5CWA


Conserved Protein Domain Family
Anth_synt_I_N
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pfam04715: Anth_synt_I_N 
Anthranilate synthase component I, N terminal region
Anthranilate synthase (EC:4.1.3.27) catalyzes the first step in the biosynthesis of tryptophan. Component I catalyzes the formation of anthranilate using ammonia and chorismate. The catalytic site lies in the adjacent region, described in the chorismate binding enzyme family (pfam00425). This region is involved in feedback inhibition by tryptophan. This family also contains a region of Para-aminobenzoate synthase component I (EC 4.1.3.-).
Links
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Statistics
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PSSM-Id: 398406
Aligned: 53 rows
Threshold Bit Score: 80.8191
Threshold Setting Gi: 74608189
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5CWA_A           35 DSETPLSAYRKLAAnrPGTFLLESA-E--NGrsW--SRWSFIGAGApta------------------ltVREGQAVWLG- 90 
P43761           51 qsLILVNAAVKITCl-gHNVTFKAL----NN--N--GKQVLKEIHPklt------------------alGKVSAVNFEDe 103 Haemophilus ...
Q24SC8          212 D-LQPIELLEAFKEs-eYPFFLDSG-RnyGG--L--GRYSFMGAFPflqasacrdgvevkrfdgeeglnSKEDLSSLIG- 283 Desulfitobac...
Q1DBY1           36 GALRPVDLLRALPAe--sRFLLEST-R--VS--Ae-GRYSFLGAKPflr------------------ftAKEGQCFIDG- 88  Myxococcus x...
Q2RGN9           13 D---PEALYAALAGgrENSFLLESA-L--FH--PrlGRYSFLGSAPflv------------------lkTRGNEARLFRp 66  Moorella the...
WP_012174522     21 LDEPFETTAARFADr-pHTVVLLSG----GD--AdsARYHLLATDPwli------------------ftARSRRLELQT- 74  Desulfococcu...
jgi:Sfum_3709    24 SDLEFIAVARRCAAqpDSVVLLSGGkVplEG--E--SRYSIAAWDPfll------------------fkSKGSRCLVHG- 80  Syntrophobac...
WP_011770306     16 TIAELTNIKAQIAGl-dWAVLLESA-GtdHV--D--SRWSIISAQPvan-----------------mvtYQGISTITQGn 72  Psychromonas...
jgi:Mmwyl1_2967  11 YQASLLSFFSAVRDl-pYPALLDSN-HehFP--D--TNYDILVANPlar-----------------ihpVQNNQPITWYs 67  Marinomonas ...
Q0A5Q8            9 YLADGTRLLRRIGRq-pWCQWLDSG-WpgSG--A--GRFDILVMRPrit------------------leSAGGRTRVAG- 63  Alkalilimnic...

5CWA_A           91 ------------AvPKDAPTGGd-PLRALQVTLELLaTaDRQSE----PGLPP--LSGGMVGFFAYDM---VRRLE-RLP 147
P43761          104 fsvqflpldnqlDeDSKLQSAT--IFDGLRVISSLY-QhSQ--------------TPIFLGGLFAYDL---VANFIp-MD 162 Haemophilus ...
Q24SC8          284 --------------QEWLAYPEgeSLKILDDLVERY-R---VSN----PTEFP--FVGGAVGFWTYDL---KDELE-KMP 335 Desulfitobac...
Q1DBY1           89 ------------------ALQQgtPQEVLRSLLRRW-R-G-VRH----PGMPL--FCGGAVGFFGYEA---AHCFE-SLP 137 Myxococcus x...
Q2RGN9           67 --------------GAMVERIPgnPWEIIRSLLSRY-R-L-PRH----DQPVP--FTGGAVGYLAYDL---GRYIE-KLP 119 Moorella the...
WP_012174522     75 ------------EnGSHTFTGH--PVESLKKILARF-HmA--------AADLPapVGAGLFGYLAYDV---KDCLE-HLP 127 Desulfococcu...
jgi:Sfum_3709    81 ------------PsGSESRRGD--PLAVLDELFARF-SpGYS------PVIPP--FSGGAIGYFAYDL---KNAIE-RLP 133 Syntrophobac...
WP_011770306     73 --------------KTISDSSD--PLA-LQQNLRQK-LfHDSSNdntiETEVP--FTGGVLGYYSYGLgnyFENIKnADK 132 Psychromonas...
jgi:Mmwyl1_2967  68 -----------kPlYELSNTDN--PMTLLNELMSLI-CqEPWAKs--aPKDLP--FVGGLLGYYGYESghfVEQLPdT-- 127 Marinomonas ...
Q0A5Q8           64 --------------RGPVQQTDedPLAVLQRCLGEA-GgGSPSA------HWP--FSGGAVGYFSYDL---GRRLH-GLP 116 Alkalilimnic...

5CWA_A          148 er-aVDDLC-LPDMLLLLATDVAAVDHHEGTITL 179
P43761          163 gitlKNDGInCPDYSFYLAEHLITIDHQNQQATL 196 Haemophilus influenzae Rd KW20
Q24SC8          336 qs-gINDLD-LPLWRFSWYDGIVVYDHENRRYTL 367 Desulfitobacterium hafniense Y51
Q1DBY1          138 rh-pRDDLH-LPEIDLSFIDTFLTVDHHEGQLLL 169 Myxococcus xanthus DK 1622
Q2RGN9          120 sl-aADDLP-FPEGYLAFYDTIVAIDHQEGRVYV 151 Moorella thermoacetica ATCC 39073
WP_012174522    128 rt-sVNDLC-LPDLYMFAPRLILVHDKKENTTRL 159 Desulfococcus oleovorans
jgi:Sfum_3709   134 rt-aRDDLG-LPDIWLMWPRRILVHDRIEKRLHY 165 Syntrophobacter fumaroxidans MPOB
WP_011770306    133 ----PVTLE-LPEMAVGFYDWALLIDNKNEQNYL 161 Psychromonas ingrahamii
jgi:Mmwyl1_2967 128 ----VEHDIkLETLSIGLYGWAVITCHKTKNTQL 157 Marinomonas sp. MWYL1
Q0A5Q8          117 vrs-----gaGPEMRVGLYDWALVTDHHQRLTAV 145 Alkalilimnicola ehrlichii MLHE-1
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