1UA4,5OD2


Conserved Protein Domain Family
ADP_PFK_GK

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pfam04587: ADP_PFK_GK 
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ADP-specific Phosphofructokinase/Glucokinase conserved region
In archaea a novel type of glycolytic pathway exists that is deviant from the classical Embden-Meyerhof pathway. This pathway utilizes two novel proteins: an ADP-dependent Glucokinase and an ADP-dependent Phosphofructokinase. This conserved region is present at the C-terminal of both these proteins. Interestingly this family contains sequences from higher eukaryotes..
Statistics
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PSSM-Id: 398333
Aligned: 70 rows
Threshold Bit Score: 277.572
Threshold Setting Gi: 302195665
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1UA4_A             23 KGVLLGYNTNIDAIkyl-dsKDLEER-------------------II---KAGKEev--iKYSEELPDKINTVSQLLGSI 77  Pyrococcus...
jgi:Maeo_0005      23 iSIFLAYNVNVDAIkyytsgKEIQNL-------------------IE---RYGEDdi--iEKYNEYPRKICNPIDYIARL 78  Methanococ...
jgi:Mvol_0050      19 iSIFLGYNANVDALkyisneKEFYELfellngdckknlnknlnenLNenlKIDINkv--iENMEIYPREIKTVEEFLARL 96  Methanococ...
Q6LXQ3             13 VSIFLAYNVNVDALkyltdlSDIEEL-------------------KE---NFSDSei--kTKIEEYPRTIEKPIDFVARL 68  Methanococ...
bsuwp:MCON_0234     6 MKIICAYPVNLDALydl-geERISRF-------------------IQsadPSGIK--------SEMKGSIRSREDLISSL 57  Methanothr...
WP_013038083        1 mNILCGYNANIDAVyri-tgREVESI-------------------IG---EVDKIel--lMKIEHQPRIINSLEDFLAGL 55  Methanohal...
jgi:Metho_2034      1 mKILCAYNANIDALysi-tgAEVSDM-------------------LA---SEDAAel--vEKIATPTGVINSMSDLLAGL 55  Methanomet...
jgi:Mzhil_0819      1 mRILCAYNVNIDSVyri-ngNEISTL-------------------IR---SMNLDekeilKKVDDPPGLICSISDFFSGL 57  Methanosal...
HusnBIG:Mpsy_1159   1 mKILCAYNANIDAIykv-ngLQMSSF------------------------AQDYEee-isARLQKPPGSISSIPDFFAGL 54  Methanolob...
jgi:Metev_0817      1 mNILCGYNANIDSVyri-tgDEINRL-------------------LE---HQNQDni--iKKIENPPNRIDSIDDFIAGL 55  Methanohal...
1UA4_A             78 LWSIRRGKAAELFVE----SCPVRFYMK--RWGWNELRMGGQAGIMANLLGGVYGvPVIVHVpQLSRLQANLFLDGpiy- 150 Pyrococcus...
jgi:Maeo_0005      79 IHAMANGKPAEVPLLd---DENLNKWFD--NFKYDEERMGGQVGIIANLLSILRTkKVIAYSpILSKKQAEMFVDNdnl- 152 Methanococ...
jgi:Mvol_0050      97 ILAMKSGKPVEIPLIsadlSPKFKKWLE--NLKFNEERIGGQVGIIANLLSILNLdKIVAYTpLLSQKQSEMFENKgsht 174 Methanococ...
Q6LXQ3             69 IHAMKSGKPAEVPLKn---NLEIDTFLN--RLTYNEERIGGQVGIISNLLSILNLkKIIFYSpILAKKQAEMFENNenl- 142 Methanococ...
bsuwp:MCON_0234    58 LYCIQQGSGAEILVE----SLQLAEEIEa-SFPWS-FRLGGNAGIMANLLAELGA-RPILNApALEPRLGALLHPgvg-- 128 Methanothr...
WP_013038083       56 IHCMEYGRGAEWFIY----SQDVLDFLKkrFFDRAEIRIGGNMGIMANVLSGLNVdMVVPNVvYLSGAQEALFSKRgmv- 130 Methanohal...
jgi:Metho_2034     56 LICMKEGTGAEWLVH----RPEAFKLLKdkFINGSRLRMGGNMGIMANVLSEMGAeLVIANVvKPTKRQLSFFS-Kkavl 130 Methanomet...
jgi:Mzhil_0819     58 IGCMQKGEGAEWIVY----KDPVFEFLKstFFDRSSIRMGGNAGIMANVLSELGAdEVIPNVvAPSKTQLSLFSRKsmii 133 Methanosal...
HusnBIG:Mpsy_1159  55 FLCMQNGIGAEWMVR----DEDVFQWLKssFLEGSFMRMGGNMGIMANVLSELGAsRVIPNIpNPSPLQMSFFSDRaiyv 130 Methanolob...
jgi:Metev_0817     56 IICIRNGSGAEWLVH----DDSVFEFLKnyFFDNSIIRMGGNCGIMSNVLSLMGAgEVVPNIaKPSKTQLDAFTDNesi- 130 Methanohal...
1UA4_A            151 ---vpTLeng-evKLIHPKEfsgDee-------nCIHYIYEFPRGFRVf----eFEAPRENRFIGSADDYNTTLFIREEF 215 Pyrococcus...
jgi:Maeo_0005     153 --vypSVvdg-nlVLKKPIEsykEnd------plKINRIFEYKEGIEFklgdkhIITPIANRFIVASRPDKLRLEIKEDL 223 Methanococ...
jgi:Mvol_0050     175 niyypVStnegdiVLKNINKahkNde-------tKINRIFEYKE-FSFefdnkkIEVPRANRLILASRPENLRINIPDET 246 Methanococ...
Q6LXQ3            143 --vfpNItng-klVLKKPIEsfkNde-------lKINRIFEYKEDIEFylenekITTPQSNRFIVASRPENLRIEIKDEL 212 Methanococ...
bsuwp:MCON_0234   129 -----------ipVSGRLIEpslAaerpd-lsseVLHFVFQFKESDRIpspqgpISAAKDNRFIATYDPVNTRMVSNQDF 196 Methanothr...
WP_013038083      131 --------------lpPKFEsksGde-------epIHFVFDFRQGDSFelygrrIIVSRENRFIATFDEFNPQMTISDFF 189 Methanohal...
jgi:Metho_2034    131 ----------ipgDGTYSQEtrcEed-------epIHFVFDFKKGDKVawgnvhFTVPRENRFIATYDIMNMSLLVNPCF 193 Methanomet...
jgi:Mzhil_0819    134 -pkemFRkevedkIDSAPNKqinDhr-------elIHFVFDFDRGDRLsiagneIRVPRENRFIATYDTENIKLEIDSGF 205 Methanosal...
HusnBIG:Mpsy_1159 131 -pdggSLk----------rSsdiHnsepsayaheMIHFVFDFSKDDNFflsgkeMSVPRENRFIATYDPLNFELHIDEEF 199 Methanolob...
jgi:Metev_0817    131 ------------iipGYNNQndiNed------keLIHFVFDFKKGEKVtlngysMVAPRENRFIATYDCLNIELTINPDF 192 Methanohal...
1UA4_A            216 RESFSEVIknVQLAILSGLQALTKen-----ykEPFEIVKSNLEVLN--ErEIPVHLEFAFTPDEKVREEILN-VLGMFY 287 Pyrococcus...
jgi:Maeo_0005     224 KEKLPEIGeqIDCAIFSGYQGIKEkysdgktyeYYFTKAEEDLDLLRqkNkKIKIHLEFASIQNINLRKNIINrILPKMD 303 Methanococ...
jgi:Mvol_0050     247 KTGLSELGknIDCAIVSGYQSIKEqysdgktdeYYFKRAVEDINLLKskNpNLKVHLEFASVQNPKLRKQIVEyLYSVVD 326 Methanococ...
Q6LXQ3            213 KSHLPEIGqlVDCAIISGVQAIKEeysdgktseYYLNKVKEDIKSLKkeNkDLKVHFEFASIQNTEMRKKIAEsILPEVD 292 Methanococ...
bsuwp:MCON_0234   197 DAYCQDHIqeIEGAILSGFHLAPLdr-----yrEIFPPRIEQIRSWKeaNpNIYIHVEMGSFQSPGIARHFLR-LLEKAD 270 Methanothr...
WP_013038083      190 KQYATEHIgeMDGAVVSGFHMLQSsypdgssfeEKLSPVLAQIDEWNs-MsGFFIHAELGHFATSDIAKHVFLiLAGRVD 268 Methanohal...
jgi:Metho_2034    194 EEYAIRHAgeMDGLLISGFHMMLEsypdgstfrDKLNKVMEQLNVWGhmNnDMSIHAEFGHFSNPVLAQDVFSrISPLVS 273 Methanomet...
jgi:Mzhil_0819    206 ELYAMRHIheINGGVVSGFHLLMEtypdsttysDRLEKVIMQIRSWKklNpKLKIHAECGDFSSEEIAYNVFSsLSGSVD 285 Methanosal...
HusnBIG:Mpsy_1159 200 SKYAFSNIkeIDGALIAGYHMLREtypdgsgyeGKLRRSLEQLRAWKdrNsKLHIHAELGHFSSAGIASAVFSgLAPLVD 279 Methanolob...
jgi:Metev_0817    193 KHYADEHIdeMDGALISGYHMLQEyypdgssyvDKFQKSLDQIKNWKqlNkQLLLHAELGHFSNVEIAQYVFTsLTDHVD 272 Methanohal...
1UA4_A            288 SVGLNEVEL-ASIMEI--LgekklAKELLAHd---pVDPIAVTEAMLKLAKKT-GVKRIHFHTYGYYLALT--------- 351 Pyrococcus...
jgi:Maeo_0005     304 CLGMDETEV-GNLIST--MgyeelGQKIIk-----dSKMEDVVEASKIIMETYpNLELLQVHTLYYILVMCkk-----dn 370 Methanococ...
jgi:Mvol_0050     327 CAGLDETEI-ANILNS--VgyselSEKILk-----nSKIEDVIEGSKIVLENY-NLEMIQIHTIYYIMFICkkiedkakn 397 Methanococ...
Q6LXQ3            293 CVGMDETEI-ANIIHV--LgyeelSEGILk-----hSKIEDVLKASKILLEKY-NLEGMQVHTMYYIMYLCkk-----gg 358 Methanococ...
bsuwp:MCON_0234   271 SLGLNEDELeTATAEYsaIgsstvLSTVLSTarpkmSQWQERMQKAAGLREHL-GIFRVSVHTRDYILSIMee------g 343 Methanothr...
WP_013038083      269 SMGLNEDEL-ATLTQKmgFgiegiHEMDISAm----------FQAAHNCIKSS-LARALVVHTRDFVFCLSa-------s 329 Methanohal...
jgi:Metho_2034    274 SIGMNEDEL-AMLTSIhqVdaakiLRMEVFSl----------MEAARRSIVAS-GLRKMIVHTREYILSISsq------k 335 Methanomet...
jgi:Mzhil_0819    286 SIGMNEDEL-SMIAEIyeIpskkiKEMDCKAi----------LEVTVKIMLLT-GHKKIIIHTRDFIISVFkn------n 347 Methanosal...
HusnBIG:Mpsy_1159 280 SIGINEDEL-AMLAGMynIdssgiLEMDALSi----------IRASAALCESF-GIRRILIHTREFVISVSpt------s 341 Methanolob...
jgi:Metev_0817    273 GMGMNEDEL-AMLHGIhnIpvndiLQMNAISi----------LEASLQCVLKS-GLQKFIIHTREFTLCVCkp------d 334 Methanohal...
1UA4_A            352 EYKGEHVrdALLFAALAAAAKAMKgniTslEEIREAT-SVPVNEKatQVEEKLRAEYgikegi---------gevegYQI 421 Pyrococcus...
jgi:Maeo_0005     371 PLTTKQLkkILELATILAATKAKLgeiSkvSDLLKGL-TVPHNKYn-ELFKSIVDNLqkee------------kyknYKI 436 Methanococ...
jgi:Mvol_0050     398 DIKIAQLkkSLEFATILASTKAKNgliTsiEDLKMGL-ETPYNQYg-DLLRNLVYKInestse---------ityndYNI 466 Methanococ...
Q6LXQ3            359 ILSDESLekTLEFATVLASTKAALgqiSsiEDLKTGL-KIPHNKHg-ELLKEIVENIskek------------elggYKI 424 Methanococ...
bsuwp:MCON_0234   344 KITAKEEllSLQKGADAAAALAATgsaK----------GMPPNEVnpRGLEA-QREFcrlgaeaagvgrgafhkrdgLVV 412 Methanothr...
WP_013038083      330 DNMDKEKidAIDFGLKCAAYFASSgslPdrSKLEEKCgQFKRSEYgsLQVKRIKSITgakqkgfg-----iygifneYYF 404 Methanohal...
jgi:Metho_2034    336 DILPEEQleAMGFGVACAGVFASTgqlHdrNKLWSMSsDMKESEIglGQMQRFIEATaavqlgrg-----aagtyneYQV 410 Methanomet...
jgi:Mzhil_0819    348 CSSPEVEieSMNFGIKAAATFAATgklEgrRFIESTVsNLKESSYgiDQMKKIAENIsgtiygrg-----lyavkddCTV 422 Methanosal...
HusnBIG:Mpsy_1159 342 ASESVKTfeALHFGVKCAAAFACTgklAdrNTLLAVAsGIDESETgrMQMAKLEDNIpiqyreng-----iigeyrgYSV 416 Methanolob...
jgi:Metev_0817    335 VFDAVCEleSMKFGVKCAAVFADTgilKnrNYVEKTAsKLEESDFglNEVEKIKEFIngksynng-----tygsrsgLSV 409 Methanohal...
1UA4_A            422 AFIPTKIVAKPKSTVGIGDTISSSAF 447 Pyrococcus furiosus
jgi:Maeo_0005     437 VATPSRLVDVPKSTVGLGDTISSGAF 462 Methanococcus aeolicus Nankai-3
jgi:Mvol_0050     467 VLVPSRLVNNPKSTVGLGDTISSGAF 492 Methanococcus voltae A3
Q6LXQ3            425 ILVPSRIVENPKSTVGLGDTISAGAF 450 Methanococcus maripaludis
bsuwp:MCON_0234   413 SLMPSLLAREPRITVGLGDTATAATF 438 Methanothrix soehngenii GP6
WP_013038083      405 CAIPTLVVNEPAVTVGLGDTFTASSF 430 Methanohalophilus mahii
jgi:Metho_2034    411 CMIPALLTDDPVSTVGLGDTVTASMF 436 Methanomethylovorans hollandica DSM 15978
jgi:Mzhil_0819    423 CIIPSILTEKPVSTVGLGDTVSAATF 448 Methanosalsum zhilinae DSM 4017
HusnBIG:Mpsy_1159 417 CVVPTRLCIHPVSTVGLGDTVSSAIF 442 Methanolobus psychrophilus R15
jgi:Metev_0817    410 GIIPTLISKNPISTVGLGDTFCAGTY 435 Methanohalobium evestigatum Z-7303
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