Conserved Protein Domain Family
Dickkopf_N
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pfam04706: Dickkopf_N 
Dickkopf N-terminal cysteine-rich region
Dickkopf proteins are a class of Wnt antagonists. They possess two conserved cysteine-rich regions. This family represents the N-terminal one. The C-terminal region has been found to share significant sequence similarity to the colipase fold, pfam01114, pfam02740.
Links
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Statistics
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PSSM-Id: 487287
Aligned: 41 rows
Threshold Bit Score: 32.3486
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
NP_001016283  73 GCTEDDDCALDEFCHSSRNgnslVCLACRKRRKRCLRDAMCCTGNYCSNGICV 125
KAI2558788   118 ECIIDEDCGPSMYCQFASFq--yTCQPCRGQRMLCTRDSECCGDQLCVWGHCT 168
XP_006642678 153 ECIINEDCGSGKYCSYELLq--sKCLPCKTQDSKCTKDEECCNDQLCILGQCS 203
NP_001083014 136 ECMIDEDCGDGSFCLYEIVt--sKCVPCQTTNMECTKDVECCGDQLCVWGVCA 186
XP_005810470 116 GCLTNDDCGKGKYCLSDTHr--sKCKPCKDTDVSCTKDDECCGDQMCVWGQCS 166
7_pfamImport   1 KCLSDGDCVKGTYCLNNTHk--sKCVPCKAIDMSCTKDNECCGEQLCVWGQCS 51 
XP_005796296 123 ECMVDEDCGDLKYCLYEIEn--sRCLPCIATDMPCSKDEECCSDQMCVWGQCT 173
XP_006001038 151 ECILDEDCGAGTYCLSTILe--tKCLPCKPEDMNCTRDGECCEEHLCVWGQCA 201
XP_003224232 146 ECIIDEDCVNGKYCEFSGLe--yKCRDCKIEHKRCSRDVECCGHQLCVWGECM 196
XP_056658058 158 ECIIDEDCGTGKYCQFSSFe--yTCELCKSQQTLCSRDSECCGDQLCVWGHCV 208 gray short-tailed opossum
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