Conserved Protein Domain Family
AMH_N

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pfam04709: AMH_N (This model is not part of the current CDD release)
Anti-Mullerian hormone, N terminal region
Anti-Mullerian hormone, AMH is a signalling molecule involved in male and female sexual differentiation. Defects in synthesis or action of AMH cause persistent Mullerian duct syndrome (PMDS), a rare form of male pseudohermaphroditism. This family represents the N terminal part of the protein, which is not thought to be essential for activity. AMH contains a TGF-beta domain (pfam00019), at the C terminus.
Statistics
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PSSM-Id: 516387
Aligned: 15 rows
Threshold Bit Score: 290.904
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P49000        74 HSYEHAFLEAV-QESRWGPQDLATFGVCS-TDSQTTLPALQRLGAWLGETgEQQLLVLH------LAEVIWEPQLLLKFQ 145 Norway rat
8_pfamImport   1 SSYEHAFLEAV-GRSHWEPQDLATFGVCNlSDVQTALPSLRHLGSWLGER-RGLLLVLH------LVEVTWEPVPSLRFQ 72 
5_pfamImport   1 SSYERAFLEAV-WGARWGPRDLATFGVCSpGHSR-ALPALQHLGAWLREPgGRQLLVLH------LAEVTWDPTPLLRFQ 72 
6_pfamImport   1 SSYEWAFLRAV-QQAHWGPQDLATFGVCNpGDKQAALLLLQRLGAWLGAPqGQQLLVLH------LEEVTWEPIPSLRFQ 73 
XP_004059745  77 STYEQAFLGAV-QRARWGPQDLATFGVCNtGDRQAALPSLRRLGAWLRDPgGQRLVVLH------LEEVTWEPTPSLRFQ 149
XP_009294509  74 QKTLNEFLSALkSAGELGKMDFV--GTCSpETQSSQVSHLVQSVLQK----QSGLKGVHat--edIWDADNEGGITLTLT 145
1_pfamImport   1 DDTYAALREAAgGDGELANRSRSQFGICGvSDGSAGSALLQLAKETGGDP-GRGLEVLHptgavlVSEEDERGALVLTFD 79 
2_pfamImport   1 DDLVAALHDATgKDGELLASSPASFGICSeSDSSSRLVLSELSVGIRRND-RRGVEVLDpaa-vfVSDEDDQESIMVTFD 78 
XP_013130583  56 EDIFAALRDGVgDSGELTNSSLVLFGFCSqSARSSASVSLDLANK------KSSLEVLHpaa-vhVSEEEEQGTITLTFD 128
P03972        91 SSYEQAFLEAV-RRTHWGLSDLTTFAVCPaGNGQPVLPHLQRLQAWLGEPgGRWLVVLH------LEEVTWEPTPLLRFQ 163 domestic cattle
P49000       146 Epp---pGGASRWEQALLVLYPGPG----PQVTVTGAGL-QGTQSlcptrdtrylvltvhfpAGAWSG------SGLALT 211 Norway rat
8_pfamImport  73 Ep----pGGASPHEQALLVLYPGPG----PEVTVTGAGL-PGAQV-----------------SGSCKGq----sWATRSP 122
5_pfamImport  73 Epp---lGAANLPEQAVLVLYPGPG----PEVTVTGAEL-LAAQSlcptadtrylvlvvdrpERAWLG------AGLALT 138
6_pfamImport  74 Epp---lGGAGPPELALLVLYTGRG----PEVTVAGAGL-PGTQRlcpsrdtrylalaldrpEEAWRG------SGLALT 139
XP_004059745 150 Epp---pGGAGPPELALLVLYPGPG----PEVTVTRTGL-PGAQSlcpsrdtrylvlavdrpAGAWRG------SGLALT 215
XP_009294509 146 FpkhslpAGPAS---VMLLFSVNPvkgdslRVQFNSQSIhPNTQTvcises-----trflivTGGWSHghihlkLKTMVE 217
1_pfamImport  80 LppspllRRRPA----LLLALEGPptggnlDVTCTSRSLqPHAQTacisge-----twyitlTGKASEddvpqkWRISVE 150
2_pfamImport  79 Lpq---sQLLKL-KPVLVLAFKSPltdgelDIIFSSQSLqPNTQSacisgr-----tlyillTGKSSEgnveqkWNISVQ 149
XP_013130583 129 LprppslMTNPV----LLLVFENPlargdlEVAFTSQFLqPNTQAvcisgd-----tqyvllTGKSSEgsvndrWQITAQ 199
P03972       164 Epp---pGGASPPELALLVVYPGPG----LEVTVTGAGL-PGTQSlcltadsdflalvvdhpEGAWRR------PGLALT 229 domestic cattle
P49000       212 LqPSKE-GATLTIAQLQAFLFGSDSRCFTRMTPTLVLLPp-TGPTPQPAHGQLDTVPFPQPGLSLEPED----LPHSADP 285 Norway rat
8_pfamImport 123 C-PPTT-GGPMSTAQLQTLLFGSDLHCFTRMTPALFLLP--SGPTPLPAHGQLDIVPFPPPRSSPEPEE----LPPSTDP 194
5_pfamImport 139 LqPHGDaGATLSTAQLQTLMFGSDPRCFTRMTPALLLLPq-SEPVLLPARGQLDTVSFPPPRPSLDTVE----LLPSADP 213
6_pfamImport 140 LrSRGD-DSPLSTTQLQVLLFADNPRCFTRMTPALLLLPg-SQLTPLPAQGQLDTVPFPPPRPSRGPEE----PPPSADP 213
XP_004059745 216 LqPRGE-GSRLSTARLQALLFGDDHRCFTRMTPALLLLPr-SEPAPLPAHGQLDTVPFPPPRPSAELEE----SPPSADP 289
XP_009294509 218 TsMDDN-RPKLSVSELKEVLMRKVDSSSTMIKPVLLFLSdlee-----------------prlkHHRIPqderLPSRTYL 279
1_pfamImport 151 A------KSPDMNRSLKEILTGGRSGSNISVVP-LLLFSgkrg-------------------tdtrYHQnsspASSQTs- 203
2_pfamImport 150 A------KSPGTRQSLKDVLIGGKSGSDVRLTP-LLLFSaetg---------------------tdtrSgsstASSQTAS 201
XP_013130583 200 T------KLPHMKQNLKSILIGEKSGSNISMSP-LLLFSggtg-------------------tdtrCASgsppASLQTs- 252
P03972       230 LrRRGN-GALLSTAQLQALLFGADSRCFTRKTPALLLLLpaRSSAPMPAHGRLDLVPFPQPRASPEPEE----APPSADP 304 domestic cattle
P49000       286 --FLETLTRLVRALRgpltraS---NTRL-----ALDPGALASFPQGLVNLSDPVA-LGRLLDGEEPLLLLLspaaatVG 354 Norway rat
8_pfamImport 195 --FLETLTRLVRALRgsptraS---SPRL-----ALDPGALAGFPQGLVNLSDPAA-LKRLLDGEEPLLLLLppaaatPG 263
5_pfamImport 214 --FLQTLTRLVRALRgsparaS---PMRL-----ALDTGALASFPQGLVNLSDPAA-LERLLEVDEPFLLLTppaaasAG 282
6_pfamImport 214 --FLETLTRLVRALRvfpaqaS---APRL-----SLDPDALASFPQGLVNLSDPAA-LERMLDGEEPLLLLLpp--vaDA 280
XP_004059745 290 --FLETLTRLVRALRgpparaS---APRL-----ALDPDALAGFPQGLVNLSDPAA-LERLLDGEEPLLLLLrptaasTG 358
XP_009294509 280 --FLCELQKFLRDIL------PqskSTTPqddpsAVSLDTLHSLPPLRLGVSSTESlLSGLVNSSTPTVFVF------PQ 345
1_pfamImport 204 --FLCELKRFLGDVL------PqdlRESS-----PLQLDSLKSLPPLTLGPSSSDTlLAGLINSSSITVFSF------RS 264
2_pfamImport 202 lsFLCELRRFLDASL------PqqhAEPL-----LLRLDSLQSLPPLALGLSTSETlLAEIINSSAPTIFSF------SS 264
XP_013130583 253 --FLCEMKRFLGAVL------PqehFTSP-----PLPLDSLQSLPPLSLGLSSSETlLAVMINSTAPTVFGF------TS 313
P03972       305 --FLETLTRLVRALAgpparaS---PPRL-----ALDPGALAGFPQGQVNLSDPAA-LERLLDGEEPLLLLLpptaatTG 373 domestic cattle
P49000       355 EPMRLHSpTSAPWAA--GLARRVAVELQAAASELRDL---PGLPPTAPPLLSRLLALCPNDSr-sAG---------DPLR 419 Norway rat
8_pfamImport 264 DPTRLQGpASAPWAA--GLVHRVAIELQAAAAELRGL---PGLPPAATPLLARLLELCPGDS---SDtkgp-gspgDPMR 334
5_pfamImport 283 QPAPLRGpSSVPWAA--GLAHRVAVELQAAAAELRGL---PGLPPAAPPLLTRLLALCPGDPs-dPGsp-----paDPLR 351
6_pfamImport 281 DRAAPQSpTSAPWTE--SLTRRVAAELQAAAAELRGL---PGLPPAAVPLLARLLALCPGDSg-gPG---------GPLR 345
XP_004059745 359 DPAPLHDpTSAPWAT--ALARRVAAELQAAAAELRSL---PGLPPAAAPLLARLLALCPGGPg-gLG---------DPLR 423
XP_009294509 346 RQQGLQT-HRVEVTLdsPLLSVLRMRLDEAMAQVKQ----QEAGRKMIDRLQKLTELSALSPdgeDSeaatkdhkeAQYR 420
1_pfamImport 265 RASGFQV-HSGELAFspELLEELRRRLEAEVVKITAVmreEQVGRGATERLGRLRELSALPmmep-------apggRQYR 336
2_pfamImport 265 WSSSFPV-RPGQLALspALLGELGQRLEMNERQMRELvrqGMVPQRASEKLERLRQLSAFQKq-dSSae----------- 331
XP_013130583 314 WGSVLPV-CHGELALsaALLEELRQRLDQTLVQMTEIireEEVSLGAKESLGRLKELSALQekeh-------atggSQFR 385
P03972       374 VPATPQGpKSPLWAA--GLARRVAAELQAVAAELRAL---PGLPPAAPPLLARLLALCPGNPd-sPG---------GPLR 438 domestic cattle
P49000       420 ALLLLKALQGLRAEWRGRE 438 Norway rat
8_pfamImport 335 ALLLLKALQGLRAEWRGRD 353
5_pfamImport 352 ALLLLKALQSLRREWRGRD 370
6_pfamImport 346 ALLLLKALQGLRAEWRGRD 364
XP_004059745 424 ALLLLKALQGLRVEWRGRD 442
XP_009294509 421 SVLLLKALQMVLSNWESER 439
1_pfamImport 337 AFLLLKALQTAARAYEAQR 355
2_pfamImport 332 -----aALFHFTCSITKTQ 345
XP_013130583 386 VFLLLKALQTVAQTYDAQR 404
P03972       439 ALLLLKALQGLRAEWRGRE 457 domestic cattle
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