6C26


Conserved Protein Domain Family
OST3_OST6
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pfam04756: OST3_OST6 
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OST3 / OST6 family, transporter family
The proteins in this family are part of a complex of eight ER proteins that transfers core oligosaccharide from dolichol carrier to Asn-X-Ser/Thr motifs. This family includes both OST3 and OST6, each of which contains four predicted transmembrane helices. Disruption of OST3 and OST6 leads to a defect in the assembly of the complex. Hence, the function of these genes seems to be essential for recruiting a fully active complex necessary for efficient N-glycosylation. These proteins are also thought to be novel Mg2+ transporters.
Links
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Statistics
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PSSM-Id: 398430
Aligned: 177 rows
Threshold Bit Score: 111.948
Threshold Setting Gi: 209558178
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6C26_3        26 NRLLKLANKSp-------kKIIPLKD-SSFENILa---PPHeNAYIVALFTATAPEIGCSLCLE-LESEYDTIVASWFDD 93  Saccharomyces c...
XP_002968974  27 SDLLRRQAGSk-------dGIIELDD-TGIRHLAa--sANR-PYALLVFFDAHHLRERSGLKLDeLRGEFSLLARSYIKN 95  Selaginella moe...
XP_018509225  30 KELVSLRSSSe-------sGVIRLTD-DTVSKFItsvsTPR-PYSLIIFFNSIDLNSNP---LQeFRREFAFVSASFIAN 97  field mustard
XP_005849823  28 QRLLALQRSHg--------GVIELDP-KTFQELLvg--kSR-PYSVIIVADAKDLRSQGKLKLGqLVSEFRLVAKSFAAT 95  Chlorella varia...
CBN74884      45 RSLEKLRAAGdskgqagggAVVVVDG-TKFDRYItg--vPR-QYEAVVFFTAAGANYKCTSCRV-HLDEFTTMAESYQAA 119 Ectocarpus sili...
7_pfamImport   1 EKLAKLQQRAr-------nGVVPFTS-DLFTRFAv--rPER-PYHLVLLLTATSAKHKCDACLQ-LAPEFELLGQSYQAA 68 
EGC30798      49 KEFRDLAVKEg--------GIIQLKTlTQTKKFLqa--kNR-PYEVLALFTSSNPKYGCAGCLV-L-----NYGASYIQY 111 Dictyostelium p...
Q54N33        46 NDLYDRAKKAg--------GVVEFKSnLDSKKFVta--qNR-PYDLLALFTSSNPKYGCSGCVQ-LKNQIESFSLSYEPY 113 Dictyostelium d...
XP_001022369  30 EALRELASKSp-------nGIIHFNS-TGYRYFLl--eQPR-PYEVVLFFTAP----KCDFCEQ-MLTQYELTSNYYYAN 93  Tetrahymena the...
RAW35072      43 EKLAQLQGRVr-------dGVIPFTS-ELFGRYAv--rPDR-PYHLVLLFTATAAKYKCETCAQ-VSPEFEALGESYEAA 110 Phytophthora ca...

6C26_3        94 hpda---kssNSDTSIFFTKVNLedpsKT-IPKAFQFFQLNNVPRLFIFKP---NS-PS-ILDH----SVISISTDTG-- 158 Saccharomyces c...
XP_002968974  96 na------ggSGESKIFFCALEF----QR-AQASFAMFGVNALPHGRFLAP---GSgPL---NA----SESMMELNDM-- 152 Selaginella moe...
XP_018509225  98 nnnr-----sdvaNKVFFCEIDE----SS-DSEAFGLFGIQFLPQICLVDP-----------------LMENLQDKTGrm 150 field mustard
XP_005849823  96 hagk------gsvGSVIFARLEF----SK-AKDLFGRMGIQALPYLARIPP----------SLAisegGAVTLGKEEVmp 154 Chlorella varia...
CBN74884     120 rantp---etlngVDVYFFVADF----GQ-NQLPFQKLGLQTVPKILHFPP------------AlaegDDGRYAIDQSqh 179 Ectocarpus sili...
7_pfamImport  69 aqvkvd---trdglDVVFGVADY----EA-NQEVFRHYELTSAPFVVYVAPdanSDvGAaLPTKeqvnPQYLYNVYTQ-- 138
EGC30798     112 lesp-----qfleKPIFVVILEV----DS-TLEFFQHVGFNTIPHLVFIPS----------GSKpiqtKGFTFT------ 165 Dictyostelium p...
Q54N33       114 lnsa-----gfleKPIFIVILEV----DY-NMEVFQTIGLNTIPHLLFIPS----------GSKpitqKGYAYT------ 167 Dictyostelium d...
XP_001022369  94 nghipfkdssKKLRAVYFGMMSF----DQnTRETFLDLEFKSVPNLLVSVP---QHaLVsDQERnnflKGFKWSISGS-- 164 Tetrahymena the...
RAW35072     111 kqvkvd---trdglEVFFGVVDF----ET-NQEAFGMYEFTSAPHVVYVAPdrsIDaGDrMPKKakvePQNLYNVYSQ-- 180 Phytophthora ca...

6C26_3       159 --SE---RMKQIIQAIKQFSQv--NDFSLHLPM-DWTPIITSTIITFITVLLFKKQSKLM--F-SI----ISSRIIWATL 223 Saccharomyces c...
XP_002968974 153 --VR---SAEGMAAYVESKIRh--KVGAIDRPP-LVSRNQLLLVAAAAIVAAPYVLKKLL--I-EGkdtpFHNSKLWCVG 221 Selaginella moe...
XP_018509225 151 eeEDvdgTAESVVEFIESRTNl--TVGPLHRPP-LLSKTQISVIVALIAISTPFLIKKVL--K-GEt--vLHNSRVWLFC 222 field mustard
XP_005849823 155 ttGYp-wSAEAIAEWVLERSGv--AVGEIKRPT-LISTRLMPLLSLAVLACVAFVGYHLY----YAs--fMRHQWLYALG 224 Chlorella varia...
CBN74884     180 mhMAgqvKAEDMARFVKEKTG---VSFPIIRP--EPPVMIILVGLLVVAALAIKPILSNLgaLlRV----IRNKYLWLAT 250 Ectocarpus sili...
7_pfamImport 139 --GL---QAEGMATFVHQRTG---FEVTVLRSK-TYLYVLVAVASVGVAIAAKLALDHLD--F-LLm--kLRRKQLWMTV 204
EGC30798     166 --KVdqaTPAQISNFILSHSKiniEPVRTLYE--KYSQQFFGTIIFIASLRFIITAYKKR-----------NNPMFWYFL 230 Dictyostelium p...
Q54N33       168 --GFeqtSSQSISDFIYSHSKiriEPVKTFYE--KYSVQILSFVVFLASVRFLITAYRKR-----------KSPMFWYFL 232 Dictyostelium d...
XP_001022369 165 --DGl-vTHHKLLEYINKRTG---REIEYQPPIhEVLRNLGILLILIILTIVVFRLYKSF----------FLNTKLWFVG 228 Tetrahymena the...
RAW35072     181 --GK---EAEAMATFVKQRTG---FEFAIQRSK-TFLYVLLVVALASTALTAKLVLSHLD--F-VLa--kLRRKQLWMTV 246 Phytophthora ca...

6C26_3       224 STFFIICMISAYMFNQIRNTQLAGVGPKGE--V-MYFLPNEfQHQFAIETQVMVLIYGTLAALVVVLVKGIQFLRShlyp 300 Saccharomyces c...
XP_002968974 222 ALLVYFFSVAGGMHNIIRKMPLFMPDRNDPskI-VAFYQGS-GMQLGAEGFAVGFLYTVVGLVVAFITHVLVRIKN---- 295 Selaginella moe...
XP_018509225 223 TVLVYFFSVSGTMHNIIKGMPMFVRDHEDSn-KlVFFYKGE-NFQLGAEGLSVGLLYNVVGLLLAYVTNALVRVRS---- 296 field mustard
XP_005849823 225 AIAVYWFSVSGGMFNIIRGVPLVGFDHRKRq-S-MLFMPG--QGQLGAEGFIMGSLYTTVGLAVAALIILAPKVKD---- 296 Chlorella varia...
CBN74884     251 SLLVYTFGISGGVYDIIRNPAPFMVKQDGF--I-MWFHPQS-NVQFVAEGFITGIMTLMCGLSGILLVHVAPKLRN---- 322 Ectocarpus sili...
7_pfamImport 205 SLLFYGLSVSGMVYCIIRNPPPYAADRQGN--V-QYFHPQG-RQQFVYEGLIVGSYDVAAAVCVILLSQWALYVRN---- 276
EGC30798     231 TILLFSAVIMGIFYDFIHKPALYDYDHRNQk-Y-NYFSRGS-RSQTVSEGFIMGVSTLAITLVFIYISDILPNYSRfg-- 305 Dictyostelium p...
Q54N33       233 TILLFACVIMGIFYDFIHKPNFYEFDHRQQt-Y-NYFSRGS-RSQTVSEGMIMGVSTIAITLIFVFLSDILPNYTNfs-- 307 Dictyostelium d...
XP_001022369 229 SIVIYFVCIAGFIYNQIHGVPMTTVDSKGN--F-QWMLDNQ-RMQLGAEGFVMSGL-IILSALTIISYQLIARLNQk--- 300 Tetrahymena the...
RAW35072     247 SLLFYGLSVSGMVYCIIRNPPPYSADRKGN--I-QYFHPQG-RQQFVYEGLIVGGYDVAAAVFMILLSQWALYVRN---- 318 Phytophthora ca...

6C26_3       301 etkkaYFIDAIL-ASFCALFIYVFFAALTTVFTIKSPAY----------PF 340 Saccharomyces cerevisiae S288C
XP_002968974 296 -----KTTHRAI-LLVGMGVCFLAVRWVVALDHWK-TGY----------EI 329 Selaginella moellendorffii
XP_018509225 297 -----VSGQRVF-MMLAMVVSLLAVKKVVYLNSWK-TGYeiqtywpsswH- 339 field mustard
XP_005849823 297 -----PNTQRVA-AYGIILVAFMAFRLVTSNHLWK-TGMntdwylf----- 335 Chlorella variabilis
CBN74884     323 -----SGYRQVA-VCVCGVIFLMLFSKVMSLYKSKNMWYr---------PV 358 Ectocarpus siliculosus
7_pfamImport 277 -----PVVRYLA-IVGCSLGFVFLYRQMTDAYKMKNRWYtgwmgf------ 315
EGC30798     306 ----tKVKNVLFfLGMGAIISFLYFQSI--AFSMK---Yy--------rPL 339 Dictyostelium purpureum
Q54N33       308 ----sKSKGLLFfMGMSSIIVLLFFQSL--AFQIK---Yy--------rPL 341 Dictyostelium discoideum
XP_001022369 301 -----NIVNQLL-LIAIFGTTFIIVIKIEELYKFK-GWY----------NI 334 Tetrahymena thermophila SB210
RAW35072     319 -----PAVRYLS-IVGCAIGFVFMYRQMTNAYKFKNRWYtgwmgf------ 357 Phytophthora cactorum
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