Conserved Protein Domain Family
Adeno_E1B_55K_N
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pfam04623: Adeno_E1B_55K_N 
Adenovirus E1B protein N-terminus
This family constitutes the amino termini of E1B 55 kDa (pfam01696). E1B 55K binds p53 the tumor suppressor protein converting it from a transcriptional activator which responds to damaged DNA in to an unregulated repressor of genes with a p53 binding site. This protects the virus against p53 induced host antiviral responses and prevents apoptosis as induced by the by the adenovirus E1A protein. The role of the N-terminus in the function of E1B is not known.
Links
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Statistics
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PSSM-Id: 113396
View PSSM: pfam04623
Aligned: 5 rows
Threshold Bit Score: 74.2501
Threshold Setting Gi: 119030
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9YL98     1 MEPGHPTEQGLHPGLRSHAPVEGLdqaAGTENLELLASTAs---SSGSSSSTQTNIHVGGRNeAGHGREpEER 70  Human adenovirus D9
Q64819     1 MEREIPPELGLHAGLHVNAAVEGM---AEEEGLHLLAGAA----FDHAAAADVARGEGGGAE-PCGGGE-VNM 64  Human adenovirus 12
ACH90443   1 MERPNPSVGGIYSGLHDNGPVENPa--AEEEGLRLLAGAAsarsGSS------A---GGGGG-GGGGGE---P 58  Human adenovirus 41
P03245     1 MDPPNSLQQGIRFGFHSSSFVENMegsQDEDNLRLLASAAsgssRDTETPTDHA---SGSAG-GAAGGQ-SES 68  Human adenovirus 7
P03243     1 MERRNPSERGVPAGFSGHASVESGcetQE-------SPATvvfrPPGDNTDGGAAAAAGGSQaAAAGAEpMEP 66  Human adenovirus 5
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