Conserved Protein Domain Family
Hox9_act

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pfam04617: Hox9_act (This model is not part of the current CDD release)
Hox9 activation region
This family constitutes the N termini of the paralogous homeobox proteins HoxA9, HoxB9, HoxC9 and HoxD9. The N terminal region is found to act as a transcription activation region. Btg1 and Btg2 - the B-cell translocation gene products - may function as cofactors for Hoxb9-mediated transcription. The Btg proteins modulate Hoxb9 transcriptional activity by recruiting a multiprotein Ccr4-like complex.
Statistics
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PSSM-Id: 516344
Aligned: 37 rows
Threshold Bit Score: 167.194
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003446426   1 MSISGTLSNYYVDSIISHDSDELSsQTRF-PSAQYSGSssaasasgRLPGGaa-gHTEhphpdsYPSCSFQPKPPVFSSS 78 
XP_001507161   1 MSISGTLSSYYVDSIISHESEDAP-PGKF-PGGQHPGP--------RQPG-----HTEhl---dFPSCSFQPKAPVFSAS 62 
NP_032296      1 MSISGTLSSYYVDSIISHESEDAP-PAKF-PSGQYANP--------RQPG-----HAEhl---dFPSCSFQPKAPVFGAS 62 
Q9YGT5         1 MSTLGTLS-YYADSHIPHENDDHL-APRF-SSGPVVQQq-------SRELTll-eYSE------QEPYTFQAKSSIFGAS 63  zebrafish
XP_003454433   1 MSTLGT--SYYIDSRILPEQEDm--APRYsSSAAGVEQa-----------Vvt-eYGG------QESCPLQAKSSIFGGS 58 
XP_040022280   1 MSTMG---SYYVESPLISEQEDm--APRY-SSSAGVEQa-----------Mls-gYGG------QESFPLQAKSSIFGGS 56 
Q9PWL6         1 MSTSGALTGYYVDSIVIPGSEET----RF-SSGLGLIQh-------RPTILpa-dLSD------LGPCTFPAKQPVYGTS 61  zebrafish
O42506         1 MSTSGTLTSYYVDSLILPENEELS-VPRY-SAGPGHQHs-------RQPASigdpHSE------LGTCSFPSKPPVFGPS 65  torafugu
XP_003448915   1 MSTSGTLTSYYVDSLILPESEELS-VPRY-TSGPGLQHa-------RQHASis-dPSE------VGTCTFPSKPQVFGPS 64 
XP_005802781   1 MSTSGALTSYYVDSLILPESEELS-TPRY-PSGVGVQHa-------RQPAPvv-dHSE------LGACGFPSKTPVFGPS 64 
XP_003446426  79 -WSPFNPhH--GASGLPAVYHPYI--PAQHVP-AADTRYIRSW-LDCAPRsSeSGPV-----QGqt--gQVKLEPQLGHL 144
XP_001507161  63 -WTPLNP-H--PPGTLPSVYHPYI--QHQAVP-PAESRYLRSW-LEPVAR-TdTVPG-----QG-----LVKAEPLAGGS 123
NP_032296     63 -WAPLSP-H--ASGSLPSVYHPYL--QPQGAP-AAESRYLRTW-LEPAPR-AeAAPG-----QGq---aAVKAEPLLGAP 125
Q9YGT5        64 -WSPVQP----TGASIA--YHPYIh-HPCSTg-DSDGASVRPWaLEPLPAl--PFTGl-----StdthqDIKLEPLVGS- 126 zebrafish
XP_003454433  59 -WSAISA-HppNTAAPTYIHHPYA-------SgDSDGMFTRSWaLDPVSAsL-CLTGl----PStgmhyEIKPEPLIGS- 123
XP_040022280  57 -WSPIPT-HppNTTAPTYIHHHYT-------SgDNDGMFTRSWaLDPVSAsL-CLTGl----PSttmhyDIKPEPMIGT- 121
Q9PWL6        62 dWGHIPT-H--FSTGVPSVYQPHA--QPPVV-----GDYVQSWlLD-------SACGlpqtePPtvnhnHAKSDTNETND 124 zebrafish
O42506        66 -WSHVPA-Q--FPGTVSSVYHHHYghHQGPVGtETDGRY-QSWlLEPMSGsL-PMAGl----PTth-hyGIKPDGLGVRS 134 torafugu
XP_003448915  65 -WSHVPA-Q--FPATVSSVYHPHYghPQGPVGgDTDGRY-QSWlLEPMSGsL-PLTGl----PTth-hyGIKPEGLGTRA 133
XP_005802781  65 -WNHVPA-Q--FPGAVSSVYHHYGh-PQGPMAaETDARY-QSWlLEPV-----SMTGl----PPshhhyAIKPEGLGTPP 129
XP_003446426 145 GGeiASKImgqhqhepttYILEs--tSTAARELShh-saAIqATGFEENKDICEGNEDK-DGLDQ 205
XP_001507161 124 GEqlLKPGsg------qeYNLE----TAAGREAIl----SNqRPGYEDNK-ICEGSEDK-ERADQ 172
NP_032296    126 GE--LLKQgt------peYSLE----TSAGREAVl----SNqRAGYGDNK-ICEGSEDK-ERPDQ 172
Q9YGT5       127 -GecTth----------tLLVAet-dNNTtqte--rkvpDD--AVSNGSHDEKIPAETK-LDLDP 174 zebrafish
XP_003454433 124 -AecTTLEth-------tHLLSdienGASLVEIPce--------tASKATEENPSVEEK-REVDP 171
XP_040022280 122 -AecTTLEth-------tPLLSdienGASLTEISce------sTSTSKATEDKPSVEDK-EEINA 171
Q9PWL6       125 DGteYSph---------tILQPevftNG---------------GCSTKTEAESSRTAEKsGDIEG 165 zebrafish
O42506       135 GGalPGsh---------tALLL----SDYANGTVatappVEkDAVSSHTGD-GVDTEEK-PGLDP 184 torafugu
XP_003448915 134 EGglPGsh---------tALLL----SDYANGTVasaspVEkDELSVQAGDLSGEGEEK-PGLDP 184
XP_005802781 130 Gsh--------------tALLL----SDYANGTVatpspGEkDELSAQGGELSTEGEDK-PALDP 175
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