6SPT


Conserved Protein Domain Family
Pex14_N
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pfam04695: Pex14_N 
Pex14 N-terminal domain
Family of peroxisomal membrane anchor proteins which bind the PTS1 (peroxisomal targeting signal) receptor and are required for the import of PTS1-containing proteins into peroxisomes. Loss of functional Pex14p results in defects in both the PTS1 and PTS2-dependent import pathways. Deletion analysis of this conserved region implicates it in selective peroxisome degradation. In the majority of members this region is situated at the N-terminus of the protein.
Links
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Statistics
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PSSM-Id: 487281
Aligned: 29 rows
Threshold Bit Score: 64.5116
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6SPT_A         9 EREKRVSNAVEFLLDSRVRRTPTSSKVHFLKSKGLSAEEICEAFTK 54  Trypanosoma brucei brucei
Q6FV35         6 ERKELFDSAVSFLQDSAIKDAPLDKKVEFLKSKGLGDEEVELALQE 51  [Candida] glabrata
XP_003290632 136 IREDMVKKAYSFLSNPSVKNTPLARKVAYLEKKGLTSDEIKEALKR 181
XP_004365822  53 LREDLLDTATKFLRNPKVQQAPKAKRVAFLEQKGLTAAEIDEAFRR 98 
EPB87385      64 IREDMIKPAVSFLSSPNVRSADREKKIAFLQKKGLTQAEITEAFKR 109
XP_003834497   2 VREDIVTSAVSFLQDPSVASAPLEKRIAFLQSKNLTQEEIDVSLAR 47 
EPE05119       3 IREDLVASAAKFLQDPSVAASSSDSRVAFLKAKNLTPEEVSAALAR 48 
XP_001525316   1 MNDELINSAVAFLQDPNVATSPLAKKIEFLESKGLDQVEIEEAMKR 46 
Q5K827         8 DRVQLIQNAILFLNDPKTQNSSLTSRVQFLESKGLTEKEIEQAIRE 53  Cryptococcus neoformans
XP_001465481  29 DADTTVQSAIRFLQDSRVRRSPVESQIRFLKGKGVPDEQIKYALAK 74
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