDQTKEEQTEqsdak---------------pveeELKEMTLDEWKAQIAAAR-SKPQY-NIRKAGE 290 yellow fever mosquito
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