Conserved Protein Domain Family
Pinin_SDK_memA

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pfam04696: Pinin_SDK_memA 
pinin/SDK/memA/ protein conserved region
Members of this family have very varied localizations within the eukaryotic cell. pinin is known to localize at the desmosomes and is implicated in anchoring intermediate filaments to the desmosomal plaque. SDK2/3 is a dynamically localized nuclear protein thought to be involved in modulation of alternative pre-mRNA splicing. memA is a tumor marker preferentially expressed in human melanoma cell lines. A common feature of the members of this family is that they may all participate in regulating protein-protein interactions.
Statistics
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PSSM-Id: 398393
Aligned: 93 rows
Threshold Bit Score: 62.6782
Threshold Setting Gi: 74883846
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002501619 108 EGEKRRGRRMLAGLL-GTLKRHRDEEKAv------aAVTAQRRSVIEQAETKAREVSEKL----R---QESFASNALRRA 173 Micromonas commoda
A0EHT4        96 iaQKEKDRRIVKSLFgNHLQRAKQDLDGekq---klD---KQIEINKRLEDKDRQDLMAFkedqD---KRKEQLVTERKQ 166 Paramecium tetr...
A0CSJ7        79 ttmKEKDRRLAKSLLgNHLQRAKQDLMGekl---klD---KQIEISKRLDDRDKQDLQTLkedqN---KKKSQLVNERKQ 149 Paramecium tetr...
CBJ26439     435 GDTKKRNRRMFGGLM-AHLGRARQQLDHdks---iiQ---RQKSVVEMAAIRQAQEKRQRrqmaE---------TAAREE 498 Ectocarpus sili...
EEY62967     150 kdGIARSRRMFGALM-GHLGKAKRQIEKdtd---lfK---RQDTKQHEAEQREKKQSQNLeiqaR------------YEA 210 Phytophthora in...
ESS30660     101 EKTATRNRRMFGALA-GHLQRAKRQLLMeqst-dlaH---KQKQQEERVAQKLAMSQKNIakiaRlewEE------RRQQ 169 Toxoplasma gond...
Q4N6H7        78 SETVHRHKRLMKVGLfGYLLKAKDALVKekddqkilKHIEKEKLIDTKLEEKQKEQSTLL----------QKDIQDEYDV 147 Theileria parva
CAQ41920      80 ETTVTRNRRLLQVGLlEHLKKAKDALEQek----snEKVIRQQMQNKRVEQKLQEEKKKFekhqLddiEK------RIIT 149 Plasmodium know...
Q7RS89        68 ETTVTRNKRLLQNFLfDHLKKAKDALEDek----tnKTIIMQQTQNKRVEAKLLEEKKKIekneIfdiEK------KTNV 137 Plasmodium yoel...
RAW40307     149 keGIARSRRMFGALM-GHLGKAKRQIEKdtd---lfK---RQDTKQHEAEQREKMQSQNLenqaR------------HEA 209 Phytophthora ca...
XP_002501619 174 RDHRRTAEidlrvaEKELEVKR---AARLEKDAKTAGCA--RTSKEcgrPRVFYRPKAHTKDTEAAVEVTAK 240 Micromonas commoda
A0EHT4       167 L-------------ERELAADEfrrQQLLLELQLKTMRDffITKTA---PYLLWQPVKTNEGMNPLKEYSNE 222 Paramecium tetraurelia
A0CSJ7       150 L-------------ERDLAADEykrQVLLLELQIKIMRDffITKTY---PHILWQPAKTNEGMNPLKEYSTE 205 Paramecium tetraurelia
CBJ26439     499 RDEELHKRdyirarQQKTLVAL---HGNGFIANQEQLKGfiFTKTL---PKLAWSPNEHTDVTQALLADSSK 564 Ectocarpus siliculosus
EEY62967     211 EVARLEASiartelDRSEQITRaklEHLQMLRKSASQSKflVTIAS---PPIYYLPAKHTKETKELVAASME 279 Phytophthora infestans ...
ESS30660     170 EQLRLEEV------STELSNKEnelMRLHLAKHYKNMEVfiGTEAQ---PTLFWAPAKWDDATRRLQEQTkl 232 Toxoplasma gondii VEG
Q4N6H7       148 NKKRLEEI------TTELNKKQtqlMRMRLCEHYESMGNfiATSTQ---PTIFWAPFKFNHHLNTLrdttrn 210 Theileria parva
CAQ41920     150 HIKEIKNV------DTHIKTDEaklMKLTLINHYEKMKNfiSTNCQ---PTIFWCPFKFNSKTEILQKEtdn 212 Plasmodium knowlesi str...
Q7RS89       138 LINDIKMI------EKNIKKNEgkfMKMSLINHYDKMKNfiSTNTS---PTIFWSPLKFNEKMKTLQKATHE 200 Plasmodium yoelii yoelii
RAW40307     210 EVARLQALiartelDRSEQIARaklEHLQLLRKSESQSKflVTIAS---PPIYYLPSRHTKETKELVAASME 278 Phytophthora cactorum
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