6XQN,6K7Y


Conserved Protein Domain Family
MCU

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pfam04678: MCU (This model is not part of the current CDD release)
Mitochondrial calcium uniporter
MCU functions with MICU1, an essential gatekeeper component of calcium-channel transport, to facilitate Ca2+ uptake into the mitochondrion.
Statistics
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PSSM-Id: 516370
Aligned: 77 rows
Threshold Bit Score: 116.203
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6XQN_D         1 GPTAAALERLTTEEVQGLSDVKTlvNQLYEalnvrehqlqkevelttqletlQQELLPLEEKKLELEQVANRR------- 73  red flour beetle
Q9FJV7       119 DEQGSQMAKSLDHSGCVVVLGD----------------------------------IVFLHPHQIAKSMEAMIkq----- 159 thale cress
Q1PE15       157 PSQGALIAKMLDDSGNVIVMGN----------------------------------SVCLRPHQLTKSIEGLLpl----- 197 thale cress
XP_001419914 173 AEETAIKVKLLEECGAVLILED----------------------------------MVYLHPRDVTSAVLRVL------- 211
XP_002503501   9 DEAQDETLATLQKAGVIIKLDD----------------------------------VVYTNPGQLTRDVLAVL------- 47 
Q387B7       112 VEDTDKALQLLCESGVVVSISD-------------------------------G-AAVHLRPVQFLQMHNDAAdasdak- 158 Trypanosoma brucei
Q4CZP7       108 VENSDEALRLLEESGSVVSLSN-------------------------------G-EGVHLRPLQFAHMYEDLTgegeek- 154 Trypanosoma cruzi
XP_001564901  48 DAEAVKYIDTLKRAKMVVVVED----------------------------------YVYTDVKAVIDAVHLKSglp---- 89 
ESK91690     193 AASAAEFLICISREKEKELDSDE--QTPED----------------------GSETVISVRVPTFADR------------ 236
XP_003392651 111 VEDPDAALADLEAAGVVVVLDG-------------------------------G-SMVHLRPVLYLETLEMICnvarpss 158 Leishmania infa...
6XQN_D        74 ------------------SNWMAWAGLGLMSVQFGILARLTWWEYSWDIMEPVTYFVTYGTAMAAYAYFVLTREEYILND 135 red flour beetle
Q9FJV7       160 -----------------tSVL-----------PNDPR-KEELVQLATTKKSIDIEARRIVQAELYCGLGFLAVQTIGFMR 210 thale cress
Q1PE15       198 -----------------sQIH----------NPNDPR-RKELNELEAIKTVIDQKAHSLVRRELWAGLGYLIIQTAGFMR 249 thale cress
XP_001419914 212 --------------------PGVPSKVYGITDADLQAMTNEFETMKENYKVARRRAEARSRTIISSGLIVLCLQLATFVR 271
XP_002503501  48 --------------------PRVPSYVYGVSDAELVSLEADLAAQEAEVTAAAERARWRSNVVVGSGLALMCTQLVVFMR 107
Q387B7       159 ------------vktpfeDYIRAAQNRLADAEAEEMAMRVALQPAID-------NAAKRRRLLWSGALCLMAVQLAVISR 219 Trypanosoma brucei
Q4CZP7       155 -------------gstlaFFLEEATKRLKAAQAEEAAMRSELQPALM-------RAAKWRRVVWGGALCFSGAQMAIISR 214 Trypanosoma cruzi
XP_001564901  90 ---------------lvpSTSKGFMCFHHMMSESLAAFNRECSLAME-------RAVRREKEFWAFTALVSGIQMLVLAY 147
ESK91690     237 ---------------------------TRFLRRRLDVINAELSSMEGLKCQCDKEAHRGARRMAVGGFGMLIVYWGAVAR 289
XP_003392651 159 sgnetsetnskpsvavrsFMVEEAERRVATLTEREKAMRNRLQPAIA-------RAARWRRTVWGAALLYAGAQLAIISR 231 Leishmania infa...
6XQN_D       136 VRDRQQLLLLHKKAKKTGFDVNQYNVLKDQIAKLELDLKRLRDPLKLRLPPKAAAKEEGGWSHPQFEK 203 red flour beetle
Q9FJV7       211 LTFWELSWDVMEPICFFVTTIHFILGYIFFLRTSTEPSFEGLFRQRFKTKQKKLMERHGFDFLRYNEL 278 thale cress
Q1PE15       250 LTFWDLTWDVMEPICFYVSSVYFMAGYTFFLKTSREPSFQGFYQSRFEAKQRKLMQSEDFDVGRYDEL 317 thale cress
XP_001419914 272 LTYYEFSWDVMEPLSYFVGLCNAILVYVYYLWNRRDFSFETWQNSLAGKYADSHLRRSGFDLDRYVAL 339
XP_002503501 108 LTYVELSWDVMEPISYFVGVFNAILVYIYFMVYKRDFSFNDWTSRMQTSYTKSAVSKKGIDWERYKKI 175
Q387B7       220 LTFVDLDWDIMEPVSYFLGSGTSILFLIYLLRNGRVKSYKEYEEKAAASRV-RLHAPADFEWRKYDAV 286 Trypanosoma brucei
Q4CZP7       215 LTFFDFDWDTMEPVSYFLGTGTSLLFFLYFLRHGRSHTYEDYDRTTLPKKL-RKYAPPGFDWEKYEAI 281 Trypanosoma cruzi
XP_001564901 148 LTFQVYGWDVMEPVTFFVTTATALCSYAYFLCFRTEHSYESVDDNFLPHLLMKELSALRVDANKVIHD 215
ESK91690     290 LTFWDYGWDVMEPITYLSGLSTVICGYLWFLYRGREVSYSSVLDSSISARREALYKTKGLDIERWVEL 357
XP_003392651 232 LTYFDLDWDIMEPVSYMITVANTLFFFLYYLRFNEEHSYTAFDQRFLPRKV-RQYAPRDFDWAAYADV 298 Leishmania infantum JPCM5
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