Conserved Protein Domain Family
AgrB
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pfam04647: AgrB 
Accessory gene regulator B
The arg locus consists of two transcripts: RNAII and RNAIII. RNAII encodes four genes (agrA, B, C, and D) whose gene products assemble a quorum sensing system. AgrB and AgrD are essential for the production of the autoinducing peptide which functions as a signal for quorum sensing. AgrB is a transmembrane protein.
Links
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Statistics
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PSSM-Id: 487255
Aligned: 143 rows
Threshold Bit Score: 62.6894
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_015390267    4 AEKIAIRIGNNaklflKV-DEDQ--EQVIVYGAINLFQVIFAFLWVIIAGVFFGVLYEALVFTATVGILRKYSGGAHASS 80  Clostridium sa...
12_pfamImport   1 AMGLVDQMAEE-----KMiDKEA--EEYYVYTLVSLMEKFITIGTILLISVLIEKLVPTAFFLLFFLSLRKRTGGYHMNT 73 
CCY60281        6 AEHLVDQFEKE-----KLmDHTM--REHYIYAVVSIIERFLTVGSIICLGFIHKNVDLTVLFMIFFFSLRKRTGGYHAKH 78 
WP_013656908    6 CNRISNKLVLY-----NIiEKEE--QCIYDYGIYLTLMTIITTSTIIVLGFLWGEIGLTIVFLLVLASMRHYTGGYHANH 78  Cellulosilytic...
Q38VH8          1 --mITNLLVRK-----QViSADE--QVFYNYGIELTINEFLITASILIFGLITHQFWFTVAYVILFRIIHTQTGGYHCRT 71  Lactobacillus ...
WP_022410070    8 ASNISLFLYKN-----NIvDRHD--LEIYQYGFEMIISTILGFIITLIIGIILNMSLLSIAYYIIFVFLRQLTGGYHANT 80  Ruminococcus s...
CDF01459        8 AQYITGILLKN-----NIiENEH--LDIYIYGFEVLISGALSLFIGLILGLMFSQLMECIVFLIVFVTLRKYCGGYHADI 80 
CDF00821        6 ttrILDFLKSS-----EAiECDEnnLDIYKYGIEITLSTILNILIILILSLIYGSFFTGIIFLLVFIPLRKFTGGYHADT 80 
10_pfamImport   1 VSQIVNFITEQ-----DViSDESdvQDFYRYGIEISISSLLNIVLVVIAGILIHHIIESIVFLSLFILIRSFTGGYHADT 75 
11_pfamImport   1 ----LNFLTEQ-----EAiGKADevQDFYRYGIEITISSMLNIVLVLLMGALTGHLLESVIYLAVFIAVRVITGGYHADT 71 

WP_015390267   81 SSRCI-IIGTILAVLAGIIINNVLYIAnny----lvlLISVAFMIFSFMIVAKNAPV--DSIKKPINNIEMRKQFRK-KS 152 Clostridium sa...
12_pfamImport  74 FFQCY-LGTVVTYMLVLGLCMVLVDYP----------QLVFGLLLVAICIVEVIGTV--NHPNIHMDAVELSESKRA-AR 139
CCY60281       79 YWQCY-IMTIIVYMTVMYLCHHVQEVA----------CLIWILLGISVVVISVIGTV--NHPNLDLDAEEMQISQKS-AR 144
WP_013656908   79 YWQCY-LLSCMSYCTVMYLVVNNMLLNsvvlvvlgggAMIYNLV---------VGSL--NSDKNPKTSKEMLQRTKKaRF 146 Cellulosilytic...
Q38VH8         72 YFNCY-LTSVSLAIAAIYLAQWLLFNPtiaiifsllsALAFWF----------GTPLieDKRVK------NEKFKRNrIT 134 Lactobacillus ...
WP_022410070   81 YLKCNtLFAIITFTT-------LGTTKllckvgkynmILLLIIVLFSLFVVLRYAPV--ENPNKSLGQKQIKQNRKV--S 149 Ruminococcus s...
CDF01459       81 YLKCNtVFAINIAIVMAILKLDFEYSCav----------hMMLCVLCVLTYFVLLPI--ENIYKPITDEEKKKYRLI--A 146
CDF00821       81 YMKCN-IVFAILYTSVFWLTKILYKyt--------dvHIIEAILAISFIVVYIFSPI--ENPHKALDTDEKRKYRML--S 147
10_pfamImport  76 YFRCN-LLMCTTFILTALANSIFSNkf--------slLIIIVLICVTELIVSILGPI--ENKNKPIDDSKRIKLKII--G 142
11_pfamImport  72 YFRCN-LLMCSTFIATAFLNDKVCGyi--------niWVIVAFVVFEEIIAFVFCPV--ENKNKPIEKDKKPKFKAM--G 138

WP_015390267  153 ITVLSIYSIIIMILfilnkkyleLHYIKLMEIISLGVL----WQTITL 196 Clostridium saccharoperbutylacetonicum
12_pfamImport 140 ILCAVEVCVIYTFTl-------lGADMMYVCHMAVAVIlcavLLLI-- 178
CCY60281      145 YVLLIECGILCIAWy-------lRIDDSYVYCMMLAVIlcgfLMILak 185
WP_013656908  147 IFVLYDIVSIVGVLf-------hLGEVGIWLIIIWSQIivmfSLLIFq 187 Cellulosilyticum lentocellum
Q38VH8        135 IIVFGLFSVLCLFFh-------fL-------VVPIGAAtlatLVLVTI 168 Lactobacillus sakei subsp. sakei 23K
WP_022410070  150 LFSFVFFNLLSFILy--------FSMIKASLLISLTLLnitlLIVISK 189 Ruminococcus sp. CAG:330
CDF01459      147 VTLAFITVILSSVIy--------MYFIKSTIVMDMAMLsvavSMIIEK 186
CDF00821      148 IITYILFTAIAIAIs--------HVFYYISVCMMITMLsiivLMIipv 187
10_pfamImport 143 IVITLIINCTGLFL----------SRSYLGTMIILTTFlialLMIAAK 180
11_pfamImport 139 MIVFLLLDLFGGAIi--------NRYQMVGSMILLTNLliavLIISAK 178
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