8YQT


Conserved Protein Domain Family
RNA_pol_Rpb2_7
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pfam04560: RNA_pol_Rpb2_7 (This model is not part of the current CDD release)
RNA polymerase Rpb2, domain 7
RNA polymerases catalyze the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Rpb2 is the second largest subunit of the RNA polymerase. This domain comprised of the structural domains anchor and clamp. The clamp region (C-terminal) contains a zinc-binding motif. The clamp region is named due to its interaction with the clamp domain found in Rpb1. The domain also contains a region termed "switch 4". The switches within the polymerase are thought to signal different stages of transcription.
Links
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Statistics
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PSSM-Id: 516314
Aligned: 46 rows
Threshold Bit Score: 105.734
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
8YQT_B       1143 GGLRLGEMEHWVLTAQGAMQTIIEKSHDDSDgcisYICRNCGEPAIynashp-iykcmNCDVQADIGMVdSRRSSIVFQH 1221 African swine...
P08518       1126 GGLRFGEMERDCMIAHGAASFLKERLMEASDafrvHICGICGLMTViaklnhnqfeckGCDNKIDIYQIhIPYAAKLLFQ 1205 Saccharomyces...
XP_009156909 1168 GGLRFGEMERDCMIAHGASSFLKERLFDVSDpfrvHVCDICGLMTViaklkkntfeckNCNNKNKISQIyLPYAAKLLFQ 1247
P30876       1082 GGLRFGEMERDCQIAHGAAQFLRERLFEASDpyqvHVCNLCGIMAIantrth-tyecrGCRNKTQISLVrMPYACKLLFQ 1160 human
P08266       1084 GGLRFGEMERDCQISHGAAQFLRERLFEVSDpyrvHICNFCGLIAIanlrnn-tfeckGCKNKTQISQVrLPYAAKLLFQ 1162 fruit fly
P25167       1049 GGLRLGEMERDCLISYGASMLIMERLMISSDafevDVCRTCGRMAYcsw-------chFCQSSANVSKIsMPYACKLLFQ 1121 fruit fly
Q9NW08       1043 GGLRLGEMERDCLIGYGASMLLLERLMISSDafevDVCGQCGLLGYsgw-------chYCKSSCHVSSLrIPYACKLLFQ 1115 human
Q27492       1064 GGLRLGEMERDCLIAYGASMLLIERLMVSSDefkvDVCTGCGVIGSkgw-------cqKCRSSKSMANIkIPYACKLLFQ 1136 Caenorhabditi...
Q10233       1074 GGLRLGEMERDCLIAYGASQLLLERLMISSDacdvDVCGQCGLLGYkgw-------cnSCQSTREVVKMtIPYAAKLLFQ 1146 Schizosacchar...
XP_003392438 1043 GGLRVGEMERDCMVGYGASNLLNERLLISSDmftaDICHVCGNLGYnnr-------ctYCKTKGTTSKVnMPYAFKLLIQ 1115

8YQT_B       1222 EMRAANVNITSVLS 1235 African swine fever virus
P08518       1206 ELMAMNITPRLYTD 1219 Saccharomyces cerevisiae S288C
XP_009156909 1248 ELWAMNIAARLYTK 1261
P30876       1161 ELMSMSIAPRMMSV 1174 human
P08266       1163 ELMSMNIAPRLMVT 1176 fruit fly
P25167       1122 ELTSMNVVPKMILE 1135 fruit fly
Q9NW08       1116 ELQSMNIIPRLKLS 1129 human
Q27492       1137 ELQSMNIVPRLDLA 1150 Caenorhabditis elegans
Q10233       1147 ELLSMNIVPRLALE 1160 Schizosaccharomyces pombe 972h-
XP_003392438 1116 ELQGMGVSLRLTMD 1129
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