Conserved Protein Domain Family
Hox9_act

?
pfam04617: Hox9_act 
Hox9 activation region
This family constitutes the N termini of the paralogous homeobox proteins HoxA9, HoxB9, HoxC9 and HoxD9. The N terminal region is found to act as a transcription activation region. Btg1 and Btg2 - the B-cell translocation gene products - may function as cofactors for Hoxb9-mediated transcription. The Btg proteins modulate Hoxb9 transcriptional activity by recruiting a multiprotein Ccr4-like complex.
Statistics
?
PSSM-Id: 398350
Aligned: 41 rows
Threshold Bit Score: 91.6931
Threshold Setting Gi: 348501466
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_003446426   1 MSISGTLSNYYVDSIISHDSDELSsQTRFPSAQYSGSSsaasasgRLPGGAAGHTEhphpdsYPSCSFQPKPPVFSSSWS 80  Nile tilapia
XP_015154931   1 MSISGTLSNYYVDSIISHESEDSP-SAKFSSGQYTSS--------RQAG-HNEHLE------FPSCSFQPKPPVFSASWT 64  chicken
XP_006638381   1 MSISGALSSYYVDSIISHESEDPT-SVKFSNVQYPSP--------RQPGG---HAEhp---eFPSCSFQPKPPVFSATWS 65  spotted gar
Q3V615         1 MSISGTLSNYYVDSIISHDSDELSgPARFSAVQYSSPNssvaagvRQPV-AAAHAEhphsdsYPSCSFQPKPPVFSPSWS 79  Japanese medaka
XP_005811970   1 MSISGTLSNYYVDSIISHDSDELSgAPRFSSVQFPVSTsavtdgaA-------HSEhahsepYPSCSFQPKGPVFSSPWG 73  southern platyfish
XP_007232294   1 MSISGTLSNYYVDSIISHEGEDPS-AARFANVQYSNS--------RQPG----TGEhp---eFPSCSFQPKPPVFSSSWS 64  Mexican tetra
XP_003222671   1 MSISGTLSNYYVDSIISHDSEEPP-AAKFSSGQYSNS--------RQSS----HTEhl---eFPSCSFQPKSSVFSASWT 64  green anole
XP_001507161   1 MSISGTLSSYYVDSIISHESEDAP-PGKFPGGQHPGP--------RQPG----HTEhl---dFPSCSFQPKAPVFSASWT 64  platypus
NP_001093967   1 MSISGTLSSYYVDSIISHESEDAP-PAKFPSGQYANP--------RQPG----HAEhl---dFPSCSFQPKAPVFGASWA 64  Norway rat
XP_005990103   1 MSISGALSNYYVDSIISHESEEAS-SAKFSSGQYVSS--------RQPG----HSEhl---eFPSCSFQPKPPVFSASWT 64  coelacanth
XP_003446426  81 PFNPhHGASGlpavYHPYIPAQHVp--AADTRYIRSWLDCAPRSSeSGPVQGQTGQVKLEPQLGHLGGEIASkimgqhqh 158 Nile tilapia
XP_015154931  65 PLNP-HSSGTlpavYHPYIQHQSV---PSDSRYLRSWLDPVPRAE-TLPGQG---SVKAEPLLGR-PGDVHKq------- 128 chicken
XP_006638381  66 PFNP-HSSNGlpavYHSYIPAQAIp--SPDNRYLRTWLDSAPR-TePLAGQG---HVKLEPLLGHLGE--PPklg----- 131 spotted gar
Q3V615        80 PFSPhHGAGAlpavYHPYLPAQHVp--AADTRYLRSWLDAAPRDPdSVSGQSQTGQVKLEPQLGHQGGDIPLkvsvqhph 157 Japanese medaka
XP_005811970  74 PFSPhHGTSGlpavYHPYIPGQHVaagAADTRYIRSWLDCAPRDSeSFPGQSQTGQVKLEPQLSHQGGELPIkisg--qh 151 southern platyfish
XP_007232294  65 PFSP-HTSNGlpavYHPYIPTQPVp--STDTRYLRSWLDCAPR-AePLPGQS---QVKMEPLLGHLGE--PPklg----- 130 Mexican tetra
XP_003222671  65 PLTP-HAAASlpsvYHPYLQHQNLp--SSESRYLRSWLDPVPR-AeSLAGQG---AVKTEPLLGE-----IRkqg----- 127 green anole
XP_001507161  65 PLNP-HPPGTlpsvYHPYIQHQAVp--PAESRYLRSWLEPVAR-TdTVPGQG---LVKAEPLAGGSGEQLLKpgs----- 132 platypus
NP_001093967  65 PLSP-HASGSlpsvYHPYLQPQGAp--AAESRYLRTWLEPAPR-AeAAPGQGQA-AVKAEPLLGAPGE--LLkqg----- 132 Norway rat
XP_005990103  65 PLNP-HSAGTlssvYHPYIQHQTVp--PSDNRYLRTWLEPLPR-TdSLSGQG---SIKAEPLLGL-GE--ILkpg----- 129 coelacanth
XP_003446426 159 ePTTYILEst--sTAARELSHh-----SAAIqATGFEENKDICEGNEDKDGLDQ 205 Nile tilapia
XP_015154931 129 gTQEYNLEt----SAAREGIV------SNQR--PSFEDNK-VCEGSEDKDRTDQ 169 chicken
XP_006638381 132 -gqdYSLEc----PSARDIN---------SNqGSGFEDNKDICEGSEDKEGPDQ 171 spotted gar
Q3V615       158 eTTTYILDpv--sTAARELSLh-----PAAVpGRGFEESKEGCEGSEDKDGPDQ 204 Japanese medaka
XP_005811970 152 eTTTYILEsi--sTAGRELNLh-----PTSIqGSGFEESKDVCEGSKDKDSADQ 198 southern platyfish
XP_007232294 131 gqhEYVLEs----SSAREMN---------SGhSSGFEDSKDICEGSEDKEGPDQ 171 Mexican tetra
XP_003222671 128 -aqdYPIDpaaaaAAGREGVApapvpvPRPSsSGGFEDNK-VCEGSEDKSRPDQ 179 green anole
XP_001507161 133 -gqeYNLEt----AAGREAIL--------SNqRPGYEDNK-ICEGSEDKERADQ 172 platypus
NP_001093967 133 -tpeYSLEt----SAGREAVL--------SNqRAGYGDNK-ICEGSEDKERPDQ 172 Norway rat
XP_005990103 130 -gpeYNLEt----ATGREGSS--------SNqGSSYGDNK-VSEGSEDKDRPDQ 169 coelacanth
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap