Conserved Protein Domain Family
Filament_head

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pfam04732: Filament_head 
Intermediate filament head (DNA binding) region
This family represents the N-terminal head region of intermediate filaments. Intermediate filament heads bind DNA. Vimentin heads are able to alter nuclear architecture and chromatin distribution, and the liberation of heads by HIV-1 protease liberates may play an important role in HIV-1 associated cytopathogenesis and carcinogenesis. Phosphorylation of the head region can affect filament stability. The head has been shown to interaction with the rod domain of the same protein.
Statistics
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PSSM-Id: 487307
Aligned: 41 rows
Threshold Bit Score: 48.1562
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q05AI8      9 SSSSSYRRMFGGpgymtppmsRGVFGRASTGG-SGSSRVSSRVYEVSksstsSPGFSGYRASSYSMPNLSAGYTRsyggm 87  zebrafish
Q0GEX9      9 AVTSIYRRYFGEptk----yrASYEMPGYKVS-AAGYG--TRSVSVGst--lGVPVGSFRRTHSRYSSMSIPAT------ 73  sea lamprey
Q6PF56      8 YLSSSYRKIFGDs--------PRASSSRPGPS-GSSRTTVPSGYRSHslsrtNVPSSAYRRAGYLA-------------- 64  African clawed frog
P35616      9 YYTP-YKRRVVE------------SSPRVHIR-SSYVSPSRTTYS-------PLVSTTMRRSYATSSSSSFLPS------ 61  African clawed frog
NP_006149   9 YYSTSYKRRYVE-----------TPRVHISSV-RSGYSTARSAYSSYsa--pVSSSLSVRRSYSSSSGSLMPS------- 67 
Q02916      9 FFPS-YKRRYAD-----------SPRLHVSAMrSGGYSSARSAYSSLs----APVSSVSVRRSYATSSASGSLLHs---- 68  Japanese quail
Q6DDQ8      6 LYTSSYKKIFGD---------SPRSSSHLYTS-SGGG-SSSRSYRPRea--yTSSISSYRKVSRSPGHLSSA-------- 64  African clawed frog
Q16352     10 CSSSSYRKVFGD---------GSRLSARLSGA-GGAGGFRSQSLSRSnv--aSSAACSSASSLGLGLAYRRPPA------ 71  human
Q4SG66      7 YTQSSYRKIFGDsl-----rlSVSSSRMSRAS-SGLRA--------------MPPSHGPVSAYRRVGRPSGAFSVm---p 63  spotted green puff...
Q4S7N7      8 YSSSSYRKIFGD-------------SPRYA-S-SPSRNLSSRGGYRYss--sSSVGRSNISSLGAHSRKSGRSLAm---p 67  spotted green puff...
Q05AI8     88 GETLDFSLADALNQEFLHTRT 108 zebrafish
Q0GEX9     74 SDMIDLSQAESLGNELKSIRT 94  sea lamprey
Q6PF56     65 ADAVDLSQTSAVNNEYKIIRT 85  African clawed frog
P35616     62 VDTMDLSQVAAISSDLKIVRT 82  African clawed frog
NP_006149  68 LENLDLSQVAAISNDLKSIRT 88 
Q02916     69 VDSLDLSQVAAISNDLKSIRS 89  Japanese quail
Q6DDQ8     65 QDHFDLSQSTALSNELKIVRT 85  African clawed frog
Q16352     72 SDGLDLSQAAARTNEYKIIRT 92  human
Q4SG66     64 AESLDLTQTSVVNNELKVIRT 84  spotted green pufferfish
Q4S7N7     68 LDTVDLAQSSVLNNEFKIIRT 88  spotted green pufferfish
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