6DZ6


Conserved Protein Domain Family
ApoC-I

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pfam04691: ApoC-I 
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Apolipoprotein C-I (ApoC-1)
Apolipoprotein C-I (ApoC-1) is a water-soluble protein component of plasma lipoprotein. It solubalises lipids and regulates lipid metabolism. ApoC-1 transfers among HDL (high density lipoprotein), VLDL (very low-density lipoprotein) and chylomicrons. ApoC-1 activates lecithin:choline acetyltransferase (LCAT), inhibits cholesteryl ester transfer protein, can inhibit hepatic lipase and phospholipase 2 and can stimulate cell growth. ApoC-1 delays the clearance of beta-VLDL by inhibiting its uptake via the LDL receptor-related pathway. ApoC-1 has been implicated in hypertriglyceridemia, and Alzheimer's disease.
Statistics
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PSSM-Id: 398390
Aligned: 10 rows
Threshold Bit Score: 61.7233
Threshold Setting Gi: 0
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6DZ6_A        28 PDVsSAL----DKLKEFGNTLEDKARELISRIKQSELSAKMREWFSETFQKVKEKLKID 82  human
ACF94991      28 PDF-STLelipDKLKEFGNTLEEKARMAIEHIKQSEITTKTRNWFSETISKVKEKFKST 85  rabbit
EHB18937      28 PDFtSTLeglpAKLKEFGSILEDKALAAIEHIKQSELPAKTRNWFSDAFSKVQEKFKAT 86  naked mole-rat
P19939        28 PDFsSAMeslpDKLKEFGNTLEDKARAAIEHIKQKEIMIKTRNWFSETLNKMKEKLKTT 86  Norway rat
P56595        28 GEIsSTFeripDKLKEFGNTLEDKARAAIESIKKSDIPAKTRNWFSEAFKKVKEHLKTA 86  dog
XP_003464714  28 PDLgSALeslpGKLKEFGSTVESKARAAIEHIKQSDFPTKTWKWLSKTVSKVREKFKAT 86  domestic guinea pig
P0CE37        28 PEVsNPF----DGLEELGKTLEDNTREFINRITQSELPAKMWDWFSETFRKVKEKLKID 82  chimpanzee
1_pfamImport   2 QTVeQRFnrfgEQVAEVSKGLAEKAKTTFEEISTSQFAEDTRNWFQTQFESLKAKL--- 57 
NP_001278816  24 PTLeQHFtkfgTQMKEIAEDLADKTKTAFQNIEQSELGTKTRNWFNDQYEKLKQKMTET 82  zebrafish
XP_007491635  53 ssLaQSFeqfqKKVKEFTETVVEKTKAAITQIKHSDLPSKTRTWITENIQKVKDKVEST 111 gray short-tailed opossum
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