Conserved Protein Domain Family
Pellino_FHA
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pfam04710: Pellino_FHA (This model is not part of the current CDD release)
Pellino, FHA domain
Pellino proteins are E3 ubiquitin ligases that play important roles in immunity, being involved in Toll-like signalling pathways, and associate with the kinase domain of the Pelle Ser/Thr kinase. Mammalian Pellinos have been shown to mediate polyubiquitination of interleukin-1 receptor-associated kinase (IRAK). They consist of a forkhead-associated (FHA) domain at the N-terminal and a RING domain at the C-terminal. This entry represents the FHA domain, which is sufficient to interact with the ubiquitination substrates, such as IRAK1. This domain contains an unusual 'wing-like'appendage.
Links
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Statistics
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PSSM-Id: 516388
Aligned: 14 rows
Threshold Bit Score: 417.143
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_015784371  27 SNYPIFYGELVILGYNGNLPHGEKGRRRSKFILTQRNVPNGVKKSKHYVVKQPQQTKAIQD-KGKHSISYTLSRTQAVIV 105
EDO33726       3 STEPLTYGMLVVLGYNGAPPQGNQERRKSSYLLQKKSLASGVKPFKQHLASSQTGMQVVHS-NQAHSVSYTLARGPSVVV 81 
XP_007230783  12 SKDPVKYGELVILGYNGSLPGGDKGRKRSRFALYRRAKANGVKPSTVHILSNPQDSKAVNS-RGQHSISFTLSRNQTVVV 90 
XP_009008738  18 TSNSVKYGELVILGYNGCLFNGDKGRRRSKFQLFKRQVPNGVKAAKHHIVNNPQQSELIQN-CHQHSVSYTLSRSQAVIV 96 
KYB26669      62 PKQLVKYGELVILGYNGFLPQGDRGRRRSKFVLYKRPTANGVKRSKHYVVKTPHSSQAILD-ANQHSISYTLSRNHAVIV 140
XP_025154861  60 PKQLVKYGELVILGYNGYLPPGDRGRRRSKFVLYKRPVPNGVKRSKHYIVKTPHSSQAILN-TKQHSISYTLSRTQAVIV 138
XP_002426083   7 EKKSIKYGELVILGYNGFLPPGDRGRRRSKFVLYKRLQPNGVKKSKHYVVKTPHSSQAILD-SKQHSISFTLSRNQAIIV 85 
XP_783149     75 GSLATRYGQLVVLGYNGVLPAGNRGRRRSTFGLFKRDTANGVKPDKQYEINASKQGEAIKNsSSKHTIAYTLSRHQTVVV 154
O77237        22 DKPRLRYGELVILGYNGYLPQGDRGRRRSKFVLHKRTEASGVKRSKHYIVQSPQTSKAILD-ANQHSISYTLSRNQAVIV 100 fruit fly
XP_029688483  23 SKDPVKYGELVVLGYNGSLPNGDRGRRKSRFALYRRTKANGVKPSTVHIINTPQASKVVNC-KGQHSISYTLSRNHTVVV 101 torafugu

XP_015784371 106 EYTPDNETDMFQIGRSSESPIDFVVIDTVSPDKPVG---DTLAQQSTISRFACRILVERNPPYTARIYAAGFDSSRNIFL 182
EDO33726      82 EYCRDNKTDMFQIGRSSDSKIDFVVMDTVPGVKDGAv--QPNPQKSTISRYACRITVDRHPPYTARVFAAGFDKSNNIFL 159
XP_007230783  91 EYCHDNDTDMFQIGRSTESPIDFVVTDTPGGSKESE---DSSVAPSTISRFACRVVCERNPPYTARIYAAGFDSSKNIFL 167
XP_009008738  97 EYDHDCNTDMFQIGRSSEEQIDFVVMDTIPGTQRGD---QSVIMQSTISRYACRILVDRTHPYAARIYAAGFDNGKNIFL 173
KYB26669     141 EYTPDDDTDMFQIGRSSEAPIDFVVMDTVPGDKTG----ETKVMQSTISRFACRILCDRKNPKIARIYAAGFDTSKNIFL 216
XP_025154861 139 EYTEDEETDMFQIGRSSESPIDFVVMDTCAGGGDGGpanEGRVAQSTISRFACRILADRSDPRIARIYAAGFDSSRNIFL 218
XP_002426083  86 EYMPDEETDMFQIGRSSDPPIDFVIMDTIPGEKQG----EERVNQSTISRFACRILADRSNPKICKIFAAGFDSSRNIFL 161
XP_783149    155 EYANDTSTDMFQIGRSTEPVIDFVVMDTVPGAKTQK---DCVVSESTISRFACRIIVERSPPHTARIYAAGFNSTNNIFL 231
O77237       101 EYKEDTETDMFQVGRSSESPIDFVVMDTLPGDKK-----DAKVMQSTISRFACRILVNRCEPAKARIFAAGFDSSRNIFL 175 fruit fly
XP_029688483 102 EYSHDKDTDMFQIGRSTESPIDFVVTDTVAGGQEGE---ETPITQSTISRFACRVVCERGPPYTARIYAAGFDSSKNIFL 178 torafugu

XP_015784371 183 GEKATKWQHD-GEMDGLTTNGILIMHPKTTFcsngnviddipnsGQKYCLWREVSVCGGIYAIRETRSASEKGDKIDLET 261
EDO33726     160 GEKAPKWKNEdDMMDGLTTNGVLLMNPRGGP-------------NCPPGIWREISVCGHVYGLRDTRSAPEKGKTVQNES 226
XP_007230783 168 GEKATKWKNPdGHMDGLTTNGVLVMHPQ-GFp-----------eESKQGMWREISVCGDVYTLRETRSGPIRGQMAQGES 235
XP_009008738 174 GEKATKWYTD-GEIDGLTTNGILIMHPINGFt-----------eNSKTGLWRELSVEGGLYALRESRSAPNKGNLVSTEN 241
KYB26669     217 GEKATKWQENgREIDGLTTNGVLIMHPRGTFcg----------gDAKCSYWLETSVGGGVFSLRESRSAQQKGQVVENET 286
XP_025154861 219 GEKATKWQEN-REIDGLTTNGVLIMHPRGQFcg----------gEAQCGFWREVSVGGGVFSLRESRSAQQKGNVVEDEN 287
XP_002426083 162 GEKATKWQEG-REIDGLTTNGVLIMHPIGNFvd----------gDSKPGVWREVSVGGGVFSTRESRSAQQKGSVIANET 230
XP_783149    232 GEKACKWKTEsG-MDGLTTNGVLIMRPKGGFq-----------sDATPGVWREVSVCGNVYSLRETRSSPQRGKLIEDED 299
O77237       176 GEKATKWQDN-VEIDGLTTNGVLIMHPKGSFcg----------gNAKCGLWRECSVGGDVFSLRESRSAQQKGQPIYDEC 244 fruit fly
XP_029688483 179 GEKAAKWKNPdGHMDGLTTNGVLVMHPRGGFt-----------eESKPGVWREISVCGDVYTLRETRSAQTPGKLVENES 247 torafugu

XP_015784371 262 NILKDGTLIDLCGATLIWRSAEGLLRSPTKKSLEDM 297
EDO33726     227 NVLFDGSLIDLCGAVLMWRSADAIPTMPTEGMIDAM 262
XP_007230783 236 SALQDGSLVDLCGATLLWRTAEGLLKAPTLRHLDAL 271
XP_009008738 242 NVLKDGTLIDLCGATLVWRSNEGLVQGPTLVELEKQ 277
KYB26669     287 NILEDGTLIDLCGATLLWRSAEGLTKSPSKRDLERE 322
XP_025154861 288 NILQDGTLIDLCGATLLWRSAEGLAKSPTKQDLEEL 323
XP_002426083 231 NILQDGTLIDLCGATLLWRSAEGLAKSPNRDYIEAL 266
XP_783149    300 NILEDGTLVDLCGATLLWRSAMGLVNTPTQRHLERL 335
O77237       245 NILQDGTLIDLCGATLLWRSAEGLQHSPTKHDLEKL 280 fruit fly
XP_029688483 248 NILQDGSLVDLCGATLLWRTTEGLFHTPTQKHLEAL 283 torafugu
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