Conserved Protein Domain Family
Motilin_ghrelin

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pfam04644: Motilin_ghrelin 
Motilin/ghrelin
Motilin is a gastrointestinal regulatory polypeptide produced by motilin cells in the duodenal epithelium. It is released into the general circulation at about 100-min intervals during the inter-digestive state and is the most important factor in controlling the inter-digestive migrating contractions. Motilin also stimulates endogenous release of the endocrine pancreas. This family also includes ghrelin, a growth hormone secretagogue synthesized by endocrine cells in the stomach. Ghrelin stimulates growth hormone secretagogue receptors in the pituitary. These receptors are distinct from the growth hormone-releasing hormone receptors, and thus provide a means of controlling pituitary growth hormone release by the gastrointestinal system.
Statistics
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PSSM-Id: 398361
Aligned: 15 rows
Threshold Bit Score: 45.739
Threshold Setting Gi: 17865464
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q7T1B9        24 GSSFLSPAYKNIQqQKDTRKPTARLHPR 51  turkey
Q99MP5        27 VPIFTYSELRRTQeREQNKRLRKSLRVQ 54  domestic guinea pig
XP_001510662  24 IPIFTHSDVQRMQeRERNKGQKKSLTVQ 51  platypus
P01307        27 VPIFTYGELQRMQeKERNKGQKKSLSVQ 54  pig
XP_003421106  27 VPIFTYSEIRRMQeRERNNGQKKLLSVQ 54  African savanna elephant
KFV84533      24 GSSFLSPEYKKIQkQKDPKKPTTKLHRR 51  Struthio camelus australis
XP_006024197  53 GSSFLSPEYPRTQqQKDAKKPNTKLHRR 80  Chinese alligator
KFM01350      24 GSSFLSPEYKKAQqQNGPKKPTAQLHRR 51  emperor penguin
AFO54703      24 GSSFLSPEYKKLQqQNDPKKPSAQLHRR 51  rock pigeon
OPJ72116      24 GSSFLSPEYKKLQqQNDPKKSSAQLHRR 51  Patagioenas fasciata monilis
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