Conserved Protein Domain Family
Zfx_Zfy_act

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pfam04704: Zfx_Zfy_act (This model is not part of the current CDD release)
Zfx / Zfy transcription activation region
Zfx and Zfy are transcription factors implicated in mammalian sex determination. This region is found N terminal to multiple copies of a C2H2 Zinc finger (pfam00096). This region has been shown to activate transcription when fused to a GAL4 DNA binding domain.
Statistics
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PSSM-Id: 516384
Aligned: 9 rows
Threshold Bit Score: 326.819
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q95LI3        71 NVVIEDVQCSDILEEADVS--ENVIIPEQMLSSDVT--------EEVSL-AHCTVPDdVLASDITSASMSMPEHVLTSES 139 domestic cattle
P20662        68 NVLIEDVHCSHILEETDIS--DNVIIPEQVLDLDTA--------EEVSL-AQFLIPD-ILTSSITSTSLTMPEHVLMSEA 135 house mouse
XP_003218933  71 DVVIEDVQCPDIMEDTDVS--QTVIIPETVLDSVVT--------EEVSL-AHCNVPDdVLSSEITPSTMSVPEQVLTNES 139
XP_002935227  71 DVVIEDVQCSDILDGARVS--EAVIIPEQVLEDEVGtgdeeqvlEDDSL-TSCDVPDnVLDSELVDGELTIPDSETGVHS 147
XP_005045771  65 GLAAEVVQGPDIIAETDVVt-EGVIVPDSVLEADVA--------IEEALdS----GDhVLTSDLITETVRVPEQVFVADL 131
XP_006632917  65 GLEAEVVEGPEI-GQGDVVtaDGVIVPESVLGAEVA--------IEEALd----aDHhVLTTDLIAESVRVPDQVFVADL 131
XP_007228472  65 GLEAEVVEGPDI-GHEDVItaEGVIMSESILEAEVA--------IEEALd----aDHhVLTTDLIEETV--PDQVFVADL 129
2_pfamImport   1 SLQSQGVEAHEITTEDMVSseHSVIMPDNILGSEVA--------IEDDLd-------pILTSDLIQVS-DMPDQVFVAEL 64 
XP_064413301  75 DVVTDDVNCHNLMAETDVS--ETVIIPEQVLDMDVA--------TEVSL-AHCTVPEdVLASDITAETMTIPEHVLTGES 143 coelacanth
Q95LI3       140 VHVSDVGHVEHIVHGSv--vEAEIVTDPLTADVvsEEVLVADCASEAVIDA------NGIPVDQ---QDDD----KGNCE 204 domestic cattle
P20662       136 IHVSNVGHFEQVIHDSl--vEREIITDPLTADI--SDILVADWASEAVLDS------SGMPLEQ---QDDA----RINCE 198 house mouse
XP_003218933 140 LHIPDVGHMEHVIHDHnnvvESEIVTGSLGEDVvsE-VLVADCASEAVIDA------SGIPVE----HDED----KGNCE 204
XP_002935227 148 VS----GH------VV----GEEITDDALEEDMisEEVLVADCVSEAVIDA------NGIPVHE---NDSE----EVNCD 200
XP_005045771 132 VTGPE-GHLEHVVQ--------DAVAEAESPTMvsEEVLVTNSDSEAVIQAagtvpgSTVTIKT---EDDDd--gKSTSE 197
XP_006632917 132 VSHQD-GHLGH--------------------EMvsEEVMVTNSDSETVIQAhegvpaSTVTIKT---EDDEd--gKSTSE 185
XP_007228472 130 MSAHE--NLDH--------------------ELvsEEVMVT--DTEAVIQAhet-mpSSVTLKNddeDDDDdedgKSTSE 184
2_pfamImport  65 LSEHQDNTLDH--------------------QLvsEGLMVAEANSENIIHQql--psETVTLQT---DEDDd--aRSSSE 117
XP_064413301 144 IHVPEVGHVEHVSHAVs---ETEIVADALSTDVipEEVLVTDCASEAVIDA------NGIPIET---QEED----KGSCD 207 coelacanth
Q95LI3       205 DYLMISLDD-DGKMEHDCSSGMTMDA---ESEI--DPCKVDGTCPEVIKVYIFKADPGEDDL--GGTVDIVESEPENDHG 276 domestic cattle
P20662       199 DYLMMSLDE-PSKTDHEGSSEVTMNA---ESET--DSSKLDEASPEVIKVCILKADSEVDDV--GETIQAVESETDNGNE 270 house mouse
XP_003218933 205 DYLMISLDE-AVKAETDNSVDIKSDS---EG----DPCKMDGICPEVIKVYIFKADPGEDDI--GGTVDIVESESENDHG 274
XP_002935227 201 DYLMISLDD-AEKIDEDGAEEITMRG---AVEG--DSSKLDGSCPEVIKVYIFKADPGEEDL--GGTVDIVESESENDHG 272
XP_005045771 198 DYLMISLDDvGEKLDHIGSTPLKIST---EVANd-DVAKDDGFGSEVIKVYIFKAE-AEDDVeiGGTEIVTESDFHNGHS 272
XP_006632917 186 DYLMISLDDvGEKLD-IGNTPLKIST---EVTQd-DGSKEDGFGSEVIKVYIFKAE-AEDDVeiGGTEVVTESDFHNGHA 259
XP_007228472 185 DYLMISLDDvGEKLD-IGDTPLKITA---DVVQddDGSKEDEFGSEVIKVYIFKAE--DEDVeiGGTEVVAESDFPNGHA 258
2_pfamImport 118 DYLMISLDEvGEKLD-IGDTPLEMST---EVME--DKECKE----EVIKVYIFKAE-ADDDL--GGTEVITEDDYQNGHP 184
XP_064413301 208 DYLMISLDD--AKIEHDGHAEITMEPeilEQGI--DSSKANGSCPEVIKVYIFKADPGDDDL--GGTVDIVESEMDNGVG 281 coelacanth
Q95LI3       277 VELL-DQNNSIRM--PREKmVYMTVNDSQQEDEDlnvaeiadevyMEVIVGEEDAAVAaaaattvHEQEMDDSE--I-KT 350 domestic cattle
P20662       271 AEVT-DQRTSIHV--PRVN-IYMLASDSQKEEED-----------TKVIVGDEDAGGTaad-tpeHEQQMDVSE--IkAA 332 house mouse
XP_003218933 275 DTLV-NQNSSVRI--PREKmVYMAVNDSQHEDEElnvaeiadevyMEVIVGEEDAAAA-------HEQPIDDNE--M-KS 341
XP_002935227 273 DGFL-DSHNGGRM--PREKmVYMAVNDSQNDD-DldvaeiadevyMEVIVGEEDAAVA-------HEHQLEDAE--LsKT 339
XP_005045771 273 VAGViEQGGVGRM--QREKmVYMAVKDSSQEDEDiscaeiadevyMEVIVGEEEATSL-------PDTQLEDSG--VnKT 341
XP_006632917 260 VL---EPGSVGRL--PREKmVYMAVKDTSQEDEDincaeiadevyMEVIVGEEEAPAM-------QETQLDDST--VnKT 325
XP_007228472 259 VL---ESASTGRL--PRDKmVYMAVKDTSQGDEEtnvsemtdqvyMEVIVGEDEAPAL-------QEAQLEDST--CnKT 324
2_pfamImport 185 DL---EAASSGRLgvGRDKmVYMAVKNHTKEDMFlnvtcfspfslTDCVVRSQSQLYC-------QFLDVMQTGkgVeKT 254
XP_064413301 282 --LL-EQGTTGRV--SREKmVYMTVNDSQQEDEElnvtdiadevyMEVIVGEEEAAVA-------HEQQIDDTD--IsKT 347 coelacanth
Q95LI3       351 FMPIAWAAAY----------------GNNSD---GIENRSGTASALLHIDESAGLGRLTKHKPKKRRRPDSRQYQ 406 domestic cattle
P20662       333 FLPIAWTAAY----------------DNNSD---EIEVQNATASAMLHHDESGGLDRVPKQKSKKKKRPESKQYQ 388 house mouse
XP_003218933 342 FMPIAWAAAY----------------GNNTD---AVENRNGTASALLHIDESAGLGRLAKQKPRKRRRLESRQYQ 397
XP_002935227 340 FMPVAWAAAY----------------GNNTD---GIEHRNGTASALLHIDESDGLDRLTKQKPKKKRRGENRQYQ 395
XP_005045771 342 FVPVAWAAAYgderrlprryedgqaaGNNLDt--RLENKNGNATQYLQICDSISTNRVLKQKTKKRRRGEARQWQ 414
XP_006632917 326 FVPVAWAAAY----------------GNNLDt--RLENKNGAATQYLQISDSISTSRALKQKAKKKKRGETRQCQ 382
XP_007228472 325 FVPVAWAAAY----------------GNNLEs--RLESKNGTPTPYLQISDSISTSRALKQKIKKKRKGETRQCQ 381
2_pfamImport 255 FLS---SLTY----------------KVNTDkydKVQVKNGAASPFLQIREGLSANRVLKPKLRKKKKGDTRQCQ 310
XP_064413301 348 FMPIAWAAAY----------------G--TD---GIENRNGTASALLHIDESASIEKLTKPRPKKRRRAESRQYQ 401 coelacanth
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