Conserved Protein Domain Family
Rtf2

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pfam04641: Rtf2 
Rtf2 RING-finger
It is vital for effective cell-replication that replication is not stalled at any point by, for instance, damaged bases. Replication termination factor 2 (Rtf2) stabilizes the replication fork stalled at the site-specific replication barrier RTS1 by preventing replication restart until completion of DNA synthesis by a converging replication fork initiated at a flanking origin. The RTS1 element terminates replication forks that are moving in the cen2-distal direction while allowing forks moving in the cen2-proximal direction to pass through the region. Rtf2 contains a C2HC2 motif related to the C3HC4 RING-finger motif, and would appear to fold up, creating a RING finger-like structure but forming only one functional Zn2+ ion-binding site. This domain is also found at the N-terminus of peptidyl-prolyl cis-trans isomerase 4, a divergent cyclophilin family.
Statistics
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PSSM-Id: 398360
Aligned: 18 rows
Threshold Bit Score: 198.353
Threshold Setting Gi: 144579265
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q5K8P8         1 MGADGGSIPDRRDLVKT--KGKTEQA----D-KESLK-ALFFLCALSKKPLKKPVVIDPLGKLYNKDDLIEYFLDKsk-y 71  Cryptococcus ne...
A0DTQ1         1 MGNDGGSFAERAELVKL--KKPEKRV----E-SLLVAkQRAQFCSLTKEKLRKPIACCRIGYLYNYDSLLKAFMEK---- 69  Paramecium tetr...
Q23KD1         1 MGNDGGSFQTRTDLVKE--KPKEVKI----D-NTILAkFRARLCTLSKQRLKKPIVMCRLGNFYNFEEILKNLMEK---- 69  Tetrahymena the...
Q2UTA9         1 MGNDGGSIPTRRELVRE--AARAPSTaqvkEaQRELQeHYWKTCPLSHKPLMRPIVADCVGNMYNKDAILKFLLPGeeie 78  Aspergillus oryzae
Q10154         1 MGNDGGSLPTRNELVKEpgKVPPLDI----DfKRSVKsSQFSQCAITDEPLYPPIVSCGLGKLYNKASILQMLLDRs--- 73  Schizosaccharom...
XP_011392039   1 MGNDGGAIAKRDELVRT--KATFEKV----D-PELLRqSLWTVCSLSRQPLEPPVASDALGHLYNKDAVVTHLLERhqng 73  Ustilago maydis...
NP_956036      1 MGCDGGTIPKRHELVKG--PKKVEKV----D-KNAELaAKWKYCALSQEKLKRPIVACELGRLYNKDAIIEYLLDKsa-e 72  zebrafish
Q5ZJN1         1 MGCDGGTIPKRHELVKG--PRKAVKV----D-KTAELvARWYYCTLSQEKLCRPIVACELGRLYNKDAVIEFLLDKsa-d 72  chicken
Q99K95         1 MGCDGGTIPKRHELVKG--PKKVEKV----D-KDAELvAQWNYCTLSQEILRRPIVACELGRLYNKDAVIEFLLDKsa-e 72  house mouse
XP_002646542   1 MGADGGTIPKRCELVQQ--KKKKEKL----D-KHVKNaTKWRNCQLTQLPLKKPVIACRFGKLYNKEDVINAILSKt--- 70  Caenorhabditis ...
Q5K8P8        72 gDGEQICG------HLKGVKDLTTLNLTPNPdftfs----sasatVTTSRAPFICPLSLREMAGTFPFIALKSCGCVFSD 141 Cryptococcus ne...
A0DTQ1        70 -KIPQEFK------HLQNLKKIKKLNITENP--------------DQNNEFPFVCLFSQKSLNGKEKFQALWTCGCVFYK 128 Paramecium tetr...
Q23KD1        70 -SMPSSFA------HIKKAKDVKEVKLEPNP--------------DQKSEYPYICPLSQIEFNGLNKFVGLWDCGCVFSE 128 Tetrahymena the...
Q2UTA9        79 gISSKADCeeilcgRVKGLRDVVELKFEIDTeqsq------hpstKLDKQEGWICPVTAKQLGPNVKAVYLVPCGHVFSE 152 Aspergillus oryzae
Q10154        74 -SVPKSPS------HIKSLKDVVQLQVELD----------------DSGKVLWLCPITRHVMSDTYQFAYIVPCGHVFEY 130 Schizosaccharom...
XP_011392039  74 sSASSTKAidp-ipHIRGLRDITQLKLTPNTlyrpps---ptrssNEYSVYPFMCPLSSKQMDGQQRFIYIIDCGCVMSA 149 Ustilago maydis...
NP_956036     73 rPNTEVVA------HIRSLKDVKELNLTDNPawegerrnikgdcyEDMHLAMFICPVVGLEMSGKHKFFFLQTCGCVFSE 146 zebrafish
Q5ZJN1        73 kTPMEAAS------HIKSLKNVTELNLADNPawsgdkeskkgdtyDDIQSARFICPVVGLEMNGRHRFCFLRNCGCVFSE 146 chicken
Q99K95        73 kALGKAAS------HIRSIKNVTELRLSDNPawegdkgntkgdkhDDLQRARFICPVVGLEMNGRHRFCFLRCCGCVFSE 146 house mouse
XP_002646542  71 iSKSAAAS------HIKGPRDFVELKLTENKdfkrgd--vkgddyNDVNQTEFLCPITNVPMNGIQSFLVNWQCGCVYSE 142 Caenorhabditis ...
Q5K8P8       142 AALRAV--V---PNltkgtgakvipkddvpeegkpvvkenttevaCPNCGKTFNPTis---------aAIIPVNPPKEvQ 207 Cryptococcus ne...
A0DTQ1       129 KLIKDL--KikgLK-------------------------------CPICTKPYTEK------------DIVQLCPTNE-E 162 Paramecium tetr...
Q23KD1       129 KLIQNL--KgdsKK-------------------------------CPVCSKSYSSK------------DVVQLNMSVE-E 162 Tetrahymena the...
Q2UTA9       153 EAVRQL--K---GDk------------------------------CLQCNESYTEE------------NVIPILPTKSeD 185 Aspergillus oryzae
Q10154       131 SALKQF--G---EKm------------------------------CFQCNQVYEEK------------DVIPINPNAE-Q 162 Schizosaccharom...
XP_011392039 150 TGLRTTvaAakpSQpipnr---------------------pehkpCPVCGKAFNAAglakgkqpevggSVVTINPSDA-E 207 Ustilago maydis...
NP_956036    147 RALREV--K---TVi------------------------------CHKCGDPFQEE------------DLVVLNGTKE-E 178 zebrafish
Q5ZJN1       147 RALKEI--K---TEv------------------------------CHKCGVPFQEE------------DVIILNGNKE-D 178 chicken
Q99K95       147 RALKEI--K---AEv------------------------------CHTCGAAFQEE------------DIIVLNGTKE-D 178 house mouse
XP_002646542 143 KAQQEV--K---SEn------------------------------CHVCGGPYDAT------------KMVILNPEDE-Q 174 Caenorhabditis ...
Q5K8P8       208 DVLLEDLL-TSRAAAk----sSKKRKADKSTKANNDTGSPATLEPPPKSARISssspapra--------------tptvn 268 Cryptococcus ne...
A0DTQ1       163 AEIKKAQLyKEIELK------EKQKKDQKKQLKVSDAVNNLELQQKKKVCTEE--------------------------- 209 Paramecium tetr...
Q23KD1       163 QEKKKIEI-LSESSK------KDKKSSQKDEKKNHASGEKVEKKVKTEKNSSLt-------------------------- 209 Tetrahymena the...
Q2UTA9       186 KQQLMARA-QKLAEQglthslKKAPGS-KKRKKQ-ANGDSAETEGASRsnts--------------------------tp 236 Aspergillus oryzae
Q10154       163 LKTLSKRL-LDLALS------EKTHSLNKASKKSNKNGDKKRKHVSKSNSKHAk-------------------------- 209 Schizosaccharom...
XP_011392039 208 EAEMRAAM-ENARAE------QTKKKKAKTRTADQAIESG---------------------------------------- 240 Ustilago maydis...
NP_956036    179 VETLQKAM-EERRSK------AKIAKKSKKSKDTKVSKTQDSTAESCKSPQNPsesksasengegssgsssdsapgpsts 251 zebrafish
Q5ZJN1       179 VEVLKKRM-EDRRLK------SKLEKKSKKCKSA-ESAAQQVTTEDSPGPSKVknskdciasssgek--rhiiftkssdd 248 chicken
Q99K95       179 VEMLKKRM-EERRLR------AKLEKKTKKPKTATECASKPGTTQDSAGPSKVksgkpeeadpdpre--kkstpaprgaa 249 house mouse
XP_002646542 175 LELYKLKW-EAEKAE------KAAAKKEKAKKTAEKMEAAAMASEGPSTSSDApgpsapgsrgmasvgksadlakkleia 247 Caenorhabditis ...
Q5K8P8       269 tpASLARSVHEKLAEqekKRLQAQENMSEAVK---------AMFkpKTNEK 310 Cryptococcus neoformans
A0DTQ1       210 --QKFKGQTMEDNKL---QNHTQDLKNNEIYQ---------SLF--HQQHK 244 Paramecium tetraurelia
Q23KD1       210 --SSGVSTLGSHKAAlieQLTETQKEQSQVFK---------SLFhtDKDLK 249 Tetrahymena thermophila SB210
Q2UTA9       237 kpSASNGIKHAATAMltaRVLEEENEKKKRRKmmglnenldSLFtkDSKDG 287 Aspergillus oryzae
Q10154       210 ------------hELrtnRMLDGENVKSETSV---------TDMerVKRVK 239 Schizosaccharomyces pombe 972h-
XP_011392039 241 --GLDSGHAKEDQAEqkrRKAERKSEMRARLA---------ALTaeLTAEQ 280 Ustilago maydis 521
NP_956036    252 geSLKTVKATAGPFTgskRSIQDMKDKSEAFK---------SLFtsHSSAK 293 zebrafish
Q5ZJN1       249 rsSSVPGKVNKASTat-kRSIADTATRNLRHT---------NLFttHSSAK 289 chicken
Q99K95       250 tnGSASGKVGKPPCGalkRSIAD-SEESETYK---------SIFtsHSSAK 290 house mouse
XP_002646542 248 klGAGASDRKAEKRKatsSDIQSDPTKSDTYK---------KLFttCEAAK 289 Caenorhabditis briggsae
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