Conserved Protein Domain Family
tRNA_synt_1c_R1

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pfam04558: tRNA_synt_1c_R1 
Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1
This is a region found N terminal to the catalytic domain of glutaminyl-tRNA synthetase (EC 6.1.1.18) in eukaryotes but not in Escherichia coli. This region is thought to bind RNA in a non-specific manner, enhancing interactions between the tRNA and enzyme, but is not essential for enzyme function.
Statistics
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PSSM-Id: 398315
Aligned: 123 rows
Threshold Bit Score: 134.627
Threshold Setting Gi: 505754660
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CCX04759        13 PLFAALGLGPKALKEATLNKKVAATWEEVLKEGGVDEsttAIDPKAGTALTELVAATAkgdGNLAGKREFVVKQILEGKI 92  Pyronema omph...
ESX01400         7 SLFSRIGFQESKAREILKNQKVSSSLAHLIQLAGDNVs---wDKTKSTLLHHLATLLK---GEDLPHDKNIVDAITDGRL 80  Ogataea parap...
CCD27477        12 EQFSQIGFEDAKVKEITKNKKVSDSLSQLISQAPKDYq---wNKSTRALVHNLATLIK---GSSLDKSELIVNGIINEDL 85  Naumovozyma d...
CAR27022         9 KLFTSVGFEEPKVKEIVRNKKLSESLYDLIKEAPAETq---wEKSTRGQVQNLATFTK---GEPLPKSKLIVDGIANKEL 82  Zygosaccharom...
CCE64878         9 SLFSAVGFEDGKVKEIVKNKKVSEALAQFLAQAPADYk---wGKTERALVHNLASSAK---GAELPGSELIVNGIVIGDL 82  Tetrapisispor...
Q6CJ91           9 NLFSKIGFEEAKVKEILKNAKVSSSLESLVNLASDDFp---wNKNSRALIHTLAASLK---GAEVPHLQYIVDGIGKNDL 82  Kluyveromyces...
ybcl:Ecym_3135   9 EVFSNIGFEEPKIKEILKNKKVSHSLETLIKNAPSDFn---wDKSSRALLHTLASFLK---GSELSNQNLIVQGIVKGDL 82  Eremothecium ...
Q74ZE0           9 QLFADVGFEEAKVKEIVKNKKVAHSLEELVREAGARAe---wDKGKRALLHTLASSLK---GATVTGQNLVAEGIRSGEL 82  Eremothecium ...
XP_007872899     7 KAFRAIGLSDLKIKETLKNDKLSYILFENVMHTDILNs--GCTKIQGNLLYILSTHGG---SLGEYGRSYICDAIMLNKL 81  Pneumocystis ...
XP_018229967    14 NAFRLIGLSDLKIQETLKNTKLSKLLAQNVLQAGVLVs--GCTKTQGKLLYILSTSGR---LLGECGRDYICRGIMSNKF 88  Pneumocystis ...
CCX04759        93 KTKPQVAEAVKYCrENKDKQVDEEfvkGFERECGVGIEFTAESLTAAVAEYIEKIKADIEEQRYKGLPATLVAIKn-TAL 171 Pyronema omph...
ESX01400        81 VSTLQVTEAYKYV-KSAGDNFDEK---EMEKSSGVGIKITEEDVENAIRRYIESIKAEFLEKRYKMVPNVLGSVRslPEL 156 Ogataea parap...
CCD27477        86 KTNLQISAAFKYI-KAKGTDATQV---EMNENSGVGIVVTDDDVRKSVQNYIEENKEAILEQRYKLVPGLFANIKnlPEL 161 Naumovozyma d...
CAR27022        83 KTNLQVEEAYKYV-KENGEKATKQ---GLNEHAGVGAEVSDEQVRASVAKYIEDNKEKIVTERYKLVPGIMADVKklPEL 158 Zygosaccharom...
CCE64878        83 KTAMQVTAAFKYV-KSEGSNATVE---KMNEESGVGIEVTEDQVRARVAKYIEDDKEKILAERYKLVPGLFANIKnlPEL 158 Tetrapisispor...
Q6CJ91          83 KTALQIDAALKYL-KTKGEDATVV---DLNKESGVGIEVTEDQVRNRVAKYVEDNKDTILKERYKLVPGLFAKIKalPEL 158 Kluyveromyces...
ybcl:Ecym_3135  83 KTVLQVDAAYKYV-KRASENASLD---EMNVESGVGIDVSEEEATRHVVNYLEANKERVIAERYKLVPSIFAEVKslPEL 158 Eremothecium ...
Q74ZE0          83 KTSLQVDAALKYV-KRAGEGATVA---EMHAESGVGVQVTEDQVQARVVQYLEENRAKIESERYKLVPGIFAQIKalPEL 158 Eremothecium ...
XP_007872899    82 QTTLQVKTAISYL-MDCNCVFDSD---SFDKACGVGVIMNEEDILSEVQAYINENKERICSIGIKKVGAVLSTLRqvPAL 157 Pneumocystis ...
XP_018229967    89 QTALQVETAIRYA-LDKNDVFDSD---LLDKASGVGITINEKELHYEVHTYIKNNRKAIKGAMSKKVALVLSSLRqhPLL 164 Pneumocystis ...
CCX04759       172 KWAPA 176 Pyronema omphalodes CBS 100304
ESX01400       157 KWASP 161 Ogataea parapolymorpha DL-1
CCD27477       162 KWADP 166 Naumovozyma dairenensis CBS 421
CAR27022       159 KWADP 163 Zygosaccharomyces rouxii
CCE64878       159 KWAEP 163 Tetrapisispora phaffii CBS 4417
Q6CJ91         159 KWAEP 163 Kluyveromyces lactis
ybcl:Ecym_3135 159 KWAEP 163 Eremothecium cymbalariae DBVPG#7215
Q74ZE0         159 KWADP 163 Eremothecium gossypii
XP_007872899   158 KWADP 162 Pneumocystis murina B123
XP_018229967   165 KWADQ 169 Pneumocystis jirovecii RU7
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