4AB7


Conserved Protein Domain Family
NAT

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pfam04768: NAT 
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NAT, N-acetyltransferase, of N-acetylglutamate synthase
This is the C-terminal NAT or N-acetyltransferase domain of bifunctional N-acetylglutamate synthase/kinases. It catalyzes the first two steps in arginine biosynthesis. This domain contains the putative NAGS - N-acetylglutamate synthase - active site. It is found at the C-terminus of Neurospora crassa acetylglutamate synthase - amino-acid acetyltransferase, EC: 2.3.1.1. It is also found C-terminal to the amino acid kinase region (pfam00696) in some fungal acetylglutamate kinase enzymes. it stabilizes the yeast NAGK, N-acetyl-L-glutamate kinase, slows catalysis and modulates feed-back inhibition by arginine. This domain is found to be the N-acetyltransferase (NAT) domain, and it has a typical GCN5-related NAT fold and a site that catalyzes NAG synthesis which is located >25 Angstrom away from the L-arginine binding site in the N-temrinal domain pfam00696.
Statistics
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PSSM-Id: 398437
Aligned: 27 rows
Threshold Bit Score: 172.052
Threshold Setting Gi: 121919719
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4AB7_F       284 DLQKELFTDSGAGTMIRRGYKLVKRSSIGEF----------PSADALRKALQRDAgisSGKESVASYLRYLENSDFVSYA 353 baker's yeast
A7TQL5       366 GIDIKIFDYPKLTQFNSLSLPVEFRVKDSPQtnp----lhkIDLSKLKGLIDRSF---KRSLNLNHYLHRINGNIASIIV 438 Vanderwaltozyma...
P40360       364 GVHIKTYDYKTLTQFNSIGLPKKFHVPEKGAkpss--nspkLDINKFKSIIDQSF---KRSLDLHDYIKRINGKIATIIV 438 Saccharomyces c...
Q75A07       342 GVDIKLYDYSTLTKENSVGFHELLSTAGSAQlpa----hkrVNLTKLKGIIEHSF---DRNLDMSHYLKRINGKIASIIV 414 Eremothecium go...
O94330       320 PITKT--------TVLRSGVPVYTFLGPKCLtd------gsVSWERLWVLINDSF---KRTLDMDAYLDRLKNSLAAVII 382 Schizosaccharom...
Q6CEE1       380 PTLET--------TLLREGMPVITLKSDKGLnlitehekgnIDLDRLWHLIEDSF---GRRIDKQHYLNRVNGKIAGIII 448 Yarrowia lipoly...
XP_007180285 190 tLLTELFSNKGSGTLFKNAERMLRVRSLDSL-----------DQGLLVNLVNASF----GKKLRDDYLASLRPRLHSVYV 254 Balaenoptera ac...
EDO33374     280 SLITELFTHNGSGTLFQVSEQINAYHSLENV-----------DVERLRSLIIRSF----DQDLSLDYFSKIERQLHTIYI 344 starlet sea ane...
WP_013301233 271 GLVRELFTHGGDGTLVRRGEIITAHTHFETL-----------DITKLSTLIEDAF----GRSLKPGYLDNL--QVAKIYA 333 Parvularcula be...
Q8P8J6       255 DLAKELFTHKGSGTLVRRGERVLRATSWDEL-----------DLPRLTSLIESSF----GRTLVPDYFSNT--KLLRAYV 317 Xanthomonas cam...
4AB7_F       354 DEPLEAVAIV-----KKDT-------------------------------------------NVPTLDKFVCSDAAWLN- 384 baker's yeast
A7TQL5       439 IGDYDGIAILtnegpNDNP--------------------------------------------FVYLDKFAISPEMKGSl 474 Vanderwaltozyma...
P40360       439 IGDYEGIAILtyegsEENS--------------------------------------------FVYLDKFAVLPHLKGSl 474 Saccharomyces c...
Q75A07       415 IGDYEGIAILtyegpEKRP--------------------------------------------FAYLDKFAVLPHLRGSl 450 Eremothecium go...
O94330       383 AGDYLGTAIVtyeqpDGTTn-----------------------------------------eKVPYLDKLAVSQGAQGSa 421 Schizosaccharom...
Q6CEE1       449 AGDYEGAAIItwediDPVKaqedrdaadraaaeaaaayaagiplpspplyqklgdavplnpnQVAYLDKFAVLKRSQGSs 528 Yarrowia lipoly...
XP_007180285 255 SEGYNAAAILtte--pvLG-------------------------------------------GTPYLDKFVVSSSRQGQ- 288 Balaenoptera ac...
EDO33374     345 SESYSAAAIItv--pKDTG-------------------------------------------GVPYLDKFTVSKESQGK- 378 starlet sea ane...
WP_013301233 334 SADMRAAAVVie-----vE-------------------------------------------GMAVLDKFAVSRGARGE- 364 Parvularcula be...
Q8P8J6       318 SENYRAAVILtdegmLGAS-------------------------------------------ALIYLDKFAVLDDAQGE- 353 Xanthomonas cam...
4AB7_F       385 NVTDNVFNVL-RRDFPA-LQWVVSENDANIAWHFDKSQGSYL-------------KGGKVLFWYG--------IDDINTI 441 baker's yeast
A7TQL5       475 CISDIIFNLM-VKKFPKeLLWRSRNDNVVNKWYFQRSVGVLDlsidlg--dgnqtKSNFNLFYYGepkstnygFHNLARL 551 Vanderwaltozyma...
P40360       475 GISDIIFNLM-FKKFPNeILWRSRKDNVVNKWYFQRSVAVLDlsidldpehcdekQSQFKLFYYGnpqyakraLRDKKRL 553 Saccharomyces c...
Q75A07       451 CISDVIFNLM-FKKFGDeLVWRSRRENVVNNWYFQRSVGVLDlsidig--hgpkkDNIFKLFYYGgkk--gtqFYDFDRL 525 Eremothecium go...
O94330       422 AISDVMFNVM-TDLFPKeLIWRSRLTNPVNKWYFERSVGSLKs-----------sKTPWKLFWTGds-----hVRNLDRV 484 Schizosaccharom...
Q6CEE1       529 SVADVVFKGMvMSQFPNeLLWRSRKNNPVNKWYFDRSKGSFKi-----------pGSEWCMFWTG-----------RKTR 586 Yarrowia lipoly...
XP_007180285 289 GSGQMLWERL-RRDLQT-LFWRSRVTNPINPWYFKHSDGSFS-------------NKQWIFFWFG--------LADIRDS 345 Balaenoptera ac...
EDO33374     379 GTSEKLWKKI-TKDFEK-LFWRSRGTNRINPWYFMRSNGSWT-------------NGLWTVFWYG--------ITEQHHT 435 starlet sea ane...
WP_013301233 365 GLSHALWRRM-SEDFPL-LFWRSRAQNGFNAFYSERADGCVR-------------RGMWQVFWQG--------EIDLNTV 421 Parvularcula be...
Q8P8J6       354 GLGRAVWNVM-REETPQ-LFWRSRHNNQVNIFYYAESDGCIK-------------QEKWKVFWYG--------LENFEQI 410 Xanthomonas cam...
4AB7_F       442 SELV-------ENFVKS 451 baker's yeast
A7TQL5       552 KEYA-------KHIRDI 561 Vanderwaltozyma polyspora DSM 70294
P40360       554 REFM-------RSVRDI 563 Saccharomyces cerevisiae S288C
Q75A07       526 REYI-------TYVRDI 535 Eremothecium gossypii ATCC 10895
O94330       485 NQYM-------SVIDKI 494 Schizosaccharomyces pombe 972h-
Q6CEE1       587 EQYL-------ERFVDI 596 Yarrowia lipolytica CLIB122
XP_007180285 346 YELV-------NHAKgl 355 Balaenoptera acutorostrata scammoni
EDO33374     436 LKLVmyanslpSSFDPI 452 starlet sea anemone
WP_013301233 422 APAV-------AAIAGR 431 Parvularcula bermudensis
Q8P8J6       411 QHCV-------AHCATR 420 Xanthomonas campestris pv. campestris str. ATCC 33913
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