Conserved Protein Domain Family
Pinin_SDK_memA
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pfam04696: Pinin_SDK_memA (This model is not part of the current CDD release)
pinin/SDK/memA/ protein conserved region
Members of this family have very varied localisations within the eukaryotic cell. pinin is known to localise at the desmosomes and is implicated in anchoring intermediate filaments to the desmosomal plaque. SDK2/3 is a dynamically localised nuclear protein thought to be involved in modulation of alternative pre-mRNA splicing. memA is a tumour marker preferentially expressed in human melanoma cell lines. A common feature of the members of this family is that they may all participate in regulating protein-protein interactions.
Links
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Statistics
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PSSM-Id: 516379
Aligned: 85 rows
Threshold Bit Score: 59.5864
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q4N6H7        78 SETVHRHKRLMKVGLfGYLLKAKDALVKekddqkilKHIEKEKLIDTKLEEKQKEQSTLL---QKDIQDEYDVNKKRLEE 154 Theileria parva
XP_067751161 147 kdGIARSRRMFGALM-GHLGKAKRQIEKdtd---lfK---RQDSKQHEAEQREKMQSQNLenr-----arHEAEVARLET 214
XP_002981279 128 PKLAKRNRRMFGALL-GTLEKFRKEEMSn------sESVMRRSDSLKRAVQKAQEESDKLrqeEREHLTERRKRDLMLRA 200
Q9C5G2       157 PKLVNRNRRMLGNLL-GTLEKFRKEDKQrs----gtDAYARRTAALQRAEEKAREESERLrlqERENLTEKRRRDLTLRA 231 thale cress
XP_003547561 162 PSLVNRNKRMLGQLL-GTLEKFRKEDKQls----gtEAYMRRSSSLQRAEQRAREESERLrkeEREQIAEKRRRDLTLRA 236
XP_015166150 163 PKLVSRNKRMLGQLL-GTLEKFRKEDMQls----gtEAYMRRSDSLKRAEQRAREDSEKLrqqEREQLDEKLKRDLTLRA 237
CBI19999     166 PSLVNRNKRMLGQLI-GTLEKFRKEDMKls----gtEAFMRRSNSLQRAEQRAREESEKLrqqEREQIAENRRRDLTLRA 240
XP_002501619 108 EGEKRRGRRMLAGLL-GTLKRHRDEEKAv------aAVTAQRRSVIEQAETKAREVSEKLrqeSFASNALRRARDHRRTA 180
XP_002898490 150 kdGIARSRRMFGALM-GHLGKAKRQIEKdtd---lfK---RQDTKQHEAEQREKKQSQNLeiq-----arYEAEVARLEA 217 Phytophthora in...
XP_008908666 148 keGIARSRRMFGALM-GHLGKAKRQIEKdtd---lfK---RQDTKQHEAEQREKLQSQNLeiq-----arHEAEVARLEA 215 Phytophthora ni...

Q4N6H7       155 I------TTELNKKQtqlMRMRLCEHYESMGNF--------IATSTQ---PTIFWAPFKFNHHLNTL 204 Theileria parva
XP_067751161 215 LvartelDHSEQIARaklEHLTMVRKSESQSKF--------LVTISS---PPIYYLPTQHTKETEDL 270
XP_002981279 201 KisakaeEKQIEL-----LYMQWTAHQSKVSSF--------LKTKAE---PGIHYLPVKQTERDKHQ 251
Q9C5G2       232 RvaakaeQKKLEL-----LFLQWSEHQKKLSNF--------IRTKAE---PRIYYAPVKPLEEDTSE 282 thale cress
XP_003547561 237 RvaakteEKKLEL-----LFLQWTEHHKRLSNF--------IRTKAE---PPIYYLPNKPLDEDPTL 287
XP_015166150 238 RlaakaeEKRLEL-----LFLRWSEHHKKLANF--------IRTKAE---PPIFYSFAKPLEEDPTL 288
CBI19999     241 RvaakaeEKKLEL-----LFLRWSEHQKRLCNYlrlflildLRTKAE---PPIYYSFSKPLEEDATV 299
XP_002501619 181 EidlrvaEKELEVKR---AARLEKDAKTAGCA----------RTSKEcgrPRVFYRPKAHTKDTEAA 234
XP_002898490 218 SiartelDRSEQITRaklEHLQMLRKSASQSKF--------LVTIAS---PPIYYLPAKHTKETKEL 273 Phytophthora infestans T30-4
XP_008908666 216 LivrtelDRSEQIARaklEHLQMLRKSESQSKF--------LVTIAS---PPIYYLPAKHTKETKEL 271 Phytophthora nicotianae INRA...
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