Conserved Protein Domain Family
ICA69

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pfam04629: ICA69 (This model is not part of the current CDD release)
Islet cell autoantigen ICA69, C-terminal domain
This family includes a 69 kD protein which has been identified as an islet cell autoantigen in type I diabetes mellitus. Its precise function is unknown.
Statistics
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PSSM-Id: 516351
Aligned: 18 rows
Threshold Bit Score: 191.142
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_011604502 261 QYQFTTLKDLRDPLEEIADLTKQ---------EKTKENSPSNTD-----------------SLVS--LDDDKHADAEPAS 312
XP_008259908 260 PYEFTTLKSLQDPVKKLVEKEEKrk-----vaQQDSVEAPMQESs----------------QLIS--LEDENQRTDSPGF 316
XP_004767870 261 PYEFTTLKSLQDPMKKLIEKEERkk-----itQQESAEATVEEPr----------------QLIS--LEDENQHKESSSF 317
XP_005041116 263 PYEFTMLKSLQDPVNKLTEKVERed------qQIESTNTVEDQQs----------------QLIS--LDEESHTKESNYS 318
3_pfamImport   1 PYEFTMLKNLQDPVNKLIEQATQne-----eaSADNSKEAAEQDd----------------QLIS--LDENKGLADAPGN 57 
7_pfamImport   1 PYEFTTLKSLQDPANKLTDQGAKkksrrrikgKKDSRERSPDVDe----------------QISStkLFQTTHSLSVSN- 63 
XP_015213690 263 PYEFTTLKSLQDPANKLTDQGAKkksrrrikgKKDSRERSPDVDe----------------QLIS--LDSEKHKEESSH- 323
4_pfamImport   1 HYEFSTIKTLQDPVDKLAKKKG-------------KNKAKAETE------------------------------------ 31 
XP_015214860 262 PYEFTTLKDLRDPLEMLVNDPE----------KEKMENIQDDVDnfvfiknhahlralfnqTLIL--LDEEKPVGADSET 329
XP_005995470 259 PYEFTTLKNLQCPLDQLTE-------------DQEEKTVIDDVD-----------------KLIL--LDDETLPESKLGT 306
XP_011604502 313 NRDGqndtrahesiaapPAAMGSNDDQMLMDCDVpqfpqpvnaplqpqlplpppagdptesrgfeslpcslpplpgPSls 392
XP_008259908 317 QTED-------------GKDVFSALDRSAMHSACsgpidglldmk---------------------seegagpgpgVG-- 360
XP_004767870 318 KTED-------------GKSVLSTLDKSSTHNACsdelldmkp------------------------eegaclgpmAG-- 358
XP_005041116 319 ADD--------------GKDVISTLQGHCHHEQNsgaidall---------------------------dlqpeenASke 357
3_pfamImport  58 -----------------SEISNKMSVPRILNSSSatsvddmld-------------------------lkpeekapAGtd 95 
7_pfamImport  64 -------------------VAYTSCFlgvfkmqivrsqlsvlh------------------------lrpkvlqqtqtcl 100
XP_015213690 324 -------------------TVHSASLHHSGEGFSpgfeevnlsgnqn----------------------------taqhd 356
4_pfamImport     --------------------------------------------------------------------------------    
XP_015214860 330 AQSAdg---------qsKDTDSSLCASLNSGRPSdtaktlteaadddllmildt--lntpssptapwspvtqfcdmVPkd 398
XP_005995470 307 VIGDqn---------diSCLSKDTEDCLFQSHDT------------------------------------------IPrd 335
XP_011604502 393 tgtmLQTEEDVERGEMAFLKDLLSPGVGANDEFSREWQDAFGVFEPSNTPQSTTESLNSGATAnppssSPTGFLPSQLLD 472
XP_008259908 361 ----TLDPEGADKDDLLLLTEMFSASSLEEGEFGREWAAVFGDGRLRESAAAAGLGEPDLKLQ-----AGSSFLPSQLLD 431
XP_004767870 359 ----TPEPDGADKDDLLLLNEIFNASSLDEGEFSKEWAAVFGDDRLKEPVPTVAPGEPDPRPQ-----TGSGFLPSQLLD 429
XP_005041116 358 kfvrSSEPEPGDKDDMVLLNEILNASSLDEGEFSKEWTAVFGQ--AADLTMNSSARDGESTSSsa-vpAPSGYLPSQLLD 434
3_pfamImport  96 lltdSVEPDANNKDEMTLINEILNTSSLEEDDFSREWKAVFGDDMLSSGATNPAAGEPDHVTS------SSGFLPSQLLD 169
7_pfamImport 101 pkqpSKSAEGSEKDEMALLSEILNSTSLEEGGFSQEWQAAFGEETLANSGAQPAAGEPVQEAS------SSGFLPSQLLD 174
XP_015213690 357 llsslpeqEGSEKDEMALLSEILNSTSLEEGGFSQEWQAAFGEETLANSGAQPAAGEPVQEAS------SSGFLPSQLLD 430
4_pfamImport  32 ------ESEAEEKDSMALLNEILGGLSVDEGDFSQEWTEVFGETEEGTSAASTRPTETQDK-------ENSFFLPSQLLD 98 
XP_015214860 399 lladLPEGEDAERSDLSFLKDLLSPGPAGNEEFNREWHDAFGNFEASTASAPLPGPTAALSPDqp--sSPTGFLPSQLLD 476
XP_005995470 336 lladALQGEDPEKNDLAFLNKLLNPGPSGTGDFSQEWQNAFGSLEPSPAALAPKNEIEQST-------KPAGFLPSQLLD 408
XP_011604502 473 HSLSSS-----GWSTP---PMFqALPLQPPSGQNPSAel------aSGSTANAPPg-gSKDMSAWFNLFADLDPLSNPDA 537
XP_008259908 432 QNMKDLqaslkGWSESsvsPPP-PRPAPKTSCPNDNS---------RAVKEPAKA---ASDLTAWFSLFADLDPLSNPDA 498
XP_004767870 430 QNMKDLqaslqGWSESsvsPPPtPWPAPQASSPNDNS---------PATKEPAKA---ASDLTAWFSLFADLDPLSNPDA 497
XP_005041116 435 QNMNDLqsslhGWAASsvsPPSiPQPAQKPHSLNVNDg-------kTPGKESTKN---PKDLTAWFSLFADLDPLSNPDA 504
3_pfamImport 170 QNMNDLqssfsSWAASnvnPQSiPLPAQQSDSLNQNVn-------kTPVKGPLKN---SKDLSAWFNLFADLDPLSNPDA 239
7_pfamImport 175 QNLNNLqssfaDWAMSnrqPAT--QALEQSGS-DQNIs-------rPSVKGTPDTpqpAKDLSAWFNLFADLDPLSNPDA 244
XP_015213690 431 QNLNNLqssfaDWAMSnrqPAT--QALEQSGS-DQNIs-------rPSVKDTPQP---AKDLSAWFNLFADLDPLSNPDA 497
4_pfamImport  99 QSLNNLqssisDWA-----PHSaTQATEHSSEANQSTs-------kPAEREAEGT---SKDLSAWFNLFADLDPLSNPDA 163
XP_015214860 477 RSFSST-----GWATP---PMFqAQPLQTPQAPSQPVspptpppnaPKMTSKASKs-sRRDMSAWFNLFADLDPLANPDA 547
XP_005995470 409 LSLKTSge-fiNWTTPsalPTq-SVPLHQPQSVPPQDvpe----ipPRVTKNNPP-----DMSPWFSLFADLDPLSNPDA 477
XP_011604502 538 IGRSAD--ELLNA 548
XP_008259908 499 VGKTDKehELLNA 511
XP_004767870 498 VGKTDKehELLNA 510
XP_005041116 505 VGKTDKehELLNA 517
3_pfamImport 240 VGKTDKdhELLNA 252
7_pfamImport 245 VGKTDKehELLNA 257
XP_015213690 498 VGKTDKehELLNA 510
4_pfamImport 164 IGKTNTehELHNA 176
XP_015214860 548 IGRSDD--ELLNA 558
XP_005995470 478 IGRSDE--ELLNA 488
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