Conserved Protein Domain Family
Lipin_N

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pfam04571: Lipin_N 
lipin, N-terminal conserved region
Mutations in the lipin gene lead to fatty liver dystrophy in mice. The protein has been shown to be phosphorylated by the TOR Ser/Thr protein kinases in response to insulin stimulation. The conserved region is found at the N-terminus of the member proteins.
Statistics
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PSSM-Id: 398325
Aligned: 47 rows
Threshold Bit Score: 142.276
Threshold Setting Gi: 667639715
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_011660375   1 MNYVGRL----ISGVKTFYSEINPATLTGAIDVIVVQQPDGSLVCSPFHVRFGKM-GVLRSREKIVDIQINGEPVDLYMK 75   purple sea urchin
Q8SWG3         1 MGIVHKL----ITSVSGLYNNINPITLSGVNDVIVVEDKDGNLRCTEFQLRFGRL-YFYGINNQTVHLFVNGKMCDITMS 75   Encephalitozoo...
XP_008089491   1 MQYVRNL----SASVSSTWNSINPATLSGAIDVIVVEQEDGTLACSPFHVRFGKF-SLLRPYEKKVEFKVNGVKQDYSMK 75   Colletotrichum...
XP_003852942   1 MQYVRAV----SGAVSSTWNSINPATLSGAIDVVVVEQADGSLACSPFHIRFGKF-SLLRPHEKKVEFRVNGEKKDFPMK 75   Zymoseptoria t...
EER34385       1 MQYVGKV----GDYVYSQWNSLNPATLSGAIDVIVVEHPDGTLHTSPWHVRFGVL-QIAKPSQKKIDLYVNGTKTNLPMK 75   Candida tropic...
ABN64273       1 MQYVGKV----GGYVYNQWNSLNPSTLSGAIDIIVVEQPDGTLHCSPWHVRFGKF-QIIKPSQKKIDLYVNDVKTDLPMK 75   Scheffersomyce...
KRH51975       1 MQAVGRi---iSQGVVRFSGPFHP--FGGAVDIVVVEQKDGTFKSSPWYVRFGKFqGVLKAREKVVDICVNGVQADFQMH 75   soybean
KRG95867       1 MNVVGKVgsliTQGVYSVATPFHP--FGGAVDVIVVQQQDGTFRCTPWYVRFGKFqGVLKGAEKIVRINVNGIEANFHMY 78   soybean
XP_006339049   1 MNVVGKVssfiTQGVYSVATPFHP--FGGAVDIIVVKQNDETFRSTPWHVRFGKFqGVLKGAEKVVRIEVNGVEADFHMY 78   potato
Q9SF47         1 mslVGRVgsliSQGVYSVATPFHP--FGGAIDVIVVQQQDGSFRSTPWYVRFGKFqGVLKGAEKFVRISVNGTEADFHMY 78   thale cress
XP_011660375  76 LGESGEAFFVEEI-----EEEDNVPDHLATSP 102  purple sea urchin
Q8SWG3        76 ITSQGELFFEKDTeddlgIDYDVILEYNNKLs 107  Encephalitozoon cuniculi
XP_008089491  76 LGEEGEAFFVFET-------SDTIPRDLQTSP 100  Colletotrichum graminicola M1.001
XP_003852942  76 LGEGGEAFFVFET-------QDSVPEALQTSP 100  Zymoseptoria tritici IPO323
EER34385      76 LSEGGEAHFVFELe----GDHPGLSQHVLTSP 103  Candida tropicalis MYA-3404
ABN64273      76 LGDGGEGFFVFET-----DSRDGLSQSVLTSP 102  Scheffersomyces stipitis CBS 6054
KRH51975      76 LDHTGEAFFLREId----AQGQEEEDAILMFP 103  soybean
KRG95867      79 LDNSGEAYFVKEVd----DDCGDKGIKSNGSP 106  soybean
XP_006339049  79 LDNSGEAYFIREVv---aDNVNEVNGDIRDSA 107  potato
Q9SF47        79 LDNSGEAYFIREVd----PAANDTNNLISGSE 106  thale cress
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