7P2P


Conserved Protein Domain Family
SPC22

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pfam04573: SPC22 (This model is not part of the current CDD release)
Signal peptidase subunit
Translocation of polypeptide chains across the endoplasmic reticulum membrane is triggered by signal sequences. During translocation of the nascent chain through the membrane, the signal sequence of most secretory and membrane proteins is cleaved off. Cleavage occurs by the signal peptidase complex (SPC) which consists of four subunits in yeast and five in mammals. This family is common to yeast and mammals .
Statistics
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PSSM-Id: 516325
Aligned: 89 rows
Threshold Bit Score: 135.38
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7P2P_B         2 MNTVLSRANSLFAFSLSVMAALTFGCFITTA-FKdrsvpVRLHVSRIMLKNVE---------DFTGPr--ERSDLGFITF 69  human
A0BS79         1 MYSITARFNQIVFFTSWTLVVLSLLNQGTAYfFK-------TGKPTVDLKILSadkfqhykaTYYNGg-aTDWDQVTFKF 72  Paramecium tetr...
XP_002141553   1 MESTLSRINILVCTFVAALATCAAGNFVTSLfYKp---nPSGVVEFHSVLDIG-------------IspyLRNDQANIAF 64 
Q8I3A5         1 MDSFLNRLNVLFYSMALCFLILCAFNYGTSFyLFd----EKEIKTNIQVKSIK---------RFVYNr-yINADEAVLSL 66  Plasmodium falc...
Q4UAJ0         1 MMNFLSRSYSVLHAGAMIGLIALFLNYYTGVnLR------TNKHMIGDVKHIK---------THELTldkSKVDRALIEL 65  Theileria annulata
XP_006680536   1 MHDLQSRISAIASFFLTVLATQFSLVALLQLvLVfs--kSAIVVNSFEPARVKlvsgrvgggDYYMYg-sPYTNLGVISF 77 
B0G180         1 MHSLSQRANTIVCFGGIVLVGVLLLNVLSRAfFSd---hVDVDIKLNEIHRFNt---------------qRNFEYSFISI 62  Dictyostelium d...
Q57ZR2         1 MHSLWVRVAEICSMAMMSCFTGVMLLVASSIvMSql-qpPKPIIKDFNVGISPlvqtrlplvFAQGEyppPMQDVLLVGI 79  Trypanosoma brucei
XP_034420227   1 MDSLLNRINVIFYSMALCFVTLCLFNYGTSFyLFd----ENSIVTDVKVKSVK---------RLVYNk-yINGDEAVLSL 66  Plasmodium berg...
XP_001614583   1 MDNVLNRLNVLSYSMALCFFTLCLFNYGTSFyLFd----EKEMSTSIKVKSVK---------RLVYNr-hIKGDEAVLSL 66  malaria parasit...
7P2P_B        70 DITADLENIFDWNVKQLFLYLSAEYSTKN----NALN-----QVVLWDKIVLR-GDN------P-KLLLKDMKTkYFFFD 132 human
A0BS79        73 SLEADFEPVYNWNLKQLFLYVNVHHEHQQk---GYES-----DCVIYDKIISR-PDDpsswstSsKLVLKNQRAeYPLKD 143 Paramecium tetr...
XP_002141553  65 NMKISLKDIFQWNTNQLFVYVYATYQNQD----TPIN-----NVIIWDHIISNpKLD------A-NSDLIGIINeYPIRD 128
Q8I3A5        67 DVSYDMRKAFNWNLKQLFVYVLVTYETPK----KIKN-----EVIIQDYIVKN-KKQ------A-KKNYRNFITkYSLKD 129 Plasmodium falc...
Q4UAJ0        66 NMRYDLRGAFDWSTHMIFIYVTANYITNR----HERS-----EVIIFDKIINN-KSE------A-YQPSINIFAkYFLYD 128 Theileria annulata
XP_006680536  78 DLDADLSSYFQWNTKLLFVSAIVEFTNSQ----YHVN-----QAVIWDDLISD-KED------A-VIVLKNQRHeYQVHD 140
B0G180        63 DLDANLEPLFNWNTKMLFLYVTAEYRTKQ----NVLS-----QVVVWDHILTE-KSK------A-NIH-EKRLSkYPIIN 124 Dictyostelium d...
Q57ZR2        80 SLKADFSAVWDWNTKHMYVACIGRYHTKSnmtvGGVNlqkthDVTIFDKVLRS-KEE------AaNWTLDNAKK-YALEN 151 Trypanosoma brucei
XP_034420227  67 DLSYDMTKAFNWNLKQLFVYVLVTYKTPE----KAEN-----EVIIQDYIINN-KKS------A-KKTYKNFITkYSLKD 129 Plasmodium berg...
XP_001614583  67 DLSYDMSKAFNWNLKQLFLYVLVTYETPE----KVKN-----EVIIQDYIITN-KKM------A-KKTHKNFFTkYSLKD 129 malaria parasit...
7P2P_B       133 DGN-GLKGnRNVTLTLSWNVVPNAGILPLVTGS---GHVSVPFPDT 174 human
A0BS79       144 IHK-QLRN-ATVNFEVWIEVMPYVGYIRREKL----GDFEYKMPQQ 183 Paramecium tetraurelia
XP_002141553 129 IGR-HLRN-QKFKLNIAYCYMPIVGFIHYKQLG---TSKMAKLPSH 169
Q8I3A5       130 YYN-GLRN-NLIHLQVCYKYMPIVGFSRSFEG----AKISYQLPPE 169 Plasmodium falciparum 3D7
Q4UAJ0       129 FGR-SLRN-RDISLKFFYELVPIGGFIKQYQL----SHNKFTMPKQ 168 Theileria annulata
XP_006680536 141 LTN-SLAN-SKANLTLQLQVVPWVGVMRTYRHV---VADGITFPDA 181
B0G180       125 QGL-GLKN-NTIKLTFNYNVVPISGILTRHQV----GTSEFKFPTT 164 Dictyostelium discoideum
Q57ZR2       152 EELgSLAG-AAVELMILYHPMRHYGYSPYYTVQpgkNPVMFQLPTA 196 Trypanosoma brucei
XP_034420227 130 YYN-GLRN-NLINIQVCYKYMPLIGLSRTYHG----AKTSYMMPDE 169 Plasmodium berghei ANKA
XP_001614583 130 YNN-GLRN-NNINLQVCYKYMPIVGLSRSYEG----AKISYKLPAE 169 malaria parasite P. vivax
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