8BWA


Conserved Protein Domain Family
Tsg

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pfam04668: Tsg (This model is not part of the current CDD release)
Twisted gastrulation (Tsg) protein conserved region
Tsg was identified in Drosophila as being required to specify the dorsal-most structures in the embryo, for example amnioserosa. Biochemical experiments have revealed three key properties of Tsg: it can synergistically inhibit Dpp/BMP action in both Drosophila and vertebrates by forming a tripartite complete between itself, SOG/chordin and a BMP ligand; Tsg seems to enhance the Tld/BMP-1-mediated cleavage rate of SOG/chordin and may change the preference of site utilisation; Tsg can promote the dissociation of chordin cysteine-rich-containing fragments from the ligand to inhibit BMP signalling.
Statistics
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PSSM-Id: 516364
Aligned: 28 rows
Threshold Bit Score: 133.995
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8BWA_A        64 PPTSKSTVEEL---HEPIPSLFRALTEG-DTQL--NWNivs---fpvAEELSHHENLVS--------FLETVnqP-HhQN 125 human
XP_002010294  80 AMTLRSEIGDV----DGVPELFDTLTAEdDDQ----WStiripmrvgFk-----------------qRMEDEsnL-I-SL 132
XP_001991879  81 SLTPRSEIGDV----EGVPELFDTLTAEdDDDN---WStiripmrpgFk-----------------qRLEGEsnQ-L-LL 134
ELV12750      11 PPTSKSTVEEL---HEPIPSLFRALTEGdTQL---NWNivs---fpvAEELSHHENLVS--------FLETVnqPhH-QN 72 
Q98SR9        85 PATGRSTVEDL---FQPIPSLFRALTEGdAPT---HTLvlt---lplAEELQYQHNLHN--------YLETLhnTqH-NN 146 zebrafish
XP_006012404  83 HPTSRSSVEDL---LVPIPSLFRALTTIsDNDPpmGWSvvs---ipvTEELRHQHHRH---------HIMLGshKvA-EL 146
XP_008121138  83 RPAQRSSMHNL---MSPVPSLFRALTAIsDNESpmGWSilt---lpvEEELRQNHVETD--------HLLLGphT-G-LV 146
NP_001015756 101 HSARRSSLEEL---PVSVPSLFRAVSSMqEGESalGWTahn---lpiLEELAQSTHMD---------HILLGahSvV-TA 164
XP_794111     85 DIASYSTINDLrmeSDWTDTLFNALTQVdKPHPdsHWT---------VERVTPQEEGVNlpglvpatPSEGStsDvS-PS 154
XP_003975395  88 PATSRSTVEEL---HRPIPSLFRALTEGeSPI---NMMvvs---fpiAEELSHHENLVS--------FLESLdnP-H-QN 148 torafugu
8BWA_A       126 -VSVPsNNVHA-----PyssdkehmCTVVYFDDCMSIHQCKISCESMGASKYRWFHNACCECIGPECIDYGSKTVKCMNC 199 human
XP_002010294 133 -PRHSrPADTV-----N--------CTVIYVNSCIRSNKCKQQCESMGANSYRWFHDGCCECVGAHCLNYGINESRCSSC 198
XP_001991879 135 -ARHT-ASESV-----N--------CTVIYVNSCIRSNKCRQQCESMGANSYRWFHDGCCECVGAHCLNYGINESRCSAC 199
ELV12750      73 -VSVPsNNVHapyas-----dkehmCTVVYFDDCMSIHQCKISCESMGASKYRWFHNACCECIGPECIDYGSKTVKCMNC 146
Q98SR9       147 tTSVPeNSIHssyht------qdkqCTVVYFDECVSIRQCKQYCESMGGSKYRWFHNACCQCIGPECVDYGSKSVRCLNC 220 zebrafish
XP_006012404 147 -LPGSsENSTa-------------vCTVLYFHSCMSMNRCKQSCESLGASRYRWFHNACCECVGPDCHAYGSKEAACQNC 212
XP_008121138 147 -LPDAeGLNAT-----Ap------pCQSIFFNECLSMSRCRTACQSVGAWRYRWFHNACCQCVGPDCRGYGGAQAICSNC 214
NP_001015756 165 -SPLTnISGS---------------CTVLYFNPCMSMRRCHQSCESVGSPRYRWFHNGCCQCVGPDCHGYGSKEPLCLQC 228
XP_794111    155 -SKTAtTAISV-----NqtivpidiCTVAYIKICLGLEKCVDACHHMGAAKYRWFHTGCCECIGSSCLSYGKKKALCSEC 228
XP_003975395 149 -VSVPgNSIHTsydaqEn------mCTVVYFDECVSIRQCKMYCESMGGSKYRWFHNACCQCIGPECVDYGSKAVKCMNC 221 torafugu
8BWA_A       200 M 200 human
XP_002010294 199 P 199
XP_001991879 200 P 200
ELV12750     147 M 147
Q98SR9       221 L 221 zebrafish
XP_006012404 213 N 213
XP_008121138 215 R 215
NP_001015756 229 Q 229
XP_794111    229 P 229
XP_003975395 222 L 222 torafugu
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