Conserved Protein Domain Family
Lant_dehydr_N

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pfam04738: Lant_dehydr_N 
Lantibiotic dehydratase, C-terminus
Lantibiotics are ribosomally synthesized antimicrobial agents derived from ribosomally synthesized peptides. They are produced by bacteria of the Firmicutes phylum, and include mutacin, subtilin, and nisin. Lantibiotic peptides contain thioether bridges termed lanthionines that are thought to be generated by dehydration of serine and threonine residues followed by addition of cysteine residues. This family constitutes the N-terminus of the enzyme proposed to catalyze the dehydration step, via glutamylation of the substrate during lantibiotic biosynthesis. The enzyme dehydrates Ser/Thr residues in the precursor by glutamylation.
Statistics
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PSSM-Id: 398421
Aligned: 62 rows
Threshold Bit Score: 251.047
Threshold Setting Gi: 359836586
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
BAJ26322            81 VLREAIEISSPSLADLLERAVPAVAApeDgpraaelhlaelrpAALRR---AAEAVGRYRLRMATRATPFGLMAAVGTAR 157  Kitasato...
CCH03582            46 LTEWALYSASPNLHQVWQLWQQD--------------------GKQRPtlaARLALWRYAIRMSSRSTPFGVMAGVSKIS 105  Fibrella...
jgi:Sph21_4476      47 EVLEAISFASKDLYHTYLSWLENGYMpd---------------------lkLLVTLYKYVSRMASRATPFGSFAGVCMGH 105  Sphingob...
WP_002985198        43 LFMNAIYLSSRDFYYKSTNWMEKEVSdfNys-----------dS-------VLQSMYKYYIRMCSRSTPYGLFAGVGLGK 104  Myroides...
EHQ41400            43 IFCSALYLAAPDLYQEWLKCSST-----P--------------KDNIKdsrINKSILKYYIRSCSNPIPFGLFATYSq-- 101  Myroides...
MPITM:COCOR_03285   70 EVHEALLVASSNLVSGLEHWLRTPDGpsg--------------------skVERALVRYLARMTGRATPFGLFAGCSVGQ 129  Coralloc...
WP_014396470        71 EVREALFVASPSLEEGLPLWFQAPDSeyg--------------------lkVERALVRYFLRMAGRCTPFGLFASCSVGK 130  Coralloc...
WP_022561948        45 TTLEALYLASPSLVERLRQ---------Ndmlisd---skiqsETGKKnrkLKQSLIKYMIRMCFRATPFGLFSGIGTGG 112  Vibrio n...
jgi:Cpin_3392       37 AFLEAIYLASPVLYSECIKWREGGITn------------------kKDidkLTRSLTKYVIRMSRRCTPFGLFSGCAVTA 98   Chitinop...
jgi:Runsl_2466      37 WFLEAIYLASPELYRTAVAWRDGATLe------------------kRKeekLWASLTKYYSRMMSRCTPFGLFASCAALE 98   Runella ...
BAJ26322           158 FgARAE-VGWEGGERRAF----RPDLGWLLPLLDRLRTDPQVLGSLLLAVDQQAVLRGDRLVLPYLpdrstlpestaeaV 232  Kitasato...
CCH03582           106 IsEQTE----GKIDADKIavnvRPDSGWLVALAEQLTKHPDIRWQLHYQVNNSLYSLGSQLRYSDYt------------V 169  Fibrella...
jgi:Sph21_4476     106 InDNTStLTLTGHATIYA----RVSLDHLMRQLHQLQQSQDWLNDIVFYTNNSIYAVGGYFRYIRFe------------T 169  Sphingob...
WP_002985198       105 TtMDKTkIKIATNNLQPFv---RVDNLFINKMKEEIVRKNKTNN-LPFYPNNTLYSIGDYWRYISW-------------- 166  Myroides...
EHQ41400           102 --IDNRlKPTNKKSNSEYfcfaDLDTSYFRKVIHAITKNYSLNSILKYRFNNSIFKIGNSFRYIEYqd----------tP 169  Myroides...
MPITM:COCOR_03285  130 PgRETR-LSLQGREAYQRq--tRLDMDYLASLLNALQRQGEVRHPPRYLPNSSLYRIAGRFRYVESs------------Q 194  Coralloc...
WP_014396470       131 LgARTH-LPVADARECQRd--tRLDMDYLTRLVEALVRHPALRDVLRYRPNGSLYRAAGRLRYVETr------------H 195  Coralloc...
WP_022561948       113 IsSQTKiESSTLHGDSRKt---RLDSFYLFALKEHISKNHFQLSDTKYQPNQSLYNIGDQYRYIEAq------------Q 177  Vibrio n...
jgi:Cpin_3392       99 WsEQPTaVTVSGTTFSRh---tRLDMHYLCALSQQLATMPGVKEYLLYMPNSSVYTIGDELRYVEYl------------Y 163  Chitinop...
jgi:Runsl_2466      99 WgEASI-IAFEETKRh-----tRLDMHFLCALALALSRHPNIRKQLRYFTNDSLYTIGDELRYVEYi------------Y 160  Runella ...
BAJ26322           233 PGAGRPVAERTVRATPVVRAVVRLAER---PVSHAELLAGLAAGFPt--aPAEAIAGLVRTLVAQGFLLTDLVPPPH-ST 306  Kitasato...
CCH03582           170 EPGHRAFFINAIEPDETILGVLQYVRSkvgGVVGQDLCSWIEQLGE----EPAEARQLVDELIEAHILVSELDPGVT-GK 244  Fibrella...
jgi:Sph21_4476     170 VKDKRTFFQVKLKINPLLKLLYDYARE---GRTFSELITFLMDFd----iERNEITAYLSKLLDNQFLISELEPTIL-GD 241  Sphingob...
WP_002985198       167 -DHNFNYEILEIKKNVILEQVLSIAYH---GITKADIKLFLIKNSNchskSILEIEEYIRLLIDANFLVDRMPPYMTsLA 242  Myroides...
EHQ41400           170 EKVSRNYTLGLIEENEVFNRLLSVFTA---EHALSEIVEYLLHNIEn--iSKEEITNYLHDLISNKILVCSLDLNLN--T 242  Myroides...
MPITM:COCOR_03285  195 QGAERAYSLASVEATPYLEFVLERARQ---GARREELAQALAEREGd--vSVTEAGEYIDELVTLQVLVSEFAPAVT-QP 268  Coralloc...
WP_014396470       196 AGAVRQHHLSSVRPDAYLEAVLECARP---GARPEQLVRTLVALDAe--vDAQEAAGYVRTLVDNDLLVPELAVPVT-GP 269  Coralloc...
WP_022561948       178 SKDALTYQLSSVEIDEYVSYLVDLAKN---RPNLEALTNGFLEKYVd--aDKAEVESFVLGLISESLLTPDIPLPFT-GI 251  Vibrio n...
jgi:Cpin_3392      164 VGGTRLHQISAVSASEYLDKMVTAAYN---GATIGQLCNWLADDn----iAEEDARIFIDELIAAQILVCEIEPAIT-GK 235  Chitinop...
jgi:Runsl_2466     161 SEGKRVHQLSAVEGSEPVRRVLEAARS---GTDYRDLVRLLCSDd----iSKEEAGDFVDELIAAQLLVSDLEPALT-GE 232  Runella ...
BAJ26322           307 DLLGHVLERL---------------PGEHP------------VRGELAAVRGLLARAAGLPRGRATG-VLREARRRMLRL 358  Kitasato...
CCH03582           245 DAFEHLIQRLps------------sPNKDG------------IRRSLAALQKWLQQPFESVE------KEQQLDRDLQRV 294  Fibrella...
jgi:Sph21_4476     242 QDIHKLTHKL------------------KG------------TDAAVVEMRDLL--------------TLSSCPDRIASL 277  Sphingob...
WP_002985198       243 NPLLEVEQYLiq------------yKIDTK------------LLMPIINLEKTIHSDYFKSSECID--DIEKIRSEISGI 296  Myroides...
EHQ41400           243 SPILYLESVF-----------------EKEkqnfltntplydMYQRIIKVRNLLNGMEFNEIKKDGVsYLQKIENQIKSI 305  Myroides...
MPITM:COCOR_03285  269 DPLREAITQLgs------------hPSTAP------------QAGQLERVHGLLAGLDAAGLGQPES-RYQAVASCVEAL 323  Coralloc...
WP_014396470       270 EPLPYLVARLralaqesgpgeaaqvALEAA--------------TCLEDVGGQLSMLDAGGPGRSKE-AYLAIATRLEAL 334  Coralloc...
WP_022561948       252 SPDLALIETLt-------------kTGQLD------------LADTLSTILDRLKEIDANKGTSPD--IYKQIYQRLKKL 304  Vibrio n...
jgi:Cpin_3392      236 EFLQQVIEVLqr------------iELLDPavv-------kdLLTVLSKVATLLEQLDDTATNSIE--RYREIMQLLDML 294  Chitinop...
jgi:Runsl_2466     233 PFIEQMVQVLqr------------vFVQTQsse------aaiIIRQLEQIRQSVDTFDSSTSNTIE--DYRRLIAMIKAL 292  Runella ...
BAJ26322           359 ---GPAERPLHADLALV--GGVV----LPEQVRVEVEQAAGVLWRLS----PPVGAP-EHLRSYHAEFVERYGIDSPVPL 424  Kitasato...
CCH03582           295 ---VGGVDTRQLDLYRPveKLK-----LSQKVVRQIGQELAELSALR----LNRQAPa--LSTFAERFYARYG-MQPQPL 359  Fibrella...
jgi:Sph21_4476     278 defpfnvvLPQVDKKFIakEVN-----LKQSVIQLIARELCELHPLF----TSSIPQe--LQVFIQKFKRRYE-MMEVPL 345  Sphingob...
WP_002985198       297 i--DINDQVFQVDTRINlnLNQ-----VNKNVVELLAQRMKEIMPLR----GKNVNPd--LVSFIERFYNKFE-TKEVPL 362  Myroides...
EHQ41400           306 lkiEHNRSVLLINLKKNafQQMPhnydEPR-----LLKALDIYQSFTlsnyERKLQSdKNLEVFCKDFINRYGDAIELPL 380  Myroides...
MPITM:COCOR_03285  324 lpppelsrLVQVDLFKPvvEAT-----LGREVMDALRSAVALLHRIT----PPRRNP---LQKFKEDFLRRYE-QQEVPL 390  Coralloc...
WP_014396470       335 pvkvelprLFQVDLYRPapGAT-----LGPEVLAEATRAVELVRRMG----PQLHTGnSLLSAFCEAFTRRYE-GREVPL 404  Coralloc...
WP_022561948       305 pvdveeskLFQTDSFKHfdVCM-----LGDKTVNHILSQAQLLKSLC----PKVGNP---FSEFIRKFNERFE-GQFVPL 371  Vibrio n...
jgi:Cpin_3392      295 evaydeskLFQTDVVKHvsGNG-----INIDVQNQLQNALNVMNKLS----EYKANPh--LETFMQRFRERYE-EQEMPL 362  Chitinop...
jgi:Runsl_2466     293 kvpveenkLFQTDLFRQlpQGQ-----LPMEAQQDIRAALEVLNRLS----TKRKANh--LTAFVQRFTARYE-TREVPL 360  Runella ...
BAJ26322           425 AELLDADTGLGPPAGYRRpvgpr------gaanPEPARARTEREAARNRVLAELVAGALVDREpggplPEVVLDDELLDR 498  Kitasato...
CCH03582           360 LVALDHESGIGYAANADRrtghlal--lrtltdHENLTTAAQSDRLD-NLRLNKLTQFLTTRE-----SVQEITEQELTE 431  Fibrella...
jgi:Sph21_4476     346 LEVLDGDLGIGYGDLDNQykrehpl--innldiSEGK-----------KQLTSTLEEQVMTNAlfsgsRHIDL--ETIYP 410  Sphingob...
WP_002985198       363 MLALDPDYGVGYSVFVRSnleelpllqdvyfpfQDAAIYEGTVSPLI-DMIIKEYIQCFSTTIi----QPIVLTKERIST 437  Myroides...
EHQ41400           381 LEVLDNDTGIGYLKGRKEesgfspllddfempaWQVKSESITVNDEIDRFWTTNIINAIRTKQ-----SSIDLSTLELPE 455  Myroides...
MPITM:COCOR_03285  391 AEALDEDVGVGFEAASGPeascspl--lkglvfPGAPEDTPEWSRAG-DLLLDRVQQVVRAGG-----RVLELTDKDIEA 462  Coralloc...
WP_014396470       405 LEALDEESGVGFQVSHAPaadgapl--lrglafPAATETGGTLGARE-LHLMRRLTASPGA-------RVLTLGEEDLKA 474  Coralloc...
WP_022561948       372 AMVLDEENGIGFSSESSYdaplis---glplgrFSSGQSEFESNETWDKLLHRELGLNALRGS-----DVIQLSSEAIlh 443  Vibrio n...
jgi:Cpin_3392      363 LEVLDGETGIGYVDSSSTniapll----ddismPGKMNEVRFSWGALEQLLSGKLVDMYAEGR-----QSIEINEEDLKD 433  Chitinop...
jgi:Runsl_2466     361 LEALDTETGIGYLPDQGTpllplv----edivrSGNEQKTSMEWDKVQDWLFQQLKTATEQGR-----YTVALDADQLAD 431  Runella ...
BAJ26322           499 LAPlaeeseeqesqagSAAETPPASLELYAELAADSLAELDAGRFrlvlSPTAGSDRAGATFGRFASHLANsgSNSGSgs 578  Kitasato...
CCH03582           432 AAk------------sTLSTPKAHSWAVLGDLYSTSGEAADQGDYqf-lVKNVTGSSGASLMARFGSGDEEiaKAIQQ-- 496  Fibrella...
jgi:Sph21_4476     411 LLEk-----------rQENSAVAPTCYAIGNLLTKKVEDLDNGNFqf-hLAACSGSSAVNLMSRFAYMDEAlkNNLRS-- 476  Sphingob...
WP_002985198       438 LQSe-----------eSTFIPFGANCHLFGSFICDTQEDIDNGNFkfmpLSNIPTSNVSDILSRYAYYDKElfDSLKE-- 504  Myroides...
EHQ41400           456 CPN------------------FSNNLGGTFPIIYSKYDDml-------fDIRAGAHSALHYIARFTFIDNDlaQFTNE-- 508  Myroides...
MPITM:COCOR_03285  463 LSv-------------PEPLPLPDTFFAMATLGAASEESLRRGDFsl-lVRMVDGPSGVRLLGRFCHGDEAlgAAVRH-- 526  Coralloc...
WP_014396470       475 LSs-------------EKAAPAPDALSVGFSVQAASDEAFTRGDFsl-vLRGAGGPSGANTLGRFCHGDEAlrDAVER-- 538  Coralloc...
WP_022561948       444 ei-----------detPNPEDLPASFMASVSLYLNES-----GEEli-kLNGFSGPSAADLLGRFCHLDDElkHNVRQ-- 504  Vibrio n...
jgi:Cpin_3392      434 FT--------------ANWHDLPPSFSVMFRIVDEKDNai--------yLESAGGSSAANLLGRFAYADNAinRLVCD-- 489  Chitinop...
jgi:Runsl_2466     432 LPe-------------ADWEDLPPSLAVLFRWAEDEQ-----GQKri-vIDHAGGASAVNLLGRFAYGDKRifDTVTD-- 490  Runella ...
BAJ26322           579 gsggsdpdsygndsygddnsngggrlLAEAAGALPddDEVLYAHLEFTPYRPRhANIALTPRWLGHRV-VVSAFPDPSgp 657  Kitasato...
CCH03582           497 --------------------------VTDWEANQY--SDALLAEIVHLPAGRI-GNVVHRPALRAYEIpYVTPASVDEe- 546  Fibrella...
jgi:Sph21_4476     477 --------------------------CAIYEEQCF--DNVILADIKHIPENKV-GNILRRPKLYSYEIpVLGLTCTKNe- 526  Sphingob...
WP_002985198       505 --------------------------ITEVDS-----ENCIHAELLYHKKNRL-ANVLMRPNLYNYSIvYLAACSEDEes 552  Myroides...
EHQ41400           509 --------------------------IVNDESLAF--QDCLTAEIFHHASNNS-GNVTLRKIKRPYEIsILTNPTGDS-- 557  Myroides...
MPITM:COCOR_03285  527 --------------------------HLRLEEALR--PDALFAEVVHVPAGRV-GNVLTRPALRAYEIpYLGRSAVPPe- 576  Coralloc...
WP_014396470       539 --------------------------HLRAEEALR--PDAVFAEVVHLPEGRI-GNVLLRPQLRGHEIpFLGASGAPEa- 588  Coralloc...
WP_022561948       505 --------------------------HLKKEEAQS--EDVIFAEIVHVPEGRD-CNVIARPHLRDYEIvFLADSSLPDe- 554  Vibrio n...
jgi:Cpin_3392      490 --------------------------ITEKEQAMD--PEVVYAEIIHLPESRT-GNILLHPVFRGYEIpYLAKSSLDKe- 539  Chitinop...
jgi:Runsl_2466     491 --------------------------IATTEQAQN--PDCVFAEILHLPESRT-GNILLHPAFRACEIpFLGKSSLPLd- 540  Runella ...
BAJ26322           658 AVLALDDLVVVA-DAERLGVYSRELGREVRADAHH--ALNLRTGAPNAARFLQETALGGHR-PWQ----PWDWG-AAASS 728  Kitasato...
CCH03582           547 HTLLLEDLWVRVsAGSTVELWSKKHNRRVIPRNTT--AHNY-HHSDEVYRFLSDLSHQEES-FTQ----NWSWGlLSDQ- 617  Fibrella...
jgi:Sph21_4476     527 KQIPLSDLTVTV-RNNQVILFSKKLDKRVIPRLSC--AHNF-RQGISVYRFLCDLQYQDTP-FSI----YWNWDkYKRA- 596  Sphingob...
WP_002985198       553 NTISMNDIYIRY-EEGRIKLVSKKLNKEIKIRYSN--AYNLDNSQLSVIKFLGDYQYYNLD-HGF----KWNWGyLKNN- 623  Myroides...
EHQ41400           558 QPISLSDIYIKI-VDNKVVLTSKKFQKEIIPFLSS--AQNFHFDSLSIYQLVCDLQAQYRHnYFTldlnPF----LLNNF 630  Myroides...
MPITM:COCOR_03285  577 AQIPLGDLLVSV-RDGRLVLRSRKLGREIIPRLTTahAHRY-PHHLAIYRFLGALQSEGHA-GGL----AWRWGaLEGA- 648  Coralloc...
WP_014396470       589 QQLPVEDLRVSV-VDGRVVLRSKRLGREVLPRLTT--AHNF-SRGLGVYRFLCMLQHDGRA-VGL----SWNWGaLEGL- 658  Coralloc...
WP_022561948       555 NQIPLSDLYVWV-EDSKVKLWSRRLKKQVIPRLSC--AHNYSFGSLGEYKFLNMIPNQYALpPIL------KFPkYLDEA 625  Vibrio n...
jgi:Cpin_3392      540 QQIDLQDLYISV-RNNRVVMRSRRLGKQVIPRLST--AHNYTNNSLPVYRFLCDLQLQDKR-GGM----SFHWGaLESKY 611  Chitinop...
jgi:Runsl_2466     541 RQISVQDLYVSI-RQGQVILRSQRLDKIVVPRLSN--AHNYSHNALPVYQFLCDLQHQNKR-TRF----GFDWGnMAGKY 612  Runella ...
BAJ26322           729 PVLPRVRRG-RVVLAPASWRLTAP-VPDSAAPYGDW-ADGLARWRRRWGVPAAVRLLSGDQ-RISLDLDDPWHRRLL 801  Kitasatospo...
CCH03582           618 PHLPRVVYK-HLIVARAQWKLTMSaQWTSAQV-------MVDELRQHLALPQLVTLVERDN-ELLLDLDVVICRQLL 685  Fibrella ae...
jgi:Sph21_4476     597 PFLPRISYK-HLILSRARWYIKQRhRFDIN---------WFRQLQKDLRLPNEILIAEGDN-ELYIDIRTSWGMQLL 662  Sphingobact...
WP_002985198       624 DFLPRVEYK-EIILSVAQWKIHKNqNINQQ---------TLQQILRERNIPTFCTIRQRDN-ILILDLSLDICLDIL 689  Myroides od...
EHQ41400           631 QFIPRICYGsNIILSTATWKIWKSeLTSNTESSKTIhLNEFEKIKKSRSIPRFVFFMDNNEaKFIFDLENTIQLEIL 707  Myroides od...
MPITM:COCOR_03285  649 PFLPRVVAG-RVVLARARWLLRANvLEALAQGPTHEqARRMLELRTQLGLPRFVLLADGDN-ELPVDLENVLCVESF 723  Corallococc...
WP_014396470       659 DFLPRVVSG-RVVLSLARWRLGPDvLKPLGAARGEEcFRAVQQLRERLGLPRHVALVSGDN-VLPLDLDNVLCVETL 733  Corallococc...
WP_022561948       626 SFSPRIMID-NIILAEKTWRIPRAeLQALKKNSSIQ-KDAWKALQEKYRLENIITIAHGDN-VIQLDLRNPMMLDIL 699  Vibrio nigr...
jgi:Cpin_3392      612 RFFPRVTCR-NTILHLARWTFAQKdIAQLLNESGMElTAALQAFRERWKLPQTIVLADGDN-ELMIDFSCHSMVSAW 686  Chitinophag...
jgi:Runsl_2466     613 SFLPRVTYK-NTILHAATWRLQKDqIKALLADTPV---VGLPAFQ-----DRLVTLADGDN-ELIIDWKNPLSVQAF 679  Runella sli...
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