Conserved Protein Domain Family
RFX1_trans_act

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pfam04589: RFX1_trans_act (This model is not part of the current CDD release)
RFX1 transcription activation region
The RFX family is a family of winged-helix DNA binding proteins. RFX1 is a regulatory factor essential for expression of MHC class II genes. This region is to found N terminal to the RFX DNA binding region (pfam02257) in some mammalian RFX proteins, and is thought to activate transcription when associated with DNA. Deletion analysis has identified the region 233-351 in human RFX1 as being required for maximal activation.
Statistics
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PSSM-Id: 516332
Aligned: 14 rows
Threshold Bit Score: 157.74
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EGW00641      107 STSKTAGAPAGTv-QQLQVHS--VQQsVPVSQERS--------------------VVQATPQT-KAGPVQQLTVQGLQPV 162 
XP_008101930  305 VQNSSSAAKPGQv-QQLQLHG--VQQ-VPVAQERS--------------------VVQTTPSApKAGSVQQLAVQGLQQV 360 
XP_031755324  152 PDGDSPSLKAGQa-QPLQLHG--------TQQERS--------------------VVQANPQ--KSSPVHQLTVQALQHV 200 
XP_014326517  121 NDSLSDSSPP----APGIPTQ--VVQaVQTPPQRS--------------------VLQAVTQPtKR--IQTGHISSLQSV 172 
XP_023205156  127 SDSVSDSSPPPAvvQTGVPTQ--VVQqVQAAQQRS--------------------VVQATSQIaKTEPGTQLSVTNLQPV 184 
XP_012810994    4 SDSGSDSATSVAl-RTSASAQapVVQpVPASQQRS--------------------LSQASGSApKGAHGQGISVPRAHQL 62  
NP_001125003    4 SEGGADSPASVAl-RPSAAAPp-----VPASPQRV--------------------LVQAASSApKGAQMQPISLPRVQQV 57  
XP_030112506    4 PEGGSDSAASVAl-HTSAPAQapVVQpVPASQQRV--------------------LVQATGSApKGAQMQQISVPRVQQV 62  
XP_028907672   21 SEDGRDSMTSGAl-RSAAAVQapVVQpVPASQQRV--------------------LIQSSESApKIAHMQQIPVPRVQQV 79   platypus
XP_056678588  193 SSAQASKGGPAS----LTVHS--VQQ-AHSPPERSpgqgnsstskagsvqqlqrsVVQTAPQTsKSGSVQQLTVQGLQPV 265  gray short-ta...
EGW00641      163 HVTQEvq------------------------------------------------------------------------- 169 
XP_008101930  361 HVTQEvq------------------------------------------------------------------------- 367 
XP_031755324  201 QGAAEvq------------------------------------------------------------------------- 207 
XP_014326517  173 HINQE--------------------------------------------------------------------------- 177 
XP_023205156  185 HITQEvq------------------------------------------------------------------------- 191 
XP_012810994   63 Q------------------------------------------------------------------------------- 63  
NP_001125003   58 P------------------------------------------------------------------------------- 58  
XP_030112506   63 P------------------------------------------------------------------------------- 63  
XP_028907672   80 P------------------------------------------------------------------------------- 80   platypus
XP_056678588  266 HVTQEcsgsqfparkgeqqepaaeppgvraepgerageaplllecsseapqlgsgspeprlhylpaaaaaaaaaaaaepg 345  gray short-ta...
EGW00641      170 -------------------------------------------------------------qLQQV-PVSHVYSSQVQYV 187 
XP_008101930  368 -------------------------------------------------------------qLQQV-PVQHVYPNQVQYV 385 
XP_031755324  208 -------------------------------------------------------------qLQQV-PVQHVYPSQVQYV 225 
XP_014326517  178 --------------------------------------------------------------V------EHVYSDQVQYV 189 
XP_023205156  192 ------------------------------------------------------------qqLASV-PVQHVYANQVQYV 210 
XP_012810994   64 ---------------------------------------------------------------QQVqTVQHVYPAQVQYV 80  
NP_001125003   59 ---------------------------------------------------------------QQVqPVQHVYPAQVQYA 75  
XP_030112506   64 ---------------------------------------------------------------QQVqSVQHIYPAQVQYV 80  
XP_028907672   81 ---------------------------------------------------------------QQVqPVQHIYPTQVQYV 97   platypus
XP_056678588  346 seqwvelvrvlpqqlllpqqkvvieplpglssraspdqrvriqrvpqvlvfgtaatalkvqqLQQV-PVQHVYPGQVQYV 424  gray short-ta...
EGW00641      188 EGG-DASYTASAIRSSTYPY-PETPIYTQP---AGTSYYEAS-GTAAQVSTPATSQTV--------ASSGSVPMYVSG-S 252 
XP_008101930  386 EGG-DASYTASTIRSNTYSY-TETPLYTQN---AGANYYESQ-GTSTQVSSPATSQTV--------ASSGSVPMYVSG-G 450 
XP_031755324  226 EGT-DATYTGSTIRSGSYPY-TETPLYTQA---TGSTYYEAQ-GATGQVSSPTSSPAL--------ASSPSVPMYVSG-G 290 
XP_014326517  190 DGAeDAAFTTSAIRSNSFPF-SDSPLYTQTppaSSSAFYEATaSSDSDLPGSVTSQAVsvataganSGAGTAGYVIQG-G 267 
XP_023205156  211 EGG-DTNYTTSTIRSSNFPY-TETPLYTQS---TAAQYYEGQpTSGAQASSPGTSLTVav-----tAGATG------GvS 274 
XP_012810994   81 E-G-DTVYTNGAIR-TAYSYnAEAQIYAPS---SGSSYFDSQ-GGGAQVTTVVSSPTAip-----sHSMVGIAMDVSG-S 147 
NP_001125003   76 EGG-DAVYTNGAIR-TAYTYnPEPQMYAPS---SAASYFEAP--GGAQVTVAASSPPAvp-----sHSMVGITMDVGG-S 142 
XP_030112506   81 EGG-EAVYTNGTIR-AAYSYsSEAQIYAPA---GAAPYFEAQgGGGAQVTTATSSP-Tai----psHNMVGITMDIGG-S 149 
XP_028907672   98 E-G-DTVYTNGTIR-AAYTYnPEAQIYAPS---SAASYFEAQ-GGGAQVTAVAASP-Sai----psHSMVGIAMDVGG-S 164  platypus
XP_056678588  425 EGG-DASYTASTIRSGTYPY-TETPLYTQN---AGTSYYESQ-GTTAQVSTPATSQAV--------ASSGSVPMYVSG-G 489  gray short-ta...
EGW00641      253 PIVASSSSSEAG 264 
XP_008101930  451 QIIANPSGGSSA 462 
XP_031755324  291 QILTNTTQSAAS 302 
XP_014326517  268 YMLGGGGAAAAG 279 
XP_023205156  275 MFVAQPTSAAGA 286 
XP_012810994  148 QIISSSGAYLIH 159 
NP_001125003  143 PIVSSTGAYLIH 154 
XP_030112506  150 QILSGSGAYLIH 161 
XP_028907672  165 QIISSSGAYVIH 176  platypus
XP_056678588  490 QIVTNssgsssg 501  gray short-tailed opossum
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