Conserved Protein Domain Family
Methyltransf_19

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pfam04672: Methyltransf_19 
S-adenosyl methyltransferase
This family contains a SAM (S-adenosyl methyltransferase) domain, with a central beta sheet with 3 alpha-helices on both sides. Crystal packing analysis of the structure PDB:3giw suggests that a monomer is the solution state oligomeric form. An unidentified ligand (UNL, cyan) was found at the putative active site surrounded by the residues His57, His170, Phe171, Tyr216 and Met22. The UNL is likely to be a phenylalanine or phenylalanine-like molecule.
Statistics
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PSSM-Id: 252734
Aligned: 12 rows
Threshold Bit Score: 356.645
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9WX26  10 PAELRRRIDSSKAHPARVYDVFLGGKDHYPADLAAAAAGLAANPRGYLDVRHNRDFLRRAVTALAREDGIRQFLDIGTGL 89  Streptomyces coelicolor
O86540  37 SAAHPDRIDTSRPHPARMYDYFLGGKDNYEVDQRAAEQFMKSAPEVREGVLANRHFMHRAVRHVVAEGGVRQILDVGTGL 116 Streptomyces coelicolor
Q9RCY1   4 PAWAPRSIDISVPSVSRIYDFYLGGSHNFEVDREAARRAMEFMPGLPKIMQANRAFMRRAVRFAAGE-GIDQFLDIGSGI 82  Streptomyces coelicolor
Q9L2K3   4 DKQLSTEIDANVPTAARMYDFYLGGKDNYAADRAAVGELDKVVPSTRRLALNNRRFLQRVVRVLAEDYGIRQFLDHGSGL 83  Streptomyces coelicolor
Q9RJT1   1 MTGESSSIDSTRPTIARVYDYLLGGKDNYAADREIGDVFKRDLPGSVAIAFANRAALTRAVGEIVTRTGVRQFIDLGSGL 80  Streptomyces coelicolor
O86718   4 PEPASAPLDTSRPHPARVYDWWLGGKDNYPVDEELARRILAADSTAVRGARANRRFMHRAVRTLAEA-GIRQFLDIGTGI 82  Streptomyces coelicolor
Q9L173   4 DHTQPPQIDTGRAHPARVYDWLLGGKDNYPVDEAVGETLP---PEARDAARQNRAFMNRAVAHLAAR-GIDQFLDIGTGI 79  Streptomyces coelicolor
O86541   3 AGTPRPDIDTSKPHPARVYDWLLGGKDNYPVDQRVGETLP---AEARGNAARNRAFMHRAAAWLAKN-GVDQFLDIGTGI 78  Streptomyces coelicolor
Q9RK84   9 GHTAQQKIDTSVPHSARIWNYWLGGKDNYPVDEQAGDAYTAVFPGIVTVARSSRAFLRRNITHLVAEAGIRQFLDIGTGL 88  Streptomyces coelicolor
Q9AK13   5 REEAGARLQTDRPHSARVWNYLLGGKDNYPVDSEAGDVILTTFPEFAAVARLQRRFLARAVRFLAGEVGIRQFLDIGTGL 84  Streptomyces coelicolor
Q9F395   4 SGWPADRIDTEHAHSARIYDYILGGKDYYPADREAGDAMAREWPALPVHMRANRDWMNRAVRWLAEEAGIRQFLDIGTGI 83  Streptomyces coelicolor
Q9F3E0   3 STQGARSLDTSRPHSARMYDFYLGGKDHFPVDKQAAEAVAEAYPGIFTCARENRAFMHRATRVLAQEHGIRQWLDIGTGI 82  Streptomyces coelicolor
Q9WX26  90 PTAENVHQIAQRIAPESRVVYVDDDPVVLAHARALlTSGPEgrTDYIDADLKSPAQILE--QAAATLDFDQPVALCLVAI 167 Streptomyces coelicolor
O86540 117 PTEPNVHQIARSVAPGTRVAYVDNDPIVATHSRAL-ADDPD--TAVVLADLRDPRSILEhpEVRAVIDFDRPVALLLVAV 193 Streptomyces coelicolor
Q9RCY1  83 PTFGNVHEVAGRSRPGARVVYVDHDPVAVAHSEAVlAGHDD--ADVVAGDLLKPREILAspQVERLLDLNRPVALLLVAI 160 Streptomyces coelicolor
Q9L2K3  84 PTQDNVHQVAQRVAPDSRVVYVDNDPMVLVHGRALlDQNDQ--TAVIHADMRATEEIFShpDTQRLIDFSQPVAVLFNSV 161 Streptomyces coelicolor
Q9RJT1  81 PTADNVHQVAQRRAPETRVVYVDTDPQVLVHGRALlEENDR--TRFVPVDVRDPEGIRShpDTRQLIDFDRPVAVMFSAI 158 Streptomyces coelicolor
O86718  83 PTEPNLHQVAQAVAPESRVVYADNDPIVLRHAEALlHGSAEgaTEYVHADVRDPDRILR--LAGESLDFDRPVALSLVAL 160 Streptomyces coelicolor
Q9L173  80 PTEPNLHQIVQRTVPAARVVYADNDPIVLRHAEALlVSSPEgaTDYIQADVREPGEIVR--HARGILDFDRPIALSLIAL 157 Streptomyces coelicolor
O86541  79 PTEPNLHQIVQAISPAARIVYADNDPIVLRHAEALlTGTPEgvTDFLHADVRQPATILE--RAREVLDFDRPIALSLIAL 156 Streptomyces coelicolor
Q9RK84  89 PTADNTHEVAQRIAPESRIVYVDNDPMVLAHARALlYSTPEgaTSYIDSDVLDPDTVLE--AAARTLDFDRPIALILSNI 166 Streptomyces coelicolor
Q9AK13  85 PTADNTHELAQRIAPESRIVYVDNDPLVLTHARALlTSTPEgaCAYVDADVRHPERILA--EAARTLDLSRPVALTALGI 162 Streptomyces coelicolor
Q9F395  84 PTSPNLHEIAQSVAPESRVVYVDNDPIVLTLSQGLlSSTPEgrTTYIEADFQRPEAVLEsdEFRKTLDLGEPVALTVIAI 163 Streptomyces coelicolor
Q9F3E0  83 PTEPNVHQVAQSVVPDARVVYADNDPLVLKYAERLmRSTPQgrTTYIEADVNDPDALLNapELAEVLDLSRPVALSLNAL 162 Streptomyces coelicolor
Q9WX26 168 LHFV---ED-EEAYPIVRELMDALPAGSRLVLSHLTEDLNPENI---RAVQRTYTER--GFTFVLRSRKDVERFFTeaGL 238 Streptomyces coelicolor
O86540 194 VHFV---ADaQDPAGIVATLRDALPAGSYLVLSHATGDVHEDRR---EDAAAVYNKA--TASLNLRSHAAVLDLFG--DF 263 Streptomyces coelicolor
Q9RCY1 161 LHFV---EDeDDPYAAVAELSDALAPGSLLVLTHASYEGIPLPAeraGGAVDVYKDI--RNPLIMRSREDIARFFK--GY 233 Streptomyces coelicolor
Q9L2K3 162 FHCIp-dSDtDGPRAVVRRVTERLAPGSFAVMCQLVSEDAEVR----KFVTDFMDQAtqGHWGRVREPKDVEALFD--GM 234 Streptomyces coelicolor
Q9RJT1 159 LHHV---NDdEDPAAIVRYWRGQVPSGSLFFVSHFRSGNNPETV---E-AEKVLQET--FGRGRWRTDAEIEALLD--GL 227 Streptomyces coelicolor
O86718 161 THYLgdaADgDDVHGLLKRYKDVLAPGSHLVLSQVTPDLNPAAV---GKAAELFARG--GTPFHPRSLTEFARFFD--GL 233 Streptomyces coelicolor
Q9L173 158 MHFV---PDdQDAHGIVRGLVETLPAGSHLVLSHAALDLFPELA---EQVIAQYAKG--GIRLGFRTRAEVARFFD--GL 227 Streptomyces coelicolor
O86541 157 LHFL---PDdEDPYRVVSTLVDTLPRGSYLLLSHGTADQHPELK---QETESAYKKG--AIPLRMRTRSEVEPFFC--GL 226 Streptomyces coelicolor
Q9RK84 167 LGHI---PDyDQARSVAARLVDALPSGSYLSINDGSRGIDPEFD---RAQDGYNESG--AAPYILRTVDQITAFFD--GL 236 Streptomyces coelicolor
Q9AK13 163 MGQI---SDaERPAELLDTLMAALPRGSCLALSDGTDN-NEALN---RAVQVYNGQS--ANTYHLRSPQEIAAFLT--GL 231 Streptomyces coelicolor
Q9F395 164 VHFV---LDeDDAVGIVRRLLEPLPAGSYLAMTIGTAEFAPEEV---GRVAREYAAR--DMPMRLRTIDEAHEFFE--GL 233 Streptomyces coelicolor
Q9F3E0 163 MHFI---TDaRDPYGIVDRLMAALPAGSALALSHCTPDFDPPTW---EKVTDIYTGG--GTPVQFRSQQDVARFFD--GL 232 Streptomyces coelicolor
Q9WX26 239 ELAEPGVVPVHHWRPDHAAPvpeqpeesylaglddiekvryrdindVTDADINVYGGLGAKG 300 Streptomyces coelicolor
O86540 264 SLVEPGLVRVTDWRPEEARR--------------------------PDAPPIGIYGGVARKD 299 Streptomyces coelicolor
Q9RCY1 234 DMVEPGLVPMPRWRPEGEPEe-------------------------EDPYAFSGFAGVGRTA 270 Streptomyces coelicolor
Q9L2K3 235 DILEPGLVEVSTWRPDTEVAp------------------------rQLTDEWIEFGGLGRLR 272 Streptomyces coelicolor
Q9RJT1 228 EILEPGIVPASLWRPGTTAGtyddg-----------------gereLTVWERLIAAGMARKP 272 Streptomyces coelicolor
O86718 234 ELLGPGIIPVTGWRPDPEDVa------------------------aQTEGIVPVYAGVARKP 271 Streptomyces coelicolor
Q9L173 228 ELVPPGLVTATEWYGEGLEP--------------------------PAPEASGIYAGVARIP 263 Streptomyces coelicolor
O86541 227 ELVKPGLVFATEWYQEEPA---------------------------PVRERSGFYAGVARIP 261 Streptomyces coelicolor
Q9RK84 237 ELVEPGVVPVTRWRPDAD-T--------------------------EDPGLIGEHGGLARKP 271 Streptomyces coelicolor
Q9AK13 232 DLVDPGVVATASWRPDAGRP--------------------------EEPTADVSVCGVAVKN 267 Streptomyces coelicolor
Q9F395 234 ELVAPGIVQVHKWHPDGT-Geq-----------------------gIRDEDIAMYGAVARKP 271 Streptomyces coelicolor
Q9F3E0 233 DLLTPGVTVGHRWRPDLPAGpd-----------------------aPTDAQVSLWAGVGIKA 271 Streptomyces coelicolor
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