2DZE


Conserved Protein Domain Family
ASF1_hist_chap

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pfam04729: ASF1_hist_chap 
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ASF1 like histone chaperone
This family includes the yeast and human ASF1 protein. These proteins have histone chaperone activity. ASF1 participates in both the replication-dependent and replication-independent pathways. The structure three-dimensional has been determined as a a compact immunoglobulin-like beta sandwich fold topped by three helical linkers.
Statistics
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PSSM-Id: 398417
Aligned: 69 rows
Threshold Bit Score: 147.664
Threshold Setting Gi: 134068583
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2DZE_B                     1 MSIVNILSVNVL-NNPAKFSDPYKFEITFECLEP-----LKSDLEWKLTYVGSATSQSYDQILDTLLVGPIPI-GINKFV 73  fis...
Q5CQH0                    10 MSLVNVTSVKVF-KNPTEITDPFEFEISFECLQN-----LEEDLEWKIVYISCAESKDMDQELDCIALGPITR-GALKFI 82  Cry...
WGS:AAFB:cds.EHI_127360A   1 --masLTKINSLfPNPSTMNDGYSFEIYINVSEQ-----LQEDIGIKVIYVGSSFSNEYDQILEDIAVGPLSV-GLNKFT 72  Ent...
EGR28891                   1 MALVNIQNIQFQ-NNPSPFQSPLRLDITFECLKQ-----IPEEIEWQLIYIGSAKDELYDQVLDKFSMGDLDQ-GVMQFT 73  Ich...
A0CU44                     1 MAFVSITNIVVE-DKPQPFTSPITMDIYFDVIAD-----IEDEIEWTLLYIGSPKDEAHDQILDQFSMGPLTK-GTKQFT 73  Par...
A0CKQ8                     1 MALVEVTNIIFE-NELALFQTPISMQITFEVLND-----LTDEIEWNLIYIGSPLSEKFDQVLDNFSMGPLQR-GVMQFT 73  Par...
A0DPW8                     1 MALINITNIVFD-QDTALFNSPIQMQITFDVMRQ-----LDEEIEWKLIYIGSPNSDKYDQVLEQFSMPPLQQ-GTMQFT 73  Par...
Q4CQS3                     2 aTRVELRGISVVgSNPAPFSDPIVLKVLLEVFEKppvqaIDVKFTWKLIWDFPV-----DQELDEFEVGPLTTlGVHELT 76  Try...
CAM66879                   2 tTRVELRKVQVLgPNPSKFDTPIRLHLVLDVFEKppkdaIDVTFTWSPVWDFPV-----DQELDEMEVGPFTTlGRHEFT 76  Lei...
Q4GZF6                     4 qpIVQLLEIELIgDNPSSYTQPMHWRMRLEALEA-----LDDTISIAFVWVGSAASPNHDQVLDSFDVGPLAQ-GVTEFT 77  Try...
2DZE_B                    74 FEADPPNIDLLPQlSDVLGVTVILLSCAYEDNEFVRVGYYVNNEMEG--LNLQEmdDAEikkVKVDISKVWRSILa-EK- 149 fis...
Q5CQH0                    83 FKAPSPDFTKIPP-EDIHGMAVVLILGSYRNEEFIRIGYYVHNVYTD--PLLED--NPP---DIPILDKLQRIILs-ES- 152 Cry...
WGS:AAFB:cds.EHI_127360A  73 ITTGPIDMSKLPD-DEILGNTLILISASYKDKEFCRIGYYVNNEFEG----I----DPT-------IDVVKREMLvpEKi 136 Ent...
EGR28891                  74 IESNPPDHTKIPSkEDLLGVTAIILTVSYRNQEFFRVGYYVYNQYTD--PELIE--NDP---TEVLIDKVERNILa-NQ- 144 Ich...
A0CU44                    74 LESNPPDWKKIPQ-DEVLGITAFILTCSYRQREFFRVGYYVYNTYTS--PENIE--NDP---QEVIIEDIARQIFn-NK- 143 Par...
A0CKQ8                    74 ITSQPPNYQLIPSkEDLFSVSALILTAKYRQKEFFRVGYYVYNNYTE--AELIE--NEP---QVVLIDRVYRQIMg-SN- 144 Par...
A0DPW8                    74 LMSSGPNFELIPSkDDLFGASAIILSVKYRKQEFFRVGYYVYNTYLE--PELIE--NDP---PQVLIDRVYRQINt-SA- 144 Par...
Q4CQS3                    77 LQSDPPDFSKIP---DPTGPTALIISFTYEGREFLHIGYNAVVTCEGemPD-----------VFESAEQLRRHLTq-CF- 140 Try...
CAM66879                  77 IESDPPNVADIP---DPTGPTALIVSLKYQGDEFLHIGYNITVTCEGdlPD-----------VFTSADMLTRHIGk-CY- 140 Lei...
Q4GZF6                    78 MECDPPQVELVPT-QEVLGVTILVISFQYREQEFLRVGYYTQVAYFD--GRMNN--CPP---PVPQVELMGRFIAm-PR- 147 Try...
2DZE_B                   150 ------PRVTRFNIQWD 160 fission yeast
Q5CQH0                   153 ------PRLTRFNIGWD 163 Cryptosporidium parvum
WGS:AAFB:cds.EHI_127360A 137 trtlsePRVTLFPCYWD 153 Entamoeba histolytica HM-1:IMSS
EGR28891                 145 ------PRITHFNIKWg 155 Ichthyophthirius multifiliis
A0CU44                   144 ------PRITRFEIDWN 154 Paramecium tetraurelia
A0CKQ8                   145 ------PRITKFPIDWE 155 Paramecium tetraurelia
A0DPW8                   145 ------PRVTRINIDWE 155 Paramecium tetraurelia
Q4CQS3                   141 ------PKQ--LSIVWD 149 Trypanosoma cruzi
CAM66879                 141 ------PKL--RDISWD 149 Leishmania infantum JPCM5
Q4GZF6                   148 ------PTVTVTPIAWN 158 Trypanosoma brucei
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