Conserved Protein Domain Family
RFX1_trans_act

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pfam04589: RFX1_trans_act 
RFX1 transcription activation region
The RFX family is a family of winged-helix DNA binding proteins. RFX1 is a regulatory factor essential for expression of MHC class II genes. This region is to found N terminal to the RFX DNA binding region (pfam02257) in some mammalian RFX proteins, and is thought to activate transcription when associated with DNA. Deletion analysis has identified the region 233-351 in human RFX1 as being required for maximal activation.
Statistics
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PSSM-Id: 398335
Aligned: 15 rows
Threshold Bit Score: 156.974
Threshold Setting Gi: 1774927535
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_009297596  120 SDSVSDSSPPAAVvQTGVPTQ--VVQQVQSAQQRSVVQATSQTtKTEPGTQLNVTSLQSVHLTQEvqqqLQQV-PVQHV- 195  zebrafish
EGW00641      107 STSKTAGAPAGTV-QQLQVHS--VQQSVPVSQERSVVQATPQT-KAGPVQQLTVQGLQPVHVTQEvq-qLQQV-PVSHV- 179  Chinese hamster
XP_008101931  274 vQNSSSAAKPGQV-QQLQLHG--VQQ-VPVAQERSVVQTTPSApKAGSVQQLAVQGLQQVHVTQEvq-qLQQV-PVQHV- 346  green anole
XP_012397563  216 gqgnSSTSKAGSV-QQLQVHS--VQA-VPVTQERSVVQTTPQTpKSGPVQQLTVQGLQQVHVAQEvq-qLQQV-PVQHV- 288  Tasmanian devil
XP_014326517  121 nDSLSDSSPP----APGIPTQ--VVQAVQTPPQRSVLQAVTQPtKR--IQTGHISSLQSVHINQE----V------EHV- 181  southern plat...
XP_011602212  127 SESVPDSNPPPAVvQTGVPTQ--VVQQVQTAQQRSVVQATSQItKTEPGTQLSVTSLQPVHITPEvqqqLSSV-PVQHV- 202  torafugu
XP_023205157  127 SDSVSDSSPPPAVvQTGVPTQ--VVQQVQAAQQRSVVQATSQIaKTEPGTQLSVTNLQPVHITQEvqqqLASV-PVQHV- 202  southern plat...
XP_009250925    4 SEGGADSPASVAl-RPSAAAP-----PVPASPQRVLVQAASSApKGAQMQPISLPRVQQVP---------QQVqPVQHV- 67   Sumatran oran...
XP_012426658    4 PEGGSDSAASVAl-HTSAPAQapVVQPVPASQQRVLVQATGSApKGAQMQQISVPRVQQVP---------QQVqSVQHI- 72   zebra finch
XP_028907672   21 SEDGRDSMTSGAl-RSAAAVQapVVQPVPASQQRVLIQSSESApKIAHMQQIPVPRVQQVP---------Qq--VQPVQh 88   platypus
XP_009297596  196 -YTNQVQYVEGG-EANYTTSTIRSSSFPY-TETPLYTQS---SAGQYYEATpASGSEAASPGTPLTVsv-----tSGSPG 264  zebrafish
EGW00641      180 -YSSQVQYVEGG-DASYTASAIRSSTYPY-PETPIYTQP---AGTSYYEAS-GTAAQVSTPATSQTV--------ASSGS 244  Chinese hamster
XP_008101931  347 -YPNQVQYVEGG-DASYTASTIRSNTYSY-TETPLYTQN---AGANYYESQ-GTSTQVSSPATSQTV--------ASSGS 411  green anole
XP_012397563  289 -YPSQVQYVEGG-DASYTASTIRSGTYPY-TETPLYTQN---AGTSYYESQ-GTTAQVSTPATSQAV--------ASSGS 353  Tasmanian devil
XP_014326517  182 -YSDQVQYVDGAeDAAFTTSAIRSNSFPF-SDSPLYTQTppaSSSAFYEATaSSDSDLPGSVTSQAVsvataganSGAGT 259  southern plat...
XP_011602212  203 -YTNQVQYVEGT-DTNYTTSTIRSSTFPY-SETPLYTQT---TPTQYYEGQqTPGSQASTPGTPLTVsv-----tAGTTG 271  torafugu
XP_023205157  203 -YANQVQYVEGG-DTNYTTSTIRSSNFPY-TETPLYTQS---TAAQYYEGQpTSGAQASSPGTSLTVav-----tAGATG 271  southern plat...
XP_009250925   68 -YPAQVQYVEGG-DAVYTNGAIR-TAYTYnPEPQMYAPS---SAASYFEAP--GGAQVTVAASSP-Pav----psHSMVG 134  Sumatran oran...
XP_012426658   73 -YPAQVQYVEGG-EAVYTNGTIR-AAYSYsSEAQIYAPA---GAAPYFEAQgGGGAQVTTATSSP-Tai----psHNMVG 141  zebra finch
XP_028907672   89 iYPTQVQYVE-G-DTVYTNGTI-RAAYTYnPEAQIYAPS---SAASYFEAQ-GGGAQVTAVAASP-Sai----psHSMVG 156  platypus
XP_009297596  265 VPMFVAGtGQIVANPTTAAG 284  zebrafish
EGW00641      245 VPMYVSG-SPIVASSSSSEA 263  Chinese hamster
XP_008101931  412 VPMYVSG-GQIIANPSGGSS 430  green anole
XP_012397563  354 VPMYVSG-GQIVTNSSGASS 372  Tasmanian devil
XP_014326517  260 AGYVIQG-GYMLGGGGAAAA 278  southern platyfish
XP_011602212  272 ------GvSMFVAQPTSATA 285  torafugu
XP_023205157  272 ------GvSMFVAQPTSAAG 285  southern platyfish
XP_009250925  135 ITMDVGG-SPIVSSTGAYLI 153  Sumatran orangutan
XP_012426658  142 ITMDIGG-SQILSGSGAYLI 160  zebra finch
XP_028907672  157 IAMDVGG-SQIISSSGAYVI 175  platypus
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