5YFG


Conserved Protein Domain Family
Mog1

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pfam04603: Mog1 
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Ran-interacting Mog1 protein
Segregation of nuclear and cytoplasmic processes facilitates regulation of many eukaryotic cellular functions such as gene expression and cell cycle progression. Trafficking through the nuclear pore requires a number of highly conserved soluble factors that escort macromolecular substrates into and out of the nucleus. The Mog1 protein has been shown to interact with RanGTP which stimulates guanine nucleotide release, suggesting Mog1 regulates the nuclear transport functions of Ran. The human homolog of Mog1 is thought to be alternatively spliced.
Statistics
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PSSM-Id: 398340
Aligned: 124 rows
Threshold Bit Score: 108.388
Threshold Setting Gi: 121807301
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5YFG_A         8 PLFGGAFS-AILPMG----AIDVSDLRPVPDNQEVFc------hPVT------------DQSLIVELLELQAHVRGEAAA 64  human
XP_002142144   7 QLYGDSIR-VEIPRN----FIDISKIRDVPDHQEVFv------dDLS------------ESSIIFEILQQTDLKSDQ-IG 62  Cryptosporidium...
Q7RLM9         8 yfFGKYIK-MNIPDD----YIDISKYRTIPDNQEVYa------hKYN------------NNCLIIEIVCYKD-IDIKEKG 63  Plasmodium yoel...
EJT41512       7 ELYGGAII-TVVPPG----FLDASTLREVPDTQEVYv------nSRRetedfg-dglatNESIIVDLLETVDKADLKEAW 74  Saccharomyces k...
CCC67800       7 QLYGGAIT-TVIPKG----FLDASLLRQVPDAQEVYv------nSRDeneqfn-dglqlNESIIVDLLQPVAPKDLKEAL 74  Naumovozyma cas...
XP_004179344   6 QLYGGAIT-TVMPEG----FVDVSMIREVPDTQEVYv------nNREsketft-dglgyNESIIVDLLEQVTSMDLKLAL 73  Tetrapisispora ...
ABN67046       6 QLYSGAIC-TAIPAPikacLVDVSHIRQIPDNQEVFliedhrknPKF------------DKSLIFDLLESVPAKSYTEAI 72  Scheffersomyces...
CCE39847       5 ELYGGAITiNKLPSS----FIDVSQIRQVPDSQEVFi------nEIDstnptlsslltfDQALIFDLLERVDGNDYESAI 74  Candida parapsi...
Q5A4J5         4 ELYGGAITiSKLPNS----FIDISQIRQVPDTQEVFi------nQLSshndshdvsgsfDHSFIIDLLERVDPIDYQEAI 73  Candida albicans
EDK46550      15 PLYGGAITiPKLPQT----FIDVSQIRQVPDTQEVFi------nQIPdntsspesqscyDQSLIIDLLEQVNSIEYAQAI 84  Lodderomyces el...
5YFG_A        65 RYHFEDVGGVQGARa------------------vHVESVQPLSl--En--lALRGRCQEAWVLSGKQ-QIAKEnq--qvA 119 human
XP_002142144  63 EYYFKDLADCNESTss-----------------eVLYSEPLV----------QYNKEFFTSTCFGIQ-QVQKRyqegerN 114 Cryptosporidium...
Q7RLM9        64 KYYFDDLANENTSLen-----------------kIILNNESV-----------PHSQKNYILVVGAQ-KITKCnt--qmH 112 Plasmodium yoel...
EJT41512      75 KFHVEDLTELNGTTawetlqe-------dtvqqgTK------------------------LTGLVVE-VANKWgkldlaQ 122 Saccharomyces k...
CCC67800      75 KVHVEDIVSLNETTkddnqtfdwevlqvdqvqekPC--------------------------CIAAQyTVKKWgkedskQ 128 Naumovozyma cas...
XP_004179344  74 GEHLEDIFQLNGSTkykveql-------kqidnhNI-------------------------TCIVWE-ETHKSgkqartE 120 Tetrapisispora ...
ABN67046      73 ATHIEELVEPNESAtnwfienlt----------------------------rdnfqqevNFSFIEHA-NSRKDaaepdsP 123 Scheffersomyces...
CCE39847      75 EQHLQDFAPHGVHNn-------------------PLQEVQLG-----------GSNEILYFSYVTFK-PEYKRket-nqA 122 Candida parapsi...
Q5A4J5        74 HLHLQDIVPPHVHNq-------------------LIEQIKQQQqeeEdneeDDDDGIIRYFSFVQFK-PQYKKsdpnesP 133 Candida albicans
EDK46550      85 AEHMQDIVPAHVHNq-------------------PLEEIQ-------------VDGVTRYFSYVVFT-PEYKRkeetgqA 131 Lodderomyces el...
5YFG_A       120 KDVTLHQALLRLPQYQTDLLLTFNQP 145 human
XP_002142144 115 ENLYLYVLVIRILMKKTDILISFNSv 140 Cryptosporidium muris RN66
Q7RLM9       113 ENVLLYLCIIPYKEHNADILITWNIP 138 Plasmodium yoelii yoelii
EJT41512     123 -TVVVGVALIRLPQFDTDVVISINVP 147 Saccharomyces kudriavzevii IFO 1802
CCC67800     129 ETVVSCVGLIRLQEFQVDVVITVNAP 154 Naumovozyma castellii CBS 4309
XP_004179344 121 -IVMSCIGLIRLAEFTTDVLVTMNVP 145 Tetrapisispora blattae CBS 6284
ABN67046     124 VAVFTFIAFIRLDRVETDVLITLNVP 149 Scheffersomyces stipitis CBS 6054
CCE39847     123 EQIIILVCLLRLEKVGTDVLIQYNLP 148 Candida parapsilosis
Q5A4J5       134 KQIITLICLIRLEKVDTDVLLQYiip 159 Candida albicans
EDK46550     132 EKIVMFICLIRLVKVETDVIVQFNVP 157 Lodderomyces elongisporus NRRL YB-4239
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