Conserved Protein Domain Family
APH_6_hur

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pfam04655: APH_6_hur 
Aminoglycoside/hydroxyurea antibiotic resistance kinase
The aminoglycoside phosphotransferases achieve inactivation of their antibiotic substrates by phosphorylation utilising ATP. Likewise hydroxyurea is inactivated by phosphorylation of the hydroxy group in the hydroxylamine moiety.
Statistics
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PSSM-Id: 398368
Aligned: 4 rows
Threshold Bit Score: 255.61
Threshold Setting Gi: 81545895
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_000480968  10 HWHVSQPVLIADTFSSLVWKVS---LPDGTPAIVKGLKpiedIADELRGADY-LVWRNGRGAVRLLGRE--NNLMLLEYA 83  eubacteria
Q9RX60        17 RWHLTPDGEPLRTHGSDLLPVLwhgQGEGQAAMLKLAR----SEEERRGAGL-MQFWQGDGAARVLAVSedGAALLLERV 91  Deinococcus rad...
Q9I2N7        13 RWALQPDGEPFATHSSRLLPV----RHRGAAAMLKISS----AEEERFGHVL-LNWWDGQGAARVLAYD--HQALLMERA 81  Pseudomonas aer...
Q9KYR5        38 RGLTVERVQVPGGRSSLVVLVR---TAEGAPAVLKLAPrrarPESER----AaLVHWGGRGAVQVREEGdeEGVLLLERL 110 Streptomyces co...
WP_000480968  84 -GERMLSHIVAEHGDYQATEIAAELMAKLYAASEEPLPSaLLPIRDRFAALFQRA-RDdqn-----agCQTDyVHAAIIA 156 eubacteria
Q9RX60        92 sGCRSLTALVHAGHDDEATRLLCAAAARLHRPRPGPLPP-LLPLADWFRGLFAGE-KQ----------DTRL-HFPAAVA 158 Deinococcus rad...
Q9I2N7        82 tGGRSLLEMVRRGDDDEATRILCQAIERIHAPRPGPLPE-LTPLERWFDSLYAAE-RR----------YGGLyVDCANAA 149 Pseudomonas aer...
Q9KYR5       111 hPDVSVRSLP-E---AKALLEAAGTLRRLWVEPPGSH-----PFETVAERTGRQAeAMragaaadaqvA-PLvDAALAAR 180 Streptomyces co...
WP_000480968 157 DQMMSNASELRGLHGDLHHENIMFSS------RGWLVIDPVGLVGEVGFGAANMFYDPADRDd-lCLDPRRIAQMADAFS 229 eubacteria
Q9RX60       159 RQLLASPQEVGPLHGDLHHANVLDGGdpgqggRGWLAIDPKGLHGERGYDHANLLCNPDPAT---ALRPGRLERQLAVAA 235 Deinococcus rad...
Q9I2N7       150 RYLLETAREQRPLHGDIHHGNVLDFGe-----RGWQVIDPKRLYGERGYDYANLFTNPDAKT---AQAPGRFERQLEIVI 221 Pseudomonas aer...
Q9KYR5       181 AELLGGPSEQRLLHGTFRQSKVLAGDr-----MPWLAVGPDPVVGESAFDLARLVRDRVEDLiaqPSGASTTRRRIKRLA 255 Streptomyces co...
WP_000480968 230 RALDVDPRRLLDQAYAYGCLSAAWNAD 256 eubacteria
Q9RX60       236 HAARLDPARLARWVMAYTGLSAAWWLE 262 Deinococcus radiodurans
Q9I2N7       222 AASGLQRRRLLQWILAWTGLSAAWFDE 248 Pseudomonas aeruginosa
Q9KYR5       256 ESLEVDQERLRGWTLFRAVESGVRARR 282 Streptomyces coelicolor
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