5CK7,5K27,1UA4


Conserved Protein Domain Family
ADP_PFK_GK

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pfam04587: ADP_PFK_GK (This model is not part of the current CDD release)
ADP-specific Phosphofructokinase/Glucokinase conserved region
In archaea a novel type of glycolytic pathway exists that is deviant from the classical Embden-Meyerhof pathway. This pathway utilizes two novel proteins: an ADP-dependent Glucokinase and an ADP-dependent Phosphofructokinase. This conserved region is present at the C-terminal of both these proteins. Interestingly this family contains sequences from higher eukaryotes.
Statistics
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PSSM-Id: 516330
Aligned: 61 rows
Threshold Bit Score: 295.66
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5CK7_A        36 RRVAVGVNACVDVV------ISGVKLLQALGLS---PGSGKDHAILHSRSDLEEAFLYFMGKGAAAERFFS-DKETFHDI 105 house mouse
WP_013194282  25 KGIFVAYNSNIDAIkhi-ekDDFDKLLKHVNLKnvkHRSMSFPRVIKDPDDLMARLVIAMRDGKAAEVPTY-STDVHEWL 102 Methanohalobium...
WP_013038084  25 NGIFVAYNSNVDAIkhi-gpGDVENLLRKVDADivqQRIYSYPRQIDSPADFLARLLIAMKDGKAAEIPTY-STDIHEWL 102 Methanohalophil...
WP_015325369  25 NGIFVAYNSNVDAIkhv-teKDIHKLISIVGAKavqQRIAGYPREVQDPVDLLARLVIAMRDGKAAEVPTY-TTDIHQWL 102 Methanomethylov...
P58847        25 DGMFVAYNSNIDAIrhl-teEDLSKLVGFFDESdiqDRVAAYPREIAEPLDFVARLLISMREGKAAEVPAY-TADIHEWL 102 Methanosarcina ...
Q9V2Z7         8 LGIYTAYNANVDAIvnl-naEIIQRLIEEFGPDkikRRLEEYPREINEPLDFVARLVHALKTGKPMAVPLV-NEELHQWF 85  Pyrococcus furi...
Q5JD05        12 LSMFTAYNTNVDAIvyl-ngETVQRLIDEFGAEavkRRMEEYPREINEPLDFVARLVHALKTGKPMAVPLV-NEELQAWF 89  Thermococcus ko...
Q58999        17 TKLFTAYNTNVDAIkyl-kdEDVQKLVDEFNHKdiiERMEEYPRIIEEPLDFVARLVHSIKTGKPAEVPIKdDKKLHEWF 95  Methanocaldococ...
Q6LXQ3        13 VSIFLAYNVNVDALkyltdlSDIEELKENFSDSeikTKIEEYPRTIEKPIDFVARLIHAMKSGKPAEVPLKnNLEIDTFL 92  Methanococcus m...
5K27_A        28 isIFLAYNVNVDAIkyl-keEDIQKLIEEFGEEeiiEKIEEYPRKIKEPLDFVARLIHAIKTGKPAEVPLD-NEELNKWF 105 synthetic const...
5CK7_A       106 AQAasEFPGAQhYVGGNAALIGQRFAaNTDL-K-VLLCG-PI-GPKLHELLDD---------N------VF-----V--- 158 house mouse
WP_013194282 103 TN---HIDFDNaYMGGQAGIISNFLA-NIDIkN-VVTYVpWL-SKEQAEYFTN---------SknllypVVensklSfkh 167 Methanohalobium...
WP_013038084 103 TD---NLVFDEaRMGGQAGIISNLLA-NMDLnN-VIAYIpWL-SPEQADYFVS---------SpnllhpFVregrmEllp 167 Methanohalophil...
WP_015325369 103 MD---NLVFDKaRMGGQAGIISNLLA-NLGIkN-VITYVpWL-SREQAEYFVD---------SpnlkypVIedgvlKlrh 167 Methanomethylov...
P58847       103 KE---HLGFDYaRMGGQAGIISNLLG-RLGLkK-VVAYVpWL-SEEQAEYFTA---------TgnilhpKVengkvLlkp 167 Methanosarcina ...
Q9V2Z7        86 DK---TFKYDTeRIGGQAGIIANILV-GLKVkK-VIAYTpFL-PKRLAELF-----------KegilypVVeedklVlkp 148 Pyrococcus furi...
Q5JD05        90 DS---HFKYDVeRMGGQAGIIANLLA-NLDFrE-VLVYTpHL-AKRQAEMFVK---------KpnlfypVVeggklVlkh 154 Thermococcus ko...
Q58999        96 D----RIKYDEeRMGGQAGIVSNLMA-TLQIdK-IIVYTpFL-SKKQAEMFVD---------YdnllypLVengnlVlkk 159 Methanocaldococ...
Q6LXQ3        93 N----RLTYNEeRIGGQVGIISNLLS-ILNLkK-IIFYSpIL-AKKQAEMFEN---------NenlvfpNItngklVlkk 156 Methanococcus m...
5K27_A       106 DSL---FKYDEeRMGGQVGIIANLLA-ILDL-KkVIAYS-PLlSKKQAEMFNNdllypivenG------KL-----Vlkk 168 synthetic const...
5CK7_A       159 PPEsl--qeED--EFHLILEYLAGEEW----GP-FKAPHANRFIFSHDLSNG-AMNMLEVFVSSLEEFQ--PDLVVLSGL 226 house mouse
WP_013194282 168 PINaynpeyEP--KVNWIMEFSKGLEVqc-gEEeFVVPRDNRLILSSRPTWL-RIDMSKELYEQLPELGknVDGAILSGY 243 Methanohalobium...
WP_013038084 168 PAEacnpdyKA--KVNWIIEFNKGLSVky-aEDrIIVPRNNRLIISSRPPWV-RIDMSDEVYEHLPEMGktVDGAILSGY 243 Methanohalophil...
WP_015325369 168 PSEaydpdqRP--KVNWILEFSKGTKVey-yEDsFEVPRDNRLIISSRPSWL-RIDMSEQLYDQIPHMNgvIDGAILAGY 243 Methanomethylov...
P58847       168 PGEafkpgiGS--KVNWILEYSKDMNVtc-aGNtFKVPRDNRLIISSRPKWL-RLDMDKQIYEQLDTLLp-VDGAMLSGY 242 Methanosarcina ...
Q9V2Z7       149 IQSayregdPL--KVNRIFEFRKGTRFkl-gDEvIEVPHSGRFIVSSRFESIsRIETKDELRKFLPEIGemVDGAILSGY 225 Pyrococcus furi...
Q5JD05       155 PWEayrendPV--KVNRIFEFRAGTTFrl-gNEtITVPFSGRFIVSARFESI-RIYTEPELKPFLPEIGqrVDGAILSGY 230 Thermococcus ko...
Q58999       160 VREayr-ddPI--KINRIFEFKKGLKFkl-nGEeITAKQSTRFIVASRPEAL-RIEIKDDVRKFLPKIGeaVDCAFLSGY 234 Methanocaldococ...
Q6LXQ3       157 PIEsfkndeL---KINRIFEYKEDIEFyl-eNEkITTPQSNRFIVASRPENL-RIEIKDELKSHLPEIGqlVDCAIISGV 231 Methanococcus m...
5K27_A       169 PIEay--kdNDpiKINRIFEFKEGIKFklgdEK-IIAPQANRFIVASRPENLaRIEIKEDLKKYLPEIGemVDCAILSGY 245 synthetic const...
5CK7_A       227 HMMEGQSKElq--rKRLLEVVTAISDIPt---GIPVHLELASMTNRELMSSIVHQVFPA-VASLGLNEQELLFLSQSAs- 299 house mouse
WP_013194282 244 QMIKENYEDgstyhNYVKKSVDAIKRLKngnpDIRIHVEFTSIQDKFIRERILKDIVSQhVHSLGLDTIEVANALNVLdy 323 Methanohalobium...
WP_013038084 244 QMIKEEYEDgktyrDYIARAVGAIGQLKkanpDICIHVEFTSIQNKFIRSAILNDIVRNhVHSLGLDTVEVANALNVLgy 323 Methanohalophil...
WP_015325369 244 QMIKEKYEDgttyrDYVKKAVQVIKRLKegnpDMRIHVEFTSIQNKVIRKTILKDIVYKhVSSLGLDTVEVANALNVLgh 323 Methanomethylov...
P58847       243 QMIKEEYEDgstykDYVENSVKVIEKLKslnpELRIHVELTSIQNRLIRKAILTEIVARhVHSLGLDTVEVANALNVLgh 322 Methanosarcina ...
Q9V2Z7       226 QGIRLQYSDgkdanYYLRRAKEDIRLLKkn-kDIKIHVEFASIQDRRLRKKVVNNIFPM-VDSVGMDEAEIAYILSVLgy 303 Pyrococcus furi...
Q5JD05       231 QGIKLRYSDgkdanYYLREAKKDILLLKre-kDVKVHLEFASIQNRELRKKVIYNLFPL-VDSVGMDEAEIAYVLSALgy 308 Thermococcus ko...
Q58999       235 QAIKEEYRDgktakYYFERAEEDIKLLKkn-kNIKTHLEFASISNIEIRKMVVDYILSN-VESVGMDETEIANVLHILgy 312 Methanocaldococ...
Q6LXQ3       232 QAIKEEYSDgktseYYLNKVKEDIKSLKkenkDLKVHFEFASIQNTEMRKKIAESILPE-VDCVGMDETEIANIIHVLgy 310 Methanococcus m...
5K27_A       246 QGIKEKYSDgktaeYYFKRAKEDIKLLKk--kDIKVHLEFASIQNIKIRKKVVDYILPN-VDSVGMDETEIANILNILg- 321 synthetic const...
5CK7_A       300 --gPHSSLSS-WDgvPDVGMVSDILFWILKEHGrsenRSSDLTRIHFHTLVYHILATvDGH-WANQLA--AVAAGARVAG 373 house mouse
WP_013194282 324 eelAYAVINKt---eKGISALYEGAVRLLY-------EL-ELERVHVHSLGYFICVVkNTHpVDIEDHrnALLFASTASA 392 Methanohalobium...
WP_013038084 324 eelAYSVIKKe---eDAIVALYEGAVRLLH-------EL-KLQRIHVHSLGFYICVVsKDCpIDVEQHldSLLFASTTAA 392 Methanohalophil...
WP_015325369 324 eelAYAVISKg---eNSISALYEGAVKLLC-------EL-KLERVHIHCLGFYICVAcRDFpLSVEEHrdALMFSSTLAA 392 Methanomethylov...
P58847       323 eelSYSVIRKg---eNGIMSLYQGAVQLMK-------DL-DLERVHVHSLGFYICILaKGHpLTLKEHrdSLLFSSVLAA 391 Methanosarcina ...
Q9V2Z7       304 sdlADRIFm-----yNRIEDAILGGMIILD-------EL-NFEILQVHTIYYLMYIThRDNpLSEEELmrSLDFGTILAA 370 Pyrococcus furi...
Q5JD05       309 dklAERIFt-----yNRIEDTVLGGKILID-------EM-NLELLQIHTIYYIMYIAhANNpLSEAELrqSLELATTLAA 375 Thermococcus ko...
Q58999       313 delSNNILk-----dSFIEDVIEGAKILLD-------KFKNLEVVQVHTIYYILFVCrADNpLSKEELeeCLEFSTILAS 380 Methanocaldococ...
Q6LXQ3       311 eelSEGILk-----hSKIEDVLKASKILLE-------KY-NLEGMQVHTMYYIMYLCkKGGiLSDESLekTLEFATVLAS 377 Methanococcus m...
5K27_A       322 --yEELSEKIlKDs--kIEDVIEGAKILLDKFN--------LEVVQVHTIYYILFISkKDNpLSKEELkkTLEFATILAA 389 synthetic const...
5CK7_A       374 TQACA---TetidtNRVSLRApqefttshlesgsRIVLNPD--KPV----VEWHREG--------------------ITF 424 house mouse
WP_013194282 393 AKAKIgniKs---iDDIKKGL-------------GTPVSEKgyNHL----QELAKYLekegiclteefekgyirtpyHDV 452 Methanohalobium...
WP_013038084 393 ARALQggiNs---fEDIKAGL-------------DVPISTQgmDQI----DKLGAYLirqgkcnledfekgcictrnHDV 452 Methanohalophil...
WP_015325369 393 AQALHggiGs---lREGEIGL-------------SVPISSQghHDL----DQLEKYLvrrdvctgtefedgcvcaltHDL 452 Methanomethylov...
P58847       392 AQALNgniEn---lAEAEAGL-------------EVPVSSIglEDL----ENFQLYCtgrklctpdefeygyvygseHDA 451 Methanosarcina ...
Q9V2Z7       371 TRASLgdiNd---pRDVKVGM-------------SVPYNERs-EYI----KLRFEEAkrkl------------rlkeYKV 417 Pyrococcus furi...
Q5JD05       376 SRASLgdiAs---pDQISVGM-------------NVPYNERg-EYV----KLRFEEAkrrl------------rtkeYKL 422 Thermococcus ko...
Q58999       381 TKAKLgniRa---iDDLHEGL-------------KIPHNKYg-DLL----KEIAEKFnd----------------nnYKI 423 Methanocaldococ...
Q6LXQ3       378 TKAALgqiSs---iEDLKTGL-------------KIPHNKHg-ELL----KEIVENIskek------------elggYKI 424 Methanococcus m...
5K27_A       390 TKAKL---GdikniEDLKVGL-------------KVPHNKY--GELlkeiVEKLKKKkkk---------------edYKI 436 synthetic const...
5CK7_A       425 HFTPVLVCKDPVRTVGLGDAISAEGLFY 452 house mouse
WP_013194282 453 IIIPTKVVEKPVATVGIGDIISASAFAA 480 Methanohalobium evestigatum
WP_013038084 453 LIIPTRVVDHPVDTVGIGDTISASAFAA 480 Methanohalophilus mahii
WP_015325369 453 IVIPSKVVPDPVATVGIGDTISAGAFVA 480 Methanomethylovorans hollandica
P58847       452 ILIPSKVVERPKATVGIGDTISAGAFVA 479 Methanosarcina acetivorans C2A
Q9V2Z7       418 VIVPTRLVPNPVSTVGLGDTISTGTFLS 445 Pyrococcus furiosus DSM 3638
Q5JD05       423 VIIPTRLVQNPVSTVGLGDTISTGAFTS 450 Thermococcus kodakarensis KOD1
Q58999       424 ALSPSRYVEKPKSTVGLGDTISSGAFVY 451 Methanocaldococcus jannaschii DSM 2661
Q6LXQ3       425 ILVPSRIVENPKSTVGLGDTISAGAFVG 452 Methanococcus maripaludis
5K27_A       437 VLIPSRFVENPKSTVGLGDTISTGAFVs 464 synthetic construct
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