6S7T,6C26


Conserved Protein Domain Family
OST3_OST6

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pfam04756: OST3_OST6 (This model is not part of the current CDD release)
OST3 / OST6 family, transporter family
The proteins in this family are part of a complex of eight ER proteins that transfers core oligosaccharide from dolichol carrier to Asn-X-Ser/Thr motifs. This family includes both OST3 and OST6, each of which contains four predicted transmembrane helices. Disruption of OST3 and OST6 leads to a defect in the assembly of the complex. Hence, the function of these genes seems to be essential for recruiting a fully active complex necessary for efficient N-glycosylation. These proteins are also thought to be novel Mg2+ transporters.
Statistics
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PSSM-Id: 516414
Aligned: 169 rows
Threshold Bit Score: 115.804
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6S7T_H         42 SQLMEWTNKRp---------VIRMNG-DKFRRLVk--aPPRNYSVIVMFTALQLHRQCVVCKQ-ADEEFQILANSWRYS- 107 human
13_pfamImport   1 KELVSLRSSSes-------gVIRLTD-DTVSKFItsvsTPRPYSLIIFFNSIDLNSNP---LQeFRREFAFVSASFIANn 69 
EFH66133       32 NELVSLRSAAes-------gLIPLND-EDVSKFItsvaTPRPYSLIIFFDAIHLHGNSQLRLPeFRREFGLVSATFIANn 103
XP_005849823   28 QRLLALQRSHg--------gVIELDP-KTFQELLvg--kSRPYSVIIVADAKDLRSQGKLKLGqLVSEFRLVAKSFAATh 96 
CBN74884       45 RSLEKLRAAGdskgqagggaVVVVDG-TKFDRYItg--vPRQYEAVVFFTAAGANYKCTSCRV-HLDEFTTMAESYQAAr 120
12_pfamImport   1 EKLAKLQQRArn-------gVVPFTS-DLFTRFAv--rPERPYHLVLLLTATSAKHKCDACLQ-LAPEFELLGQSYQAAa 69 
XP_067750298   43 EKLVQLQDRVrd-------gVIPFTN-ELFGRYAv--rPDRPYHLVLLFTATAAKYKCETCAQ-VAPEFSTLGESYEAAk 111
XP_003292688   49 KEFRDLAVKEg--------gIIQLKTlTQTKKFLqa--kNRPYEVLALFTSSNPKYGCAGCLV-L-----NYGASYIQYl 112
Q54N33         46 NDLYDRAKKAg--------gVVEFKSnLDSKKFVta--qNRPYDLLALFTSSNPKYGCSGCVQ-LKNQIESFSLSYEPYl 114 Dictyostelium ...
XP_001022369   30 EALRELASKSpn-------gIIHFNS-TGYRYFLl--eQPRPYEVVLFFTAP----KCDFCEQ-MLTQYELTSNYYYANn 94 
6S7T_H        108 ---------SAFTNRIFFAMVDFDE-GSDVFQMLNMNSAPTFINFPA---KGKPK-RG--------DTYELQVR----GF 161 human
13_pfamImport  70 nnr---sdvA---NKVFFCEIDESS-DSEAFGLFGIQFLPQICLVDPl-----------------mENLQDKTGrmeeED 125
EFH66133      104 n-------nGTNGKKLFFCEIESTH-SVASFQRFAVENLPHISLVSP---MTENLte--------sDQMDGGDF----TG 160
XP_005849823   97 ag----kgsV---GSVIFARLEFSK-AKDLFGRMGIQALPYLARIPP----------SlaiseggaVTLGKEEVmpttGY 158
CBN74884      121 antp-etlnG---VDVYFFVADFGQ-NQLPFQKLGLQTVPKILHFPPalae------------gddGRYAIDQSqhmhMA 183
12_pfamImport  70 qvkvdtrdgL----DVVFGVADYEA-NQEVFRHYELTSAPFVVYVAPdanSDVGAaLPtkeqvnpqYLYNVYTQ----GL 140
XP_067750298  112 qlkvdtrdgL----DVFFGVVDFEA-NQEAFGMYEFTSAPHVVYVAPdrsQDAGErMPkktkvdpqNLYNVYSQ----GK 182
XP_003292688  113 esp---qflE---KPIFVVILEVDS-TLEFFQHVGFNTIPHLVFIPS----------GskpiqtkgFTFT--------KV 167
Q54N33        115 nsa---gflE---KPIFIVILEVDY-NMEVFQTIGLNTIPHLLFIPS----------GskpitqkgYAYT--------GF 169 Dictyostelium ...
XP_001022369   95 ghip-fkdsSKKLRAVYFGMMSFDQnTRETFLDLEFKSVPNLLVSVP---QHALVsDQernnflkgFKWSISGS----DG 166
6S7T_H        162 ---SAEQIARWIADRTD---VNIRVIRPP-NYAGPLMLGLLLAVIGGLVYLRRSNM----EF--LFNKTGWAFAALCFVL 228 human
13_pfamImport 126 vdgTAESVVEFIESRTNl--TVGPLHRPP-LLSKTQISVIVALIAISTPFLIKKVLk---GEtvLHNSRVWLFCTVLVYF 199
EFH66133      161 ---LAESMAEFVERLTKl--TVGPIQRPP-LLSKTQIGIIVAFLIISTPILIKKILkg-eTL--LHDRRIWLVGAVFVYF 231
XP_005849823  159 p-wSAEAIAEWVLERSGv--AVGEIKRPT-LISTRLMPLLSLAVLACVAFVGYHLY----YAsfMRHQWLYALGAIAVYW 230
CBN74884      184 gqvKAEDMARFVKEKTG---VSFPIIRP--EPPVMIILVGLLVVAALAIKPILSNLgallRV--IRNKYLWLATSLLVYT 256
12_pfamImport 141 ---QAEGMATFVHQRTG---FEVTVLRSK-TYLYVLVAVASVGVAIAAKLALDHLDf---LLmkLRRKQLWMTVSLLFYG 210
XP_067750298  183 ---EAEAMATFVKHRTG---FEFAIQRSK-TYLYVLLVAALASTGVTAKLVLAHLDv---VLakLCRKQLWMTVSLLFYG 252
XP_003292688  168 dqaTPAQISNFILSHSKiniEPVRTLYE--KYSQQFFGTIIFIASLRFIITAYKKR---------NNPMFWYFLTILLFS 236
Q54N33        170 eqtSSQSISDFIYSHSKiriEPVKTFYE--KYSVQILSFVVFLASVRFLITAYRKR---------KSPMFWYFLTILLFA 238 Dictyostelium ...
XP_001022369  167 l-vTHHKLLEYINKRTG---REIEYQPPIhEVLRNLGILLILIILTIVVFRLYKSF--------FLNTKLWFVGSIVIYF 234
6S7T_H        229 AMTSGQMWNHIRGPPYAHKNPHtGH--V-NYIHGSSQAQFVAETHIVLLFNGGVTLGMVLLCEAATSDMD---IGKRKIM 302 human
13_pfamImport 200 FSVSGTMHNIIKGMPMFVRDHE-DSn-KlVFFYKGENFQLGAEGLSVGLLYNVVGLLLAYVTNALVRVRS---VSGQRVF 274
EFH66133      232 FSVSGTMHNIIREMPMYIKDYE-DSnkF-VFFIEESEMQLGAEGFFVGFLYTVVGLLLAFVTNVLVRVKK---LEEQRMA 306
XP_005849823  231 FSVSGGMFNIIRGVPLVGFDHR-KRq-S-MLFMPG-QGQLGAEGFIMGSLYTTVGLAVAALIILAPKVKD---PNTQRVA 303
CBN74884      257 FGISGGVYDIIRNPAPFMVKQD-GF--I-MWFHPQSNVQFVAEGFITGIMTLMCGLSGILLVHVAPKLRN---SGYRQVA 329
12_pfamImport 211 LSVSGMVYCIIRNPPPYAADRQ-GN--V-QYFHPQGRQQFVYEGLIVGSYDVAAAVCVILLSQWALYVRN---PVVRYLA 283
XP_067750298  253 LSVSGMVYCIIRNPPPYSADRK-GN--I-QYFHPQGRQQFVYEGLIVGGYDVAAAICMILLSQWALYVRN---PTVRYVA 325
XP_003292688  237 AVIMGIFYDFIHKPALYDYDHR-NQk-Y-NYFSRGSRSQTVSEGFIMGVSTLAITLVFIYISDILPNYSRfgtKVKNVLF 313
Q54N33        239 CVIMGIFYDFIHKPNFYEFDHR-QQt-Y-NYFSRGSRSQTVSEGMIMGVSTIAITLIFVFLSDILPNYTNfssKSKGLLF 315 Dictyostelium ...
XP_001022369  235 VCIAGFIYNQIHGVPMTTVDSK-GN--F-QWMLDNQRMQLGAEGFVMSGL-IILSALTIISYQLIARLNQk--NIVNQLL 307
6S7T_H        303 -CVAGIGLVVLFFSWMLSIFRSKYHGY----------PY 330 human
13_pfamImport 275 -MMLAMVVSLLAVKKVVYLNSWK-TGYeiqtywpsswH- 310
EFH66133      307 -MLLSLSISFWAVRKVVYLDNWK-TGY----------EI 333
XP_005849823  304 -AYGIILVAFMAFRLVTSNHLWK-TGMntdwylf----- 335
CBN74884      330 -VCVCGVIFLMLFSKVMSLYKSKNMWYr---------PV 358
12_pfamImport 284 -IVGCSLGFVFLYRQMTDAYKMKNRWYtgwmgf------ 315
XP_067750298  326 -IVGCALGFVFMYRQMTDAYKFKNRWYtgwmgf------ 357
XP_003292688  314 fLGMGAIISFLYFQSI--AFSMK---Yy--------rPL 339
Q54N33        316 fMGMSSIIVLLFFQSL--AFQIK---Yy--------rPL 341 Dictyostelium discoideum
XP_001022369  308 -LIAIFGTTFIIVIKIEELYKFK-GWY----------NI 334
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