3O2S,3OMW


Conserved Protein Domain Family
Ssu72
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pfam04722: Ssu72 (This model is not part of the current CDD release)
Ssu72-like protein
The highly conserved and essential protein Ssu72 has intrinsic phosphatase activity and plays an essential role in the transcription cycle. Ssu72 was originally identified in a yeast genetic screen as enhancer of a defect caused by a mutation in the transcription initiation factor TFIIB. It binds to TFIIB and is also involved in mRNA elongation. Ssu72 is further involved in both poly(A) dependent and independent termination. It is a subunit of the yeast cleavage and polyadenylation factor (CPF), which is part of the machinery for mRNA 3'-end formation. Ssu72 is also essential for transcription termination of snRNAs.
Links
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Statistics
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PSSM-Id: 516397
Aligned: 101 rows
Threshold Bit Score: 201.913
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3O2S_B        26 LRVAVVCSSNQNRSMEAHNILSKRGF-SVRSFGTGTHVKLPGPAPDKPNVYDFKTTYDQMYNDLLRKDKELYTQNGILHM 104 human
Q8SRQ6         4 MKLAVTCAMNQNRSMQTHDLLAKKGI-PVKSFGTNPVIKLPGETMDKPNVYNFGVTYQQIYDDLCMKNEDHYRESGILYL 82  Encephalitozoon...
EJW03286       2 KRIAICCAMNQNRSMEVHRLLLENNI-KCKSFGTQSVVRLPSPDALKANTYKYDNTFADIKKDLESKHDVWYEQTGLIDM 80 
XP_024331879   1 MKIAVCCAMNQNRSMEAHKILKDAGY-KIDSYGTNQHIKIPGESLETPNIYQFGTSYKEIYKDLIYKNASFYEKIGILKM 79 
EOB12435       1 MKIAVVCAMNQNRSMEAHKVLLEAGF-QVDSYGTNKNIKIPGESIDKPNVYPFGVSYLEIYEDLKNNNEIFYERIGMLKM 79 
XP_015618526   9 MRFAMVCSSNMNRSMEAHSLLGRAGL-DVASYGTGTHVKLPGPSLHEPNVYDFGTPYNVIYDDLRRKDPDLYKRNGLLPM 87 
XP_002515629   3 LRYAMVCSSNQNRSMEAHSLLKMQGF-DVSSYGTGAHVKLPGPSLREPNVYDFGTPYKQMFDDLRRKDPDLYKRNGILPM 81 
Q9C9T0         3 FRYAMVCSSNQNRSMEAHALLKRQGL-DVASYGTGSHVKLPGPSLREPNVYDFGTPYKQMFDELRRKDPELYKRNGILQM 81  thale cress
Q558Z3        22 KRIAMVCASNQNRSLEAHHLFVKNGFkNIRSFGTSAHCKLPGPSIHQPNIFSFGTPYQEIYTSLKNQDQELYIRNGLLNM 101 Dictyostelium d...
XP_020435719  40 KRLAMVCASNQNRSVEAHNLFLLKGYrNIRSFGTSGNCKLPGPSQDRPNIFPFGTPYQSIHESLRQQNQELYTQNGILNM 119

3O2S_B       105 LDRNKRIKPRPERFQNCKD--------LFDLILTCEERVYDQVVEDLNSRE---------QETC--QPVHVVNVDIQDNH 165 human
Q8SRQ6        83 LERNMGVKERPENFFQRSE--------DFDLVITCEERVFTSIFEYYA------------DAPSctQCFFMVNFDIRDTP 142 Encephalitozoon...
EJW03286      81 VDKNIKTKEKPENIFQYAEsmnknlieLFDLIVSCDKRCYNALIEYAEYEEeerkkikkiVSRD--SHCWVVNFHIKDSI 158
XP_024331879  80 LERNMAIKDSAEYFFNKDT--------YHDLIITSEEKCFVTIYENM-------------VKCNgsYKSFIVNFDIKDTI 138
EOB12435      80 LKRNMKIKEKALNYYQCNNv-------IYDLVITAEEKCFTSIFNEINYK-------------------FLINFDIKDNL 133
XP_015618526  88 LKRNTSVKLAPQRWQDNAGd------gLFDVIFSFEERVFDLIVDDMHNRE---------QRML--KNALIINMDVKDNH 150
XP_002515629  82 LKRNSSVKLAPQRWQDNAAd------gSFDVVFSFEEKVFDMVIEDLHNRD---------HVLM--RSVLVINLEVKDNH 144
Q9C9T0        82 IKRNLSVKLAPQRWQDNAGd------gVFDVVMTFEEKVFDSVLEDLNNRE---------QSLT--KTILVMNLEVKDNH 144 thale cress
Q558Z3       102 LERNISVKLAPEKWQEEQQs-------KFEIVYTFDQRVYDAVIEDLLQRD---------VSSSllQPVHIINLQVKDTH 165 Dictyostelium d...
XP_020435719 120 LERNQRVKLAPEKWQEEQLa-------RFDIVFTFDQRVFDMVVDDLTQRD---------ITAPm-QPVHIVNLQVKDTH 182

3O2S_B       166 EEATLGAFLICELCQCI--QHTED----MENEIDELLQEFEEKSGRTFLHTVCFY 214 human
Q8SRQ6       143 SDAIAGAQEILEFVEDVlaKEEER----LEYAVDSALRRYFERKGVMLLFTVVNL 193 Encephalitozoon cuniculi
EJW03286     159 ADAQSAANSVVDFVKRI--FRRTEagisYDNAVKRVITDFSQEMNEDMLFKV--L 209
XP_024331879 139 LDASAGALEIKDFVDSC--MTITGn---YEFRIMKALELYNRKYSKNNIFTVIEF 188
EOB12435     134 LDASEGAQEILKFVKNV--AELKGg---FEEKVKGALEKYTETTGKMLIFTCKCV 183
XP_015618526 151 EEAGVGAKLALDLCQKL--EGADEd---WEEIIDDLIITFEKQHKRKLTYNMAFY 200
XP_002515629 145 EEAAIGARLALELCQEI--EAAES----WEDSIDEIITAFETKHRRKLLYSVSFY 193
Q9C9T0       145 EEAAIGGRLALELCQEI--EGNET----WEDTIDDIVAGFEKQHRRKLVYSISFY 193 thale cress
Q558Z3       166 EEAVGGAQHALEITSII--EKTLN----WEEKLDQILEDFYKQTSRQFLHTLMFY 214 Dictyostelium discoideum
XP_020435719 183 EEAAGGASHALQLLNLI--DETEDn---WEDSMDDILEKFYRKTGRQLLYTLMFY 232
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