8B8T,7D9Y,3GDE,7RPO,3L2P


Conserved Protein Domain Family
DNA_ligase_A_N
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pfam04675: DNA_ligase_A_N (This model is not part of the current CDD release)
DNA ligase N terminus
This region is found in many but not all ATP-dependent DNA ligase enzymes (EC:6.5.1.1). It is thought to be involved in DNA binding and in catalysis. In human DNA ligase I, and in Saccharomyces cerevisiae, this region was necessary for catalysis, and separated from the amino terminus by targeting elements. In vaccinia virus this region was not essential for catalysis, but deletion decreases the affinity for nicked DNA and decreased the rate of strand joining at a step subsequent to enzyme-adenylate formation.
Links
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Statistics
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PSSM-Id: 516367
Aligned: 382 rows
Threshold Bit Score: 40.2508
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
8B8T_A        27 PYL-AVARTFEKIEEv---Sar--------lRM-----VETLSNLLrs---vVA-----------LSPPDLLPVLYLsln 75   human
XP_065950620   4 TFG-AICGLLQSIEKitsqRpqp------rpRQiaeskRQIIRNWF------ENqrd-----sldDPGTDGGAVLSV--- 62  
XP_007678729   4 PFS-HITDILEKLEDiesrDppy------lpADkavqlRVETTNWF------KAhrra----ineLEV--GGSVAFLs-- 62  
XP_016759776   4 PFK-EVCQLLDRLETvelhEnl-------lpSAkpdryKELVNSWF------SShrrq----ineLDV--LGSCALLs-- 61  
XP_009648539   4 SFA-HVCDLLDQLQQqqqqQqq--------qSGdrnvtRRIISSWF------AKhrh-----aikQTP--ATAAALFs-- 59  
EPE02709       4 PFS-HVCDLLQQTSDlpplR-----------RNqtrvvNQIVYSWF------CKhrqaidqlgedVSS--AKPAVALls- 62  
XP_002547018  28 TFTlLTNELFDKLDAvrrenln--efrtiteKK-----SFIIKKFIdvfrthI-------------GQ-DIYPSVKL--- 83  
P52496        19 SFTlLTKELFDKLDGv--rKeslgdfrtvteKK-----AFIIKTFInt---fRT-----------HIGNDIYPSAKL--- 74   Candida albica...
EMG50892      19 TFTlLTTELFDKLDGvrrenlg--dfrtiteKK-----AFIIRTFMetfrthI-------------GI-DIYPSVKL--- 74  
EGV66395      17 EFSfLVTELFNPLDAvnreslg--sfpnitsKK-----RDIISRFLktykahI-------------GS-DIYPSIRL--- 72  

8B8T_A        76 hLGPPQQ-GLELGVGDGVLLKAVAQATGRQ-LEsvrAea------------------aeKGDVGLVAENSRsTQRLM--L 133  human
XP_065950620  63 -IFPHRRkDRVYGIGPPRLAKKLIRLLRLNhNQkaifdg---------------wnsgtLGDLGVYAEKAL-QSRDGtfQ 125 
XP_007678729  63 aLLPERRtDRVYGLQATRLCRLLSRGLGLSaAR---Akdlqa------------yraprRGDLAVCLQR---AMQAGgpP 124 
XP_016759776  62 tLVPHWRtDRVYSLQAAGLCRILGRALGLStAR---Rtslaa------------ytqpgAGDLATCFER---VHAAGgpP 123 
XP_009648539  60 tLLPDTRtDRVYGIQAPSLQRIVGRALCLGsSR---Fahlrry-----------enpgsGEDLADCVAGIL-TETPNpvS 124 
EPE02709      63 tLLPERRpDRVYGLQARGLQRILVRILGLGhSR---Aaelsrwe--------rpveygeAVDLADCVEAIL-LRTPNp-A 129 
XP_002547018  84 -IFPEKVg-RLYFIKEIALARLLIRMYKIP-KDsddYkllhnwnqqyqrskrfvvdekkIRDLPLQASRIIgKRRPYv-E 159 
P52496        75 -IFPEKS-GRIYFIKEVALARLLIKMYKIP-KEsedYitlhdwnksyqrsrrfsidekkIRDLPLQASRIIsKRRPIv-D 150  Candida albica...
EMG50892      75 -IFPEKVg-RLYFIKETALARLVIKMYKIP-KEtddYnllhnwnksyqpskrfasdekkLRDLPLQASRVIgKRRQFn-G 150 
EGV66395      73 -VLPNKDs-RKYYMRHTELVSFIIKMYNIP-NEsnhTkllrewktqfh-hlqlqnsdpnLSHLPRKICQVIgNRRSLqhK 148 

8B8T_A       134 PPPPLTASGVFSKFRDIAr------------lTGSASTak-kIDIIKGLFVACrhSEARFIARSLSGRLRL-GLAEQSVL 199  human
XP_065950620 126 AKPIIPIEHIDRLLGQLAaksrfsdalvrkkgNGETNTdaelNNILIRLd----sWEVKWLVRLILRDYCTiDIDEEFVF 201 
XP_007678729 125 AKPSVTLEEVDAMLFQVAeqchfsaptvrsklSGSSEVn---ERLVCDIVKRLspQEGKWLVRLLLKDFAPvRVDEHLVL 201 
XP_016759776 124 ATPAVTVEHVDHMLHSLAgrssfsdpsiarlpPSSSETr---DRLLSNVFCRTspQEGKWLVRLILKDFRPvQCDETIIL 200 
XP_009648539 125 KLDQVTVEEIDALLNGLAancrfsshtvrqshRNTGCEn---KETLGELYRQVhaREAKWLTRIILKQIQLtALDPSIVY 201 
EPE02709     130 TAHPVTVEEIDAVLEIVAsrcrfsapsirqndDVSSPT----QAALGGLYQRLdaCGAKWLTRLILKDFRPaVLDGTTVA 205 
XP_002547018 160 KPKEFTVQQINSILDQLTma---------------kMSqd-qMEILKPVLDELgiSEVRWLIHIVLKKTIL-SNMERVFF 222 
P52496       151 KLEEYTVPQINSSLDQLA---------------LEKVSqg-qIDILKPLFDNLsiPEVRWLIHILLNKSIL-TSMERFFF 213  Candida albica...
EMG50892     151 KPSEYTVDEINRILDQLVla---------------kLSqd-qIELLKPVFDSLsiSEVRWLIQIILKKSIL-VNVEKFFF 213 
EGV66395     149 ITKKYSVNQINEVLDQLSna---------------tKTed-rIKILRPVFDNLqiDEIRWLLNIILKISNA-GYMERFVF 211 

8B8T_A       200 AALS 203  human
XP_065950620 202 QQYH 205 
XP_007678729 202 KSFH 205 
XP_016759776 201 KSFH 204 
XP_009648539 202 GSYD 205 
EPE02709     206 RAFH 209 
XP_002547018 223 NDWH 226 
P52496       214 NTWH 217  Candida albicans SC5314
EMG50892     214 NFWH 217 
EGV66395     212 ELWN 215
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