Conserved Protein Domain Family
Caudal_act

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pfam04731: Caudal_act (This model is not part of the current CDD release)
Caudal like protein activation region
This family consists of the amino termini of proteins belonging to the caudal-related homeobox protein family. This region is thought to mediate transcription activation. The level of activation caused by mouse Cdx2 is affected by phosphorylation at serine 60 via the mitogen-activated protein kinase pathway. Caudal family proteins are involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium, and are important in differentiation and maintenance of the intestinal epithelial lining. Caudal proteins always have a homeobox DNA binding domain (pfam00046).
Statistics
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PSSM-Id: 516402
Aligned: 23 rows
Threshold Bit Score: 64.396
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q90X89         13 MY-PNPVRHP-GLN---------------------LNPQNYVpAPPQYSDFPSYHHVPGInsdPHHGQ-PGGTWSS-YTP 67  tropical clawe...
10_pfamImport   1 MYhQGPVRRS-SIN---------------------LPAQNFV-STPQYSDYTGYHHVPSM---ESNPApSSGPWGPaYGA 54 
4_pfamImport    1 MH-PGSQRAT-NLGsggigtgmgsgggslgggsghLPGQAFS-STPAYSHSLSYSPMANL---DSHGP-WLGSWGStYAP 73 
XP_049729281   13 MY-PGTLRSPrGDGsadgdgt--------ggsgspLPAPNFG-AVPAYVHYTGYPHMSNM---DLQGP-SLEAWGSpFSL 78 
6_pfamImport    1 MY-SGTLRSPaGGGtaeaggt--------gscgspLQASNFA-TAPAYAHYMGYPHMPAT---DLHGP-SLGAWGSpYSP 66 
XP_004064450   13 MY-PGTLRSP-GGDgtagtgg-------tggggspMPASNFA-AAPAFSHYMGYPHMPSM---DPHWP-SLGVWGSpYSP 78 
XP_002720160   13 MY-PGSLRNPgVGStagvgss--------gssgspLPASNFT-AAPVYPHYMGYPHMPSM---DPHGQ-SLGAWSSpYSP 78 
8_pfamImport    1 MY-PGSARAN-SNN---------------------LPVQNFV-SAPAYPDYMGYHPVPAL---DSHGQ-PAPAWGShYGA 52 
7_pfamImport    1 MY-PGPARCS-NNN---------------------LPVQNFA-SAPPYSDYMGYHHVPAL---DNHGQ-PAGTWGShYGP 52 
Q90X88         16 MY-PLSVRSA-SNN---------------------HSAQNYA-SNQPYFNYVTYHHVPPM---DEQGQ-PCGVWGPqYGS 67  tropical clawe...
Q90X89         68 SREDWHPYgPGPGASS--------------ANPAQISFS-PSDYnpv-qpPGP--GL-LPPSLNSSV--------SPLSP 120 tropical clawe...
10_pfamImport  55 PREDWCAYgLGPPNSLpap--------mngSSPGQVSYCpPPDYssm-hpPAS--GVqLPPPENVAA--------AMHSP 115
4_pfamImport   74 PKEDWAPYgEGPSSSVvesspvqtlaqvlaLAPTPAPYG-ATDYsnl-vrPESs-GVvPPENM-EFT--------EPTSN 141
XP_049729281   79 PREDWNVY-SGPSNTIgsvp-------tndLTPSPAAFG-LPEYcnlgpaGGGnsGVsLPAPADRTLvpidagtaDTSSP 149
6_pfamImport   67 PREDWNVY-PGPSSTMgtvp-------mndMTSSPAAFG-SPEYsnpapaGGGnsCSgLTGPAGGSLfpvdactaDASSP 137
XP_004064450   79 PREDWSVY-PGPSSTMgtvp-------vndVTSSPAAFC-STDYsnlgpaGGGtsGSrLPGPTGGSLvptdagaaNASSP 149
XP_002720160   79 PREDWSAY-SGPSSTMgtmp-------lndMTSSPGAFC-SPDYnnlgttGGGssGGsLPAPASGSLvpidagtsDTSSP 149
8_pfamImport   53 QREDWSAYgPGPSSALpaah-------ingSSPGQGSYS-SAEYssl-hpAAA--AApLPPADTSHG--------QQISP 113
7_pfamImport   53 QREDWNAYgPGPSSTVaaaq-------ingSSPGQVSYS-SADYssl-hpAGS--GG-LPPVDTINA--------QQISP 112
Q90X88         68 PREQWNSYgAGPSNTnmaq--------ssdLSPNQFAYN-SSGYssp-hpSGT--GI-LHSVDLSHT--------AANSP 126 tropical clawe...
Q90X89        121 SAQRRNLYEWMRRTGVPTSTN 141 tropical clawed frog
10_pfamImport 116 ERERRNSYEWMRKTVQSSSTG 136
4_pfamImport  142 PPNIGGPYAWMSKTLHVSGKT 162
XP_049729281  150 RRNRHSPYAWMRKTVQVTGKT 170
6_pfamImport  138 SRSRHSPYAWMRKTVQVTGKT 158
XP_004064450  150 SRSRHSPYAWMRKTVQVTGKT 170
XP_002720160  150 NRSRHSPYAWMRKTVQVTGKT 170
8_pfamImport  114 NSQRHSSYEWMRKTVQTNTAG 134
7_pfamImport  113 NSQRHSSYEWMRKTVQSTSTG 133
Q90X88        127 SDLSQNSYEWMGKTVQSTSTG 147 tropical clawed frog
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