4WGK,2ZWS


Conserved Protein Domain Family
Ceramidase_alk

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pfam04734: Ceramidase_alk (This model is not part of the current CDD release)
Neutral/alkaline non-lysosomal ceramidase, N-terminal
This family represents N-terminal domain of a group of neutral/alkaline ceramidases found in both bacteria and eukaryotes. The EC classification is EC:3.5.1.23. The enzyme hydrolyzes ceramide to generate sphingosine and fatty acid. The enzyme plays a regulatory role in a variety of physiological events in eukaryotes and also functions as an exotoxin in particular bacteria. This N-terminal domain carries two metal-binding sites, the first for Zn2+ residing within the domain, and the second, for Mg2+/Ca2+ lying at the interface between the two domains.
Statistics
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PSSM-Id: 516404
Aligned: 111 rows
Threshold Bit Score: 552.875
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4WGK_A              4 YHIGVGRADCTGQVAD-INLMGYGKSGQNAQGILTRLYSRAFIMAEPdGSN--RTVFVSIDIGMVSQRLRLEVLNRL--Q 78  human
WP_014361832       46 YLVGAGRGDITGAIAG-QGMMGYSDLSQVATGLLQRVWARAYIIADAaTGT--RIVFVNADLACIFESHRVGVMKAL--A 120 Gordonia p...
WP_051494815       60 FLVGCGIGDTTGAVVGpSGTTGYADPNLPATGLLMRTWARAFVIADRaSGS--RLVYVTVDICLVLQSVYLAVIQEL--A 135 Nocardia nova
WP_025349187       41 YLVGAGIADVTGAVAG-QGMMGYSELDQVASGLLMRTWARAYIVVDRaTGD--RIAFVSADIACLFQSVHLAVIQRL--A 115 Nocardia nova
WP_025349911       43 YLVGCGIADVTGAVAG-QGMMGYSDLEQVAEGLLMRCWARAYIVVDQaTGD--RIAFVTVDIACLFQSVHLAVMRRL--A 117 Nocardia nova
Q4JV90             60 FQVGRGLADMTGEPWG-AGMFGYAVDEQKTVGIQRRQYARAFIFVDAnRDNs-RLVHVTCDVGLMFQSIHLEVLRRL--K 135 Corynebact...
BAI64297           90 YLVGAGAADITGEPGE-VGFMGYGETSQKGSGVHTRQYARAFIAVD--RASgkRNLIVVLDTLTSWQSLRDELVKRIraE 166
CeBiTec:AFR_19975  42 YQVGVGIGDITGEAAE-VGMLGYADPTQTTAGLASRLWARAFVVAD---GSgnHVAFVSTEIDFVTQAVQVEVLKRL--R 115
WP_014393380       53 FLIGAARSDITGPAAE-VGMMGYGQVGQKTEGIHLRLFSRAFVIASPcNGR--RVAFVSADLGMVFQAVKQQVVERL--R 127 Corallococ...
WP_012389433       74 YLVGVGISDITGPAAE-VGMMGFAETAQKTEGIYMRLWSRAYIIGD--ASK--RVVFVSADLGMIFQSIKQAVSKKI--- 145 Leptospira...
4WGK_A             79 SK---YgSLYRRDNVILSGTHTHSGPAGYFQYTVFVIASEGFSNQTFQHMVTGILKSIDIAHTNMKPGKIFINKGNVDGV 155 human
WP_014361832      121 QR---FgNAYTNENVNINATHNHNSCGGTAWDYAYVLAALGHRENSYRAEVDGIVEAIVAAHNSLAPGTLELGHSELHDA 197 Gordonia p...
WP_051494815      136 AK---FgDLYTERNVNINSTHNHSSCGGTAREYAYSLPNFGFMETSHHAEVNGIVAAIVAAHERLAPGSVLLGRGTLTDA 212 Nocardia nova
WP_025349187      116 QR---FgALYTERNVNVNATHNHNSCGGTAREYAYSLAAYGFQNNSHQAEVDGIVAALVAAHDNLAPGTLALGHGELHDA 192 Nocardia nova
WP_025349911      118 QR---FgDLYTERNVNLNATHNHNSCGGTAREYAYSLAAYGFQQNSHYAEVNGIVEAIARAHERLAPGTLGLGRGELHDA 194 Nocardia nova
Q4JV90            136 EK---FgDLYNQSNVLLAATHTHVAPGGTSQHLMVDITHGGFRPKTFEATVAGIVTAIERAHADIQPSEVTVAETTVADA 212 Corynebact...
BAI64297          167 -----FgSAYDESNIMITATHTHATPGGITHQSLYNITTLGFHQDTFNAQVDGSLKAIRQATKDLSPGNLTISSSKLTGV 241
CeBiTec:AFR_19975 116 AK---HgSTYTDQNVVLTATHTHSAPGGYSEYMLWNLTTLGFEAPVFEAIVAGIVRAVDSADADLAPGSVKIAEGNLAGA 192
WP_014393380      128 SK---LgDTFSDENVLLSATHTHSGPGGFSHYTFYNLTTFGFVPQNFEAIVSGITDSILRANARLAEGSLRLSSGDLRGA 204 Corallococ...
WP_012389433      146 ATdseLaPFYSEANVLLSATHTHSGPGGYSHYFLYNATTSGFIKENFDVIVNGIYKSIKLAHQNLVPGNVYVNQGELTDA 225 Leptospira...
4WGK_A            156 QINRSPYSYLQNPQSERARYSSNTDKEMIVLKMVDlngD---DLGLISWFAIHPVSMNNSNHLVNSDNVGYASYLLEQEK 232 human
WP_014361832      198 SANRSVQAFVRNPAADQKHFPEHIDPQVTALRLRQgg----tVIGEITWFATHGTSLTDANTLISSDNKGYASYLAESAN 273 Gordonia p...
WP_051494815      213 SANRARVAFELNPDEDKAVFPEAIDPSVTVLRLRQgg----rDVGAITWFATHGTSLTDHTSLIAGDNKGYASYRWEHEE 288 Nocardia nova
WP_025349187      193 SANRSRVAFELNPPEDKSEFPNAIDPKVTVLRLRQga----kDIGAITWFATHGTSLTDANTLISADNKGYASYRWEHDE 268 Nocardia nova
WP_025349911      195 SANRSREAFELNPAQDKAEFPNGIDPAVTVLRIRQgs----kDIGAITWFATHGTSLTDANRLISADNKGYAGYRWEHDE 270 Nocardia nova
Q4JV90            213 GVNRSKTSWDRNPEEDKKALPNGVDTRSVTLHVSRgg----kQVGLINWYSLHPTSFGAEYKHIAGDNKGYAAWATEEAH 288 Corynebact...
BAI64297          242 GVNRSREAFNLDSPEIRSKLPGGTDPTNMTLRLERng----kTRAVLNWFAIHPTSLTSKNTLISSDNKGYAEYLLENQD 317
CeBiTec:AFR_19975 193 NVNRSIEPFNANPAADKARFPDAVDTRMTVLRFEQgg----rPVGLIDFFATHGTSMTPANHLISADNKGYAAHVIEDEV 268
WP_014393380      205 SINRSPDAYLRNPESERARYPDNVDTRMTLLRMTA---AdgrELGLVNWFAVHATSFGNTNTYISGDNKGLAAHTFEVEK 281 Corallococ...
WP_012389433      226 SKNRSVAAYDKNPASERNFYPSNVDQTMTLLKLVA---AdgrELGMVNWFAVHPTNVGPTNKLIGGDNKGIASYLFEKNK 302 Leptospira...
4WGK_A            233 NKG-Yl--PGQGPFVAAFASSNlgdvspnilgprcintgescdnanstcpiggpsmciaKGPGQ---DMFDSTQIIGRAM 306 human
WP_014361832      274 -----------PGVVAAFPQTNagdmtpnl----------------------wlrkmhpGGPTA---DHRTNRVMIGDRQ 317 Gordonia p...
WP_051494815      289 KGVrYg--EGQPEFIAAFPQTNsgdmtpnl----------------------alipwqpTGPTE---DNRLNCAIIGERQ 341 Nocardia nova
WP_025349187      269 MGVrHr--EGGAGFVAAFAQTNagdmtpnl----------------------gltpwhpSGPTE---DNRLNCALIGERQ 321 Nocardia nova
WP_025349911      271 MGVrYq--DGQPGFLAAFAQTNagdvtpnl----------------------glgkfhpNGPTD---DHRANCALIGERQ 323 Nocardia nova
Q4JV90            289 GVVhRy--PEDAPFVAAFANMTpgditpn------------------------mgltpnSGPGA---DERESAQILGERM 339 Corynebact...
BAI64297          318 HGVdRnvpGSGDGFVAAFANANagdvspn------------------------twlkpgQGPTN---DQFKNVKIQGEKQ 370
CeBiTec:AFR_19975 269 HGVdWa--H-RGDFVAAFAQTSagdmspn------------------------lrnggaQGPTD---DEFENTRIIGQLQ 318
WP_014393380      282 GGRtPg--G-PDTFVAAFANSNegdvtpn-----------------------ilggtngGGAN-----DFEDAAISAKKQ 330 Corallococ...
WP_012389433      303 GTNyS---S-NQTFVAAFAQSNsgdv-----------------------------tpnlWGPADgvnD-YARQNTIANKQ 348 Leptospira...
4WGK_A            307 YQRAKELYASASQE--VTGPLASAHQWVDMTDVTVWLN---STHASKTCKPALGYSFAAGTI-DGVGGLN---FTQGK-- 375 human
WP_014361832      318 YRAAQRAFAAARP---LTGAISYAYRFLDLSDIRIDGHytpDGKPTRTTPAIMGAAAAATSTeDNTRSQLs-fLQEGV-- 391 Gordonia p...
WP_051494815      342 YQAARAAFDAARPM--SSGSIDSVVHYIDMGNVAVDAAytpDGRMARTSPGMLGTSFFAGKStDNWNRVVp-fVSEGM-- 416 Nocardia nova
WP_025349187      322 YQAGRAAFDAARPM--SGGGVDAALRYLNMADIAIDGSytpDGKPARTAPAMMGAAAAATSSeDNWKTQLs-fLQEGD-- 396 Nocardia nova
WP_025349911      324 YRSGRAVFDSATPM--RSTGVDAVLRYIDLSAITIDGAytpDGGPARTTAAMMGASAMAASSeDNTRSQLa-fLYEGQ-- 398 Nocardia nova
Q4JV90            340 MAATNDL-----GKdwSAGGIDGRMRWVNCPQLVASPRftpDKKEHKLGPAVLGAAFAGSSQeDGGGVPIl-gFNEGE-- 411 Corynebact...
BAI64297          371 ANAVRSQLKSAGTP--VGKGLDSRISYFNFSGMNVDAKytgSGHNERTCQGFLGTPFGAGSTeDGGGGWAv--YKEGS-- 444
CeBiTec:AFR_19975 319 AGKAQQLFDSATEE--LSGPIAARGRYVDFSGVQVGGAytpDGQAHTTCPGALGQNFTAGAE-DGPGPPI---VDEGD-- 390
WP_014393380      331 YDFAAHLWSTAGMP--VMGGVDYRHAYVKMDAVDVSPAf-aDGSAHRTCPAAIGLSMLAGAE-DGPGFGS-----EGAt- 400 Corallococ...
WP_012389433      349 YQKAVSLYQSANTQ--VTGTIDFRHTYVNFSNLYVSSV------GTSTCPAGMGASFSAGSVeDN--AVSvdfFDEGTtv 418 Leptospira...
4WGK_A            376 ------TE-GDPFW-DTIRDqILGkPSEEIKE----CHKPKPILLHTGE-LSK-PHPWHPD----IVDVQIITLGSLAIT 437 human
WP_014361832      392 ---------TLPFA-QALGVdTSVtPPDWAVA----IQAPKFDLFPLGY-LPP--RPWIQQ----VLPIQLIRIGDLVLA 450 Gordonia p...
WP_051494815      417 ---------TNPLV-AALGG-LNGpIEQWMRD----AQAPKLALAPVGF-ALP--RPWVPD----VVAIQLVRIGDLVLA 474 Nocardia nova
WP_025349187      397 ---------TNPVV-AALGG-LNGpVEQWMRD----VQAPKLIVAPLGV-LPP--RPWVPL----TVPIQILRIGDLVLA 454 Nocardia nova
WP_025349911      399 ---------RNPVV-EALGG-VDApIEQWMRD----AQAPKLIGAPLGI-LGP--RPWNPQ----ILAIQIMRIGDLVLA 456 Nocardia nova
Q4JV90            412 ------RG-GNP-WvRDLNNfL---APQEIKD----IHGPKECLLPMG---------YIDGmiqqVHPFTIHRLGSFVLV 467 Corynebact...
BAI64297          445 ---------GRP---SILGTlVFT-PSAAQTR----CQQPKGILFSAKNgT------IIQE----KYPVQIMRFGDYYLL 497
CeBiTec:AFR_19975 391 ------LN-TNPLL--LVAGiVVNpTPAAVRA----CQAPKDVFLGTGSqNPP----WTPQ----VMPLQVLRIGQLAIT 449
WP_014393380      401 -----cENvHD-VWsQFTCAaVTTp-----------CQGEKPIVLEMG---TMkPYPWSPE----VLPLQVVTVGPLALV 456 Corallococ...
WP_012389433      419 dsldwnSNaADAFKaSFLGGaLGVlWPASVSEsyklCHAEKPVLIPTGV-ASFdGNPWTPP----IIPIQIVKIGNLSIL 493 Leptospira...
4WGK_A            438 AIPGEFTTMSGRRLREAVQAEFASHGmqNMTVVISGLCNVYTHYITTYEEYQAQRYEAASTIYGPHTLSAYIQ 510 human
WP_014361832      451 CGPAEFTIVAGLRIRRIVADALHVP---LENVLMQGYANGYSQYVTTPEEFLSQQYEGGETLFGRYTLCAYMQ 520 Gordonia polyisop...
WP_051494815      475 AGPAEYTIVAGLRVRRLVARALGME---LESVLMQGYSNGYVGYCVTPEEYAKQLYEGGHTLFGRWTAPAYMQ 544 Nocardia nova
WP_025349187      455 SGPAEYTVVSGLRIRRVVAHALSVP---LENVLLQGYSNGYSGYVTTPEEYASQQYEGGETLYGRWTLPAYVQ 524 Nocardia nova
WP_025349911      457 SGPAEYTVVSGLRIRRVVARALNIP---VENVLMQGYANGYSGYVTTPEEYLSQQYEGGETLYGRWTLSAYMQ 526 Nocardia nova
Q4JV90            468 SLGFEPTITSGLRMKRTVAAALGVP---ENTVVVQGYTNAYGHYITTPEEYEAQNYEGGATIFGQYQLSAFQD 537 Corynebacterium j...
BAI64297          498 GMPGEFTGAVGVQYRQDAAKLFGVP---ESHIILQGYTNAYDHYVTTPEEYDSQQYEGGATLFGRYTSSAFRQ 567
CeBiTec:AFR_19975 450 TAPGEFTIVAGQRVQDAVAAQLGGV---TTHQILAGYANAYAGYVTTPEEYDLQHYEGAATHFGRYTQSAYAQ 519
WP_014393380      457 AVPFEVTTMAGRRLRDTVRAQLQGAG--VTDVVIAGPANAYSGYVATREEYARQDYEGASTHFGPWTLAALQQ 527 Corallococcus cor...
WP_012389433      494 AIPAEVSTMAGRRIRSLVKNIME-----NDYTVIAALSNSYTSYLTTREEYSSQQYEGASTQFGPNTLKAYEQ 561 Leptospira biflexa
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