Conserved Protein Domain Family
Endosulfine

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pfam04667: Endosulfine 
cAMP-regulated phosphoprotein/endosulfine conserved region
Conserved region found in both cAMP-regulated phosphoprotein 19 (ARPP-19) and Alpha/Beta endosulfine. No function has yet been assigned to ARPP-19. Endosulfine is the endogenous ligand for the ATP-dependent potassium (K ATP) channels which occupy a key position in the control of insulin release from the pancreatic beta cell by coupling cell polarity to metabolism. In both cases the region occupies the majority of the protein.
Statistics
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PSSM-Id: 398375
Aligned: 29 rows
Threshold Bit Score: 88.521
Threshold Setting Gi: 125525189
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CCE40207            21 DLSKLSPQELKIYRMYGKL-PTTQ-------QILSSKFH--DKKYFDSGDYAMQKQkgGALKNIsglgsGIGEGIPSR-- 88  Candida p...
Q9XU56              16 ATGALSPEKQQEQELMGKLaATGKlparpasSFLQKKLQ--QRKFFDSGDYAMDKS-------------KAGTGLGSKph 80  Caenorhab...
AQL07217             8 kSSASMEEEACGEKKYGGIaPKKK-------PLISKDH---ERAYFDSADWVLGKq--AA--NS-----STRATVESL-- 66  Zea mays
CBI22911            11 fPSSQDHEATSEVKKYGGLaPKKK-------PLISKDN---ERAFFDSADWALCKq--GAGMNQ-----KSTVAVETL-- 71  wine grape
NP_567486           11 FLFSQQQESTSGANKYGGLvPKKK-------PLISKDS---KRAFFDSADWALLKq--EASIDQ-----RTIAAIEKL-- 71  thale cress
XP_006855295        16 DIGSSQEEVSTLTKKYGGIvPKKK-------PLISKDH---ERAFFDSADWALDKq--GATQGQ-----QSRSDVVSL-- 76  Amborella...
XP_009405661        22 AMPSAEQEEQAIKKKYGGIlPKKP-------PLISKDH---ERAYFDSADWALGKq--GGH-AQ-----KPKGPLEAL-- 81  wild Mala...
WGS:AAAA:OsI_01178  28 SMPSAQEQELAIKKKFGGLmPKKP-------PLISKDH---ERAYFDSADWALGKSgqQG--AA-----KPKGPLEAL-- 88  long-grai...
CDR46176             9 DISSFSEQEKELFQKYGKV-PAHK-------NLLANKLK--ERKYFDSGDYAMSKA--GV---------SPPQSVGTA-- 65  Rhodotoru...
XP_006678062         4 DPSKLSDEDRAFFEKYGRLpPAKK-------AGLQQKLMggDRKYFDSGDYAMSQA--GK---------SSPNEVGSQ-- 63  Batrachoc...
CCE40207            89 ----HPSAERMKEMSVRNSISA 106 Candida parapsilosis
Q9XU56              81 plagGPPPAAPPVVAQRSPAPA 102 Caenorhabditis elegans
AQL07217            67 ----KPKLKRTPHHQLPPRKPT 84  Zea mays
CBI22911            72 ----RPKLQRTPHQRLPPRRPA 89  wine grape
NP_567486           72 ----RPKLQRTPRKQLSPRRPT 89  thale cress
XP_006855295        77 ----RPKLQRTPHQRLPLRRPA 94  Amborella trichopoda
XP_009405661        82 ----RPKLQPTPQQQVRSRRSV 99  wild Malaysian banana
WGS:AAAA:OsI_01178  89 ----RPKLQPTRQQQQRSRRLI 106 long-grained rice
CDR46176            66 ----IPSPADIPHA-SPPSNQS 82  Rhodotorula toruloides
XP_006678062        64 ----HPSPERIPHSIPQSFKKN 81  Batrachochytrium dendrobatidis JAM81
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