Conserved Protein Domain Family
Dickkopf_N

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pfam04706: Dickkopf_N 
Dickkopf N-terminal cysteine-rich region
Dickkopf proteins are a class of Wnt antagonists. They possess two conserved cysteine-rich regions. This family represents the N-terminal one. The C-terminal region has been found to share significant sequence similarity to the colipase fold, pfam01114, pfam02740.
Statistics
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PSSM-Id: 398399
Aligned: 50 rows
Threshold Bit Score: 31.9161
Threshold Setting Gi: 0
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007478408 252 CVDDKDCGLEEYCDAGSRGGgggagsigvqICLPCRKRRRRCQRSVMCCPGNYCSNGICV 311 gray short-tailed opossum
EDO42240       1 CRKDKHCGQGKYCHRHYG------------TCHDVKPLGEHCRRDHVCAAGMECVFGKCR 48  starlet sea anemone
EFX74373      96 CMEDKQCGKGRFCDLHYG------------VCRTEKSPGFACRRDRMCGKGLACMFGRCQ 143 common water flea
XP_017548588 100 CEHDRACGKGFSCDRHFG------------LCVPLRQEGKYCRRDAQCVRGLSCMFGKCI 147 red-bellied piranha
XP_014344262 127 CLVDEDCDVGFYCDSALFVS----------ECRGCKTKAMECAGDGECCSGYLCVWGHCA 176 coelacanth
XP_003224232 147 CIIDEDCVNGKYCEFSGLEY----------KCRDCKIEHKRCSRDVECCGHQLCVWGECM 196 green anole
PNI79262     119 CIIDEDCGPSKYCQFASFQY----------TCQPCRGQRMLCTRDSECCGDQLCVWGHCT 168 chimpanzee
EGC31774     145 CSSDRECAYGNFCNITSEPDqd-------nTCLPVLASSSVCTRDAQCPYNQICVKmafd 197 Dictyostelium purpureum
Q54KK1       153 CYMDEDCPSGNFCYWGSNKN----------LCKPLNKIGSNCTYGNDFTLGSICRNNKCI 202 Dictyostelium discoideum AX4
XP_003294997 122 CYSDNNCPYNYYCFLVGVSSsgnn---gdgVCVP--KTSRNCESSNECSTGYTCIYGICV 176 Dictyostelium purpureum
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